IFNB1 (interferon, beta 1, fibroblast)

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Taking over the Atlas
Dear Colleagues,
The Atlas, once more, is in great danger, and I will have to proceed to a collective economic lay-off of all the team involved in the Atlas before the begining of April 2015 (a foundation having suddenly withdrawn its commitment to support the Atlas). I ask you herein if any Scientific Society (a Society of Cytogenetics, of Clinical Genetics, of Hematology, or a Cancer Society, or any other...), any University and/or Hospital, any Charity, or any database would be interested in taking over the Atlas, in whole or in part. If taking charge of the whole lot is too big, a consortium of various actors could be the solution (I am myself trying to find partners). Could you please spread the information, contact the relevant authorities, and find partners.
Survival of the Atlas will be critically dependant upon your ability to find solutions (and urgently!).
Kind regards.
Jean-Loup Huret
Donations are also welcome

IFNB1 (interferon, beta 1, fibroblast)

Identity

Other names	IFB
	IFF
	IFNB
HGNC (Hugo)	IFNB1
LocusID (NCBI)	3456
Location	9p21.3
Location_base_pair	Starts at 21077104 and ends at 21077943 bp from pter ( according to hg19-Feb_2009)
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to How to contribute

DNA/RNA

External links

	Nomenclature
HGNC (Hugo)	IFNB1 5434
	Cards
Entrez_Gene (NCBI)	IFNB1 3456 interferon, beta 1, fibroblast
GeneCards (Weizmann)	IFNB1
Ensembl hg19 (Hinxton)	ENSG00000171855 [Gene_View] chr9:21077104-21077943 [Contig_View] IFNB1 [Vega]
Ensembl hg38 (Hinxton)	ENSG00000171855 [Gene_View] chr9:21077104-21077943 [Contig_View] IFNB1 [Vega]
ICGC DataPortal	ENSG00000171855
cBioPortal	IFNB1
AceView (NCBI)	IFNB1
Genatlas (Paris)	IFNB1
WikiGenes	3456
SOURCE (Princeton)	IFNB1
	Genomic and cartography
GoldenPath hg19 (UCSC)	IFNB1 - chr9:21077104-21077943 - 9p21.3 [Description] (hg19-Feb_2009)
GoldenPath hg38 (UCSC)	IFNB1 - 9p21.3 [Description] (hg38-Dec_2013)
Ensembl	IFNB1 - 9p21.3 [CytoView hg19] IFNB1 - 9p21.3 [CytoView hg38]
Mapping of homologs : NCBI	IFNB1 [Mapview hg19] IFNB1 [Mapview hg38]
OMIM	147640
	Gene and transcription
Genbank (Entrez)	AB451323 AB451452 BC069314 BC096150 BC096151
RefSeq transcript (Entrez)	NM_002176
RefSeq genomic (Entrez)	AC_000141 NC_000009 NC_018920 NT_008413 NW_001839149 NW_004929342
Consensus coding sequences : CCDS (NCBI)	IFNB1
Cluster EST : Unigene	Hs.93177 [ NCBI ]
CGAP (NCI)	Hs.93177
Alternative Splicing : Fast-db (Paris)	GSHG0030705
Alternative Splicing Gallery	ENSG00000171855
Gene Expression	IFNB1 [ NCBI-GEO ] IFNB1 [ SEEK ] IFNB1 [ MEM ]
SOURCE (Princeton)	Expression in : [Normal Tissue Atlas] [carcinoma Classsification] [NCI60]
	Protein : pattern, domain, 3D structure
UniProt/SwissProt	P01574 (Uniprot)
NextProt	P01574 [Medical]
With graphics : InterPro	P01574
Splice isoforms : SwissVar	P01574 (Swissvar)
Domaine pattern : Prosite (Expaxy)	INTERFERON_A_B_D (PS00252)
Domains : Interpro (EBI)	4_helix_cytokine-like_core 4_helix_cytokine_core Interferon_alpha/beta/delta Interferon_beta
Related proteins : CluSTr	P01574
Domain families : Pfam (Sanger)	Interferon (PF00143)
Domain families : Pfam (NCBI)	pfam00143
Domain families : Smart (EMBL)	IFabd (SM00076)
DMDM Disease mutations	3456
Blocks (Seattle)	P01574
PDB (SRS)	1AU1
PDB (PDBSum)	1AU1
PDB (IMB)	1AU1
PDB (RSDB)	1AU1
Human Protein Atlas	ENSG00000171855
Peptide Atlas	P01574
HPRD	00972
IPI	IPI00003088
	Protein Interaction databases
DIP (DOE-UCLA)	P01574
IntAct (EBI)	P01574
FunCoup	ENSG00000171855
BioGRID	IFNB1
IntegromeDB	IFNB1
STRING (EMBL)	IFNB1
	Ontologies - Pathways
QuickGO	P01574
Ontology : AmiGO	adaptive immune response T cell activation involved in immune response B cell activation involved in immune response natural killer cell activation involved in immune response cytokine activity cytokine activity type I interferon receptor binding extracellular region extracellular region extracellular space humoral immune response cell surface receptor signaling pathway blood coagulation response to virus cytokine-mediated signaling pathway cytokine-mediated signaling pathway natural killer cell activation B cell differentiation positive regulation of peptidyl-serine phosphorylation of STAT protein cellular response to interferon-beta B cell proliferation defense response to bacterium response to exogenous dsRNA negative regulation of viral genome replication innate immune response positive regulation of innate immune response regulation of MHC class I biosynthetic process negative regulation of T cell differentiation positive regulation of transcription from RNA polymerase II promoter defense response to virus type I interferon signaling pathway type I interferon signaling pathway regulation of type I interferon-mediated signaling pathway cellular response to exogenous dsRNA negative regulation of T-helper 2 cell cytokine production positive regulation of apoptotic signaling pathway
