Atlas of Genetics and Cytogenetics in Oncology and Haematology

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IGF2 (insulin-like growth factor 2 (somatomedin A))

Identity

Other namesC11orf43
IGF-II
PP9974
HGNC (Hugo) IGF2
LocusID (NCBI) 3481
Location 11p15.5
Location_base_pair Starts at 2150347 and ends at 2160204 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas)

Solid Tumors AmeloblastomID5945 MedulloblastomaID5065 rhab5004 rhabID5004 blad5001

External links

Nomenclature
HGNC (Hugo)IGF2   5466
Cards
Entrez_Gene (NCBI)IGF2  3481  insulin-like growth factor 2 (somatomedin A)
GeneCards (Weizmann)IGF2
Ensembl hg19 (Hinxton)ENSG00000167244 [Gene_View]  chr11:2150347-2160204 [Contig_View]  IGF2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000167244 [Gene_View]  chr11:2150347-2160204 [Contig_View]  IGF2 [Vega]
ICGC DataPortalENSG00000167244
cBioPortalIGF2
AceView (NCBI)IGF2
Genatlas (Paris)IGF2
WikiGenes3481
SOURCE (Princeton)IGF2
Genomic and cartography
GoldenPath hg19 (UCSC)IGF2  -     chr11:2150347-2160204 -  11p15.5   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)IGF2  -     11p15.5   [Description]    (hg38-Dec_2013)
EnsemblIGF2 - 11p15.5 [CytoView hg19]  IGF2 - 11p15.5 [CytoView hg38]
Mapping of homologs : NCBIIGF2 [Mapview hg19]  IGF2 [Mapview hg38]
OMIM130650   147470   180860   
Gene and transcription
Genbank (Entrez)AA040827 AF318382 AK025719 AK126688 AK313938
RefSeq transcript (Entrez)NM_000612 NM_001007139 NM_001127598 NM_001291861 NM_001291862
RefSeq genomic (Entrez)AC_000143 NC_000011 NC_018922 NG_008849 NT_009237 NW_001838018 NW_004929378
Consensus coding sequences : CCDS (NCBI)IGF2
Cluster EST : UnigeneHs.272259 [ NCBI ]
CGAP (NCI)Hs.272259
Alternative Splicing : Fast-db (Paris)GSHG0005467
Alternative Splicing GalleryENSG00000167244
Gene ExpressionIGF2 [ NCBI-GEO ]     IGF2 [ SEEK ]   IGF2 [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP01344 (Uniprot)
NextProtP01344  [Medical]
With graphics : InterProP01344
Splice isoforms : SwissVarP01344 (Swissvar)
Domaine pattern : Prosite (Expaxy)INSULIN (PS00262)   
Domains : Interpro (EBI)IGF2    IGF2_C    Insulin-like    Insulin-like_growth_factor    Insulin_CS    Insulin_family   
Related proteins : CluSTrP01344
Domain families : Pfam (Sanger)IGF2_C (PF08365)    Insulin (PF00049)   
Domain families : Pfam (NCBI)pfam08365    pfam00049   
Domain families : Smart (EMBL)IlGF (SM00078)  
Domain structure : Prodom (Prabi Lyon)IGF2_C (PD005188)   
DMDM Disease mutations3481
Blocks (Seattle)P01344
PDB (SRS)1GF2    1IGL    2L29    2V5P    3E4Z    3KR3   
PDB (PDBSum)1GF2    1IGL    2L29    2V5P    3E4Z    3KR3   
PDB (IMB)1GF2    1IGL    2L29    2V5P    3E4Z    3KR3   
PDB (RSDB)1GF2    1IGL    2L29    2V5P    3E4Z    3KR3   
Human Protein AtlasENSG00000167244
Peptide AtlasP01344
HPRD00939
IPIIPI00001508   IPI00001611   IPI00940065   IPI00215977   IPI00853573   IPI00894133   IPI00853225   
Protein Interaction databases
DIP (DOE-UCLA)P01344
IntAct (EBI)P01344
FunCoupENSG00000167244
BioGRIDIGF2
IntegromeDBIGF2
STRING (EMBL)IGF2
Ontologies - Pathways
QuickGOP01344
Ontology : AmiGOskeletal system development  osteoblast differentiation  positive regulation of protein phosphorylation  platelet degranulation  insulin receptor binding  insulin-like growth factor receptor binding  hormone activity  protein binding  extracellular region  extracellular space  plasma membrane  glucose metabolic process  regulation of gene expression by genetic imprinting  regulation of transcription, DNA-templated  multicellular organismal development  female pregnancy  blood coagulation  memory  growth factor activity  positive regulation of cell proliferation  insulin receptor signaling pathway  response to radiation  organ morphogenesis  platelet activation  receptor activator activity  exocrine pancreas development  platelet alpha granule lumen  response to nutrient levels  response to estradiol  response to nicotine  insulin receptor signaling pathway via phosphatidylinositol 3-kinase  positive regulation of activated T cell proliferation  response to drug  positive regulation of catalytic activity  positive regulation of