Atlas of Genetics and Cytogenetics in Oncology and Haematology

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IFNB1 (interferon beta 1)

Identity

Alias (NCBI)IFB
IFF
IFN-beta
IFNB
HGNC (Hugo) IFNB1
HGNC Alias symbIFB
IFF
HGNC Previous nameIFNB
HGNC Previous nameinterferon, beta 1, fibroblast
LocusID (NCBI) 3456
Atlas_Id 40924
Location 9p21.3  [Link to chromosome band 9p21]
Location_base_pair Starts at 21077104 and ends at 21077942 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  del(6q)

External links

Nomenclature
HGNC (Hugo)IFNB1   5434
Cards
Entrez_Gene (NCBI)IFNB1  3456  interferon beta 1
AliasesIFB; IFF; IFN-beta; IFNB
GeneCards (Weizmann)IFNB1
Ensembl hg19 (Hinxton)ENSG00000171855 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000171855 [Gene_View]  ENSG00000171855 [Sequence]  chr9:21077104-21077942 [Contig_View]  IFNB1 [Vega]
ICGC DataPortalENSG00000171855
TCGA cBioPortalIFNB1
AceView (NCBI)IFNB1
Genatlas (Paris)IFNB1
WikiGenes3456
SOURCE (Princeton)IFNB1
Genetics Home Reference (NIH)IFNB1
Genomic and cartography
GoldenPath hg38 (UCSC)IFNB1  -     chr9:21077104-21077942 -  9p21.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)IFNB1  -     9p21.3   [Description]    (hg19-Feb_2009)
GoldenPathIFNB1 - 9p21.3 [CytoView hg19]  IFNB1 - 9p21.3 [CytoView hg38]
ImmunoBaseENSG00000171855
genome Data Viewer NCBIIFNB1 [Mapview hg19]  
OMIM147640   
Gene and transcription
Genbank (Entrez)AB451323 AB451452 AB451491 BC069314 BC096150
RefSeq transcript (Entrez)NM_002176
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)IFNB1
Alternative Splicing GalleryENSG00000171855
Gene ExpressionIFNB1 [ NCBI-GEO ]   IFNB1 [ EBI - ARRAY_EXPRESS ]   IFNB1 [ SEEK ]   IFNB1 [ MEM ]
Gene Expression Viewer (FireBrowse)IFNB1 [ Firebrowse - Broad ]
GenevisibleExpression of IFNB1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3456
GTEX Portal (Tissue expression)IFNB1
Human Protein AtlasENSG00000171855-IFNB1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP01574   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP01574  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP01574
Splice isoforms : SwissVarP01574
PhosPhoSitePlusP01574
Domaine pattern : Prosite (Expaxy)INTERFERON_A_B_D (PS00252)   
Domains : Interpro (EBI)4_helix_cytokine-like_core    Interferon_alpha/beta/delta    Interferon_beta   
Domain families : Pfam (Sanger)Interferon (PF00143)   
Domain families : Pfam (NCBI)pfam00143   
Domain families : Smart (EMBL)IFabd (SM00076)  
Conserved Domain (NCBI)IFNB1
DMDM Disease mutations3456
Blocks (Seattle)IFNB1
PDB (RSDB)1AU1   
PDB Europe1AU1   
PDB (PDBSum)1AU1   
PDB (IMB)1AU1   
Structural Biology KnowledgeBase1AU1   
SCOP (Structural Classification of Proteins)1AU1   
CATH (Classification of proteins structures)1AU1   
SuperfamilyP01574
Human Protein Atlas [tissue]ENSG00000171855-IFNB1 [tissue]
Peptide AtlasP01574
HPRD00972
IPIIPI00003088   
Protein Interaction databases
DIP (DOE-UCLA)P01574
IntAct (EBI)P01574
FunCoupENSG00000171855
BioGRIDIFNB1
STRING (EMBL)IFNB1
ZODIACIFNB1
Ontologies - Pathways
QuickGOP01574
Ontology : AmiGOadaptive immune response  T cell activation involved in immune response  B cell activation involved in immune response  natural killer cell activation involved in immune response  cytokine activity  cytokine activity  type I interferon receptor binding  type I interferon receptor binding  extracellular region  extracellular space  humoral immune response  cell surface receptor signaling pathway  blood coagulation  chloramphenicol O-acetyltransferase activity  response to virus  cytokine-mediated signaling pathway  natural killer cell activation  B cell differentiation  positive regulation of peptidyl-serine phosphorylation of STAT protein  positive regulation of peptidyl-serine phosphorylation of STAT protein  cellular response to interferon-beta  B cell proliferation  B cell proliferation  response to exogenous dsRNA  response to exogenous dsRNA  negative regulation of viral genome replication  positive regulation of innate immune response  regulation of MHC class I biosynthetic process  negative regulation of T cell differentiation  positive regulation of transcription by RNA polymerase II  defense response to virus  type I interferon signaling pathway  type I interferon signaling pathway  cellular response to exogenous dsRNA  negative regulation of T-helper 2 cell cytokine production  positive regulation of apoptotic signaling pathway  
