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IFNAR2 (interferon alpha and beta receptor subunit 2)

Identity

Alias (NCBI)IFN-R
IFN-alpha-REC
IFNABR
IFNARB
IMD45
HGNC (Hugo) IFNAR2
HGNC Alias nameinterferon alpha/beta receptor 2
 IFNalpha/beta receptor subunit 2
 type I interferon receptor 2
HGNC Previous nameIFNABR
HGNC Previous nameinterferon (alpha, beta and omega) receptor 2
LocusID (NCBI) 3455
Atlas_Id 40923
Location 21q22.11  [Link to chromosome band 21q22]
Location_base_pair Starts at 33229895 and ends at 33264513 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
IFNAR2 (21q22.11) / TNK2 (3q29)NEAT1 (11q13.1) / IFNAR2 (21q22.11)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)IFNAR2   5433
Cards
Entrez_Gene (NCBI)IFNAR2    interferon alpha and beta receptor subunit 2
AliasesIFN-R; IFN-alpha-REC; IFNABR; IFNARB; 
IMD45
GeneCards (Weizmann)IFNAR2
Ensembl hg19 (Hinxton)ENSG00000159110 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000159110 [Gene_View]  ENSG00000159110 [Sequence]  chr21:33229895-33264513 [Contig_View]  IFNAR2 [Vega]
ICGC DataPortalENSG00000159110
TCGA cBioPortalIFNAR2
AceView (NCBI)IFNAR2
Genatlas (Paris)IFNAR2
SOURCE (Princeton)IFNAR2
Genetics Home Reference (NIH)IFNAR2
Genomic and cartography
GoldenPath hg38 (UCSC)IFNAR2  -     chr21:33229895-33264513 +  21q22.11   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)IFNAR2  -     21q22.11   [Description]    (hg19-Feb_2009)
GoldenPathIFNAR2 - 21q22.11 [CytoView hg19]  IFNAR2 - 21q22.11 [CytoView hg38]
ImmunoBaseENSG00000159110
Genome Data Viewer NCBIIFNAR2 [Mapview hg19]  
OMIM602376   610424   616669   
Gene and transcription
Genbank (Entrez)AK293059 BC002793 BC013156 BG715143 BI520056
RefSeq transcript (Entrez)NM_000874 NM_001289125 NM_001289126 NM_001289128 NM_001385054 NM_001385055 NM_207584 NM_207585
Consensus coding sequences : CCDS (NCBI)IFNAR2
Gene ExpressionIFNAR2 [ NCBI-GEO ]   IFNAR2 [ EBI - ARRAY_EXPRESS ]   IFNAR2 [ SEEK ]   IFNAR2 [ MEM ]
Gene Expression Viewer (FireBrowse)IFNAR2 [ Firebrowse - Broad ]
GenevisibleExpression of IFNAR2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3455
GTEX Portal (Tissue expression)IFNAR2
Human Protein AtlasENSG00000159110-IFNAR2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP48551   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP48551  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP48551
PhosPhoSitePlusP48551
Domains : Interpro (EBI)FN3_dom    FN3_sf    Ig-like_fold    Interferon/interleukin_rcp_dom   
Domain families : Pfam (Sanger)Interfer-bind (PF09294)    Tissue_fac (PF01108)   
Domain families : Pfam (NCBI)pfam09294    pfam01108   
Conserved Domain (NCBI)IFNAR2
PDB (RSDB)1N6U    1N6V    2HYM    2KZ1    2LAG    3S8W    3S9D    3SE3    3SE4   
PDB Europe1N6U    1N6V    2HYM    2KZ1    2LAG    3S8W    3S9D    3SE3    3SE4   
PDB (PDBSum)1N6U    1N6V    2HYM    2KZ1    2LAG    3S8W    3S9D    3SE3    3SE4   
PDB (IMB)1N6U    1N6V    2HYM    2KZ1    2LAG    3S8W    3S9D    3SE3    3SE4   
Structural Biology KnowledgeBase1N6U    1N6V    2HYM    2KZ1    2LAG    3S8W    3S9D    3SE3    3SE4   
SCOP (Structural Classification of Proteins)1N6U    1N6V    2HYM    2KZ1    2LAG    3S8W    3S9D    3SE3    3SE4   
CATH (Classification of proteins structures)1N6U    1N6V    2HYM    2KZ1    2LAG    3S8W    3S9D    3SE3    3SE4   
SuperfamilyP48551
AlphaFold pdb e-kbP48551   
Human Protein Atlas [tissue]ENSG00000159110-IFNAR2 [tissue]
HPRD03850
Protein Interaction databases
DIP (DOE-UCLA)P48551
IntAct (EBI)P48551
BioGRIDIFNAR2
STRING (EMBL)IFNAR2
ZODIACIFNAR2
Ontologies - Pathways
QuickGOP48551
