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IFNB1 (interferon, beta 1, fibroblast)

Identity

Other namesIFB
IFF
IFNB
HGNC (Hugo) IFNB1
LocusID (NCBI) 3456
Location 9p21.3
Location_base_pair Starts at 21077104 and ends at 21077943 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)IFNB1   5434
Cards
Entrez_Gene (NCBI)IFNB1  3456  interferon, beta 1, fibroblast
GeneCards (Weizmann)IFNB1
Ensembl hg19 (Hinxton)ENSG00000171855 [Gene_View]  chr9:21077104-21077943 [Contig_View]  IFNB1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000171855 [Gene_View]  chr9:21077104-21077943 [Contig_View]  IFNB1 [Vega]
ICGC DataPortalENSG00000171855
cBioPortalIFNB1
AceView (NCBI)IFNB1
Genatlas (Paris)IFNB1
WikiGenes3456
SOURCE (Princeton)IFNB1
Genomic and cartography
GoldenPath hg19 (UCSC)IFNB1  -     chr9:21077104-21077943 -  9p21.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)IFNB1  -     9p21.3   [Description]    (hg38-Dec_2013)
EnsemblIFNB1 - 9p21.3 [CytoView hg19]  IFNB1 - 9p21.3 [CytoView hg38]
Mapping of homologs : NCBIIFNB1 [Mapview hg19]  IFNB1 [Mapview hg38]
OMIM147640   
Gene and transcription
Genbank (Entrez)AB451323 AB451452 BC069314 BC096150 BC096151
RefSeq transcript (Entrez)NM_002176
RefSeq genomic (Entrez)AC_000141 NC_000009 NC_018920 NT_008413 NW_001839149 NW_004929342
Consensus coding sequences : CCDS (NCBI)IFNB1
Cluster EST : UnigeneHs.93177 [ NCBI ]
CGAP (NCI)Hs.93177
Alternative Splicing : Fast-db (Paris)GSHG0030705
Alternative Splicing GalleryENSG00000171855
Gene ExpressionIFNB1 [ NCBI-GEO ]     IFNB1 [ SEEK ]   IFNB1 [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP01574 (Uniprot)
NextProtP01574  [Medical]
With graphics : InterProP01574
Splice isoforms : SwissVarP01574 (Swissvar)
Domaine pattern : Prosite (Expaxy)INTERFERON_A_B_D (PS00252)   
Domains : Interpro (EBI)4_helix_cytokine-like_core    4_helix_cytokine_core    Interferon_alpha/beta/delta    Interferon_beta   
Related proteins : CluSTrP01574
Domain families : Pfam (Sanger)Interferon (PF00143)   
Domain families : Pfam (NCBI)pfam00143   
Domain families : Smart (EMBL)IFabd (SM00076)  
DMDM Disease mutations3456
Blocks (Seattle)P01574
PDB (SRS)1AU1   
PDB (PDBSum)1AU1   
PDB (IMB)1AU1   
PDB (RSDB)1AU1   
Human Protein AtlasENSG00000171855
Peptide AtlasP01574
HPRD00972
IPIIPI00003088   
Protein Interaction databases
DIP (DOE-UCLA)P01574
IntAct (EBI)P01574
FunCoupENSG00000171855
BioGRIDIFNB1
IntegromeDBIFNB1
STRING (EMBL)IFNB1
Ontologies - Pathways
QuickGOP01574
Ontology : AmiGOadaptive immune response  T cell activation involved in immune response  B cell activation involved in immune response  natural killer cell activation involved in immune response  cytokine activity  cytokine activity  type I interferon receptor binding  extracellular region  extracellular region  extracellular space  humoral immune response  cell surface receptor signaling pathway  blood coagulation  response to virus  cytokine-mediated signaling pathway  cytokine-mediated signaling pathway  natural killer cell activation  B cell differentiation  positive regulation of peptidyl-serine phosphorylation of STAT protein  cellular response to interferon-beta  B cell proliferation  defense response to bacterium  response to exogenous dsRNA  negative regulation of viral genome replication  innate immune response  positive regulation of innate immune response  regulation of MHC class I biosynthetic process  negative regulation of T cell differentiation  positive regulation of transcription from RNA polymerase II promoter  defense response to virus  type I interferon signaling pathway  type I interferon signaling pathway  regulation of type I interferon-mediated signaling pathway  cellular response to exogenous dsRNA  negative regulation of T-helper 2 cell cytokine production  positive regulation of apoptotic signaling pathway  
