Atlas of Genetics and Cytogenetics in Oncology and Haematology

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IFNA1 (interferon alpha 1)

Identity

Alias (NCBI)IFL
IFN
IFN-ALPHA
IFN-alphaD
IFNA13
IFNA@
leIF D
HGNC (Hugo) IFNA1
HGNC Alias symbIFNA@
IFL
IFN
IFN-ALPHA
IFNA13
IFN-alphaD
HGNC Alias nameIFN-alpha 1b
 interferon alpha 1b
LocusID (NCBI) 3439
Atlas_Id 40920
Location 9p21.3  [Link to chromosome band 9p21]
Location_base_pair Starts at 21440439 and ends at 21441316 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  T-lineage acute lymphoblastic leukemia (T-ALL)

External links

Nomenclature
HGNC (Hugo)IFNA1   5417
Cards
Entrez_Gene (NCBI)IFNA1  3439  interferon alpha 1
AliasesIFL; IFN; IFN-ALPHA; IFN-alphaD; 
IFNA13; IFNA@; leIF
GeneCards (Weizmann)IFNA1
Ensembl hg19 (Hinxton)ENSG00000197919 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000197919 [Gene_View]  ENSG00000197919 [Sequence]  chr9:21440439-21441316 [Contig_View]  IFNA1 [Vega]
ICGC DataPortalENSG00000197919
TCGA cBioPortalIFNA1
AceView (NCBI)IFNA1
Genatlas (Paris)IFNA1
WikiGenes3439
SOURCE (Princeton)IFNA1
Genetics Home Reference (NIH)IFNA1
Genomic and cartography
GoldenPath hg38 (UCSC)IFNA1  -     chr9:21440439-21441316 +  9p21.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)IFNA1  -     9p21.3   [Description]    (hg19-Feb_2009)
GoldenPathIFNA1 - 9p21.3 [CytoView hg19]  IFNA1 - 9p21.3 [CytoView hg38]
ImmunoBaseENSG00000197919
genome Data Viewer NCBIIFNA1 [Mapview hg19]  
OMIM147660   
Gene and transcription
Genbank (Entrez)AB578886 BC074928 BC074929 BC112300 BC112302
RefSeq transcript (Entrez)NM_024013
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)IFNA1
Alternative Splicing GalleryENSG00000197919
Gene ExpressionIFNA1 [ NCBI-GEO ]   IFNA1 [ EBI - ARRAY_EXPRESS ]   IFNA1 [ SEEK ]   IFNA1 [ MEM ]
Gene Expression Viewer (FireBrowse)IFNA1 [ Firebrowse - Broad ]
GenevisibleExpression of IFNA1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3439
GTEX Portal (Tissue expression)IFNA1
Human Protein AtlasENSG00000197919-IFNA1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP01562   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP01562  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP01562
Splice isoforms : SwissVarP01562
PhosPhoSitePlusP01562
Domaine pattern : Prosite (Expaxy)INTERFERON_A_B_D (PS00252)   
Domains : Interpro (EBI)4_helix_cytokine-like_core    Interferon_alpha/beta/delta   
Domain families : Pfam (Sanger)Interferon (PF00143)   
Domain families : Pfam (NCBI)pfam00143   
Domain families : Smart (EMBL)IFabd (SM00076)  
Conserved Domain (NCBI)IFNA1
DMDM Disease mutations3439
Blocks (Seattle)IFNA1
PDB (RSDB)3UX9   
PDB Europe3UX9   
PDB (PDBSum)3UX9   
PDB (IMB)3UX9   
Structural Biology KnowledgeBase3UX9   
SCOP (Structural Classification of Proteins)3UX9   
CATH (Classification of proteins structures)3UX9   
SuperfamilyP01562
Human Protein Atlas [tissue]ENSG00000197919-IFNA1 [tissue]
Peptide AtlasP01562
HPRD00974
IPIIPI00003072   IPI00604550   
Protein Interaction databases
DIP (DOE-UCLA)P01562
IntAct (EBI)P01562
FunCoupENSG00000197919
BioGRIDIFNA1
STRING (EMBL)IFNA1
ZODIACIFNA1
Ontologies - Pathways
QuickGOP01562
