Atlas of Genetics and Cytogenetics in Oncology and Haematology


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IFNG (interferon gamma)

Identity

Other aliasIFG
IFI
HGNC (Hugo) IFNG
LocusID (NCBI) 3458
Atlas_Id 40925
Location 12q15  [Link to chromosome band 12q15]
Location_base_pair Starts at 68154770 and ends at 68159741 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
TSFM (12q14.1) / IFNG (12q15)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 2 ]
  del(9p) in Acute Lymphoblastic Leukemia
Subcutaneous panniculitis-like T-cell lymphoma


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Gastric Tumors: an overview


External links

Nomenclature
HGNC (Hugo)IFNG   5438
Cards
Entrez_Gene (NCBI)IFNG  3458  interferon gamma
AliasesIFG; IFI
GeneCards (Weizmann)IFNG
Ensembl hg19 (Hinxton)ENSG00000111537 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000111537 [Gene_View]  chr12:68154770-68159741 [Contig_View]  IFNG [Vega]
ICGC DataPortalENSG00000111537
TCGA cBioPortalIFNG
AceView (NCBI)IFNG
Genatlas (Paris)IFNG
WikiGenes3458
SOURCE (Princeton)IFNG
Genetics Home Reference (NIH)IFNG
Genomic and cartography
GoldenPath hg38 (UCSC)IFNG  -     chr12:68154770-68159741 -  12q15   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)IFNG  -     12q15   [Description]    (hg19-Feb_2009)
EnsemblIFNG - 12q15 [CytoView hg19]  IFNG - 12q15 [CytoView hg38]
Mapping of homologs : NCBIIFNG [Mapview hg19]  IFNG [Mapview hg38]
OMIM147570   607948   609135   609423   609532   613254   
Gene and transcription
Genbank (Entrez)AB451324 AB451453 AF506749 AM903379 AY044154
RefSeq transcript (Entrez)NM_000619
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)IFNG
Cluster EST : UnigeneHs.856 [ NCBI ]
CGAP (NCI)Hs.856
Alternative Splicing GalleryENSG00000111537
Gene ExpressionIFNG [ NCBI-GEO ]   IFNG [ EBI - ARRAY_EXPRESS ]   IFNG [ SEEK ]   IFNG [ MEM ]
Gene Expression Viewer (FireBrowse)IFNG [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3458
GTEX Portal (Tissue expression)IFNG
Human Protein AtlasENSG00000111537-IFNG [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP01579   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP01579  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP01579
Splice isoforms : SwissVarP01579
PhosPhoSitePlusP01579
Domains : Interpro (EBI)4_helix_cytokine-like_core    4_helix_cytokine_core    Interferon_gamma   
Domain families : Pfam (Sanger)IFN-gamma (PF00714)   
Domain families : Pfam (NCBI)pfam00714   
Domain structure : Prodom (Prabi Lyon)Interferon_gamma (PD002435)   
Conserved Domain (NCBI)IFNG
DMDM Disease mutations3458
Blocks (Seattle)IFNG
PDB (SRS)1EKU    1FG9    1FYH    1HIG    3BES   
PDB (PDBSum)1EKU    1FG9    1FYH    1HIG    3BES   
PDB (IMB)1EKU    1FG9    1FYH    1HIG    3BES   
PDB (RSDB)1EKU    1FG9    1FYH    1HIG    3BES   
Structural Biology KnowledgeBase1EKU    1FG9    1FYH    1HIG    3BES   
SCOP (Structural Classification of Proteins)1EKU    1FG9    1FYH    1HIG    3BES   
CATH (Classification of proteins structures)1EKU    1FG9    1FYH    1HIG    3BES   
SuperfamilyP01579
Human Protein Atlas [tissue]ENSG00000111537-IFNG [tissue]
Peptide AtlasP01579
HPRD00957
IPIIPI00307209   
Protein Interaction databases
DIP (DOE-UCLA)P01579
IntAct (EBI)P01579
FunCoupENSG00000111537
BioGRIDIFNG
STRING (EMBL)IFNG
ZODIACIFNG
Ontologies - Pathways
QuickGOP01579
Ontology : AmiGOprotein import into nucleus, translocation  negative regulation of transcription from RNA polymerase II promoter  neutrophil apoptotic process  positive regulation of protein phosphorylation  regulation of the force of heart contraction  adaptive immune response  CD8-positive, alpha-beta T cell differentiation involved in immune response  cytokine activity  interferon-gamma receptor binding  extracellular region  extracellular region  extracellular space  cytoplasm  apoptotic process  movement of cell or subcellular component  humoral immune response  cell cycle arrest  cell surface receptor signaling pathway  positive regulation of cell proliferation  response to virus  external side of plasma membrane  positive regulation of autophagy  positive regulation of gene expression  negative regulation of gene expression  positive regulation of epithelial cell migration  regulation of protein ADP-ribosylation  antigen processing and presentation  neutrophil chemotaxis  negative regulation of epithelial cell differentiation  endoplasmic reticulum unfolded protein response  positive regulation of protein complex assembly  negative