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IFNAR2 (interferon alpha and beta receptor subunit 2)

Identity

Alias_namesIFNABR
interferon (alpha
Other aliasIFN-R
IFN-alpha-REC
IFNARB
IMD45
HGNC (Hugo) IFNAR2
LocusID (NCBI) 3455
Atlas_Id 40923
Location 21q22.11  [Link to chromosome band 21q22]
Location_base_pair Starts at 33229895 and ends at 33262757 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
IFNAR2 (21q22.11) / TNK2 (3q29)NEAT1 (11q13.1) / IFNAR2 (21q22.11)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)IFNAR2   5433
Cards
Entrez_Gene (NCBI)IFNAR2  3455  interferon alpha and beta receptor subunit 2
AliasesIFN-R; IFN-alpha-REC; IFNABR; IFNARB; 
IMD45
GeneCards (Weizmann)IFNAR2
Ensembl hg19 (Hinxton)ENSG00000159110 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000159110 [Gene_View]  chr21:33229895-33262757 [Contig_View]  IFNAR2 [Vega]
ICGC DataPortalENSG00000159110
TCGA cBioPortalIFNAR2
AceView (NCBI)IFNAR2
Genatlas (Paris)IFNAR2
WikiGenes3455
SOURCE (Princeton)IFNAR2
Genetics Home Reference (NIH)IFNAR2
Genomic and cartography
GoldenPath hg38 (UCSC)IFNAR2  -     chr21:33229895-33262757 +  21q22.11   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)IFNAR2  -     21q22.11   [Description]    (hg19-Feb_2009)
EnsemblIFNAR2 - 21q22.11 [CytoView hg19]  IFNAR2 - 21q22.11 [CytoView hg38]
Mapping of homologs : NCBIIFNAR2 [Mapview hg19]  IFNAR2 [Mapview hg38]
OMIM602376   610424   616669   
Gene and transcription
Genbank (Entrez)AK293059 BC002793 BC013156 BG715143 BI520056
RefSeq transcript (Entrez)NM_000874 NM_001289125 NM_001289126 NM_001289128 NM_207584 NM_207585
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)IFNAR2
Cluster EST : UnigeneHs.708195 [ NCBI ]
CGAP (NCI)Hs.708195
Alternative Splicing GalleryENSG00000159110
Gene ExpressionIFNAR2 [ NCBI-GEO ]   IFNAR2 [ EBI - ARRAY_EXPRESS ]   IFNAR2 [ SEEK ]   IFNAR2 [ MEM ]
Gene Expression Viewer (FireBrowse)IFNAR2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3455
GTEX Portal (Tissue expression)IFNAR2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP48551   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP48551  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP48551
Splice isoforms : SwissVarP48551
PhosPhoSitePlusP48551
Domains : Interpro (EBI)FN3_dom    Ig-like_fold    Interferon/interleukin_rcp_dom   
Domain families : Pfam (Sanger)Interfer-bind (PF09294)    Tissue_fac (PF01108)   
Domain families : Pfam (NCBI)pfam09294    pfam01108   
Conserved Domain (NCBI)IFNAR2
DMDM Disease mutations3455
Blocks (Seattle)IFNAR2
PDB (SRS)1N6U    1N6V    2HYM    2KZ1    2LAG    3S8W    3S9D    3SE3    3SE4   
PDB (PDBSum)1N6U    1N6V    2HYM    2KZ1    2LAG    3S8W    3S9D    3SE3    3SE4   
PDB (IMB)1N6U    1N6V    2HYM    2KZ1    2LAG    3S8W    3S9D    3SE3    3SE4   
PDB (RSDB)1N6U    1N6V    2HYM    2KZ1    2LAG    3S8W    3S9D    3SE3    3SE4   
Structural Biology KnowledgeBase1N6U    1N6V    2HYM    2KZ1    2LAG    3S8W    3S9D    3SE3    3SE4   
SCOP (Structural Classification of Proteins)1N6U    1N6V    2HYM    2KZ1    2LAG    3S8W    3S9D    3SE3    3SE4   
CATH (Classification of proteins structures)1N6U    1N6V    2HYM    2KZ1    2LAG    3S8W    3S9D    3SE3    3SE4   
SuperfamilyP48551
Human Protein AtlasENSG00000159110
Peptide AtlasP48551
HPRD03850
IPIIPI00010193   IPI00220690   IPI00220691   IPI00893042   IPI00853210   IPI00853287   IPI00924877   IPI00925121   
Protein Interaction databases
