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IFNAR1 (interferon (alpha, beta and omega) receptor 1)

Identity

Other namesAVP
IFN-alpha-REC
IFNAR
IFNBR
IFRC
HGNC (Hugo) IFNAR1
LocusID (NCBI) 3454
Location 21q22.11
Location_base_pair Starts at 34697214 and ends at 34732128 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)IFNAR1   5432
Cards
Entrez_Gene (NCBI)IFNAR1  3454  interferon (alpha, beta and omega) receptor 1
GeneCards (Weizmann)IFNAR1
Ensembl hg19 (Hinxton)ENSG00000142166 [Gene_View]  chr21:34697214-34732128 [Contig_View]  IFNAR1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000142166 [Gene_View]  chr21:34697214-34732128 [Contig_View]  IFNAR1 [Vega]
ICGC DataPortalENSG00000142166
cBioPortalIFNAR1
AceView (NCBI)IFNAR1
Genatlas (Paris)IFNAR1
WikiGenes3454
SOURCE (Princeton)IFNAR1
Genomic and cartography
GoldenPath hg19 (UCSC)IFNAR1  -     chr21:34697214-34732128 +  21q22.11   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)IFNAR1  -     21q22.11   [Description]    (hg38-Dec_2013)
EnsemblIFNAR1 - 21q22.11 [CytoView hg19]  IFNAR1 - 21q22.11 [CytoView hg38]
Mapping of homologs : NCBIIFNAR1 [Mapview hg19]  IFNAR1 [Mapview hg38]
OMIM107450   
Gene and transcription
Genbank (Entrez)AK123813 AK222770 AK222812 AK298051 AK312631
RefSeq transcript (Entrez)NM_000629
RefSeq genomic (Entrez)AC_000153 NC_000021 NC_018932 NT_011512 NW_001838706 NW_004929426
Consensus coding sequences : CCDS (NCBI)IFNAR1
Cluster EST : UnigeneHs.529400 [ NCBI ]
CGAP (NCI)Hs.529400
Alternative Splicing : Fast-db (Paris)GSHG0033951
Alternative Splicing GalleryENSG00000142166
Gene ExpressionIFNAR1 [ NCBI-GEO ]     IFNAR1 [ SEEK ]   IFNAR1 [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP17181 (Uniprot)
NextProtP17181  [Medical]
With graphics : InterProP17181
Splice isoforms : SwissVarP17181 (Swissvar)
Domaine pattern : Prosite (Expaxy)FN3 (PS50853)   
Domains : Interpro (EBI)Fibronectin_type3    Ig-like_fold    Interferon_alpha/beta_rcpt-1    Interferon_alpha/beta_rcpt_bsu   
Related proteins : CluSTrP17181
Domain families : Pfam (Sanger)Interfer-bind (PF09294)    Tissue_fac (PF01108)   
Domain families : Pfam (NCBI)pfam09294    pfam01108   
Domain families : Smart (EMBL)FN3 (SM00060)  
DMDM Disease mutations3454
Blocks (Seattle)P17181
PDB (SRS)3S98    3SE3    3SE4    4PO6   
PDB (PDBSum)3S98    3SE3    3SE4    4PO6   
PDB (IMB)3S98    3SE3    3SE4    4PO6   
PDB (RSDB)3S98    3SE3    3SE4    4PO6   
Human Protein AtlasENSG00000142166
Peptide AtlasP17181
HPRD00126
IPIIPI00012877   IPI00877141   IPI00877162   IPI01012023   IPI00953088   IPI00853633   
Protein Interaction databases
DIP (DOE-UCLA)P17181
IntAct (EBI)P17181
FunCoupENSG00000142166
BioGRIDIFNAR1
IntegromeDBIFNAR1
STRING (EMBL)IFNAR1
Ontologies - Pathways
QuickGOP17181
Ontology : AmiGOtype I interferon receptor activity  protein binding  plasma membrane  integral component of plasma membrane  cell surface receptor signaling pathway  JAK-STAT cascade  response to virus  cytokine-mediated signaling pathway  positive regulation of interferon-gamma production  T cell activation  type I interferon biosynthetic process  defense response to virus  type I interferon signaling pathway  regulation of type I interferon-mediated signaling pathway  
Ontology : EGO-EBItype I interferon receptor activity  protein binding  plasma membrane  integral component of plasma membrane  cell surface receptor signaling pathway  JAK-STAT cascade  response to virus  cytokine-mediated signaling pathway  positive regulation of interferon-gamma production  T cell activation  type I interferon biosynthetic process  defense response to virus  type I interferon signaling pathway  regulation of type I interferon-mediated signaling pathway  
Pathways : BIOCARTAIFN alpha signaling pathway [Genes]    Bone Remodelling [Genes]   
Pathways : KEGGCytokine-cytokine receptor interaction    PI3K-Akt signaling pathway    Osteoclast differentiation    Toll-like receptor signaling pathway    Jak-STAT signaling pathway    Natural killer cell mediated cytotoxicity    Hepatitis C    Hepatitis B    Measles    Influenza A    Herpes simplex infection   
Protein Interaction DatabaseIFNAR1
DoCM (Curated mutations)IFNAR1
Wikipedia pathwaysIFNAR1
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerIFNAR1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IFNAR1
dbVarIFNAR1
ClinVarIFNAR1
1000_GenomesIFNAR1 
Exome Variant ServerIFNAR1
SNP (GeneSNP Utah)IFNAR1
SNP : HGBaseIFNAR1
Genetic variants : HAPMAPIFNAR1
Genomic VariantsIFNAR1  IFNAR1 [DGVbeta]
Mutations
ICGC Data PortalENSG00000142166 
Somatic Mutations in Cancer : COSMICIFNAR1 
CONAN: Copy Number AnalysisIFNAR1 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)21:34697214-34732128
Mutations and Diseases : HGMDIFNAR1
OMIM107450   
MedgenIFNAR1
NextProtP17181 [Medical]
GENETestsIFNAR1
Disease Genetic AssociationIFNAR1
Huge Navigator IFNAR1 [HugePedia]  IFNAR1 [HugeCancerGEM]
snp3D : Map Gene to Disease3454
DGIdb (Drug Gene Interaction db)IFNAR1
General knowledge
Homologs : HomoloGeneIFNAR1
Homology/Alignments : Family Browser (UCSC)IFNAR1
Phylogenetic Trees/Animal Genes : TreeFamIFNAR1
Chemical/Protein Interactions : CTD3454
Chemical/Pharm GKB GenePA29670
Clinical trialIFNAR1
Cancer Resource (Charite)ENSG00000142166
Other databases
Probes
Litterature
PubMed128 Pubmed reference(s) in Entrez
CoreMineIFNAR1
GoPubMedIFNAR1
iHOPIFNAR1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2014Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Dec 20 22:06:56 CET 2014

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