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IFNLR1 (interferon lambda receptor 1)

Identity

Alias_namesIL28RA
interleukin 28 receptor, alpha
interleukin 28 receptor, alpha (interferon, lambda receptor)
interferon, lambda receptor 1
Alias_symbol (synonym)CRF2/12
IFNLR
IL-28R1
Other aliasLICR2
HGNC (Hugo) IFNLR1
LocusID (NCBI) 163702
Atlas_Id 54864
Location 1p36.11  [Link to chromosome band 1p36]
Location_base_pair Starts at 24480647 and ends at 24513765 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
IFNLR1 (1p36.11) / STPG1 (1p36.11)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)IFNLR1   18584
Cards
Entrez_Gene (NCBI)IFNLR1  163702  interferon lambda receptor 1
AliasesCRF2/12; IFNLR; IL-28R1; IL28RA; 
LICR2
GeneCards (Weizmann)IFNLR1
Ensembl hg19 (Hinxton)ENSG00000185436 [Gene_View]  chr1:24480647-24513765 [Contig_View]  IFNLR1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000185436 [Gene_View]  chr1:24480647-24513765 [Contig_View]  IFNLR1 [Vega]
ICGC DataPortalENSG00000185436
TCGA cBioPortalIFNLR1
AceView (NCBI)IFNLR1
Genatlas (Paris)IFNLR1
WikiGenes163702
SOURCE (Princeton)IFNLR1
Genetics Home Reference (NIH)IFNLR1
Genomic and cartography
GoldenPath hg19 (UCSC)IFNLR1  -     chr1:24480647-24513765 -  1p36.11   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)IFNLR1  -     1p36.11   [Description]    (hg38-Dec_2013)
EnsemblIFNLR1 - 1p36.11 [CytoView hg19]  IFNLR1 - 1p36.11 [CytoView hg38]
Mapping of homologs : NCBIIFNLR1 [Mapview hg19]  IFNLR1 [Mapview hg38]
OMIM607404   
Gene and transcription
Genbank (Entrez)AF439325 AJ534330 AJ534331 AK160364 AY129151
RefSeq transcript (Entrez)NM_170743 NM_173064 NM_173065
RefSeq genomic (Entrez)NC_000001 NC_018912 NT_032977 NW_004929289
Consensus coding sequences : CCDS (NCBI)IFNLR1
Cluster EST : UnigeneHs.221375 [ NCBI ]
CGAP (NCI)Hs.221375
Alternative Splicing GalleryENSG00000185436
Gene ExpressionIFNLR1 [ NCBI-GEO ]   IFNLR1 [ EBI - ARRAY_EXPRESS ]   IFNLR1 [ SEEK ]   IFNLR1 [ MEM ]
Gene Expression Viewer (FireBrowse)IFNLR1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)163702
GTEX Portal (Tissue expression)IFNLR1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8IU57   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8IU57  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8IU57
Splice isoforms : SwissVarQ8IU57
PhosPhoSitePlusQ8IU57
Domaine pattern : Prosite (Expaxy)FN3 (PS50853)   
Domains : Interpro (EBI)FN3_dom    Ig-like_fold   
Domain families : Pfam (Sanger)Tissue_fac (PF01108)   
Domain families : Pfam (NCBI)pfam01108   
Conserved Domain (NCBI)IFNLR1
DMDM Disease mutations163702
Blocks (Seattle)IFNLR1
PDB (SRS)3OG4    3OG6   
PDB (PDBSum)3OG4    3OG6   
PDB (IMB)3OG4    3OG6   
PDB (RSDB)3OG4    3OG6   
Structural Biology KnowledgeBase3OG4    3OG6   
SCOP (Structural Classification of Proteins)3OG4    3OG6   
CATH (Classification of proteins structures)3OG4    3OG6   
SuperfamilyQ8IU57
Human Protein AtlasENSG00000185436
Peptide AtlasQ8IU57
HPRD09589
IPIIPI00216651   IPI00218008   IPI00383608   IPI00216892   IPI00974009   IPI00646490   
Protein Interaction databases
DIP (DOE-UCLA)Q8IU57
IntAct (EBI)Q8IU57
FunCoupENSG00000185436
BioGRIDIFNLR1
STRING (EMBL)IFNLR1
ZODIACIFNLR1
Ontologies - Pathways
QuickGOQ8IU57
Ontology : AmiGOmucosal immune response  cytokine receptor activity  cytokine receptor activity  protein binding  plasma membrane  negative regulation of cell proliferation  integral component of membrane  cytokine-mediated signaling pathway  interleukin-28 receptor complex  response to type III interferon  regulation of defense response to virus by host  defense response to virus  
Ontology : EGO-EBImucosal immune response  cytokine receptor activity  cytokine receptor activity  protein binding  plasma membrane  negative regulation of cell proliferation  integral component of membrane  cytokine-mediated signaling pathway  interleukin-28 receptor complex  response to type III interferon  regulation of defense response to virus by host  defense response to virus  
Pathways : KEGGCytokine-cytokine receptor interaction    Jak-STAT signaling pathway   
NDEx NetworkIFNLR1
Atlas of Cancer Signalling NetworkIFNLR1
Wikipedia pathwaysIFNLR1
Orthology - Evolution
OrthoDB163702
GeneTree (enSembl)ENSG00000185436
Phylogenetic Trees/Animal Genes : TreeFamIFNLR1
HOVERGENQ8IU57
HOGENOMQ8IU57
Homologs : HomoloGeneIFNLR1
Homology/Alignments : Family Browser (UCSC)IFNLR1
Gene fusions - Rearrangements
Fusion : MitelmanIFNLR1/STPG1 [1p36.11/1p36.11]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIFNLR1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IFNLR1
dbVarIFNLR1
ClinVarIFNLR1
1000_GenomesIFNLR1 
Exome Variant ServerIFNLR1
ExAC (Exome Aggregation Consortium)IFNLR1 (select the gene name)
Genetic variants : HAPMAP163702
Genomic Variants (DGV)IFNLR1 [DGVbeta]
DECIPHER (Syndromes)1:24480647-24513765  ENSG00000185436
CONAN: Copy Number AnalysisIFNLR1 
Mutations
ICGC Data PortalIFNLR1 
TCGA Data PortalIFNLR1 
Broad Tumor PortalIFNLR1
OASIS PortalIFNLR1 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDIFNLR1
BioMutasearch IFNLR1
DgiDB (Drug Gene Interaction Database)IFNLR1
DoCM (Curated mutations)IFNLR1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)IFNLR1 (select a term)
intoGenIFNLR1
Cancer3DIFNLR1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607404   
Orphanet
MedgenIFNLR1
Genetic Testing Registry IFNLR1
NextProtQ8IU57 [Medical]
TSGene163702
GENETestsIFNLR1
Huge Navigator IFNLR1 [HugePedia]
snp3D : Map Gene to Disease163702
BioCentury BCIQIFNLR1
ClinGenIFNLR1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD163702
Chemical/Pharm GKB GenePA134984880
Clinical trialIFNLR1
Miscellaneous
canSAR (ICR)IFNLR1 (select the gene name)
Probes
Litterature
PubMed28 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineIFNLR1
EVEXIFNLR1
GoPubMedIFNLR1
iHOPIFNLR1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:10:19 CET 2017

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