| Nomenclature |
|---|
| HGNC (Hugo) | IFNG 5438 |
| Cards |
|---|
| Entrez_Gene (NCBI) | IFNG 3458 interferon, gamma |
| GeneCards (Weizmann) | IFNG |
| Ensembl hg19 (Hinxton) | ENSG00000111537 [Gene_View] chr12:68548550-68553521 [Contig_View] IFNG [Vega] |
| Ensembl hg38 (Hinxton) | ENSG00000111537 [Gene_View] chr12:68548550-68553521 [Contig_View] IFNG [Vega] |
| ICGC DataPortal | ENSG00000111537 |
| cBioPortal | IFNG |
| AceView (NCBI) | IFNG |
| Genatlas (Paris) | IFNG |
| WikiGenes | 3458 |
| SOURCE (Princeton) | IFNG |
| Genomic and cartography |
|---|
| GoldenPath hg19 (UCSC) | IFNG - chr12:68548550-68553521 - 12q15 [Description] (hg19-Feb_2009) |
| GoldenPath hg38 (UCSC) | IFNG - 12q15 [Description] (hg38-Dec_2013) |
| Ensembl | IFNG - 12q15 [CytoView hg19] IFNG - 12q15 [CytoView hg38] |
| Mapping of homologs : NCBI | IFNG [Mapview hg19] IFNG [Mapview hg38] |
| OMIM | 147570 607948 609135 609423 609532 613254 |
| Gene and transcription |
|---|
| Genbank (Entrez) | AB451324 AB451453 AF506749 AM903379 AY044154 |
| RefSeq transcript (Entrez) | NM_000619 |
| RefSeq genomic (Entrez) | AC_000144 NC_000012 NC_018923 NG_015840 NT_029419 NW_001838060 NW_004929384 |
| Consensus coding sequences : CCDS (NCBI) | IFNG |
| Cluster EST : Unigene | Hs.856 [ NCBI ] |
| CGAP (NCI) | Hs.856 |
| Alternative Splicing : Fast-db (Paris) | GSHG0007611 |
| Alternative Splicing Gallery | ENSG00000111537 |
| Gene Expression | IFNG [ NCBI-GEO ] IFNG [ SEEK ] IFNG [ MEM ] |
| SOURCE (Princeton) | Expression in : [Normal Tissue Atlas] [carcinoma Classsification] [NCI60] |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | P01579 (Uniprot) |
| NextProt | P01579 [Medical] |
| With graphics : InterPro | P01579 |
| Splice isoforms : SwissVar | P01579 (Swissvar) |
| Domains : Interpro (EBI) | 4_helix_cytokine-like_core 4_helix_cytokine_core Interferon_gamma |
| Related proteins : CluSTr | P01579 |
| Domain families : Pfam (Sanger) | IFN-gamma (PF00714) |
| Domain families : Pfam (NCBI) | pfam00714 |
| Domain structure : Prodom (Prabi Lyon) | Interferon_gamma (PD002435) |
| DMDM Disease mutations | 3458 |
| Blocks (Seattle) | P01579 |
| PDB (SRS) | 1EKU 1FG9 1FYH 1HIG 3BES |
| PDB (PDBSum) | 1EKU 1FG9 1FYH 1HIG 3BES |
| PDB (IMB) | 1EKU 1FG9 1FYH 1HIG 3BES |
| PDB (RSDB) | 1EKU 1FG9 1FYH 1HIG 3BES |
| Human Protein Atlas | ENSG00000111537 |
| Peptide Atlas | P01579 |
| HPRD | 00957 |
| IPI | IPI00307209 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | P01579 |
| IntAct (EBI) | P01579 |
| FunCoup | ENSG00000111537 |
| BioGRID | IFNG |
| IntegromeDB | IFNG |
| STRING (EMBL) | IFNG |
| Ontologies - Pathways |
|---|
| QuickGO | P01579 |
| Ontology : AmiGO | protein import into nucleus, translocation negative regulation of transcription from RNA polymerase II promoter neutrophil apoptotic process regulation of the force of heart contraction positive regulation of mesenchymal cell proliferation adaptive immune response CD8-positive, alpha-beta T cell differentiation involved in immune response negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis cytokine activity interferon-gamma receptor binding extracellular region extracellular region extracellular space apoptotic process cellular component movement humoral immune response cell cycle arrest cell surface receptor signaling pathway response to virus external side of plasma membrane cytokine-mediated signaling pathway antigen processing and presentation neutrophil chemotaxis endoplasmic reticulum unfolded protein response negative regulation of myelination positive regulation of synaptic transmission, cholinergic negative regulation of interleukin-17 production positive regulation of interleukin-12 production positive regulation of interleukin-23 production positive regulation of tumor necrosis factor production positive regulation of peptidyl-serine phosphorylation of STAT protein positive regulation of peptidyl-serine phosphorylation of STAT protein positive regulation of smooth