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IFNA2 (interferon alpha 2)

Identity

Alias_symbol (synonym)IFNA
IFN-alphaA
Other aliasIFNA2B
INFA2
HGNC (Hugo) IFNA2
LocusID (NCBI) 3440
Atlas_Id 50296
Location 9p21.3  [Link to chromosome band 9p21]
Location_base_pair Starts at 21384255 and ends at 21385397 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)IFNA2   5423
Cards
Entrez_Gene (NCBI)IFNA2  3440  interferon alpha 2
AliasesIFN-alphaA; IFNA; IFNA2B; INFA2
GeneCards (Weizmann)IFNA2
Ensembl hg19 (Hinxton)ENSG00000188379 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000188379 [Gene_View]  chr9:21384255-21385397 [Contig_View]  IFNA2 [Vega]
ICGC DataPortalENSG00000188379
TCGA cBioPortalIFNA2
AceView (NCBI)IFNA2
Genatlas (Paris)IFNA2
WikiGenes3440
SOURCE (Princeton)IFNA2
Genetics Home Reference (NIH)IFNA2
Genomic and cartography
GoldenPath hg38 (UCSC)IFNA2  -     chr9:21384255-21385397 -  9p21.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)IFNA2  -     9p21.3   [Description]    (hg19-Feb_2009)
EnsemblIFNA2 - 9p21.3 [CytoView hg19]  IFNA2 - 9p21.3 [CytoView hg38]
Mapping of homologs : NCBIIFNA2 [Mapview hg19]  IFNA2 [Mapview hg38]
OMIM147562   
Gene and transcription
Genbank (Entrez)AY255838 BC074936 BC074937 BC104163 BC104164
RefSeq transcript (Entrez)NM_000605
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)IFNA2
Cluster EST : UnigeneHs.211575 [ NCBI ]
CGAP (NCI)Hs.211575
Alternative Splicing GalleryENSG00000188379
Gene ExpressionIFNA2 [ NCBI-GEO ]   IFNA2 [ EBI - ARRAY_EXPRESS ]   IFNA2 [ SEEK ]   IFNA2 [ MEM ]
Gene Expression Viewer (FireBrowse)IFNA2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3440
GTEX Portal (Tissue expression)IFNA2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP01563   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP01563  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP01563
Splice isoforms : SwissVarP01563
PhosPhoSitePlusP01563
Domaine pattern : Prosite (Expaxy)INTERFERON_A_B_D (PS00252)   
Domains : Interpro (EBI)4_helix_cytokine-like_core    4_helix_cytokine_core    Interferon_alpha/beta/delta   
Domain families : Pfam (Sanger)Interferon (PF00143)   
Domain families : Pfam (NCBI)pfam00143   
Domain families : Smart (EMBL)IFabd (SM00076)  
Conserved Domain (NCBI)IFNA2
DMDM Disease mutations3440
Blocks (Seattle)IFNA2
PDB (SRS)1ITF    1RH2    2HIE    2HYM    2KZ1    2LAG    2LMS    3S9D    3SE3    4YPG    4Z5R   
PDB (PDBSum)1ITF    1RH2    2HIE    2HYM    2KZ1    2LAG    2LMS    3S9D    3SE3    4YPG    4Z5R   
PDB (IMB)1ITF    1RH2    2HIE    2HYM    2KZ1    2LAG    2LMS    3S9D    3SE3    4YPG    4Z5R   
PDB (RSDB)1ITF    1RH2    2HIE    2HYM    2KZ1    2LAG    2LMS    3S9D    3SE3    4YPG    4Z5R   
Structural Biology KnowledgeBase1ITF    1RH2    2HIE    2HYM    2KZ1    2LAG    2LMS    3S9D    3SE3    4YPG    4Z5R   
SCOP (Structural Classification of Proteins)1ITF    1RH2    2HIE    2HYM    2KZ1    2LAG    2LMS    3S9D    3SE3    4YPG    4Z5R   
CATH (Classification of proteins structures)1ITF    1RH2    2HIE    2HYM    2KZ1    2LAG    2LMS    3S9D    3SE3    4YPG    4Z5R   
SuperfamilyP01563
Human Protein AtlasENSG00000188379
Peptide AtlasP01563
HPRD00950
IPIIPI00307184   
Protein Interaction databases
DIP (DOE-UCLA)P01563
IntAct (EBI)P01563
FunCoupENSG00000188379
BioGRIDIFNA2
STRING (EMBL)IFNA2
ZODIACIFNA2
Ontologies - Pathways
QuickGOP01563
