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IFNG (interferon, gamma)

Identity

Other namesIFG
IFI
HGNC (Hugo) IFNG
LocusID (NCBI) 3458
Location 12q15
Location_base_pair Starts at 68548550 and ends at 68553521 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)IFNG   5438
Entrez_Gene (NCBI)IFNG  3458  interferon, gamma
Cards
GeneCards (Weizmann)IFNG
Ensembl (Hinxton)ENSG00000111537 [Gene_View]  chr12:68548550-68553521 [Contig_View]  IFNG [Vega]
AceView (NCBI)IFNG
Genatlas (Paris)IFNG
SOURCE (Stanford)NM_000619
Genomic and cartography
GoldenPath (UCSC)IFNG  -  12q15   chr12:68548550-68553521 -  12q15   [Description]    (hg19-Feb_2009)
EnsemblIFNG - 12q15 [CytoView]
Mapping of homologs : NCBIIFNG [Mapview]
OMIM147570   191100   607948   609135   609423   609532   613254   
Gene and transcription
Genbank (Entrez)AB451324 AB451453 AF506749 AM903379 AY044154
RefSeq transcript (SRS)NM_000619
RefSeq transcript (Entrez)NM_000619
RefSeq genomic (SRS)AC_000144 NC_000012 NC_018923 NG_015840 NT_029419 NW_001838060 NW_004078075
RefSeq genomic (Entrez)AC_000144 NC_000012 NC_018923 NG_015840 NT_029419 NW_001838060 NW_004078075
Consensus coding sequences : CCDS (NCBI)IFNG
Cluster EST : UnigeneHs.856 [ SRS ] Hs.856 [ NCBI ]
CGAP (NCI)Hs.856
Alternative Splicing : Fast-db (Paris)GSHG0007611
Alternative Splicing GalleryENSG00000111537
Gene ExpressionIFNG [ NCBI-GEO ]   IFNG [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP01579 (SRS) P01579 (Uniprot)
NextProtP01579
With graphics : InterProP01579
Splice isoforms : SwissVarP01579(Swissvar)
Domains : Interpro (SRS)4_helix_cytokine-like_core    4_helix_cytokine_core    Interferon_gamma   
Domains : Interpro (EBI)4_helix_cytokine-like_core    4_helix_cytokine_core    Interferon_gamma   
Related proteins : CluSTrP01579
Domain families : Pfam (SRS)IFN-gamma (PF00714)   
Domain families : Pfam (Sanger)IFN-gamma (PF00714)   
Domain families : Pfam (NCBI)pfam00714   
Domain structure : Prodom (Prabi Lyon)Interferon_gamma (PD002435)   
DMDM3458
Blocks (Seattle)P01579
PDB (SRS)1EKU    1FG9    1FYH    1HIG    3BES   
PDB (PDBSum)1EKU    1FG9    1FYH    1HIG    3BES   
PDB (IMB)1EKU    1FG9    1FYH    1HIG    3BES   
PDB (RSDB)1EKU    1FG9    1FYH    1HIG    3BES   
Human Protein AtlasENSG00000111537
HPRD00957
IPIIPI00307209   
Protein Interaction databases
DIP (DOE-UCLA)P01579
IntAct (EBI)P01579
FunCoupENSG00000111537
REACTOMEIFNG
Protein Interaction Database3458
BioGRIDIFNG
InParanoidP01579
Interologous Interaction database P01579
IntegromeDBIFNG
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)IFNG
SNP (GeneSNP Utah)IFNG
SNP : HGBaseIFNG
Genetic variants : HAPMAPIFNG
Somatic Mutations in Cancer : COSMICIFNG 
CONAN: Copy Number AnalysisIFNG 
Mutations and Diseases : HGMDIFNG
OMIM147570    191100    607948    609135    609423    609532    613254   
GENETests147570    191100    607948    609135    609423    609532    613254   
Disease Genetic AssociationIFNG
Huge Navigator IFNG [HugePedia]  IFNG [HugeCancerGEM]
Genomic VariantsIFNG  IFNG [DGVbeta]
ClinVarIFNG
snp3D : Map Gene to Disease3458
General knowledge
Homologs : HomoloGeneIFNG
Homology/Alignments : Family Browser (UCSC)IFNG
Phylogenetic Trees/Animal Genes : TreeFamIFNG
Chemical/Protein Interactions : CTD3458
Chemical/Pharm GKB GenePA29674
Clinical trialIFNG
Cancer Resource (Charite)ENSG00000111537
Ontology : AmiGOprotein import into nucleus, translocation  negative regulation of transcription from RNA polymerase II promoter  neutrophil apoptotic process  regulation of the force of heart contraction  positive regulation of mesenchymal cell proliferation  adaptive immune response  CD8-positive, alpha-beta T cell differentiation involved in immune response  negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis  cytokine activity  interferon-gamma receptor binding  extracellular region  extracellular region  extracellular space  apoptotic process  cellular component movement  humoral immune response  cell cycle arrest  cell surface receptor signaling pathway  response to virus  external side of plasma membrane  cytokine-mediated signaling pathway  antigen processing and presentation  neutrophil chemotaxis  endoplasmic reticulum unfolded protein response  negative regulation of myelination  positive regulation of synaptic transmission, cholinergic  negative regulation of interleukin-17 production  positive regulation of interleukin-12 production  positive regulation of interleukin-23 production  positive regulation of tumor necrosis factor production  positive regulation of peptidyl-serine phosphorylation of STAT protein  positive regulation of peptidyl-serine phosphorylation of STAT protein  positive regulation of smooth muscle cell apoptotic process  positive regulation of T cell proliferation  response to drug  positive regulation of tyrosine phosphorylation of Stat1 protein  defense response to bacterium  defense response to protozoan  negative regulation of growth of symbiont in host  positive regulation of chemokine biosynthetic process  positive regulation of interleukin-12 biosynthetic process  positive regulation of MHC class II biosynthetic process  positive regulation of interleukin-6 biosynthetic process  positive regulation of nitric oxide biosynthetic process  positive regulation of neuron differentiation  positive regulation of