| Nomenclature |
|---|
| HGNC (Hugo) | IFNG 5438 |
| Cards |
|---|
| Entrez_Gene (NCBI) | IFNG 3458 interferon gamma |
| Aliases | IFG; IFI |
| GeneCards (Weizmann) | IFNG |
| Ensembl hg19 (Hinxton) | ENSG00000111537 [Gene_View] |
| Ensembl hg38 (Hinxton) | ENSG00000111537 [Gene_View] ENSG00000111537 [Sequence] chr12:68154770-68159741 [Contig_View] IFNG [Vega] |
| ICGC DataPortal | ENSG00000111537 |
| TCGA cBioPortal | IFNG |
| AceView (NCBI) | IFNG |
| Genatlas (Paris) | IFNG |
| WikiGenes | 3458 |
| SOURCE (Princeton) | IFNG |
| Genetics Home Reference (NIH) | IFNG |
| Genomic and cartography |
|---|
| GoldenPath hg38 (UCSC) | IFNG - chr12:68154770-68159741 - 12q15 [Description] (hg38-Dec_2013) |
| GoldenPath hg19 (UCSC) | IFNG - 12q15 [Description] (hg19-Feb_2009) |
| Ensembl | IFNG - 12q15 [CytoView hg19] IFNG - 12q15 [CytoView hg38] |
| Mapping of homologs : NCBI | IFNG [Mapview hg19] IFNG [Mapview hg38] |
| OMIM | 147570 607948 609135 609423 609532 613254 |
| Gene and transcription |
|---|
| Genbank (Entrez) | AB451324 AB451453 AF506749 AM903379 AY044154 |
| RefSeq transcript (Entrez) | NM_000619 |
| RefSeq genomic (Entrez) | |
| Consensus coding sequences : CCDS (NCBI) | IFNG |
| Cluster EST : Unigene | Hs.856 [ NCBI ] |
| CGAP (NCI) | Hs.856 |
| Alternative Splicing Gallery | ENSG00000111537 |
| Gene Expression | IFNG [ NCBI-GEO ] IFNG [ EBI - ARRAY_EXPRESS ]
IFNG [ SEEK ] IFNG [ MEM ] |
| Gene Expression Viewer (FireBrowse) | IFNG [ Firebrowse - Broad ] |
| SOURCE (Princeton) | Expression in : [Datasets] [Normal Tissue Atlas] [carcinoma Classsification] [NCI60] |
| Genevestigator | Expression in : [tissues] [cell-lines] [cancer] [perturbations] |
| BioGPS (Tissue expression) | 3458 |
| GTEX Portal (Tissue expression) | IFNG |
| Human Protein Atlas | ENSG00000111537-IFNG [pathology] [cell] [tissue] |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | P01579 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
| NextProt | P01579 [Sequence] [Exons] [Medical] [Publications] |
| With graphics : InterPro | P01579 |
| Splice isoforms : SwissVar | P01579 |
| PhosPhoSitePlus | P01579 |
| Domains : Interpro (EBI) | 4_helix_cytokine-like_core Interferon_gamma |
| Domain families : Pfam (Sanger) | IFN-gamma (PF00714) |
| Domain families : Pfam (NCBI) | pfam00714 |
| Domain structure : Prodom (Prabi Lyon) | Interferon_gamma (PD002435) |
| Conserved Domain (NCBI) | IFNG |
| DMDM Disease mutations | 3458 |
| Blocks (Seattle) | IFNG |
| PDB (SRS) | 1EKU 1FG9 1FYH 1HIG 3BES |
| PDB (PDBSum) | 1EKU 1FG9 1FYH 1HIG 3BES |
| PDB (IMB) | 1EKU 1FG9 1FYH 1HIG 3BES |
| PDB (RSDB) | 1EKU 1FG9 1FYH 1HIG 3BES |
| Structural Biology KnowledgeBase | 1EKU 1FG9 1FYH 1HIG 3BES |
| SCOP (Structural Classification of Proteins) | 1EKU 1FG9 1FYH 1HIG 3BES |
| CATH (Classification of proteins structures) | 1EKU 1FG9 1FYH 1HIG 3BES |
| Superfamily | P01579 |
| Human Protein Atlas [tissue] | ENSG00000111537-IFNG [tissue] |
| Peptide Atlas | P01579 |
| HPRD | 00957 |
| IPI | IPI00307209 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | P01579 |
| IntAct (EBI) | P01579 |
| FunCoup | ENSG00000111537 |
| BioGRID | IFNG |
| STRING (EMBL) | IFNG |
| ZODIAC | IFNG |
| Ontologies - Pathways |
|---|
| QuickGO | P01579 |
| Ontology : AmiGO | protein import into nucleus, translocation negative regulation of transcription by RNA polymerase II positive regulation of protein phosphorylation adaptive immune response cytokine activity interferon-gamma receptor binding protein binding extracellular region extracellular region extracellular space intracellular apoptotic process humoral immune response cell cycle arrest cell surface receptor signaling pathway positive regulation of cell proliferation response to virus regulation of signaling receptor activity positive regulation of autophagy positive regulation of gene expression positive regulation of gene expression negative regulation of gene expression positive regulation of epithelial cell migration regulation of protein ADP-ribosylation negative