IGBP1 (immunoglobulin binding protein 1)

2010-06-01  

Identity

HGNC
LOCATION
Xq13.1
LOCUSID
ALIAS
ALPHA-4,IBP1,alpha4
FUSION GENES

Other Information

Locus ID:

NCBI: 3476
MIM: 300139
HGNC: 5461
Ensembl: ENSG00000089289

Variants:

dbSNP: 3476
ClinVar: 3476
TCGA: ENSG00000089289
COSMIC: IGBP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000089289ENST00000342206P78318
ENSG00000089289ENST00000356413P78318

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Autophagy - animalKEGGko04140
Autophagy - animalKEGGhsa04140
Autophagy - otherKEGGko04136
Autophagy - otherKEGGhsa04136

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
118067522002MID1 and MID2 homo- and heterodimerise to tether the rapamycin-sensitive PP2A regulatory subunit, alpha 4, to microtubules: implications for the clinical variability of X-linked Opitz GBBB syndrome and other developmental disorders.28
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
214544892011The E3 ubiquitin ligase- and protein phosphatase 2A (PP2A)-binding domains of the Alpha4 protein are both required for Alpha4 to inhibit PP2A degradation.23
195536852009Inactivation of mammalian target of rapamycin increases STAT1 nuclear content and transcriptional activity in alpha4- and protein phosphatase 2A-dependent fashion.19
213397372011α4 is highly expressed in carcinogen-transformed human cells and primary human cancers.16
213559542011Overexpression of immunoglobulin (CD79a) binding protein1 (IGBP-1) in small lung adenocarcinomas and its clinicopathological significance.10
241451302014Progestin-inducible EDD E3 ubiquitin ligase binds to α4 phosphoprotein to regulate ubiquitination and degradation of protein phosphatase PP2Ac.9
205447962010alpha4 phosphoprotein interacts with EDD E3 ubiquitin ligase and poly(A)-binding protein.8
252078142014MID1 catalyzes the ubiquitination of protein phosphatase 2A and mutations within its Bbox1 domain disrupt polyubiquitination of alpha4 but not of PP2Ac.7
165172312006Low resolution structure of the human alpha4 protein (IgBP1) and studies on the stability of alpha4 and of its yeast ortholog Tap42.6

Citation

Dessen P

IGBP1 (immunoglobulin binding protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2010-06-01

Online version: http://atlasgeneticsoncology.org/gene/51526/igbp1