| Nomenclature |
|---|
| HGNC (Hugo) | IFNG 5438 |
| Cards |
|---|
| Entrez_Gene (NCBI) | IFNG 3458 interferon, gamma |
| Aliases | IFG; IFI |
| GeneCards (Weizmann) | IFNG |
| Ensembl hg19 (Hinxton) | ENSG00000111537 [Gene_View] chr12:68548550-68553521 [Contig_View] IFNG [Vega] |
| Ensembl hg38 (Hinxton) | ENSG00000111537 [Gene_View] chr12:68548550-68553521 [Contig_View] IFNG [Vega] |
| ICGC DataPortal | ENSG00000111537 |
| TCGA cBioPortal | IFNG |
| AceView (NCBI) | IFNG |
| Genatlas (Paris) | IFNG |
| WikiGenes | 3458 |
| SOURCE (Princeton) | IFNG |
| Genomic and cartography |
|---|
| GoldenPath hg19 (UCSC) | IFNG - chr12:68548550-68553521 - 12q15 [Description] (hg19-Feb_2009) |
| GoldenPath hg38 (UCSC) | IFNG - 12q15 [Description] (hg38-Dec_2013) |
| Ensembl | IFNG - 12q15 [CytoView hg19] IFNG - 12q15 [CytoView hg38] |
| Mapping of homologs : NCBI | IFNG [Mapview hg19] IFNG [Mapview hg38] |
| OMIM | 147570 607948 609135 609423 609532 613254 |
| Gene and transcription |
|---|
| Genbank (Entrez) | AB451324 AB451453 AF506749 AM903379 AY044154 |
| RefSeq transcript (Entrez) | NM_000619 |
| RefSeq genomic (Entrez) | NC_000012 NC_018923 NG_015840 NT_029419 NW_004929384 |
| Consensus coding sequences : CCDS (NCBI) | IFNG |
| Cluster EST : Unigene | Hs.856 [ NCBI ] |
| CGAP (NCI) | Hs.856 |
| Alternative Splicing Gallery | ENSG00000111537 |
| Gene Expression | IFNG [ NCBI-GEO ] IFNG [ EBI - ARRAY_EXPRESS ]
IFNG [ SEEK ] IFNG [ MEM ] |
| Gene Expression Viewer (FireBrowse) | IFNG [ Firebrowse - Broad ] |
| SOURCE (Princeton) | Expression in : [Datasets] [Normal Tissue Atlas] [carcinoma Classsification] [NCI60] |
| Genevisible | Expression in : [tissues] [cell-lines] [cancer] [perturbations] |
| BioGPS (Tissue expression) | 3458 |
| GTEX Portal (Tissue expression) | IFNG |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | P01579 (Uniprot) |
| NextProt | P01579 [Sequence] [Exons] [Medical] [Publications] |
| With graphics : InterPro | P01579 |
| Splice isoforms : SwissVar | P01579 (Swissvar) |
| PhosPhoSitePlus | P01579 |
| Domains : Interpro (EBI) | 4_helix_cytokine-like_core 4_helix_cytokine_core Interferon_gamma |
| Domain families : Pfam (Sanger) | IFN-gamma (PF00714) |
| Domain families : Pfam (NCBI) | pfam00714 |
| Domain structure : Prodom (Prabi Lyon) | Interferon_gamma (PD002435) |
| DMDM Disease mutations | 3458 |
| Blocks (Seattle) | IFNG |
| PDB (SRS) | 1EKU 1FG9 1FYH 1HIG 3BES |
| PDB (PDBSum) | 1EKU 1FG9 1FYH 1HIG 3BES |
| PDB (IMB) | 1EKU 1FG9 1FYH 1HIG 3BES |
| PDB (RSDB) | 1EKU 1FG9 1FYH 1HIG 3BES |
| Structural Biology KnowledgeBase | 1EKU 1FG9 1FYH 1HIG 3BES |
| SCOP (Structural Classification of Proteins) | 1EKU 1FG9 1FYH 1HIG 3BES |
| CATH (Classification of proteins structures) | 1EKU 1FG9 1FYH 1HIG 3BES |
| Superfamily | P01579 |
| Human Protein Atlas | ENSG00000111537 |
| Peptide Atlas | P01579 |
| HPRD | 00957 |
| IPI | IPI00307209 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | P01579 |
| IntAct (EBI) | P01579 |
| FunCoup | ENSG00000111537 |
| BioGRID | IFNG |
| STRING (EMBL) | IFNG |
| ZODIAC | IFNG |
| Ontologies - Pathways |
|---|
| QuickGO | P01579 |
| Ontology : AmiGO | protein import into nucleus, translocation negative regulation of transcription from RNA polymerase II promoter neutrophil apoptotic process regulation of the force of heart contraction adaptive immune response CD8-positive, alpha-beta T cell differentiation involved in immune response cytokine activity interferon-gamma receptor binding extracellular region extracellular region extracellular space intracellular apoptotic process movement of cell or subcellular component humoral immune response cell cycle arrest cell surface receptor signaling pathway positive regulation of cell proliferation response to virus external side of plasma membrane positive regulation of autophagy positive regulation of gene expression negative regulation of gene expression positive regulation of epithelial cell migration antigen processing and presentation neutrophil chemotaxis negative regulation of epithelial cell differentiation endoplasmic reticulum unfolded protein response negative regulation of myelination positive regulation of synaptic transmission, cholinergic negative regulation of interleukin-17 production positive regulation of interleukin-12 production positive regulation of interleukin-23 production positive regulation of tumor necrosis factor production positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response positive regulation of peptidyl-serine phosphorylation of STAT protein