Ontology : AmiGOT cell activation involved in immune response  natural killer cell activation involved in immune response  cytokine activity  type I interferon receptor binding  protein binding  extracellular region  extracellular space  apoptotic process  inflammatory response  humoral immune response  cell surface receptor signaling pathway  cell-cell signaling  blood coagulation  negative regulation of gene expression  cytokine-mediated signaling pathway  B cell differentiation  positive regulation of peptidyl-serine phosphorylation of STAT protein  B cell proliferation  positive regulation of phosphorylation  response to exogenous dsRNA  innate immune response  negative regulation of T cell differentiation  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  negative regulation of viral entry into host cell  defense response to virus  type I interferon signaling pathway  regulation of type I interferon-mediated signaling pathway  negative regulation of T-helper 2 cell cytokine production  negative regulation of interleukin-5 secretion  negative regulation of interleukin-13 secretion  
Ontology : EGO-EBIT cell activation involved in immune response  natural killer cell activation involved in immune response  cytokine activity  type I interferon receptor binding  protein binding  extracellular region  extracellular space  apoptotic process  inflammatory response  humoral immune response  cell surface receptor signaling pathway  cell-cell signaling  blood coagulation  negative regulation of gene expression  cytokine-mediated signaling pathway  B cell differentiation  positive regulation of peptidyl-serine phosphorylation of STAT protein  B cell proliferation  positive regulation of phosphorylation  response to exogenous dsRNA  innate immune response  negative regulation of T cell differentiation  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  negative regulation of viral entry into host cell  defense response to virus  type I interferon signaling pathway  regulation of type I interferon-mediated signaling pathway  negative regulation of T-helper 2 cell cytokine production  negative regulation of interleukin-5 secretion  negative regulation of interleukin-13 secretion  
Pathways : KEGG   
NDEx NetworkIFNA2
Atlas of Cancer Signalling NetworkIFNA2
Wikipedia pathwaysIFNA2
Orthology - Evolution
OrthoDB3440
GeneTree (enSembl)ENSG00000188379
Phylogenetic Trees/Animal Genes : TreeFamIFNA2
HOVERGENP01563
HOGENOMP01563
Homologs : HomoloGeneIFNA2
Homology/Alignments : Family Browser (UCSC)IFNA2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIFNA2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IFNA2
dbVarIFNA2
ClinVarIFNA2
1000_GenomesIFNA2 
Exome Variant ServerIFNA2
ExAC (Exome Aggregation Consortium)IFNA2 (select the gene name)
Genetic variants : HAPMAP3440
Genomic Variants (DGV)IFNA2 [DGVbeta]
DECIPHERIFNA2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisIFNA2 
Mutations
ICGC Data PortalIFNA2 
TCGA Data PortalIFNA2 
Broad Tumor PortalIFNA2
OASIS PortalIFNA2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIFNA2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDIFNA2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch IFNA2
DgiDB (Drug Gene Interaction Database)IFNA2
DoCM (Curated mutations)IFNA2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)IFNA2 (select a term)
intoGenIFNA2
Cancer3DIFNA2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM147562   
Orphanet
MedgenIFNA2
Genetic Testing Registry IFNA2
NextProtP01563 [Medical]
TSGene3440
GENETestsIFNA2
Target ValidationIFNA2
Huge Navigator IFNA2 [HugePedia]
snp3D : Map Gene to Disease3440
BioCentury BCIQIFNA2
ClinGenIFNA2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3440
Chemical/Pharm GKB GenePA29662
Clinical trialIFNA2
Miscellaneous
canSAR (ICR)IFNA2 (select the gene name)
Probes
Litterature
PubMed150 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineIFNA2
EVEXIFNA2
GoPubMedIFNA2
iHOPIFNA2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:12:46 CEST 2017

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