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IFT74 (intraflagellar transport 74)

Identity

Alias_namesCCDC2
coiled-coil domain containing 2
intraflagellar transport 74 homolog (Chlamydomonas)
Alias_symbol (synonym)CMG1
CMG-1
FLJ22621
Other aliasBBS20
HGNC (Hugo) IFT74
LocusID (NCBI) 80173
Atlas_Id 56478
Location 9p21.2  [Link to chromosome band 9p21]
Location_base_pair Starts at 26947300 and ends at 27066134 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CACNA2D3 (3p21.1) / IFT74 (9p21.2)EEF1A1 (6q13) / IFT74 (9p21.2)FOCAD (9p21.3) / IFT74 (9p21.2)
IFT74 (9p21.2) / CACNA2D3 (3p21.1)IFT74 (9p21.2) / LDLRAD3 (11p13)IFT74 (9p21.2) / WNK2 (9q22.31)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)IFT74   21424
Cards
Entrez_Gene (NCBI)IFT74  80173  intraflagellar transport 74
AliasesBBS20; CCDC2; CMG-1; CMG1
GeneCards (Weizmann)IFT74
Ensembl hg19 (Hinxton)ENSG00000096872 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000096872 [Gene_View]  chr9:26947300-27066134 [Contig_View]  IFT74 [Vega]
ICGC DataPortalENSG00000096872
TCGA cBioPortalIFT74
AceView (NCBI)IFT74
Genatlas (Paris)IFT74
WikiGenes80173
SOURCE (Princeton)IFT74
Genetics Home Reference (NIH)IFT74
Genomic and cartography
GoldenPath hg38 (UCSC)IFT74  -     chr9:26947300-27066134 +  9p21.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)IFT74  -     9p21.2   [Description]    (hg19-Feb_2009)
EnsemblIFT74 - 9p21.2 [CytoView hg19]  IFT74 - 9p21.2 [CytoView hg38]
Mapping of homologs : NCBIIFT74 [Mapview hg19]  IFT74 [Mapview hg38]
OMIM608040   617119   
Gene and transcription
Genbank (Entrez)AA888911 AI699118 AI919195 AK023707 AK026274
RefSeq transcript (Entrez)NM_001099222 NM_001099223 NM_001099224 NM_001349928 NM_025103
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)IFT74
Cluster EST : UnigeneHs.145402 [ NCBI ]
CGAP (NCI)Hs.145402
Alternative Splicing GalleryENSG00000096872
Gene ExpressionIFT74 [ NCBI-GEO ]   IFT74 [ EBI - ARRAY_EXPRESS ]   IFT74 [ SEEK ]   IFT74 [ MEM ]
Gene Expression Viewer (FireBrowse)IFT74 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)80173
GTEX Portal (Tissue expression)IFT74
Human Protein AtlasENSG00000096872-IFT74 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96LB3   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96LB3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96LB3
Splice isoforms : SwissVarQ96LB3
PhosPhoSitePlusQ96LB3
Domains : Interpro (EBI)IFT74   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)IFT74
DMDM Disease mutations80173
Blocks (Seattle)IFT74
SuperfamilyQ96LB3
Human Protein Atlas [tissue]ENSG00000096872-IFT74 [tissue]
Peptide AtlasQ96LB3
HPRD09727
IPIIPI00018090   IPI00852610   IPI01014831   IPI00978935   IPI00978146   IPI00973765   IPI00981553   
Protein Interaction databases
DIP (DOE-UCLA)Q96LB3
IntAct (EBI)Q96LB3
FunCoupENSG00000096872
BioGRIDIFT74
STRING (EMBL)IFT74
ZODIACIFT74
Ontologies - Pathways
QuickGOQ96LB3
Ontology : AmiGOkeratinocyte development  chromatin binding  nucleus  centrosome  cilium  cilium  Notch signaling pathway  determination of left/right symmetry  heart development  intraciliary transport particle B  intraciliary transport particle B  cytoplasmic vesicle  motile cilium  positive regulation of cell adhesion mediated by integrin  intraciliary transport involved in cilium assembly  intraciliary transport involved in cilium assembly  positive regulation of transcription from RNA polymerase II promoter  beta-tubulin binding  negative regulation of epithelial cell proliferation  cilium assembly  ciliary tip  non-motile cilium assembly  
Ontology : EGO-EBIkeratinocyte development  chromatin binding  nucleus  centrosome  cilium  cilium  Notch signaling pathway  determination of left/right symmetry  heart development  intraciliary transport particle B  intraciliary transport particle B  cytoplasmic vesicle  motile cilium  positive regulation of cell adhesion mediated by integrin  intraciliary transport involved in cilium assembly  intraciliary transport involved in cilium assembly  positive regulation of transcription from RNA polymerase II promoter  beta-tubulin binding  negative regulation of epithelial cell proliferation  cilium assembly  ciliary tip  non-motile cilium assembly  
NDEx NetworkIFT74
Atlas of Cancer Signalling NetworkIFT74
Wikipedia pathwaysIFT74
Orthology - Evolution
OrthoDB80173
GeneTree (enSembl)ENSG00000096872
Phylogenetic Trees/Animal Genes : TreeFamIFT74
HOVERGENQ96LB3
HOGENOMQ96LB3
Homologs : HomoloGeneIFT74
Homology/Alignments : Family Browser (UCSC)IFT74
Gene fusions - Rearrangements
Tumor Fusion PortalIFT74
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIFT74 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IFT74
dbVarIFT74
ClinVarIFT74
1000_GenomesIFT74 
Exome Variant ServerIFT74
ExAC (Exome Aggregation Consortium)ENSG00000096872
GNOMAD BrowserENSG00000096872
Genetic variants : HAPMAP80173
Genomic Variants (DGV)IFT74 [DGVbeta]
DECIPHERIFT74 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisIFT74 
Mutations
ICGC Data PortalIFT74 
TCGA Data PortalIFT74 
Broad Tumor PortalIFT74
OASIS PortalIFT74 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIFT74  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDIFT74
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch IFT74
DgiDB (Drug Gene Interaction Database)IFT74
DoCM (Curated mutations)IFT74 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)IFT74 (select a term)
intoGenIFT74
Cancer3DIFT74(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608040    617119   
Orphanet
DisGeNETIFT74
MedgenIFT74
Genetic Testing Registry IFT74
NextProtQ96LB3 [Medical]
TSGene80173
GENETestsIFT74
Target ValidationIFT74
Huge Navigator IFT74 [HugePedia]
snp3D : Map Gene to Disease80173
BioCentury BCIQIFT74
ClinGenIFT74
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD80173
Chemical/Pharm GKB GenePA134976961
Clinical trialIFT74
Miscellaneous
canSAR (ICR)IFT74 (select the gene name)
Probes
Litterature
PubMed22 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineIFT74
EVEXIFT74
GoPubMedIFT74
iHOPIFT74
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:17:23 CET 2017

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