Ontology : AmiGOcytokine receptor activity  type I interferon receptor activity  type I interferon receptor activity  protein binding  extracellular region  plasma membrane  plasma membrane  integral component of plasma membrane  cell surface receptor signaling pathway  receptor signaling pathway via JAK-STAT  response to virus  integral component of membrane  cytokine-mediated signaling pathway  protein kinase binding  response to interferon-alpha  response to interferon-alpha  response to interferon-beta  defense response to virus  type I interferon signaling pathway  type I interferon signaling pathway  type I interferon signaling pathway  type I interferon signaling pathway  regulation of type I interferon-mediated signaling pathway  
Ontology : EGO-EBIcytokine receptor activity  type I interferon receptor activity  type I interferon receptor activity  protein binding  extracellular region  plasma membrane  plasma membrane  integral component of plasma membrane  cell surface receptor signaling pathway  receptor signaling pathway via JAK-STAT  response to virus  integral component of membrane  cytokine-mediated signaling pathway  protein kinase binding  response to interferon-alpha  response to interferon-alpha  response to interferon-beta  defense response to virus  type I interferon signaling pathway  type I interferon signaling pathway  type I interferon signaling pathway  type I interferon signaling pathway  regulation of type I interferon-mediated signaling pathway  
Pathways : BIOCARTABone Remodelling [Genes]    IFN alpha signaling pathway [Genes]   
Pathways : KEGGCytokine-cytokine receptor interaction    PI3K-Akt signaling pathway    Osteoclast differentiation    Toll-like receptor signaling pathway    Jak-STAT signaling pathway    Natural killer cell mediated cytotoxicity    Hepatitis C    Measles    Influenza A    Herpes simplex infection   
NDEx NetworkIFNAR2
Atlas of Cancer Signalling NetworkIFNAR2
Wikipedia pathwaysIFNAR2
Orthology - Evolution
OrthoDB3455
GeneTree (enSembl)ENSG00000159110
Phylogenetic Trees/Animal Genes : TreeFamIFNAR2
Homologs : HomoloGeneIFNAR2
Homology/Alignments : Family Browser (UCSC)IFNAR2
Gene fusions - Rearrangements
Fusion : QuiverIFNAR2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIFNAR2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IFNAR2
dbVarIFNAR2
ClinVarIFNAR2
MonarchIFNAR2
1000_GenomesIFNAR2 
Exome Variant ServerIFNAR2
GNOMAD BrowserENSG00000159110
Varsome BrowserIFNAR2
ACMGIFNAR2 variants
VarityP48551
Genomic Variants (DGV)IFNAR2 [DGVbeta]
DECIPHERIFNAR2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisIFNAR2 
Mutations
ICGC Data PortalIFNAR2 
TCGA Data PortalIFNAR2 
Broad Tumor PortalIFNAR2
OASIS PortalIFNAR2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIFNAR2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DIFNAR2
Mutations and Diseases : HGMDIFNAR2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaIFNAR2
DgiDB (Drug Gene Interaction Database)IFNAR2
DoCM (Curated mutations)IFNAR2
CIViC (Clinical Interpretations of Variants in Cancer)IFNAR2
Cancer3DIFNAR2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602376    610424    616669   
Orphanet
DisGeNETIFNAR2
MedgenIFNAR2
Genetic Testing Registry IFNAR2
NextProtP48551 [Medical]
GENETestsIFNAR2
Target ValidationIFNAR2
Huge Navigator IFNAR2 [HugePedia]
ClinGenIFNAR2
Clinical trials, drugs, therapy
MyCancerGenomeIFNAR2
Protein Interactions : CTDIFNAR2
Pharm GKB GenePA29671
Pharm GKB PathwaysPA166126086   
PharosP48551
Clinical trialIFNAR2
Miscellaneous
canSAR (ICR)IFNAR2
HarmonizomeIFNAR2
DataMed IndexIFNAR2
Probes
Litterature
PubMed116 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXIFNAR2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:13:26 CEST 2021

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