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IFNAR1 (interferon alpha and beta receptor subunit 1)

Identity

Other namesAVP
IFN-alpha-REC
IFNAR
IFNBR
IFRC
HGNC (Hugo) IFNAR1
LocusID (NCBI) 3454
Atlas_Id 40922
Location 21q22.11
Location_base_pair Starts at 34697214 and ends at 34732128 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CALN1 (7q11.22) / IFNAR1 (21q22.11)IFNAR1 (21q22.11) / CTNNBL1 (20q11.23)IFNAR1 (21q22.11) / SF3A3 (1p34.3)
IFNAR1 (21q22.11) / USP22 (17p11.2)IFNGR2 (21q22.11) / IFNAR1 (21q22.11)PLD6 (17p11.2) / IFNAR1 (21q22.11)
SNRNP70 (19q13.33) / IFNAR1 (21q22.11)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)IFNAR1   5432
Cards
Entrez_Gene (NCBI)IFNAR1  3454  interferon alpha and beta receptor subunit 1
GeneCards (Weizmann)IFNAR1
Ensembl hg19 (Hinxton)ENSG00000142166 [Gene_View]  chr21:34697214-34732128 [Contig_View]  IFNAR1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000142166 [Gene_View]  chr21:34697214-34732128 [Contig_View]  IFNAR1 [Vega]
ICGC DataPortalENSG00000142166
TCGA cBioPortalIFNAR1
AceView (NCBI)IFNAR1
Genatlas (Paris)IFNAR1
WikiGenes3454
SOURCE (Princeton)IFNAR1
Genomic and cartography
GoldenPath hg19 (UCSC)IFNAR1  -     chr21:34697214-34732128 +  21q22.11   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)IFNAR1  -     21q22.11   [Description]    (hg38-Dec_2013)
EnsemblIFNAR1 - 21q22.11 [CytoView hg19]  IFNAR1 - 21q22.11 [CytoView hg38]
Mapping of homologs : NCBIIFNAR1 [Mapview hg19]  IFNAR1 [Mapview hg38]
OMIM107450   
Gene and transcription
Genbank (Entrez)AK123813 AK222770 AK222812 AK298051 AK312631
RefSeq transcript (Entrez)NM_000629
RefSeq genomic (Entrez)NC_000021 NC_018932 NT_011512 NW_004929426
Consensus coding sequences : CCDS (NCBI)IFNAR1
Cluster EST : UnigeneHs.529400 [ NCBI ]
CGAP (NCI)Hs.529400
Alternative Splicing GalleryENSG00000142166
Gene ExpressionIFNAR1 [ NCBI-GEO ]   IFNAR1 [ EBI - ARRAY_EXPRESS ]   IFNAR1 [ SEEK ]   IFNAR1 [ MEM ]
Gene Expression Viewer (FireBrowse)IFNAR1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3454
GTEX Portal (Tissue expression)IFNAR1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP17181 (Uniprot)
NextProtP17181  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP17181
Splice isoforms : SwissVarP17181 (Swissvar)
PhosPhoSitePlusP17181
Domaine pattern : Prosite (Expaxy)FN3 (PS50853)   
Domains : Interpro (EBI)FN3_dom    Ig-like_fold    Interferon/interleukin_rcp_dom    Interferon_alpha/beta_rcpt-1   
Domain families : Pfam (Sanger)Interfer-bind (PF09294)    Tissue_fac (PF01108)   
Domain families : Pfam (NCBI)pfam09294    pfam01108   
Domain families : Smart (EMBL)FN3 (SM00060)  
DMDM Disease mutations3454
Blocks (Seattle)IFNAR1
PDB (SRS)3S98    3SE3    3SE4    4PO6   
PDB (PDBSum)3S98    3SE3    3SE4    4PO6   
PDB (IMB)3S98    3SE3    3SE4    4PO6   
PDB (RSDB)3S98    3SE3    3SE4    4PO6   
Structural Biology KnowledgeBase3S98    3SE3    3SE4    4PO6   
SCOP (Structural Classification of Proteins)3S98    3SE3    3SE4    4PO6   
CATH (Classification of proteins structures)3S98    3SE3    3SE4    4PO6   
SuperfamilyP17181
Human Protein AtlasENSG00000142166
Peptide AtlasP17181
HPRD00126
IPIIPI00012877   IPI00877141   IPI00877162   IPI01012023   IPI00953088   IPI00853633   
Protein Interaction databases
DIP (DOE-UCLA)P17181
IntAct (EBI)P17181
FunCoupENSG00000142166
BioGRIDIFNAR1
STRING (EMBL)IFNAR1
ZODIACIFNAR1
Ontologies - Pathways
QuickGOP17181