MAPK cascade  protein serine/threonine kinase activator activity  cellular protein metabolic process  response to ethanol  positive regulation of glycogen biosynthetic process  positive regulation of mitosis  positive regulation of transcription from RNA polymerase II promoter  positive regulation of insulin receptor signaling pathway  positive regulation of peptidyl-tyrosine phosphorylation  striated muscle cell differentiation  positive regulation of cell division  positive regulation of protein kinase B signaling  extracellular vesicular exosome  cellular response to mechanical stimulus  positive regulation of protein serine/threonine kinase activity  positive regulation of steroid hormone biosynthetic process  positive regulation of receptor activity  positive regulation of glycogen (starch) synthase activity  
Ontology : EGO-EBIskeletal system development  osteoblast differentiation  positive regulation of protein phosphorylation  platelet degranulation  insulin receptor binding  insulin-like growth factor receptor binding  hormone activity  protein binding  extracellular region  extracellular space  plasma membrane  glucose metabolic process  regulation of gene expression by genetic imprinting  regulation of transcription, DNA-templated  multicellular organismal development  female pregnancy  blood coagulation  memory  growth factor activity  positive regulation of cell proliferation  insulin receptor signaling pathway  response to radiation  organ morphogenesis  platelet activation  receptor activator activity  exocrine pancreas development  platelet alpha granule lumen  response to nutrient levels  response to estradiol  response to nicotine  insulin receptor signaling pathway via phosphatidylinositol 3-kinase  positive regulation of activated T cell proliferation  response to drug  positive regulation of catalytic activity  positive regulation of MAPK cascade  protein serine/threonine kinase activator activity  cellular protein metabolic process  response to ethanol  positive regulation of glycogen biosynthetic process  positive regulation of mitosis  positive regulation of transcription from RNA polymerase II promoter  positive regulation of insulin receptor signaling pathway  positive regulation of peptidyl-tyrosine phosphorylation  striated muscle cell differentiation  positive regulation of cell division  positive regulation of protein kinase B signaling  extracellular vesicular exosome  cellular response to mechanical stimulus  positive regulation of protein serine/threonine kinase activity  positive regulation of steroid hormone biosynthetic process  positive regulation of receptor activity  positive regulation of glycogen (starch) synthase activity  
Pathways : KEGGProteoglycans in cancer   
Protein Interaction DatabaseIGF2
DoCM (Curated mutations)IGF2
Wikipedia pathwaysIGF2
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerIGF2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IGF2
dbVarIGF2
ClinVarIGF2
1000_GenomesIGF2 
Exome Variant ServerIGF2
SNP (GeneSNP Utah)IGF2
SNP : HGBaseIGF2
Genetic variants : HAPMAPIGF2
Genomic VariantsIGF2  IGF2 [DGVbeta]
Mutations
ICGC Data PortalENSG00000167244 
Somatic Mutations in Cancer : COSMICIGF2 
CONAN: Copy Number AnalysisIGF2 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)11:2150347-2160204
Mutations and Diseases : HGMDIGF2
OMIM130650    147470    180860   
MedgenIGF2
NextProtP01344 [Medical]
GENETestsIGF2
Disease Genetic AssociationIGF2
Huge Navigator IGF2 [HugePedia]  IGF2 [HugeCancerGEM]
snp3D : Map Gene to Disease3481
DGIdb (Drug Gene Interaction db)IGF2
General knowledge
Homologs : HomoloGeneIGF2
Homology/Alignments : Family Browser (UCSC)IGF2
Phylogenetic Trees/Animal Genes : TreeFamIGF2
Chemical/Protein Interactions : CTD3481
Chemical/Pharm GKB GenePA29699
Clinical trialIGF2
Cancer Resource (Charite)ENSG00000167244
Other databases
Probes
Litterature
PubMed465 Pubmed reference(s) in Entrez
CoreMineIGF2
GoPubMedIGF2
iHOPIGF2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2014Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Dec 20 22:07:32 CET 2014
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