muscle cell apoptotic process positive regulation of T cell proliferation response to drug positive regulation of tyrosine phosphorylation of Stat1 protein defense response to bacterium defense response to protozoan negative regulation of growth of symbiont in host positive regulation of chemokine biosynthetic process positive regulation of interleukin-12 biosynthetic process positive regulation of MHC class II biosynthetic process positive regulation of interleukin-6 biosynthetic process positive regulation of nitric oxide biosynthetic process positive regulation of neuron differentiation positive regulation of osteoclast differentiation positive regulation of cell adhesion positive regulation of transcription from RNA polymerase II promoter positive regulation of isotype switching to IgG isotypes negative regulation of smooth muscle cell proliferation positive regulation of interleukin-1 beta secretion regulation of insulin secretion positive regulation of membrane protein ectodomain proteolysis defense response to virus positive regulation of killing of cells of other organism interferon-gamma-mediated signaling pathway regulation of interferon-gamma-mediated signaling pathway positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity positive regulation of fructose 1,6-bisphosphate metabolic process positive regulation of vitamin D biosynthetic process positive regulation of calcidiol 1-monooxygenase activity cellular response to lipopolysaccharide cellular response to interleukin-18 negative regulation of metanephric nephron tubule epithelial cell differentiation extrinsic apoptotic signaling pathway positive regulation of tumor necrosis factor (ligand) superfamily member 11 production |
| Ontology : EGO-EBI | protein import into nucleus, translocation negative regulation of transcription from RNA polymerase II promoter neutrophil apoptotic process regulation of the force of heart contraction positive regulation of mesenchymal cell proliferation adaptive immune response CD8-positive, alpha-beta T cell differentiation involved in immune response negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis cytokine activity interferon-gamma receptor binding extracellular region extracellular region extracellular space apoptotic process cellular component movement humoral immune response cell cycle arrest cell surface receptor signaling pathway response to virus external side of plasma membrane cytokine-mediated signaling pathway antigen processing and presentation neutrophil chemotaxis endoplasmic reticulum unfolded protein response negative regulation of myelination positive regulation of synaptic transmission, cholinergic negative regulation of interleukin-17 production positive regulation of interleukin-12 production positive regulation of interleukin-23 production positive regulation of tumor necrosis factor production positive regulation of peptidyl-serine phosphorylation of STAT protein positive regulation of peptidyl-serine phosphorylation of STAT protein positive regulation of smooth muscle cell apoptotic process positive regulation of T cell proliferation response to drug positive regulation of tyrosine phosphorylation of Stat1 protein defense response to bacterium defense response to protozoan negative regulation of growth of symbiont in host positive regulation of chemokine biosynthetic process positive regulation of interleukin-12 biosynthetic process positive regulation of MHC class II biosynthetic process positive regulation of interleukin-6 biosynthetic process positive regulation of nitric oxide biosynthetic process positive regulation of neuron differentiation positive regulation of osteoclast differentiation positive regulation of cell adhesion positive regulation of transcription from RNA polymerase II promoter positive regulation of isotype switching to IgG isotypes negative regulation of smooth muscle cell proliferation positive regulation of interleukin-1 beta secretion regulation of insulin