osteoclast differentiation  positive regulation of cell adhesion  positive regulation of transcription from RNA polymerase II promoter  positive regulation of isotype switching to IgG isotypes  negative regulation of smooth muscle cell proliferation  positive regulation of interleukin-1 beta secretion  regulation of insulin secretion  positive regulation of membrane protein ectodomain proteolysis  defense response to virus  positive regulation of killing of cells of other organism  interferon-gamma-mediated signaling pathway  regulation of interferon-gamma-mediated signaling pathway  positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity  positive regulation of fructose 1,6-bisphosphate metabolic process  positive regulation of vitamin D biosynthetic process  positive regulation of calcidiol 1-monooxygenase activity  cellular response to lipopolysaccharide  cellular response to interleukin-18  negative regulation of metanephric nephron tubule epithelial cell differentiation  positive regulation of tumor necrosis factor (ligand) superfamily member 11 production  
Ontology : EGO-EBIprotein import into nucleus, translocation  negative regulation of transcription from RNA polymerase II promoter  neutrophil apoptotic process  regulation of the force of heart contraction  positive regulation of mesenchymal cell proliferation  adaptive immune response  CD8-positive, alpha-beta T cell differentiation involved in immune response  negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis  cytokine activity  interferon-gamma receptor binding  extracellular region  extracellular region  extracellular space  apoptotic process  cellular component movement  humoral immune response  cell cycle arrest  cell surface receptor signaling pathway  response to virus  external side of plasma membrane  cytokine-mediated signaling pathway  antigen processing and presentation  neutrophil chemotaxis  endoplasmic reticulum unfolded protein response  negative regulation of myelination  positive regulation of synaptic transmission, cholinergic  negative regulation of interleukin-17 production  positive regulation of interleukin-12 production  positive regulation of interleukin-23 production  positive regulation of tumor necrosis factor production  positive regulation of peptidyl-serine phosphorylation of STAT protein  positive regulation of peptidyl-serine phosphorylation of STAT protein  positive regulation of smooth muscle cell apoptotic process  positive regulation of T cell proliferation  response to drug  positive regulation of tyrosine phosphorylation of Stat1 protein  defense response to bacterium  defense response to protozoan  negative regulation of growth of symbiont in host  positive regulation of chemokine biosynthetic process  positive regulation of interleukin-12 biosynthetic process  positive regulation of MHC class II biosynthetic process  positive regulation of interleukin-6 biosynthetic process  positive regulation of nitric oxide biosynthetic process  positive regulation of neuron differentiation  positive regulation of osteoclast differentiation  positive regulation of cell adhesion  positive regulation of transcription from RNA polymerase II promoter  positive regulation of isotype switching to IgG isotypes  negative regulation of smooth muscle cell proliferation  positive regulation of interleukin-1 beta secretion  regulation of insulin secretion  positive regulation of membrane protein ectodomain proteolysis  defense response to virus  positive regulation of killing of cells of other organism  interferon-gamma-mediated signaling pathway  regulation of interferon-gamma-mediated signaling pathway  positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity  positive regulation of fructose 1,6-bisphosphate metabolic process  positive regulation of vitamin D biosynthetic process  positive regulation of calcidiol 1-monooxygenase activity  cellular response to lipopolysaccharide  cellular response to interleukin-18  negative regulation of metanephric nephron tubule epithelial cell differentiation  positive regulation of tumor necrosis factor (ligand) superfamily member 11 production  
Pathways : BIOCARTAIL 18 Signaling Pathway [Genes]    Selective expression of chemokine receptors during T-cell polarization [Genes]    IFN gamma signaling pathway [Genes]    Role of Tob in T-cell activation [Genes]    The 4-1BB-dependent immune response [Genes]    IL12 and Stat4 Dependent Signaling Pathway in Th1 Development [Genes]    Cytokine Network [Genes]    Chaperones modulate interferon Signaling Pathway [Genes]    NO2-dependent IL 12 Pathway in NK cells [Genes]    Adhesion and Diapedesis of Granulocytes [Genes]    Dendritic cells in regulating TH1 and TH2 Development [Genes]    Cytokines and Inflammatory Response [Genes]    Th1/Th2 Differentiation [Genes]   
Pathways : KEGGJak-STAT signaling pathwayNatural killer cell mediated cytotoxicityTGF-beta signaling pathwayRegulation of autophagyT cell receptor signaling pathwayType I diabetes mellitusCytokine-cytokine receptor interaction
Other databases
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
PubGeneIFNG
iHOPIFNG
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated01-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jun 14 17:45:13 CEST 2013
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