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IFNAR1 (interferon alpha and beta receptor subunit 1)

Identity

Alias (NCBI)AVP
IFN-alpha-REC
IFNAR
IFNBR
IFRC
HGNC (Hugo) IFNAR1
HGNC Alias symbIFRC
HGNC Alias nameIFNalpha/beta receptor 1
 type I interferon receptor 1
 interferon alpha/beta receptor 1
HGNC Previous nameIFNAR
HGNC Previous nameinterferon (alpha, beta and omega) receptor 1
LocusID (NCBI) 3454
Atlas_Id 40922
Location 21q22.11  [Link to chromosome band 21q22]
Location_base_pair Starts at 33324970 and ends at 33359864 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CALN1 (7q11.22) / IFNAR1 (21q22.11)IFNAR1 (21q22.11) / CTNNBL1 (20q11.23)IFNAR1 (21q22.11) / SF3A3 (1p34.3)
IFNAR1 (21q22.11) / USP22 (17p11.2)IFNGR2 (21q22.11) / IFNAR1 (21q22.11)PLD6 (17p11.2) / IFNAR1 (21q22.11)
SNRNP70 (19q13.33) / IFNAR1 (21q22.11)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)IFNAR1   5432
Cards
Entrez_Gene (NCBI)IFNAR1    interferon alpha and beta receptor subunit 1
AliasesAVP; IFN-alpha-REC; IFNAR; IFNBR; 
IFRC
GeneCards (Weizmann)IFNAR1
Ensembl hg19 (Hinxton)ENSG00000142166 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000142166 [Gene_View]  ENSG00000142166 [Sequence]  chr21:33324970-33359864 [Contig_View]  IFNAR1 [Vega]
ICGC DataPortalENSG00000142166
TCGA cBioPortalIFNAR1
AceView (NCBI)IFNAR1
Genatlas (Paris)IFNAR1
SOURCE (Princeton)IFNAR1
Genetics Home Reference (NIH)IFNAR1
Genomic and cartography
GoldenPath hg38 (UCSC)IFNAR1  -     chr21:33324970-33359864 +  21q22.11   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)IFNAR1  -     21q22.11   [Description]    (hg19-Feb_2009)
GoldenPathIFNAR1 - 21q22.11 [CytoView hg19]  IFNAR1 - 21q22.11 [CytoView hg38]
ImmunoBaseENSG00000142166
Genome Data Viewer NCBIIFNAR1 [Mapview hg19]  
OMIM107450   
Gene and transcription
Genbank (Entrez)AK123813 AK222770 AK222812 AK298051 AK312631
RefSeq transcript (Entrez)NM_000629 NM_001384498 NM_001384499 NM_001384500 NM_001384501 NM_001384502 NM_001384503 NM_001384504
Consensus coding sequences : CCDS (NCBI)IFNAR1
Gene ExpressionIFNAR1 [ NCBI-GEO ]   IFNAR1 [ EBI - ARRAY_EXPRESS ]   IFNAR1 [ SEEK ]   IFNAR1 [ MEM ]
Gene Expression Viewer (FireBrowse)IFNAR1 [ Firebrowse - Broad ]
GenevisibleExpression of IFNAR1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3454
GTEX Portal (Tissue expression)IFNAR1
Human Protein AtlasENSG00000142166-IFNAR1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP17181   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP17181  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP17181
PhosPhoSitePlusP17181
Domaine pattern : Prosite (Expaxy)FN3 (PS50853)   
Domains : Interpro (EBI)FN3_dom    FN3_sf    Ig-like_fold    Interferon/interleukin_rcp_dom    Interferon_alpha/beta_rcpt-1   
Domain families : Pfam (Sanger)Interfer-bind (PF09294)    Tissue_fac (PF01108)   
Domain families : Pfam (NCBI)pfam09294    pfam01108   
Conserved Domain (NCBI)IFNAR1
PDB (RSDB)3S98    3SE3    3SE4    4PO6   
PDB Europe3S98    3SE3    3SE4    4PO6   
PDB (PDBSum)3S98    3SE3    3SE4    4PO6   
PDB (IMB)3S98    3SE3    3SE4    4PO6   
Structural Biology KnowledgeBase3S98    3SE3    3SE4    4PO6   
SCOP (Structural Classification of Proteins)3S98    3SE3    3SE4    4PO6   
CATH (Classification of proteins structures)3S98    3SE3    3SE4    4PO6   
SuperfamilyP17181
AlphaFold pdb e-kbP17181   
Human Protein Atlas [tissue]ENSG00000142166-IFNAR1 [tissue]
HPRD00126
Protein Interaction databases
DIP (DOE-UCLA)P17181
