IFNL1 (interferon lambda 1)

2007-02-01 Affiliation

Identity

HGNC

IFNL1

LOCATION

19q13.2

LOCUSID

282618

ALIAS

IL-29,IL29

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 282618
MIM: 607403
HGNC: 18363
Ensembl: ENSG00000182393

Variants:

dbSNP: 282618
ClinVar: 282618
TCGA: ENSG00000182393
COSMIC: IFNL1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000182393	ENST00000333625	Q8IU54

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Cytokine-cytokine receptor interaction	KEGG	ko04060
Jak-STAT signaling pathway	KEGG	ko04630
Cytokine-cytokine receptor interaction	KEGG	hsa04060
Jak-STAT signaling pathway	KEGG	hsa04630
Immune System	REACTOME	R-HSA-168256
Cytokine Signaling in Immune system	REACTOME	R-HSA-1280215
Signaling by Interleukins	REACTOME	R-HSA-449147

References

Pubmed ID	Year	Title	Citations
12483210	2003	IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex.	581
12469119	2003	IL-28, IL-29 and their class II cytokine receptor IL-28R.	481
15166220	2004	Role of the interleukin (IL)-28 receptor tyrosine residues for antiviral and antiproliferative activity of IL-29/interferon-lambda 1: similarities with type I interferon signaling.	110
19798076	2009	Despite IFN-lambda receptor expression, blood immune cells, but not keratinocytes or melanocytes, have an impaired response to type III interferons: implications for therapeutic applications of these cytokines.	83
21398614	2011	Cutting edge: Ku70 is a novel cytosolic DNA sensor that induces type III rather than type I IFN.	78
22891284	2012	Type III IFNs are produced by and stimulate human plasmacytoid dendritic cells.	63
18698163	2008	IFNalpha and IFNlambda differ in their antiproliferative effects and duration of JAK/STAT signaling activity.	51
18281438	2008	Maturing dendritic cells are an important source of IL-29 and IL-20 that may cooperatively increase the innate immunity of keratinocytes.	50
22249201	2012	Expression profiles of human interferon-alpha and interferon-lambda subtypes are ligand- and cell-dependent.	47
19759281	2009	Modulation of human plasmacytoid DC function by IFN-lambda1 (IL-29).	45

Citation

Dessen P

IFNL1 (interferon lambda 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46450/ifnl1