Ontology : EGO-EBIadaptive immune response  T cell activation involved in immune response  B cell activation involved in immune response  natural killer cell activation involved in immune response  cytokine activity  cytokine activity  type I interferon receptor binding  type I interferon receptor binding  extracellular region  extracellular space  humoral immune response  cell surface receptor signaling pathway  blood coagulation  chloramphenicol O-acetyltransferase activity  response to virus  cytokine-mediated signaling pathway  natural killer cell activation  B cell differentiation  positive regulation of peptidyl-serine phosphorylation of STAT protein  positive regulation of peptidyl-serine phosphorylation of STAT protein  cellular response to interferon-beta  B cell proliferation  B cell proliferation  response to exogenous dsRNA  response to exogenous dsRNA  negative regulation of viral genome replication  positive regulation of innate immune response  regulation of MHC class I biosynthetic process  negative regulation of T cell differentiation  positive regulation of transcription by RNA polymerase II  defense response to virus  type I interferon signaling pathway  type I interferon signaling pathway  cellular response to exogenous dsRNA  negative regulation of T-helper 2 cell cytokine production  positive regulation of apoptotic signaling pathway  
Pathways : KEGGCytokine-cytokine receptor interaction    PI3K-Akt signaling pathway    Osteoclast differentiation    Toll-like receptor signaling pathway    RIG-I-like receptor signaling pathway    Cytosolic DNA-sensing pathway    Jak-STAT signaling pathway    Natural killer cell mediated cytotoxicity    Chagas disease (American trypanosomiasis)    Tuberculosis    Hepatitis C    Hepatitis B    Measles    Influenza A    Herpes simplex infection   
NDEx NetworkIFNB1
Atlas of Cancer Signalling NetworkIFNB1
Wikipedia pathwaysIFNB1
Orthology - Evolution
OrthoDB3456
GeneTree (enSembl)ENSG00000171855
Phylogenetic Trees/Animal Genes : TreeFamIFNB1
HOGENOMP01574
Homologs : HomoloGeneIFNB1
Homology/Alignments : Family Browser (UCSC)IFNB1
Gene fusions - Rearrangements
Fusion : QuiverIFNB1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIFNB1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IFNB1
dbVarIFNB1
ClinVarIFNB1
MonarchIFNB1
1000_GenomesIFNB1 
Exome Variant ServerIFNB1
GNOMAD BrowserENSG00000171855
Varsome BrowserIFNB1
Genetic variants : HAPMAP3456
Genomic Variants (DGV)IFNB1 [DGVbeta]
DECIPHERIFNB1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisIFNB1 
Mutations
ICGC Data PortalIFNB1 
TCGA Data PortalIFNB1 
Broad Tumor PortalIFNB1
OASIS PortalIFNB1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIFNB1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DIFNB1
Mutations and Diseases : HGMDIFNB1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch IFNB1
DgiDB (Drug Gene Interaction Database)IFNB1
DoCM (Curated mutations)IFNB1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)IFNB1 (select a term)
intoGenIFNB1
Cancer3DIFNB1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM147640   
Orphanet
DisGeNETIFNB1
MedgenIFNB1
Genetic Testing Registry IFNB1
NextProtP01574 [Medical]
TSGene3456
GENETestsIFNB1
Target ValidationIFNB1
Huge Navigator IFNB1 [HugePedia]
snp3D : Map Gene to Disease3456
BioCentury BCIQIFNB1
ClinGenIFNB1
Clinical trials, drugs, therapy
Protein Interactions : CTD3456
Pharm GKB GenePA29672
Clinical trialIFNB1
Miscellaneous
canSAR (ICR)IFNB1 (select the gene name)
HarmonizomeIFNB1
DataMed IndexIFNB1
Probes
Litterature
PubMed407 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineIFNB1
EVEXIFNB1
GoPubMedIFNB1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 14 14:15:21 CEST 2020
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