secretion positive regulation of membrane protein ectodomain proteolysis defense response to virus positive regulation of killing of cells of other organism interferon-gamma-mediated signaling pathway regulation of interferon-gamma-mediated signaling pathway positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity positive regulation of fructose 1,6-bisphosphate metabolic process positive regulation of vitamin D biosynthetic process positive regulation of calcidiol 1-monooxygenase activity cellular response to lipopolysaccharide cellular response to interleukin-18 negative regulation of metanephric nephron tubule epithelial cell differentiation extrinsic apoptotic signaling pathway positive regulation of tumor necrosis factor (ligand) superfamily member 11 production |
| Pathways : BIOCARTA | IL 18 Signaling Pathway [Genes] Selective expression of chemokine receptors during T-cell polarization [Genes] IFN gamma signaling pathway [Genes] Role of Tob in T-cell activation [Genes] The 4-1BB-dependent immune response [Genes] IL12 and Stat4 Dependent Signaling Pathway in Th1 Development [Genes] Cytokine Network [Genes] Chaperones modulate interferon Signaling Pathway [Genes] NO2-dependent IL 12 Pathway in NK cells [Genes] Adhesion and Diapedesis of Granulocytes [Genes] Dendritic cells in regulating TH1 and TH2 Development [Genes] Cytokines and Inflammatory Response [Genes] Th1/Th2 Differentiation [Genes] |
| Pathways : KEGG | Proteasome Cytokine-cytokine receptor interaction HIF-1 signaling pathway Regulation of autophagy TGF-beta signaling pathway Osteoclast differentiation Antigen processing and presentation Jak-STAT signaling pathway Natural killer cell mediated cytotoxicity T cell receptor signaling pathway Type I diabetes mellitus Salmonella infection Leishmaniasis Chagas disease (American trypanosomiasis) African trypanosomiasis Malaria Toxoplasmosis Amoebiasis Tuberculosis Measles Influenza A Herpes simplex infection Epstein-Barr virus infection Inflammatory bowel disease (IBD) Systemic lupus erythematosus Rheumatoid arthritis Allograft rejection Graft-versus-host disease |
| Protein Interaction Database | IFNG |
| DoCM (Curated mutations) | IFNG |
| Wikipedia pathways | IFNG |
| Gene fusion - rearrangements |
|---|
| Polymorphisms : SNP, variants |
|---|
| NCBI Variation Viewer | IFNG [hg38] |
| dbSNP Single Nucleotide Polymorphism (NCBI) | IFNG |
| dbVar | IFNG |
| ClinVar | IFNG |
| 1000_Genomes | IFNG |
| Exome Variant Server | IFNG |
| SNP (GeneSNP Utah) | IFNG |
| SNP : HGBase | IFNG |
| Genetic variants : HAPMAP | IFNG |
| Genomic Variants (DGV) | IFNG [DGVbeta] |
| Mutations |
|---|
| ICGC Data Portal | ENSG00000111537 |
| Somatic Mutations in Cancer : COSMIC | IFNG |
| CONAN: Copy Number Analysis | IFNG |
| LOVD (Leiden Open Variation Database) | Whole genome datasets |
| LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
| LOVD (Leiden Open Variation Database) | TBsLVD Tuberculosis susceptibility Locus Variation Database |
| Impact of mutations | [PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] |
| Diseases |
|---|
| DECIPHER (Syndromes) | 12:68548550-68553521 |
| Mutations and Diseases : HGMD | IFNG |
| OMIM | 147570 607948 609135 609423 609532 613254 |
| Medgen | IFNG |
| NextProt | P01579 [Medical] |
| GENETests | IFNG |
| Disease Genetic Association | IFNG |
| Huge Navigator |
IFNG [HugePedia] IFNG [HugeCancerGEM] |
| snp3D : Map Gene to Disease | 3458 |
| DGIdb (Drug Gene Interaction db) | IFNG |
| General knowledge |
|---|
| Homologs : HomoloGene | IFNG |
| Homology/Alignments : Family Browser (UCSC) | IFNG |
| Phylogenetic Trees/Animal Genes : TreeFam | IFNG |
| Chemical/Protein Interactions : CTD | 3458 |
| Chemical/Pharm GKB Gene | PA29674 |
| Clinical trial | IFNG |
| Cancer Resource (Charite) | ENSG00000111537 |
| Other databases |
|---|
| Probes |
|---|
| Litterature |
|---|
| PubMed | 499 Pubmed reference(s) in Entrez |
| CoreMine | IFNG |
| GoPubMed | IFNG |
| iHOP | IFNG |