positive regulation of peptidyl-serine phosphorylation of STAT protein positive regulation of smooth muscle cell apoptotic process positive regulation of T cell proliferation response to drug positive regulation of tyrosine phosphorylation of Stat1 protein defense response to bacterium defense response to protozoan negative regulation of growth of symbiont in host positive regulation of chemokine biosynthetic process positive regulation of interleukin-12 biosynthetic process positive regulation of MHC class II biosynthetic process positive regulation of interleukin-6 biosynthetic process positive regulation of nitric oxide biosynthetic process positive regulation of neuron differentiation positive regulation of osteoclast differentiation positive regulation of transcription from RNA polymerase II promoter positive regulation of isotype switching to IgG isotypes negative regulation of smooth muscle cell proliferation positive regulation of interleukin-1 beta secretion regulation of insulin secretion T cell receptor signaling pathway sensory perception of mechanical stimulus positive regulation of membrane protein ectodomain proteolysis defense response to virus positive regulation of killing of cells of other organism interferon-gamma-mediated signaling pathway regulation of interferon-gamma-mediated signaling pathway positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity positive regulation of fructose 1,6-bisphosphate metabolic process positive regulation of vitamin D biosynthetic process positive regulation of calcidiol 1-monooxygenase activity cellular response to lipopolysaccharide cellular response to interleukin-18 positive regulation of establishment of protein localization to plasma membrane extrinsic apoptotic signaling pathway regulation of neuronal action potential positive regulation of exosomal secretion positive regulation of tumor necrosis factor (ligand) superfamily member 11 production regulation of hepatocyte proliferation |
| Ontology : EGO-EBI | protein import into nucleus, translocation negative regulation of transcription from RNA polymerase II promoter neutrophil apoptotic process regulation of the force of heart contraction adaptive immune response CD8-positive, alpha-beta T cell differentiation involved in immune response cytokine activity interferon-gamma receptor binding extracellular region extracellular region extracellular space intracellular apoptotic process movement of cell or subcellular component humoral immune response cell cycle arrest cell surface receptor signaling pathway positive regulation of cell proliferation response to virus external side of plasma membrane positive regulation of autophagy positive regulation of gene expression negative regulation of gene expression positive regulation of epithelial cell migration antigen processing and presentation neutrophil chemotaxis negative regulation of epithelial cell differentiation endoplasmic reticulum unfolded protein response negative regulation of myelination positive regulation of synaptic transmission, cholinergic negative regulation of interleukin-17 production positive regulation of interleukin-12 production positive regulation of interleukin-23 production positive regulation of tumor necrosis factor production positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response positive regulation of peptidyl-serine phosphorylation of STAT protein positive regulation of peptidyl-serine phosphorylation of STAT protein positive regulation of smooth muscle cell apoptotic process positive regulation of T cell proliferation response to drug positive regulation of tyrosine phosphorylation of Stat1 protein defense response to bacterium defense response to protozoan negative regulation of growth of symbiont in host positive regulation of chemokine biosynthetic process positive regulation of interleukin-12 biosynthetic process positive regulation of MHC class II biosynthetic process positive regulation of interleukin-6 biosynthetic process positive regulation of nitric oxide biosynthetic process positive regulation of neuron differentiation positive regulation of osteoclast differentiation positive regulation of transcription from RNA polymerase II promoter positive regulation of isotype switching to IgG isotypes negative regulation of smooth muscle cell proliferation positive regulation of interleukin-1 beta secretion regulation of insulin secretion T cell receptor signaling pathway sensory perception of mechanical stimulus positive regulation of membrane protein ectodomain proteolysis defense