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IFNGR2 (interferon gamma receptor 2)

Identity

Alias_namesIFNGT1
Alias_symbol (synonym)AF-1
Other aliasIFGR2
IMD28
HGNC (Hugo) IFNGR2
LocusID (NCBI) 3460
Atlas_Id 46082
Location 21q22.11  [Link to chromosome band 21q22]
Location_base_pair Starts at 33402896 and ends at 33437521 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
IFNGR2 (21q22.11) / GART (21q22.11)IFNGR2 (21q22.11) / IFNAR1 (21q22.11)IFNGR2 (21q22.11) / RUNX1 (21q22.12)
MACROD2 (20p12.1) / IFNGR2 (21q22.11)PLXNA4 (7q32.3) / IFNGR2 (21q22.11)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(21;21)(q22;q22) IFNGR2/GART

External links

Nomenclature
HGNC (Hugo)IFNGR2   5440
LRG (Locus Reference Genomic)LRG_67
Cards
Entrez_Gene (NCBI)IFNGR2  3460  interferon gamma receptor 2
AliasesAF-1; IFGR2; IFNGT1; IMD28
GeneCards (Weizmann)IFNGR2
Ensembl hg19 (Hinxton)ENSG00000159128 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000159128 [Gene_View]  ENSG00000159128 [Sequence]  chr21:33402896-33437521 [Contig_View]  IFNGR2 [Vega]
ICGC DataPortalENSG00000159128
TCGA cBioPortalIFNGR2
AceView (NCBI)IFNGR2
Genatlas (Paris)IFNGR2
WikiGenes3460
SOURCE (Princeton)IFNGR2
Genetics Home Reference (NIH)IFNGR2
Genomic and cartography
GoldenPath hg38 (UCSC)IFNGR2  -     chr21:33402896-33437521 +  21q22.11   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)IFNGR2  -     21q22.11   [Description]    (hg19-Feb_2009)
EnsemblIFNGR2 - 21q22.11 [CytoView hg19]  IFNGR2 - 21q22.11 [CytoView hg38]
Mapping of homologs : NCBIIFNGR2 [Mapview hg19]  IFNGR2 [Mapview hg38]
OMIM147569   614889   
Gene and transcription
Genbank (Entrez)AI824138 AK292246 AK314005 BC003624 BG391103
RefSeq transcript (Entrez)NM_001329128 NM_005534
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)IFNGR2
Cluster EST : UnigeneHs.634632 [ NCBI ]
CGAP (NCI)Hs.634632
Alternative Splicing GalleryENSG00000159128
Gene ExpressionIFNGR2 [ NCBI-GEO ]   IFNGR2 [ EBI - ARRAY_EXPRESS ]   IFNGR2 [ SEEK ]   IFNGR2 [ MEM ]
Gene Expression Viewer (FireBrowse)IFNGR2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3460
GTEX Portal (Tissue expression)IFNGR2
Human Protein AtlasENSG00000159128-IFNGR2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP38484   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP38484  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP38484
Splice isoforms : SwissVarP38484
PhosPhoSitePlusP38484
Domaine pattern : Prosite (Expaxy)FN3 (PS50853)   
Domains : Interpro (EBI)FN3_dom    Ig-like_fold    Interferon/interleukin_rcp_dom   
Domain families : Pfam (Sanger)Interfer-bind (PF09294)    Tissue_fac (PF01108)   
Domain families : Pfam (NCBI)pfam09294    pfam01108   
Conserved Domain (NCBI)IFNGR2
DMDM Disease mutations3460
Blocks (Seattle)IFNGR2
PDB (SRS)5EH1   
PDB (PDBSum)5EH1   
PDB (IMB)5EH1   
PDB (RSDB)5EH1   
Structural Biology KnowledgeBase5EH1   
SCOP (Structural Classification of Proteins)5EH1   
CATH (Classification of proteins structures)5EH1   
SuperfamilyP38484
Human Protein Atlas [tissue]ENSG00000159128-IFNGR2 [tissue]
Peptide AtlasP38484
HPRD00956
IPIIPI00221193   IPI00658181   IPI00878832   IPI00893563   IPI00894187   IPI00893797   
Protein Interaction databases
DIP (DOE-UCLA)P38484
IntAct (EBI)P38484
FunCoupENSG00000159128
BioGRIDIFNGR2
STRING (EMBL)IFNGR2
ZODIACIFNGR2
Ontologies - Pathways
QuickGOP38484