regulation of epithelial cell differentiation positive regulation of protein complex assembly negative regulation of interleukin-17 production positive regulation of interleukin-12 production positive regulation of interleukin-23 production positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response positive regulation of peptidyl-serine phosphorylation of STAT protein positive regulation of peptidyl-serine phosphorylation of STAT protein positive regulation of protein import into nucleus, translocation positive regulation of smooth muscle cell apoptotic process interleukin-12-mediated signaling pathway regulation of growth positive regulation of tyrosine phosphorylation of STAT protein positive regulation of nitric oxide biosynthetic process regulation of regulatory T cell differentiation positive regulation of osteoclast differentiation negative regulation of transcription, DNA-templated negative regulation of smooth muscle cell proliferation regulation of insulin secretion positive regulation of membrane protein ectodomain proteolysis defense response to virus positive regulation of killing of cells of other organism interferon-gamma-mediated signaling pathway interferon-gamma-mediated signaling pathway regulation of interferon-gamma-mediated signaling pathway positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity positive regulation of fructose 1,6-bisphosphate metabolic process positive regulation of vitamin D biosynthetic process positive regulation of calcidiol 1-monooxygenase activity positive regulation of protein serine/threonine kinase activity positive regulation of protein deacetylation extrinsic apoptotic signaling pathway positive regulation of protein localization to plasma membrane positive regulation of exosomal secretion positive regulation of core promoter binding positive regulation of tumor necrosis factor (ligand) superfamily member 11 production |
| Ontology : EGO-EBI | protein import into nucleus, translocation negative regulation of transcription by RNA polymerase II positive regulation of protein phosphorylation adaptive immune response cytokine activity interferon-gamma receptor binding protein binding extracellular region extracellular region extracellular space intracellular apoptotic process humoral immune response cell cycle arrest cell surface receptor signaling pathway positive regulation of cell proliferation response to virus regulation of signaling receptor activity positive regulation of autophagy positive regulation of gene expression positive regulation of gene expression negative regulation of gene expression positive regulation of epithelial cell migration regulation of protein ADP-ribosylation negative regulation of epithelial cell differentiation positive regulation of protein complex assembly negative regulation of interleukin-17 production positive regulation of interleukin-12 production positive regulation of interleukin-23 production positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response positive regulation of peptidyl-serine phosphorylation of STAT protein positive regulation of peptidyl-serine phosphorylation of STAT protein positive regulation of protein import into nucleus, translocation positive regulation of smooth muscle cell apoptotic process interleukin-12-mediated signaling pathway regulation of growth positive regulation of tyrosine phosphorylation of STAT protein positive regulation of nitric oxide biosynthetic process regulation of regulatory T cell differentiation positive regulation of osteoclast differentiation negative regulation of transcription, DNA-templated negative regulation of smooth muscle cell proliferation regulation of insulin secretion positive regulation of membrane protein ectodomain proteolysis defense response to virus positive regulation of killing of cells of other organism interferon-gamma-mediated signaling pathway interferon-gamma-mediated signaling pathway regulation of interferon-gamma-mediated signaling pathway positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity positive regulation of fructose 1,6-bisphosphate metabolic process positive regulation of vitamin D biosynthetic process positive regulation of calcidiol 1-monooxygenase activity positive regulation of protein serine/threonine kinase activity positive regulation of protein deacetylation extrinsic apoptotic signaling pathway positive regulation of protein localization to plasma membrane positive regulation of exosomal secretion positive regulation of core promoter binding positive regulation of tumor necrosis factor (ligand) superfamily member 11 production |
