IGF2 (insulin like growth factor 2)

2003-02-01  

Identity

HGNC
LOCATION
11p15.5
LOCUSID
ALIAS
C11orf43,GRDF,IGF-II,PP9974,SRS3
FUSION GENES

Other Information

Locus ID:

NCBI: 3481
MIM: 147470
HGNC: 5466
Ensembl: ENSG00000167244

Variants:

dbSNP: 3481
ClinVar: 3481
TCGA: ENSG00000167244
COSMIC: IGF2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000167244ENST00000381389P01344
ENSG00000167244ENST00000381392P01344
ENSG00000167244ENST00000381395P01344
ENSG00000167244ENST00000381406P01344
ENSG00000167244ENST00000416167P01344
ENSG00000167244ENST00000418738P01344
ENSG00000167244ENST00000434045P01344

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Proteoglycans in cancerKEGGhsa05205
Proteoglycans in cancerKEGGko05205
Metabolism of proteinsREACTOMER-HSA-392499
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)REACTOMER-HSA-381426
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Response to elevated platelet cytosolic Ca2+REACTOMER-HSA-76005
Platelet degranulationREACTOMER-HSA-114608
Signal TransductionREACTOMER-HSA-162582
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)REACTOMER-HSA-2404192
IGF1R signaling cascadeREACTOMER-HSA-2428924
SHC-related events triggered by IGF1RREACTOMER-HSA-2428933
IRS-related events triggered by IGF1RREACTOMER-HSA-2428928

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA164713176Platinum compoundsChemicalVariantAnnotationassociatedPD30672383
PA445204Ovarian NeoplasmsDiseaseVariantAnnotationassociatedPD30672383

References

Pubmed IDYearTitleCitations
189557032008Persistent epigenetic differences associated with prenatal exposure to famine in humans.735
197677532009Identification of seven new prostate cancer susceptibility loci through a genome-wide association study.225
126377502003Loss of IGF2 imprinting: a potential marker of colorectal cancer risk.221
199567662009Cohesin is required for higher-order chromatin conformation at the imprinted IGF2-H19 locus.158
175919292007Evaluation of markers for CpG island methylator phenotype (CIMP) in colorectal cancer by a large population-based sample.156
83857451993Relaxation of imprinted genes in human cancer.149
199242802009Periconceptional maternal folic acid use of 400 microg per day is related to increased methylation of the IGF2 gene in the very young child.143
216369752011Methylation variation at IGF2 differentially methylated regions and maternal folic acid use before and during pregnancy.96
157314052005Loss of imprinting of Igf2 alters intestinal maturation and tumorigenesis in mice.94
173392712007Heritable rather than age-related environmental and stochastic factors dominate variation in DNA methylation of the human IGF2/H19 locus.93

Citation

Dessen P

IGF2 (insulin like growth factor 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/159/igf2