response to virus positive regulation of killing of cells of other organism interferon-gamma-mediated signaling pathway regulation of interferon-gamma-mediated signaling pathway positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity positive regulation of fructose 1,6-bisphosphate metabolic process positive regulation of vitamin D biosynthetic process positive regulation of calcidiol 1-monooxygenase activity cellular response to lipopolysaccharide cellular response to interleukin-18 positive regulation of establishment of protein localization to plasma membrane extrinsic apoptotic signaling pathway regulation of neuronal action potential positive regulation of exosomal secretion positive regulation of tumor necrosis factor (ligand) superfamily member 11 production regulation of hepatocyte proliferation |
| Pathways : BIOCARTA | IL 18 Signaling Pathway [Genes] Selective expression of chemokine receptors during T-cell polarization [Genes] IFN gamma signaling pathway [Genes] Role of Tob in T-cell activation [Genes] The 4-1BB-dependent immune response [Genes] IL12 and Stat4 Dependent Signaling Pathway in Th1 Development [Genes] Cytokine Network [Genes] Chaperones modulate interferon Signaling Pathway [Genes] NO2-dependent IL 12 Pathway in NK cells [Genes] Adhesion and Diapedesis of Granulocytes [Genes] Dendritic cells in regulating TH1 and TH2 Development [Genes] Cytokines and Inflammatory Response [Genes] Th1/Th2 Differentiation [Genes] |
| Pathways : KEGG | Proteasome Cytokine-cytokine receptor interaction HIF-1 signaling pathway Regulation of autophagy TGF-beta signaling pathway Osteoclast differentiation Antigen processing and presentation Jak-STAT signaling pathway Natural killer cell mediated cytotoxicity T cell receptor signaling pathway Type I diabetes mellitus Salmonella infection Leishmaniasis Chagas disease (American trypanosomiasis) African trypanosomiasis Malaria Toxoplasmosis Amoebiasis Tuberculosis Measles Influenza A Herpes simplex infection Epstein-Barr virus infection Inflammatory bowel disease (IBD) Systemic lupus erythematosus Rheumatoid arthritis Allograft rejection Graft-versus-host disease |
| NDEx Network | IFNG |
| Atlas of Cancer Signalling Network | IFNG |
| Wikipedia pathways | IFNG |
| Orthology - Evolution |
|---|
| OrthoDB | 3458 |
| GeneTree (enSembl) | ENSG00000111537 |
| Phylogenetic Trees/Animal Genes : TreeFam | IFNG |
| Homologs : HomoloGene | IFNG |
| Homology/Alignments : Family Browser (UCSC) | IFNG |
| Gene fusions - Rearrangements |
|---|
| Polymorphisms : SNP, variants |
|---|
| NCBI Variation Viewer | IFNG [hg38] |
| dbSNP Single Nucleotide Polymorphism (NCBI) | IFNG |
| dbVar | IFNG |
| ClinVar | IFNG |
| 1000_Genomes | IFNG |
| Exome Variant Server | IFNG |
| ExAC (Exome Aggregation Consortium) | IFNG (select the gene name) |
| Genetic variants : HAPMAP | 3458 |
| Genomic Variants (DGV) | IFNG [DGVbeta] |
| Mutations |
|---|
| ICGC Data Portal | IFNG |
| TCGA Data Portal | IFNG |
| Broad Tumor Portal | IFNG |
| OASIS Portal | IFNG [ Somatic mutations - Copy number] |
| Somatic Mutations in Cancer : COSMIC | IFNG |
| LOVD (Leiden Open Variation Database) | Whole genome datasets |
| LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
| LOVD (Leiden Open Variation Database) | TBsLVD Tuberculosis susceptibility Locus Variation Database |
| BioMuta | search IFNG |
| DgiDB (Drug Gene Interaction Database) | IFNG |
| DoCM (Curated mutations) | IFNG (select the gene name) |
| CIViC (Clinical Interpretations of Variants in Cancer) | IFNG (select a term) |
| intoGen | IFNG |
| Impact of mutations | [PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] |
| Diseases |
|---|
| DECIPHER (Syndromes) | 12:68548550-68553521 ENSG00000111537 |
| CONAN: Copy Number Analysis | IFNG |
| Mutations and Diseases : HGMD | IFNG |
| OMIM | 147570 607948 609135 609423 609532 613254 |
| Medgen | IFNG |
| Genetic Testing Registry | IFNG
|
| NextProt | P01579 [Medical] |
| TSGene | 3458 |
| GENETests | IFNG |
| Huge Navigator |
IFNG [HugePedia] |
| snp3D : Map Gene to Disease | 3458 |
| BioCentury BCIQ | IFNG |
| ClinGen | IFNG |
| Clinical trials, drugs, therapy |
|---|
| Chemical/Protein Interactions : CTD | 3458 |
| Chemical/Pharm GKB Gene | PA29674 |
| Clinical trial | IFNG |
| Miscellaneous |
|---|
| canSAR (ICR) | IFNG (select the gene name) |
| Probes |
|---|
| Litterature |
|---|
| PubMed | 499 Pubmed reference(s) in Entrez |
| GeneRIFs | Gene References Into Functions (Entrez) |
| CoreMine | IFNG |
| EVEX | IFNG |
| GoPubMed | IFNG |
| iHOP | IFNG |