IntAct (EBI)P17181
BioGRIDIFNAR1
STRING (EMBL)IFNAR1
ZODIACIFNAR1
Ontologies - Pathways
QuickGOP17181
Ontology : AmiGOcytokine receptor activity  type I interferon receptor activity  protein binding  lysosome  late endosome  plasma membrane  plasma membrane  integral component of plasma membrane  receptor signaling pathway via JAK-STAT  response to virus  integral component of membrane  cytokine-mediated signaling pathway  type I interferon binding  response to lipopolysaccharide  cellular response to interferon-alpha  type I interferon signaling pathway  type I interferon signaling pathway  positive regulation of cellular respiration  
Ontology : EGO-EBIcytokine receptor activity  type I interferon receptor activity  protein binding  lysosome  late endosome  plasma membrane  plasma membrane  integral component of plasma membrane  receptor signaling pathway via JAK-STAT  response to virus  integral component of membrane  cytokine-mediated signaling pathway  type I interferon binding  response to lipopolysaccharide  cellular response to interferon-alpha  type I interferon signaling pathway  type I interferon signaling pathway  positive regulation of cellular respiration  
Pathways : BIOCARTAIFN alpha signaling pathway [Genes]    Bone Remodelling [Genes]   
Pathways : KEGGCytokine-cytokine receptor interaction    PI3K-Akt signaling pathway    Osteoclast differentiation    Toll-like receptor signaling pathway    Jak-STAT signaling pathway    Natural killer cell mediated cytotoxicity    Hepatitis C    Hepatitis B    Measles    Influenza A    Herpes simplex infection   
NDEx NetworkIFNAR1
Atlas of Cancer Signalling NetworkIFNAR1
Wikipedia pathwaysIFNAR1
Orthology - Evolution
OrthoDB3454
GeneTree (enSembl)ENSG00000142166
Phylogenetic Trees/Animal Genes : TreeFamIFNAR1
Homologs : HomoloGeneIFNAR1
Homology/Alignments : Family Browser (UCSC)IFNAR1
Gene fusions - Rearrangements
Fusion : QuiverIFNAR1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIFNAR1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IFNAR1
dbVarIFNAR1
ClinVarIFNAR1
MonarchIFNAR1
1000_GenomesIFNAR1 
Exome Variant ServerIFNAR1
GNOMAD BrowserENSG00000142166
Varsome BrowserIFNAR1
ACMGIFNAR1 variants
VarityP17181
Genomic Variants (DGV)IFNAR1 [DGVbeta]
DECIPHERIFNAR1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisIFNAR1 
Mutations
ICGC Data PortalIFNAR1 
TCGA Data PortalIFNAR1 
Broad Tumor PortalIFNAR1
OASIS PortalIFNAR1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIFNAR1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DIFNAR1
Mutations and Diseases : HGMDIFNAR1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaIFNAR1
DgiDB (Drug Gene Interaction Database)IFNAR1
DoCM (Curated mutations)IFNAR1
CIViC (Clinical Interpretations of Variants in Cancer)IFNAR1
Cancer3DIFNAR1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM107450   
Orphanet
DisGeNETIFNAR1
MedgenIFNAR1
Genetic Testing Registry IFNAR1
NextProtP17181 [Medical]
GENETestsIFNAR1
Target ValidationIFNAR1
Huge Navigator IFNAR1 [HugePedia]
ClinGenIFNAR1
Clinical trials, drugs, therapy
MyCancerGenomeIFNAR1
Protein Interactions : CTDIFNAR1
Pharm GKB GenePA29670
Pharm GKB PathwaysPA166126086   
PharosP17181
Clinical trialIFNAR1
Miscellaneous
canSAR (ICR)IFNAR1
HarmonizomeIFNAR1
DataMed IndexIFNAR1
Probes
Litterature
PubMed171 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXIFNAR1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:13:26 CEST 2021

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