Ontology : EGO-EBI	adaptive immune response T cell activation involved in immune response B cell activation involved in immune response natural killer cell activation involved in immune response cytokine activity cytokine activity type I interferon receptor binding extracellular region extracellular region extracellular space humoral immune response cell surface receptor signaling pathway blood coagulation response to virus cytokine-mediated signaling pathway cytokine-mediated signaling pathway natural killer cell activation B cell differentiation positive regulation of peptidyl-serine phosphorylation of STAT protein cellular response to interferon-beta B cell proliferation defense response to bacterium response to exogenous dsRNA negative regulation of viral genome replication innate immune response positive regulation of innate immune response regulation of MHC class I biosynthetic process negative regulation of T cell differentiation positive regulation of transcription from RNA polymerase II promoter defense response to virus type I interferon signaling pathway type I interferon signaling pathway regulation of type I interferon-mediated signaling pathway cellular response to exogenous dsRNA negative regulation of T-helper 2 cell cytokine production positive regulation of apoptotic signaling pathway
Pathways : BIOCARTA	Signal transduction through IL1R [Genes] Cytokines and Inflammatory Response [Genes] Cytokine Network [Genes] Bone Remodelling [Genes] IFN alpha signaling pathway [Genes] Dendritic cells in regulating TH1 and TH2 Development [Genes]
Pathways : KEGG	Cytokine-cytokine receptor interaction PI3K-Akt signaling pathway Osteoclast differentiation Toll-like receptor signaling pathway RIG-I-like receptor signaling pathway Cytosolic DNA-sensing pathway Jak-STAT signaling pathway Natural killer cell mediated cytotoxicity Chagas disease (American trypanosomiasis) Tuberculosis Hepatitis C Hepatitis B Measles Influenza A Herpes simplex infection
Protein Interaction Database	IFNB1
DoCM (Curated mutations)	IFNB1
Wikipedia pathways	IFNB1
	Gene fusion - rearrangements
	Polymorphisms : SNP, variants
NCBI Variation Viewer	IFNB1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)	IFNB1
dbVar	IFNB1
ClinVar	IFNB1
1000_Genomes	IFNB1
Exome Variant Server	IFNB1
SNP (GeneSNP Utah)	IFNB1
SNP : HGBase	IFNB1
Genetic variants : HAPMAP	IFNB1
Genomic Variants (DGV)	IFNB1 [DGVbeta]
	Mutations
ICGC Data Portal	ENSG00000171855
Somatic Mutations in Cancer : COSMIC	IFNB1
CONAN: Copy Number Analysis	IFNB1
LOVD (Leiden Open Variation Database)	Whole genome datasets
LOVD (Leiden Open Variation Database)	LOVD 3.0 shared installation
Impact of mutations	[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor]
	Diseases
DECIPHER (Syndromes)	9:21077104-21077943
Mutations and Diseases : HGMD	IFNB1
OMIM	147640
Medgen	IFNB1
NextProt	P01574 [Medical]
GENETests	IFNB1
Disease Genetic Association	IFNB1
Huge Navigator	IFNB1 [HugePedia] IFNB1 [HugeCancerGEM]
snp3D : Map Gene to Disease	3456
DGIdb (Drug Gene Interaction db)	IFNB1
	General knowledge
Homologs : HomoloGene	IFNB1
Homology/Alignments : Family Browser (UCSC)	IFNB1
Phylogenetic Trees/Animal Genes : TreeFam	IFNB1
Chemical/Protein Interactions : CTD	3456
Chemical/Pharm GKB Gene	PA29672
Clinical trial	IFNB1
Cancer Resource (Charite)	ENSG00000171855
	Other databases
	Probes
	Litterature
PubMed	284 Pubmed reference(s) in Entrez
CoreMine	IFNB1
GoPubMed	IFNB1
iHOP	IFNB1

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S

Updated	12-2014	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Sat Feb 14 16:17:39 CET 2015

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For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.