Ontology : AmiGOGolgi membrane  interferon-gamma receptor activity  interleukin-10 receptor activity  endoplasmic reticulum  endoplasmic reticulum membrane  plasma membrane  plasma membrane  integral component of plasma membrane  cell surface receptor signaling pathway  response to virus  cytoplasmic vesicle membrane  interferon-gamma-mediated signaling pathway  regulation of interferon-gamma-mediated signaling pathway  
Ontology : EGO-EBIGolgi membrane  interferon-gamma receptor activity  interleukin-10 receptor activity  endoplasmic reticulum  endoplasmic reticulum membrane  plasma membrane  plasma membrane  integral component of plasma membrane  cell surface receptor signaling pathway  response to virus  cytoplasmic vesicle membrane  interferon-gamma-mediated signaling pathway  regulation of interferon-gamma-mediated signaling pathway  
Pathways : BIOCARTAIFN gamma signaling pathway [Genes]    Selective expression of chemokine receptors during T-cell polarization [Genes]    Th1/Th2 Differentiation [Genes]    Chaperones modulate interferon Signaling Pathway [Genes]   
Pathways : KEGGJak-STAT signaling pathway    Natural killer cell mediated cytotoxicity    Cytokine-cytokine receptor interaction   
NDEx NetworkIFNGR2
Atlas of Cancer Signalling NetworkIFNGR2
Wikipedia pathwaysIFNGR2
Orthology - Evolution
OrthoDB3460
GeneTree (enSembl)ENSG00000159128
Phylogenetic Trees/Animal Genes : TreeFamIFNGR2
HOVERGENP38484
HOGENOMP38484
Homologs : HomoloGeneIFNGR2
Homology/Alignments : Family Browser (UCSC)IFNGR2
Gene fusions - Rearrangements
Fusion : MitelmanIFNGR2/GART [21q22.11/21q22.11]  
Fusion : QuiverIFNGR2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIFNGR2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IFNGR2
dbVarIFNGR2
ClinVarIFNGR2
1000_GenomesIFNGR2 
Exome Variant ServerIFNGR2
ExAC (Exome Aggregation Consortium)ENSG00000159128
GNOMAD BrowserENSG00000159128
Genetic variants : HAPMAP3460
Genomic Variants (DGV)IFNGR2 [DGVbeta]
DECIPHERIFNGR2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisIFNGR2 
Mutations
ICGC Data PortalIFNGR2 
TCGA Data PortalIFNGR2 
Broad Tumor PortalIFNGR2
OASIS PortalIFNGR2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIFNGR2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDIFNGR2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Mendelian genes
LOVD (Leiden Open Variation Database)**PUBLIC** CCHMC Molecular Genetics Laboratory Mutation Database
LOVD (Leiden Open Variation Database)TBsLVD Tuberculosis susceptibility Locus Variation Database
BioMutasearch IFNGR2
DgiDB (Drug Gene Interaction Database)IFNGR2
DoCM (Curated mutations)IFNGR2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)IFNGR2 (select a term)
intoGenIFNGR2
Cancer3DIFNGR2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM147569    614889   
Orphanet21671    21678    21676   
DisGeNETIFNGR2
MedgenIFNGR2
Genetic Testing Registry IFNGR2
NextProtP38484 [Medical]
TSGene3460
GENETestsIFNGR2
Target ValidationIFNGR2
Huge Navigator IFNGR2 [HugePedia]
snp3D : Map Gene to Disease3460
BioCentury BCIQIFNGR2
ClinGenIFNGR2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3460
Chemical/Pharm GKB GenePA29676
Clinical trialIFNGR2
Miscellaneous
canSAR (ICR)IFNGR2 (select the gene name)
Probes
Litterature
PubMed96 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineIFNGR2
EVEXIFNGR2
GoPubMedIFNGR2
iHOPIFNGR2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jun 22 16:30:21 CEST 2018
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