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IFNL3 (interferon lambda 3)

Identity

Alias_namesIL28B
interleukin 28B
interleukin 28B (interferon, lambda 3)
Alias_symbol (synonym)IL-28B
IL28C
Other aliasIFN-lambda-3
IFN-lambda-4
IL-28C
HGNC (Hugo) IFNL3
LocusID (NCBI) 282617
Atlas_Id 51058
Location 19q13.2  [Link to chromosome band 19q13]
Location_base_pair Starts at 39243606 and ends at 39245006 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)IFNL3   18365
LRG (Locus Reference Genomic)LRG_1011
Cards
Entrez_Gene (NCBI)IFNL3  282617  interferon lambda 3
AliasesIFN-lambda-3; IFN-lambda-4; IL-28B; IL-28C; 
IL28B; IL28C
GeneCards (Weizmann)IFNL3
Ensembl hg19 (Hinxton)ENSG00000197110 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000197110 [Gene_View]  ENSG00000197110 [Sequence]  chr19:39243606-39245006 [Contig_View]  IFNL3 [Vega]
ICGC DataPortalENSG00000197110
TCGA cBioPortalIFNL3
AceView (NCBI)IFNL3
Genatlas (Paris)IFNL3
WikiGenes282617
SOURCE (Princeton)IFNL3
Genetics Home Reference (NIH)IFNL3
Genomic and cartography
GoldenPath hg38 (UCSC)IFNL3  -     chr19:39243606-39245006 -  19q13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)IFNL3  -     19q13.2   [Description]    (hg19-Feb_2009)
EnsemblIFNL3 - 19q13.2 [CytoView hg19]  IFNL3 - 19q13.2 [CytoView hg38]
Mapping of homologs : NCBIIFNL3 [Mapview hg19]  IFNL3 [Mapview hg38]
OMIM607402   609532   
Gene and transcription
Genbank (Entrez)AY129149 AY184374 AY336714 AY336717 BC130314
RefSeq transcript (Entrez)NM_001346937 NM_172139
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)IFNL3
Cluster EST : UnigeneHs.406744 [ NCBI ]
CGAP (NCI)Hs.406744
Alternative Splicing GalleryENSG00000197110
Gene ExpressionIFNL3 [ NCBI-GEO ]   IFNL3 [ EBI - ARRAY_EXPRESS ]   IFNL3 [ SEEK ]   IFNL3 [ MEM ]
Gene Expression Viewer (FireBrowse)IFNL3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)282617
GTEX Portal (Tissue expression)IFNL3
Human Protein AtlasENSG00000197110-IFNL3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8IZI9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8IZI9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8IZI9
Splice isoforms : SwissVarQ8IZI9
PhosPhoSitePlusQ8IZI9
Domains : Interpro (EBI)IFN-lambda_sf    INF_lambda   
Domain families : Pfam (Sanger)IL28A (PF15177)   
Domain families : Pfam (NCBI)pfam15177   
Conserved Domain (NCBI)IFNL3
DMDM Disease mutations282617
Blocks (Seattle)IFNL3
PDB (SRS)3HHC    5T5W   
PDB (PDBSum)3HHC    5T5W   
PDB (IMB)3HHC    5T5W   
PDB (RSDB)3HHC    5T5W   
Structural Biology KnowledgeBase3HHC    5T5W   
SCOP (Structural Classification of Proteins)3HHC    5T5W   
CATH (Classification of proteins structures)3HHC    5T5W   
SuperfamilyQ8IZI9
Human Protein Atlas [tissue]ENSG00000197110-IFNL3 [tissue]
Peptide AtlasQ8IZI9
HPRD09587
IPIIPI00969047   
Protein Interaction databases
DIP (DOE-UCLA)Q8IZI9
IntAct (EBI)Q8IZI9
FunCoupENSG00000197110
BioGRIDIFNL3
STRING (EMBL)IFNL3
ZODIACIFNL3
Ontologies - Pathways
QuickGOQ8IZI9
Ontology : AmiGOsignaling receptor binding  cytokine activity  extracellular region  extracellular space  intracellular  JAK-STAT cascade  regulation of signaling receptor activity  cytokine-mediated signaling pathway  negative regulation of viral genome replication  innate immune response  positive regulation of immune response  defense response to virus  defense response to virus  
Ontology : EGO-EBIsignaling receptor binding  cytokine activity  extracellular region  extracellular space  intracellular  JAK-STAT cascade  regulation of signaling receptor activity  cytokine-mediated signaling pathway  negative regulation of viral genome replication  innate immune response  positive regulation of immune response  defense response to virus  defense response to virus  
Pathways : KEGGCytokine-cytokine receptor interaction    Jak-STAT signaling pathway   
NDEx NetworkIFNL3
Atlas of Cancer Signalling NetworkIFNL3
Wikipedia pathwaysIFNL3
Orthology - Evolution
OrthoDB282617
GeneTree (enSembl)ENSG00000197110
Phylogenetic Trees/Animal Genes : TreeFamIFNL3
HOVERGENQ8IZI9
HOGENOMQ8IZI9
Homologs : HomoloGeneIFNL3
Homology/Alignments : Family Browser (UCSC)IFNL3
Gene fusions - Rearrangements
Fusion : QuiverIFNL3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIFNL3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IFNL3
dbVarIFNL3
ClinVarIFNL3
1000_GenomesIFNL3 
Exome Variant ServerIFNL3
ExAC (Exome Aggregation Consortium)ENSG00000197110
GNOMAD BrowserENSG00000197110
Varsome BrowserIFNL3
Genetic variants : HAPMAP282617
Genomic Variants (DGV)IFNL3 [DGVbeta]
DECIPHERIFNL3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisIFNL3 
Mutations
ICGC Data PortalIFNL3 
TCGA Data PortalIFNL3 
Broad Tumor PortalIFNL3
OASIS PortalIFNL3 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDIFNL3
BioMutasearch IFNL3
DgiDB (Drug Gene Interaction Database)IFNL3
DoCM (Curated mutations)IFNL3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)IFNL3 (select a term)
intoGenIFNL3
Cancer3DIFNL3(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607402    609532   
Orphanet20569   
DisGeNETIFNL3
MedgenIFNL3
Genetic Testing Registry IFNL3
NextProtQ8IZI9 [Medical]
TSGene282617
GENETestsIFNL3
Target ValidationIFNL3
Huge Navigator IFNL3 [HugePedia]
snp3D : Map Gene to Disease282617
BioCentury BCIQIFNL3
ClinGenIFNL3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD282617
Chemical/Pharm GKB GenePA134952671
Clinical trialIFNL3
Miscellaneous
canSAR (ICR)IFNL3 (select the gene name)
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineIFNL3
EVEXIFNL3
GoPubMedIFNL3
iHOPIFNL3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 6 11:12:45 CET 2018

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