IFNA2 (interferon alpha 2)

2008-08-01  

Identity

HGNC
LOCATION
9p21.3
LOCUSID
ALIAS
IFN-alpha-2,IFN-alphaA,IFNA,IFNA2B,leIF

Other Information

Locus ID:

NCBI: 3440
MIM: 147562
HGNC: 5423
Ensembl: ENSG00000188379

Variants:

dbSNP: 3440
ClinVar: 3440
TCGA: ENSG00000188379
COSMIC: IFNA2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000188379ENST00000380206P01563

Expression (GTEx)

0
1
2
3
4
5

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Toll-like receptor signaling pathwayKEGGko04620
Jak-STAT signaling pathwayKEGGko04630
Natural killer cell mediated cytotoxicityKEGGko04650
Autoimmune thyroid diseaseKEGGko05320
Cytokine-cytokine receptor interactionKEGGhsa04060
Toll-like receptor signaling pathwayKEGGhsa04620
Jak-STAT signaling pathwayKEGGhsa04630
Natural killer cell mediated cytotoxicityKEGGhsa04650
Autoimmune thyroid diseaseKEGGhsa05320
RIG-I-like receptor signaling pathwayKEGGko04622
RIG-I-like receptor signaling pathwayKEGGhsa04622
NOD-like receptor signaling pathwayKEGGko04621
NOD-like receptor signaling pathwayKEGGhsa04621
Cytosolic DNA-sensing pathwayKEGGko04623
Cytosolic DNA-sensing pathwayKEGGhsa04623
Hepatitis CKEGGko05160
Hepatitis CKEGGhsa05160
MeaslesKEGGko05162
MeaslesKEGGhsa05162
TuberculosisKEGGko05152
TuberculosisKEGGhsa05152
Influenza AKEGGko05164
Influenza AKEGGhsa05164
Herpes simplex infectionKEGGko05168
Herpes simplex infectionKEGGhsa05168
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
Hepatitis BKEGGhsa05161
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathwaysREACTOMER-HSA-168928
TRAF6 mediated IRF7 activationREACTOMER-HSA-933541
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Interferon SignalingREACTOMER-HSA-913531
Interferon alpha/beta signalingREACTOMER-HSA-909733
Regulation of IFNA signalingREACTOMER-HSA-912694
HemostasisREACTOMER-HSA-109582
Factors involved in megakaryocyte development and platelet productionREACTOMER-HSA-983231

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
180057342007An interferon-alpha-induced tethering mechanism inhibits HIV-1 and Ebola virus particle release but is counteracted by the HIV-1 Vpu protein.145
218549862011Structural linkage between ligand discrimination and receptor activation by type I interferons.115
211156882010Plasmacytoid dendritic cells sense skin injury and promote wound healing through type I interferons.105
177034122007Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.100
171167652006Pathogen-sensing plasmacytoid dendritic cells stimulate cytotoxic T-cell function in the atherosclerotic plaque through interferon-alpha.71
234371552013Interferon-α is the primary plasma type-I IFN in HIV-1 infection and correlates with immune activation and disease markers.64
197900492009C1q inhibits immune complex-induced interferon-alpha production in plasmacytoid dendritic cells: a novel link between C1q deficiency and systemic lupus erythematosus pathogenesis.52
195644112009Receptor density is key to the alpha2/beta interferon differential activities.43
195744592009Type I interferon (IFN)-dependent activation of Mnk1 and its role in the generation of growth inhibitory responses.41
248660202014Multifaceted activities of type I interferon are revealed by a receptor antagonist.36

Citation

Dessen P

IFNA2 (interferon alpha 2)

Atlas Genet Cytogenet Oncol Haematol. 2008-08-01

Online version: http://atlasgeneticsoncology.org/gene/50296/ifna2