Ontology : AmiGOtype I interferon receptor activity  protein binding  lysosome  late endosome  plasma membrane  integral component of plasma membrane  JAK-STAT cascade  response to virus  type I interferon binding  response to lipopolysaccharide  positive regulation of interferon-beta production  positive regulation of interferon-gamma production  cellular response to interferon-alpha  T cell activation  type I interferon biosynthetic process  positive regulation of transcription, DNA-templated  positive regulation of interleukin-1 beta secretion  regulation of peptidyl-tyrosine phosphorylation  defense response to virus  type I interferon signaling pathway  type I interferon signaling pathway  regulation of type I interferon-mediated signaling pathway  
Ontology : EGO-EBItype I interferon receptor activity  protein binding  lysosome  late endosome  plasma membrane  integral component of plasma membrane  JAK-STAT cascade  response to virus  type I interferon binding  response to lipopolysaccharide  positive regulation of interferon-beta production  positive regulation of interferon-gamma production  cellular response to interferon-alpha  T cell activation  type I interferon biosynthetic process  positive regulation of transcription, DNA-templated  positive regulation of interleukin-1 beta secretion  regulation of peptidyl-tyrosine phosphorylation  defense response to virus  type I interferon signaling pathway  type I interferon signaling pathway  regulation of type I interferon-mediated signaling pathway  
Pathways : BIOCARTAIFN alpha signaling pathway [Genes]    Bone Remodelling [Genes]   
Pathways : KEGGCytokine-cytokine receptor interaction    PI3K-Akt signaling pathway    Osteoclast differentiation    Toll-like receptor signaling pathway    Jak-STAT signaling pathway    Natural killer cell mediated cytotoxicity    Hepatitis C    Hepatitis B    Measles    Influenza A    Herpes simplex infection   
NDEx Network
Atlas of Cancer Signalling NetworkIFNAR1
Wikipedia pathwaysIFNAR1
Orthology - Evolution
OrthoDB3454
GeneTree (enSembl)ENSG00000142166
Phylogenetic Trees/Animal Genes : TreeFamIFNAR1
Homologs : HomoloGeneIFNAR1
Homology/Alignments : Family Browser (UCSC)IFNAR1
Gene fusions - Rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerIFNAR1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IFNAR1
dbVarIFNAR1
ClinVarIFNAR1
1000_GenomesIFNAR1 
Exome Variant ServerIFNAR1
ExAC (Exome Aggregation Consortium)IFNAR1 (select the gene name)
Genetic variants : HAPMAP3454
Genomic Variants (DGV)IFNAR1 [DGVbeta]
Mutations
ICGC Data PortalIFNAR1 
TCGA Data PortalIFNAR1 
Broad Tumor PortalIFNAR1
OASIS PortalIFNAR1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIFNAR1 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch IFNAR1
DgiDB (Drug Gene Interaction Database)IFNAR1
DoCM (Curated mutations)IFNAR1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)IFNAR1 (select a term)
intoGenIFNAR1
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)21:34697214-34732128  ENSG00000142166
CONAN: Copy Number AnalysisIFNAR1 
Mutations and Diseases : HGMDIFNAR1
OMIM107450   
MedgenIFNAR1
Genetic Testing Registry IFNAR1
NextProtP17181 [Medical]
TSGene3454
GENETestsIFNAR1
Huge Navigator IFNAR1 [HugePedia]
snp3D : Map Gene to Disease3454
BioCentury BCIQIFNAR1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3454
Chemical/Pharm GKB GenePA29670
Clinical trialIFNAR1
Miscellaneous
canSAR (ICR)IFNAR1 (select the gene name)
Probes
Litterature
PubMed134 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineIFNAR1
EVEXIFNAR1
GoPubMedIFNAR1
iHOPIFNAR1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sun May 8 18:50:16 CEST 2016

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