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IFNL1 (interferon lambda 1)

Identity

Alias_namesIL29
interleukin 29
interleukin 29 (interferon, lambda 1)
Alias_symbol (synonym)IL-29
Other alias
HGNC (Hugo) IFNL1
LocusID (NCBI) 282618
Atlas_Id 46450
Location 19q13.2  [Link to chromosome band 19q13]
Location_base_pair Starts at 39296325 and ends at 39298672 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
TSHZ3 (19q12) / IFNL1 (19q13.2)URI1 (19q12) / IFNL1 (19q13.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)IFNL1   18363
Cards
Entrez_Gene (NCBI)IFNL1  282618  interferon lambda 1
AliasesIL-29; IL29
GeneCards (Weizmann)IFNL1
Ensembl hg19 (Hinxton)ENSG00000182393 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000182393 [Gene_View]  chr19:39296325-39298672 [Contig_View]  IFNL1 [Vega]
ICGC DataPortalENSG00000182393
TCGA cBioPortalIFNL1
AceView (NCBI)IFNL1
Genatlas (Paris)IFNL1
WikiGenes282618
SOURCE (Princeton)IFNL1
Genetics Home Reference (NIH)IFNL1
Genomic and cartography
GoldenPath hg38 (UCSC)IFNL1  -     chr19:39296325-39298672 +  19q13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)IFNL1  -     19q13.2   [Description]    (hg19-Feb_2009)
EnsemblIFNL1 - 19q13.2 [CytoView hg19]  IFNL1 - 19q13.2 [CytoView hg38]
Mapping of homologs : NCBIIFNL1 [Mapview hg19]  IFNL1 [Mapview hg38]
OMIM607403   
Gene and transcription
Genbank (Entrez)AY129150 AY184372 AY336716 BC074985 BC117482
RefSeq transcript (Entrez)NM_172140
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)IFNL1
Cluster EST : UnigeneHs.406745 [ NCBI ]
CGAP (NCI)Hs.406745
Alternative Splicing GalleryENSG00000182393
Gene ExpressionIFNL1 [ NCBI-GEO ]   IFNL1 [ EBI - ARRAY_EXPRESS ]   IFNL1 [ SEEK ]   IFNL1 [ MEM ]
Gene Expression Viewer (FireBrowse)IFNL1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)282618
GTEX Portal (Tissue expression)IFNL1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8IU54   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8IU54  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8IU54
Splice isoforms : SwissVarQ8IU54
PhosPhoSitePlusQ8IU54
Domains : Interpro (EBI)INF_lambda   
Domain families : Pfam (Sanger)IL28A (PF15177)   
Domain families : Pfam (NCBI)pfam15177   
Conserved Domain (NCBI)IFNL1
DMDM Disease mutations282618
Blocks (Seattle)IFNL1
PDB (SRS)3OG4    3OG6   
PDB (PDBSum)3OG4    3OG6   
PDB (IMB)3OG4    3OG6   
PDB (RSDB)3OG4    3OG6   
Structural Biology KnowledgeBase3OG4    3OG6   
SCOP (Structural Classification of Proteins)3OG4    3OG6   
CATH (Classification of proteins structures)3OG4    3OG6   
SuperfamilyQ8IU54
Human Protein AtlasENSG00000182393
Peptide AtlasQ8IU54
HPRD09588
IPIIPI00216649   
Protein Interaction databases
DIP (DOE-UCLA)Q8IU54
IntAct (EBI)Q8IU54
FunCoupENSG00000182393
BioGRIDIFNL1
STRING (EMBL)IFNL1
ZODIACIFNL1
Ontologies - Pathways
QuickGOQ8IU54
Ontology : AmiGOnegative regulation of type 2 immune response  receptor binding  cytokine activity  extracellular region  extracellular region  extracellular space  intracellular  JAK-STAT cascade  negative regulation of cell proliferation  interleukin-28 receptor complex  interleukin-28 receptor binding  negative regulation of interleukin-13 production  negative regulation of interleukin-5 production  positive regulation of interferon-gamma production  positive regulation of tyrosine phosphorylation of STAT protein  negative regulation of memory T cell differentiation  innate immune response  positive regulation of MHC class I biosynthetic process  negative regulation of T cell differentiation  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of JAK-STAT cascade  positive regulation of immune response  defense response to virus  
Ontology : EGO-EBInegative regulation of type 2 immune response  receptor binding  cytokine activity  extracellular region  extracellular region  extracellular space  intracellular  JAK-STAT cascade  negative regulation of cell proliferation  interleukin-28 receptor complex  interleukin-28 receptor binding  negative regulation of interleukin-13 production  negative regulation of interleukin-5 production  positive regulation of interferon-gamma production  positive regulation of tyrosine phosphorylation of STAT protein  negative regulation of memory T cell differentiation  innate immune response  positive regulation of MHC class I biosynthetic process  negative regulation of T cell differentiation  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of JAK-STAT cascade  positive regulation of immune response  defense response to virus  
Pathways : KEGGCytokine-cytokine receptor interaction    Jak-STAT signaling pathway   
NDEx NetworkIFNL1
Atlas of Cancer Signalling NetworkIFNL1
Wikipedia pathwaysIFNL1
Orthology - Evolution
OrthoDB282618
GeneTree (enSembl)ENSG00000182393
Phylogenetic Trees/Animal Genes : TreeFamIFNL1
HOVERGENQ8IU54
HOGENOMQ8IU54
Homologs : HomoloGeneIFNL1
Homology/Alignments : Family Browser (UCSC)IFNL1
Gene fusions - Rearrangements
Fusion : MitelmanTSHZ3/IFNL1 [19q12/19q13.2]  [t(19;19)(q12;q13)]  
Fusion : MitelmanURI1/IFNL1 [19q12/19q13.2]  [t(19;19)(q12;q13)]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIFNL1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IFNL1
dbVarIFNL1
ClinVarIFNL1
1000_GenomesIFNL1 
Exome Variant ServerIFNL1
ExAC (Exome Aggregation Consortium)IFNL1 (select the gene name)
Genetic variants : HAPMAP282618
Genomic Variants (DGV)IFNL1 [DGVbeta]
DECIPHERIFNL1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisIFNL1 
Mutations
ICGC Data PortalIFNL1 
TCGA Data PortalIFNL1 
Broad Tumor PortalIFNL1
OASIS PortalIFNL1 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDIFNL1
BioMutasearch IFNL1
DgiDB (Drug Gene Interaction Database)IFNL1
DoCM (Curated mutations)IFNL1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)IFNL1 (select a term)
intoGenIFNL1
Cancer3DIFNL1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607403   
Orphanet
MedgenIFNL1
Genetic Testing Registry IFNL1
NextProtQ8IU54 [Medical]
TSGene282618
GENETestsIFNL1
Target ValidationIFNL1
Huge Navigator IFNL1 [HugePedia]
snp3D : Map Gene to Disease282618
BioCentury BCIQIFNL1
ClinGenIFNL1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD282618
Chemical/Pharm GKB GenePA134899000
Clinical trialIFNL1
Miscellaneous
canSAR (ICR)IFNL1 (select the gene name)
Probes
Litterature
PubMed90 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineIFNL1
EVEXIFNL1
GoPubMedIFNL1
iHOPIFNL1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 13:56:04 CEST 2017

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