regulation of myelination  positive regulation of synaptic transmission, cholinergic  negative regulation of interleukin-17 production  positive regulation of interleukin-12 production  positive regulation of interleukin-23 production  positive regulation of tumor necrosis factor production  positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response  positive regulation of peptidyl-serine phosphorylation of STAT protein  positive regulation of peptidyl-serine phosphorylation of STAT protein  positive regulation of protein import into nucleus, translocation  positive regulation of smooth muscle cell apoptotic process  positive regulation of T cell proliferation  response to drug  defense response to bacterium  defense response to protozoan  neuron projection  perikaryon  negative regulation of growth of symbiont in host  positive regulation of chemokine biosynthetic process  positive regulation of interleukin-12 biosynthetic process  positive regulation of MHC class II biosynthetic process  positive regulation of interleukin-6 biosynthetic process  positive regulation of nitric oxide biosynthetic process  positive regulation of neuron differentiation  positive regulation of osteoclast differentiation  negative regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  negative regulation of fibroblast proliferation  positive regulation of isotype switching to IgG isotypes  negative regulation of smooth muscle cell proliferation  regulation of defense response to virus by host  positive regulation of interleukin-1 beta secretion  regulation of insulin secretion  T cell receptor signaling pathway  sensory perception of mechanical stimulus  positive regulation of membrane protein ectodomain proteolysis  defense response to virus  positive regulation of killing of cells of other organism  regulation of glial cell proliferation  interferon-gamma-mediated signaling pathway  interferon-gamma-mediated signaling pathway  regulation of interferon-gamma-mediated signaling pathway  positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity  positive regulation of fructose 1,6-bisphosphate metabolic process  positive regulation of vitamin D biosynthetic process  positive regulation of calcidiol 1-monooxygenase activity  cellular response to lipopolysaccharide  cellular response to interleukin-18  positive regulation of protein serine/threonine kinase activity  negative regulation of glomerular mesangial cell proliferation  positive regulation of establishment of protein localization to plasma membrane  positive regulation of protein deacetylation  extrinsic apoptotic signaling pathway  regulation of neuronal action potential  positive regulation of exosomal secretion  positive regulation of core promoter binding  positive regulation of tumor necrosis factor (ligand) superfamily member 11 production  regulation of hepatocyte proliferation  
Ontology : EGO-EBIprotein import into nucleus, translocation  negative regulation of transcription from RNA polymerase II promoter  neutrophil apoptotic process  positive regulation of protein phosphorylation  regulation of the force of heart contraction  adaptive immune response  CD8-positive, alpha-beta T cell differentiation involved in immune response  cytokine activity  interferon-gamma receptor binding  extracellular region  extracellular region  extracellular space  cytoplasm  apoptotic process  movement of cell or subcellular component  humoral immune response  cell cycle arrest  cell surface receptor signaling pathway  positive regulation of cell proliferation  response to virus  external side of plasma membrane  positive regulation of autophagy  positive regulation of gene expression  negative regulation of gene expression  positive regulation of epithelial cell migration  regulation of protein ADP-ribosylation  antigen processing and presentation  neutrophil chemotaxis  negative regulation of epithelial cell differentiation  endoplasmic reticulum unfolded protein response  positive regulation of protein complex assembly  negative regulation of myelination  positive regulation of synaptic transmission, cholinergic  negative regulation of interleukin-17 production  positive regulation of interleukin-12 production  positive regulation of interleukin-23 production  positive regulation of tumor necrosis factor production  positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response  positive regulation of peptidyl-serine phosphorylation of STAT protein  positive regulation of peptidyl-serine