Ontology : AmiGOadaptive immune response  T cell activation involved in immune response  natural killer cell activation involved in immune response  cytokine activity  type I interferon receptor binding  extracellular region  extracellular space  humoral immune response  blood coagulation  cytokine-mediated signaling pathway  B cell differentiation  positive regulation of peptidyl-serine phosphorylation of STAT protein  B cell proliferation  response to exogenous dsRNA  defense response to virus  type I interferon signaling pathway  
Ontology : EGO-EBIadaptive immune response  T cell activation involved in immune response  natural killer cell activation involved in immune response  cytokine activity  type I interferon receptor binding  extracellular region  extracellular space  humoral immune response  blood coagulation  cytokine-mediated signaling pathway  B cell differentiation  positive regulation of peptidyl-serine phosphorylation of STAT protein  B cell proliferation  response to exogenous dsRNA  defense response to virus  type I interferon signaling pathway  
Pathways : KEGGCytokine-cytokine receptor interaction    Regulation of autophagy    PI3K-Akt signaling pathway    Toll-like receptor signaling pathway    RIG-I-like receptor signaling pathway    Cytosolic DNA-sensing pathway    Jak-STAT signaling pathway    Natural killer cell mediated cytotoxicity    Tuberculosis    Hepatitis C    Hepatitis B    Measles    Influenza A    Herpes simplex infection    Autoimmune thyroid disease   
NDEx NetworkIFNA1
Atlas of Cancer Signalling NetworkIFNA1
Wikipedia pathwaysIFNA1
Orthology - Evolution
OrthoDB3439
GeneTree (enSembl)ENSG00000197919
Phylogenetic Trees/Animal Genes : TreeFamIFNA1
HOGENOMP01562
Homologs : HomoloGeneIFNA1
Homology/Alignments : Family Browser (UCSC)IFNA1
Gene fusions - Rearrangements
Fusion : QuiverIFNA1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIFNA1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IFNA1
dbVarIFNA1
ClinVarIFNA1
MonarchIFNA1
1000_GenomesIFNA1 
Exome Variant ServerIFNA1
GNOMAD BrowserENSG00000197919
Varsome BrowserIFNA1
Genetic variants : HAPMAP3439
Genomic Variants (DGV)IFNA1 [DGVbeta]
DECIPHERIFNA1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisIFNA1 
Mutations
ICGC Data PortalIFNA1 
TCGA Data PortalIFNA1 
Broad Tumor PortalIFNA1
OASIS PortalIFNA1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIFNA1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DIFNA1
Mutations and Diseases : HGMDIFNA1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch IFNA1
DgiDB (Drug Gene Interaction Database)IFNA1
DoCM (Curated mutations)IFNA1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)IFNA1 (select a term)
intoGenIFNA1
Cancer3DIFNA1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM147660   
Orphanet
DisGeNETIFNA1
MedgenIFNA1
Genetic Testing Registry IFNA1
NextProtP01562 [Medical]
TSGene3439
GENETestsIFNA1
Target ValidationIFNA1
Huge Navigator IFNA1 [HugePedia]
snp3D : Map Gene to Disease3439
BioCentury BCIQIFNA1
ClinGenIFNA1
Clinical trials, drugs, therapy
Protein Interactions : CTD3439
Pharm GKB GenePA29656
Clinical trialIFNA1
Miscellaneous
canSAR (ICR)IFNA1 (select the gene name)
HarmonizomeIFNA1
DataMed IndexIFNA1
Probes
Litterature
PubMed338 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineIFNA1
EVEXIFNA1
GoPubMedIFNA1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Sep 14 14:15:18 CEST 2020
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