DIP (DOE-UCLA)P48551
IntAct (EBI)P48551
FunCoupENSG00000159110
BioGRIDIFNAR2
STRING (EMBL)IFNAR2
ZODIACIFNAR2
Ontologies - Pathways
QuickGOP48551
Ontology : AmiGOtype I interferon receptor activity  protein binding  extracellular region  extracellular space  intracellular  plasma membrane  integral component of plasma membrane  regulation of transcription from RNA polymerase II promoter  cell surface receptor signaling pathway  JAK-STAT cascade  cell proliferation  response to virus  protein kinase binding  response to interferon-alpha  response to interferon-alpha  response to interferon-beta  defense response to virus  type I interferon signaling pathway  type I interferon signaling pathway  type I interferon signaling pathway  regulation of type I interferon-mediated signaling pathway  
Ontology : EGO-EBItype I interferon receptor activity  protein binding  extracellular region  extracellular space  intracellular  plasma membrane  integral component of plasma membrane  regulation of transcription from RNA polymerase II promoter  cell surface receptor signaling pathway  JAK-STAT cascade  cell proliferation  response to virus  protein kinase binding  response to interferon-alpha  response to interferon-alpha  response to interferon-beta  defense response to virus  type I interferon signaling pathway  type I interferon signaling pathway  type I interferon signaling pathway  regulation of type I interferon-mediated signaling pathway  
Pathways : BIOCARTABone Remodelling [Genes]    IFN alpha signaling pathway [Genes]   
Pathways : KEGG   
NDEx NetworkIFNAR2
Atlas of Cancer Signalling NetworkIFNAR2
Wikipedia pathwaysIFNAR2
Orthology - Evolution
OrthoDB3455
GeneTree (enSembl)ENSG00000159110
Phylogenetic Trees/Animal Genes : TreeFamIFNAR2
HOVERGENP48551
HOGENOMP48551
Homologs : HomoloGeneIFNAR2
Homology/Alignments : Family Browser (UCSC)IFNAR2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIFNAR2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IFNAR2
dbVarIFNAR2
ClinVarIFNAR2
1000_GenomesIFNAR2 
Exome Variant ServerIFNAR2
ExAC (Exome Aggregation Consortium)IFNAR2 (select the gene name)
Genetic variants : HAPMAP3455
Genomic Variants (DGV)IFNAR2 [DGVbeta]
DECIPHERIFNAR2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisIFNAR2 
Mutations
ICGC Data PortalIFNAR2 
TCGA Data PortalIFNAR2 
Broad Tumor PortalIFNAR2
OASIS PortalIFNAR2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIFNAR2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDIFNAR2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch IFNAR2
DgiDB (Drug Gene Interaction Database)IFNAR2
DoCM (Curated mutations)IFNAR2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)IFNAR2 (select a term)
intoGenIFNAR2
Cancer3DIFNAR2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602376    610424    616669   
Orphanet
MedgenIFNAR2
Genetic Testing Registry IFNAR2
NextProtP48551 [Medical]
TSGene3455
GENETestsIFNAR2
Huge Navigator IFNAR2 [HugePedia]
snp3D : Map Gene to Disease3455
BioCentury BCIQIFNAR2
ClinGenIFNAR2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3455
Chemical/Pharm GKB GenePA29671
Clinical trialIFNAR2
Miscellaneous
canSAR (ICR)IFNAR2 (select the gene name)
Probes
Litterature
PubMed98 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineIFNAR2
EVEXIFNAR2
GoPubMedIFNAR2
iHOPIFNAR2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:19:58 CEST 2017

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