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IFT140 (intraflagellar transport 140)

Identity

Alias_namesWDTC2
WD and tetratricopeptide repeats 2
intraflagellar transport 140 homolog (Chlamydomonas)
Alias_symbol (synonym)gs114
KIAA0590
Other aliasMZSDS
SRTD9
c305C8.4
c380F5.1
HGNC (Hugo) IFT140
LocusID (NCBI) 9742
Atlas_Id 64530
Location 16p13.3  [Link to chromosome band 16p13]
Location_base_pair Starts at 1510427 and ends at 1612108 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
AXIN1 (16p13.3) / IFT140 (16p13.3)IFT140 (16p13.3) / ATP6V0A1 (17q21.2)IFT140 (16p13.3) / IFT140 (16p13.3)
IFT140 (16p13.3) / INS-IGF2 (11p15.5)PWP2 (21q22.3) / IFT140 (16p13.3)TCEB3 (1p36.11) / IFT140 (16p13.3)
TCEB3 IFT140AXIN1 IFT140

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)IFT140   29077
Cards
Entrez_Gene (NCBI)IFT140  9742  intraflagellar transport 140
AliasesMZSDS; SRTD9; WDTC2; c305C8.4; 
c380F5.1; gs114
GeneCards (Weizmann)IFT140
Ensembl hg19 (Hinxton)ENSG00000187535 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000187535 [Gene_View]  chr16:1510427-1612108 [Contig_View]  IFT140 [Vega]
ICGC DataPortalENSG00000187535
TCGA cBioPortalIFT140
AceView (NCBI)IFT140
Genatlas (Paris)IFT140
WikiGenes9742
SOURCE (Princeton)IFT140
Genetics Home Reference (NIH)IFT140
Genomic and cartography
GoldenPath hg38 (UCSC)IFT140  -     chr16:1510427-1612108 -  16p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)IFT140  -     16p13.3   [Description]    (hg19-Feb_2009)
EnsemblIFT140 - 16p13.3 [CytoView hg19]  IFT140 - 16p13.3 [CytoView hg38]
Mapping of homologs : NCBIIFT140 [Mapview hg19]  IFT140 [Mapview hg38]
OMIM266920   614620   
Gene and transcription
Genbank (Entrez)AB011162 AK001168 AK001797 AK055133 AK299035
RefSeq transcript (Entrez)NM_014714
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)IFT140
Cluster EST : UnigeneHs.389438 [ NCBI ]
CGAP (NCI)Hs.389438
Alternative Splicing GalleryENSG00000187535
Gene ExpressionIFT140 [ NCBI-GEO ]   IFT140 [ EBI - ARRAY_EXPRESS ]   IFT140 [ SEEK ]   IFT140 [ MEM ]
Gene Expression Viewer (FireBrowse)IFT140 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9742
GTEX Portal (Tissue expression)IFT140
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96RY7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96RY7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96RY7
Splice isoforms : SwissVarQ96RY7
PhosPhoSitePlusQ96RY7
Domaine pattern : Prosite (Expaxy)WD_REPEATS_2 (PS50082)    WD_REPEATS_REGION (PS50294)   
Domains : Interpro (EBI)WD40/YVTN_repeat-like_dom    WD40_repeat    WD40_repeat_dom   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Domain families : Smart (EMBL)WD40 (SM00320)  
Conserved Domain (NCBI)IFT140
DMDM Disease mutations9742
Blocks (Seattle)IFT140
SuperfamilyQ96RY7
Human Protein AtlasENSG00000187535
Peptide AtlasQ96RY7
HPRD11093
IPIIPI00642186   IPI00902637   IPI00827707   IPI01019038   IPI00045528   IPI01010093   
Protein Interaction databases
DIP (DOE-UCLA)Q96RY7
IntAct (EBI)Q96RY7
FunCoupENSG00000187535
BioGRIDIFT140
STRING (EMBL)IFT140
ZODIACIFT140
Ontologies - Pathways
QuickGOQ96RY7
Ontology : AmiGOphotoreceptor outer segment  molecular_function  cytoplasm  centrosome  cilium  axoneme  axoneme  determination of left/right symmetry  heart development  regulation of smoothened signaling pathway  neural tube patterning  intraciliary transport particle A  embryonic camera-type eye development  photoreceptor connecting cilium  intraciliary retrograde transport  intraciliary transport involved in cilium assembly  photoreceptor cell outer segment organization  ciliary basal body  embryonic digit morphogenesis  embryonic cranial skeleton morphogenesis  skeletal system morphogenesis  retina development in camera-type eye  protein localization to cilium  renal system development  ciliary tip  regulation of cilium assembly  non-motile cilium assembly  embryonic brain development  
Ontology : EGO-EBIphotoreceptor outer segment  molecular_function  cytoplasm  centrosome  cilium  axoneme  axoneme  determination of left/right symmetry  heart development  regulation of smoothened signaling pathway  neural tube patterning  intraciliary transport particle A  embryonic camera-type eye development  photoreceptor connecting cilium  intraciliary retrograde transport  intraciliary transport involved in cilium assembly  photoreceptor cell outer segment organization  ciliary basal body  embryonic digit morphogenesis  embryonic cranial skeleton morphogenesis  skeletal system morphogenesis  retina development in camera-type eye  protein localization to cilium  renal system development  ciliary tip  regulation of cilium assembly  non-motile cilium assembly  embryonic brain development  
NDEx NetworkIFT140
Atlas of Cancer Signalling NetworkIFT140
Wikipedia pathwaysIFT140
Orthology - Evolution
OrthoDB9742
GeneTree (enSembl)ENSG00000187535
Phylogenetic Trees/Animal Genes : TreeFamIFT140
HOVERGENQ96RY7
HOGENOMQ96RY7
Homologs : HomoloGeneIFT140
Homology/Alignments : Family Browser (UCSC)IFT140
Gene fusions - Rearrangements
Fusion: TCGATCEB3 IFT140
Fusion: TCGAAXIN1 IFT140
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIFT140 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IFT140
dbVarIFT140
ClinVarIFT140
1000_GenomesIFT140 
Exome Variant ServerIFT140
ExAC (Exome Aggregation Consortium)IFT140 (select the gene name)
Genetic variants : HAPMAP9742
Genomic Variants (DGV)IFT140 [DGVbeta]
DECIPHERIFT140 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisIFT140 
Mutations
ICGC Data PortalIFT140 
TCGA Data PortalIFT140 
Broad Tumor PortalIFT140
OASIS PortalIFT140 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIFT140  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDIFT140
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
BioMutasearch IFT140
DgiDB (Drug Gene Interaction Database)IFT140
DoCM (Curated mutations)IFT140 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)IFT140 (select a term)
intoGenIFT140
Cancer3DIFT140(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM266920    614620   
Orphanet283    659    17012    3243   
MedgenIFT140
Genetic Testing Registry IFT140
NextProtQ96RY7 [Medical]
TSGene9742
GENETestsIFT140
Target ValidationIFT140
Huge Navigator IFT140 [HugePedia]
snp3D : Map Gene to Disease9742
BioCentury BCIQIFT140
ClinGenIFT140
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9742
Chemical/Pharm GKB GenePA142671665
Clinical trialIFT140
Miscellaneous
canSAR (ICR)IFT140 (select the gene name)
Probes
Litterature
PubMed19 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineIFT140
EVEXIFT140
GoPubMedIFT140
iHOPIFT140
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 15:53:10 CEST 2017

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