phosphorylation of STAT protein  positive regulation of protein import into nucleus, translocation  positive regulation of smooth muscle cell apoptotic process  positive regulation of T cell proliferation  response to drug  defense response to bacterium  defense response to protozoan  neuron projection  perikaryon  negative regulation of growth of symbiont in host  positive regulation of chemokine biosynthetic process  positive regulation of interleukin-12 biosynthetic process  positive regulation of MHC class II biosynthetic process  positive regulation of interleukin-6 biosynthetic process  positive regulation of nitric oxide biosynthetic process  positive regulation of neuron differentiation  positive regulation of osteoclast differentiation  negative regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  negative regulation of fibroblast proliferation  positive regulation of isotype switching to IgG isotypes  negative regulation of smooth muscle cell proliferation  regulation of defense response to virus by host  positive regulation of interleukin-1 beta secretion  regulation of insulin secretion  T cell receptor signaling pathway  sensory perception of mechanical stimulus  positive regulation of membrane protein ectodomain proteolysis  defense response to virus  positive regulation of killing of cells of other organism  regulation of glial cell proliferation  interferon-gamma-mediated signaling pathway  interferon-gamma-mediated signaling pathway  regulation of interferon-gamma-mediated signaling pathway  positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity  positive regulation of fructose 1,6-bisphosphate metabolic process  positive regulation of vitamin D biosynthetic process  positive regulation of calcidiol 1-monooxygenase activity  cellular response to lipopolysaccharide  cellular response to interleukin-18  positive regulation of protein serine/threonine kinase activity  negative regulation of glomerular mesangial cell proliferation  positive regulation of establishment of protein localization to plasma membrane  positive regulation of protein deacetylation  extrinsic apoptotic signaling pathway  regulation of neuronal action potential  positive regulation of exosomal secretion  positive regulation of core promoter binding  positive regulation of tumor necrosis factor (ligand) superfamily member 11 production  regulation of hepatocyte proliferation  
Pathways : BIOCARTA [Genes]   
Pathways : KEGG   
NDEx NetworkIFNG
Atlas of Cancer Signalling NetworkIFNG
Wikipedia pathwaysIFNG
Orthology - Evolution
OrthoDB3458
GeneTree (enSembl)ENSG00000111537
Phylogenetic Trees/Animal Genes : TreeFamIFNG
HOVERGENP01579
HOGENOMP01579
Homologs : HomoloGeneIFNG
Homology/Alignments : Family Browser (UCSC)IFNG
Gene fusions - Rearrangements
Fusion : MitelmanTSFM/IFNG [12q14.1/12q15]  [t(12;12)(q14;q15)]  
Tumor Fusion PortalIFNG
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIFNG [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IFNG
dbVarIFNG
ClinVarIFNG
1000_GenomesIFNG 
Exome Variant ServerIFNG
ExAC (Exome Aggregation Consortium)ENSG00000111537
GNOMAD BrowserENSG00000111537
Genetic variants : HAPMAP3458
Genomic Variants (DGV)IFNG [DGVbeta]
DECIPHERIFNG [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisIFNG 
Mutations
ICGC Data PortalIFNG 
TCGA Data PortalIFNG 
Broad Tumor PortalIFNG
OASIS PortalIFNG [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIFNG  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDIFNG
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)TBsLVD Tuberculosis susceptibility Locus Variation Database
BioMutasearch IFNG
DgiDB (Drug Gene Interaction Database)IFNG
DoCM (Curated mutations)IFNG (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)IFNG (select a term)
intoGenIFNG
Cancer3DIFNG(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM147570    607948    609135    609423    609532    613254   
Orphanet8751   
DisGeNETIFNG
MedgenIFNG
Genetic Testing Registry IFNG
NextProtP01579 [Medical]
TSGene3458
GENETestsIFNG
Target ValidationIFNG
Huge Navigator IFNG [HugePedia]
snp3D : Map Gene to Disease3458
BioCentury BCIQIFNG
ClinGenIFNG
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3458
Chemical/Pharm GKB GenePA29674
Clinical trialIFNG
Miscellaneous
canSAR (ICR)IFNG (select the gene name)
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineIFNG
EVEXIFNG
GoPubMedIFNG
iHOPIFNG
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:17:19 CET 2017

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