Ontology : EGO-EBIadaptive immune response  T cell activation involved in immune response  B cell activation involved in immune response  natural killer cell activation involved in immune response  cytokine activity  cytokine activity  type I interferon receptor binding  extracellular region  extracellular region  extracellular space  humoral immune response  cell surface receptor signaling pathway  blood coagulation  response to virus  cytokine-mediated signaling pathway  cytokine-mediated signaling pathway  natural killer cell activation  B cell differentiation  positive regulation of peptidyl-serine phosphorylation of STAT protein  cellular response to interferon-beta  B cell proliferation  defense response to bacterium  response to exogenous dsRNA  negative regulation of viral genome replication  innate immune response  positive regulation of innate immune response  regulation of MHC class I biosynthetic process  negative regulation of T cell differentiation  positive regulation of transcription from RNA polymerase II promoter  defense response to virus  type I interferon signaling pathway  type I interferon signaling pathway  regulation of type I interferon-mediated signaling pathway  cellular response to exogenous dsRNA  negative regulation of T-helper 2 cell cytokine production  positive regulation of apoptotic signaling pathway  
Pathways : BIOCARTASignal transduction through IL1R [Genes]    Cytokines and Inflammatory Response [Genes]    Cytokine Network [Genes]    Bone Remodelling [Genes]    IFN alpha signaling pathway [Genes]    Dendritic cells in regulating TH1 and TH2 Development [Genes]   
Pathways : KEGGCytokine-cytokine receptor interaction    PI3K-Akt signaling pathway    Osteoclast differentiation    Toll-like receptor signaling pathway    RIG-I-like receptor signaling pathway    Cytosolic DNA-sensing pathway    Jak-STAT signaling pathway    Natural killer cell mediated cytotoxicity    Chagas disease (American trypanosomiasis)    Tuberculosis    Hepatitis C    Hepatitis B    Measles    Influenza A    Herpes simplex infection   
Protein Interaction DatabaseIFNB1
DoCM (Curated mutations)IFNB1
Wikipedia pathwaysIFNB1
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerIFNB1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IFNB1
dbVarIFNB1
ClinVarIFNB1
1000_GenomesIFNB1 
Exome Variant ServerIFNB1
SNP (GeneSNP Utah)IFNB1
SNP : HGBaseIFNB1
Genetic variants : HAPMAPIFNB1
Genomic VariantsIFNB1  IFNB1 [DGVbeta]
Mutations
ICGC Data PortalENSG00000171855 
Somatic Mutations in Cancer : COSMICIFNB1 
CONAN: Copy Number AnalysisIFNB1 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)9:21077104-21077943
Mutations and Diseases : HGMDIFNB1
OMIM147640   
MedgenIFNB1
NextProtP01574 [Medical]
GENETestsIFNB1
Disease Genetic AssociationIFNB1
Huge Navigator IFNB1 [HugePedia]  IFNB1 [HugeCancerGEM]
snp3D : Map Gene to Disease3456
DGIdb (Drug Gene Interaction db)IFNB1
General knowledge
Homologs : HomoloGeneIFNB1
Homology/Alignments : Family Browser (UCSC)IFNB1
Phylogenetic Trees/Animal Genes : TreeFamIFNB1
Chemical/Protein Interactions : CTD3456
Chemical/Pharm GKB GenePA29672
Clinical trialIFNB1
Cancer Resource (Charite)ENSG00000171855
Other databases
Probes
Litterature
PubMed284 Pubmed reference(s) in Entrez
CoreMineIFNB1
GoPubMedIFNB1
iHOPIFNB1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2014Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Dec 20 22:06:58 CET 2014
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