| Pathways : KEGG | Proteasome Cytokine-cytokine receptor interaction HIF-1 signaling pathway Regulation of autophagy TGF-beta signaling pathway Osteoclast differentiation Antigen processing and presentation Jak-STAT signaling pathway Natural killer cell mediated cytotoxicity T cell receptor signaling pathway Type I diabetes mellitus Salmonella infection Leishmaniasis Chagas disease (American trypanosomiasis) African trypanosomiasis Malaria Toxoplasmosis Amoebiasis Tuberculosis Measles Influenza A Herpes simplex infection Epstein-Barr virus infection Inflammatory bowel disease (IBD) Systemic lupus erythematosus Rheumatoid arthritis Allograft rejection Graft-versus-host disease |
| NDEx Network | IFNG |
| Atlas of Cancer Signalling Network | IFNG |
| Wikipedia pathways | IFNG |
| Orthology - Evolution |
|---|
| OrthoDB | 3458 |
| GeneTree (enSembl) | ENSG00000111537 |
| Phylogenetic Trees/Animal Genes : TreeFam | IFNG |
| HOVERGEN | P01579 |
| HOGENOM | P01579 |
| Homologs : HomoloGene | IFNG |
| Homology/Alignments : Family Browser (UCSC) | IFNG |
| Gene fusions - Rearrangements |
|---|
| Fusion : Mitelman | TSFM/IFNG [12q14.1/12q15] [t(12;12)(q14;q15)] |
| Fusion : Quiver | IFNG |
| Polymorphisms : SNP and Copy number variants |
|---|
| NCBI Variation Viewer | IFNG [hg38] |
| dbSNP Single Nucleotide Polymorphism (NCBI) | IFNG |
| dbVar | IFNG |
| ClinVar | IFNG |
| 1000_Genomes | IFNG |
| Exome Variant Server | IFNG |
| ExAC (Exome Aggregation Consortium) | ENSG00000111537 |
| GNOMAD Browser | ENSG00000111537 |
| Varsome Browser | IFNG |
| Genetic variants : HAPMAP | 3458 |
| Genomic Variants (DGV) | IFNG [DGVbeta] |
| DECIPHER | IFNG [patients] [syndromes] [variants] [genes] |
| CONAN: Copy Number Analysis | IFNG |
| Mutations |
|---|
| ICGC Data Portal | IFNG |
| TCGA Data Portal | IFNG |
| Broad Tumor Portal | IFNG |
| OASIS Portal | IFNG [ Somatic mutations - Copy number] |
| Somatic Mutations in Cancer : COSMIC | IFNG [overview] [genome browser] [tissue] [distribution] |
| Mutations and Diseases : HGMD | IFNG |
| LOVD (Leiden Open Variation Database) | Whole genome datasets |
| LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
| LOVD (Leiden Open Variation Database) | TBsLVD Tuberculosis susceptibility Locus Variation Database |
| BioMuta | search IFNG |
| DgiDB (Drug Gene Interaction Database) | IFNG |
| DoCM (Curated mutations) | IFNG (select the gene name) |
| CIViC (Clinical Interpretations of Variants in Cancer) | IFNG (select a term) |
| intoGen | IFNG |
| Cancer3D | IFNG(select the gene name) |
| Impact of mutations | [PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
|---|
| OMIM | 147570 607948 609135 609423 609532 613254 |
| Orphanet | 8751 |
| DisGeNET | IFNG |
| Medgen | IFNG |
| Genetic Testing Registry | IFNG
|
| NextProt | P01579 [Medical] |
| TSGene | 3458 |
| GENETests | IFNG |
| Target Validation | IFNG |
| Huge Navigator |
IFNG [HugePedia] |
| snp3D : Map Gene to Disease | 3458 |
| BioCentury BCIQ | IFNG |
| ClinGen | IFNG |
| Clinical trials, drugs, therapy |
|---|
| Chemical/Protein Interactions : CTD | 3458 |
| Chemical/Pharm GKB Gene | PA29674 |
| Clinical trial | IFNG |
| Miscellaneous |
|---|
| canSAR (ICR) | IFNG (select the gene name) |
| Probes |
|---|
| Litterature |
|---|
| PubMed | 499 Pubmed reference(s) in Entrez |
| GeneRIFs | Gene References Into Functions (Entrez) |
| CoreMine | IFNG |
| EVEX | IFNG |
| GoPubMed | IFNG |
| iHOP | IFNG |
