Atlas of Genetics and Cytogenetics in Oncology and Haematology

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IGF2 (insulin like growth factor 2)

Identity

Alias_namesC11orf43
chromosome 11 open reading frame 43
insulin-like growth factor 2
Alias_symbol (synonym)FLJ44734
IGF-II
Other aliasGRDF
PP9974
HGNC (Hugo) IGF2
LocusID (NCBI) 3481
Atlas_Id 159
Location 11p15.5  [Link to chromosome band 11p15]
Location_base_pair Starts at 2129112 and ends at 2141124 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
C5orf45 (5q35.3) / IGF2 (11p15.5)CTNNA3 (10q21.3) / IGF2 (11p15.5)IGF2 (11p15.5) / AP1G2 (14q11.2)
IGF2 (11p15.5) / CTNNA3 (10q21.3)IGF2 (11p15.5) / INS (11p15.5)IGF2 (11p15.5) / MCM8 (20p12.3)
IGF2 (11p15.5) / PLXNA1 (3q21.3)IGF2 (11p15.5) / SNW1 (14q24.3)INS-IGF2 (11p15.5) / IGF2 (11p15.5)
MALAT1 (11q13.1) / IGF2 (11p15.5)RPAP1 (15q15.1) / IGF2 (11p15.5)IGF2 11p15.5 / AP1G2 14q11.2
IGF2 11p15.5 / MCM8 20p12.3IGF2 11p15.5 / SNW1 14q24.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 17 ]
  Neuro-Endocrine/Endocrine system: Adrenal cortical carcinoma
Bone tumors: an overview
Colon: Colorectal adenocarcinoma
Soft Tissues: Embryonal rhabdomyosarcoma
Liver: Hepatoblastoma
Liver: Hepatocellular carcinoma
Head and Neck: Salivary gland tumors: an overview
Soft tissue tumors: an overview
Kidney: Clear cell sarcoma with t(10;17)(q22;p13) YWHAE/NUTM2E
Lung: Translocations in Squamous Cell Carcinoma
t(10;11)(q21;p15) IGF2/CTNNA3
t(10;11)(q21;p15) CTNNA3/IGF2
t(11;11)(p15;q13) MALAT1/IGF2
t(11;14)(p15;q11) IGF2/AP1G2
t(11;14)(p15;q24) IGF2/SNW1
t(11;20)(p15;p12) IGF2/MCM8
Kidney: Nephroblastoma (Wilms tumor)

Other Cancer prone implicated (Data extracted from papers in the Atlas) [ 1 ]
  Beckwith-Wiedemann syndrome

External links

Nomenclature
HGNC (Hugo)IGF2   5466
LRG (Locus Reference Genomic)LRG_1031
Cards
Entrez_Gene (NCBI)IGF2  3481  insulin like growth factor 2
AliasesC11orf43; GRDF; IGF-II; PP9974
GeneCards (Weizmann)IGF2
Ensembl hg19 (Hinxton)ENSG00000167244 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000167244 [Gene_View]  ENSG00000167244 [Sequence]  chr11:2129112-2141124 [Contig_View]  IGF2 [Vega]
ICGC DataPortalENSG00000167244
TCGA cBioPortalIGF2
AceView (NCBI)IGF2
Genatlas (Paris)IGF2
WikiGenes3481
SOURCE (Princeton)IGF2
Genetics Home Reference (NIH)IGF2
Genomic and cartography
GoldenPath hg38 (UCSC)IGF2  -     chr11:2129112-2141124 -  11p15.5   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)IGF2  -     11p15.5   [Description]    (hg19-Feb_2009)
EnsemblIGF2 - 11p15.5 [CytoView hg19]  IGF2 - 11p15.5 [CytoView hg38]
Mapping of homologs : NCBIIGF2 [Mapview hg19]  IGF2 [Mapview hg38]
OMIM130650   147470   180860   194070   616489   
Gene and transcription
Genbank (Entrez)AA040827 AF318382 AK025719 AK074614 AK126688
RefSeq transcript (Entrez)NM_000612 NM_001007139 NM_001127598 NM_001291861 NM_001291862
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)IGF2
Cluster EST : UnigeneHs.272259 [ NCBI ]
CGAP (NCI)Hs.272259
Alternative Splicing GalleryENSG00000167244
Gene ExpressionIGF2 [ NCBI-GEO ]   IGF2 [ EBI - ARRAY_EXPRESS ]   IGF2 [ SEEK ]   IGF2 [ MEM ]
Gene Expression Viewer (FireBrowse)IGF2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3481
GTEX Portal (Tissue expression)IGF2
Human Protein AtlasENSG00000167244-IGF2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP01344   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP01344  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP01344
Splice isoforms : SwissVarP01344
PhosPhoSitePlusP01344
Domaine pattern : Prosite (Expaxy)INSULIN (PS00262)   
Domains : Interpro (EBI)IGF2    IGF2_C    Insulin-like    Insulin-like_growth_factor    Insulin-like_sf    Insulin_CS    Insulin_family   
Domain families : Pfam (Sanger)IGF2_C (PF08365)    Insulin (PF00049)   
Domain families : Pfam (NCBI)pfam08365    pfam00049   
Domain families : Smart (EMBL)IlGF (SM00078)  
Domain structure : Prodom (Prabi Lyon)IGF2_C (PD005188)   
Conserved Domain (NCBI)IGF2
DMDM Disease mutations3481
Blocks (Seattle)IGF2
PDB (SRS)1GF2    1IGL    2L29    2V5P    3E4Z    3KR3    5L3L    5L3M    5L3N   
PDB (PDBSum)1GF2    1IGL    2L29    2V5P    3E4Z    3KR3    5L3L    5L3M    5L3N   
PDB (IMB)1GF2    1IGL    2L29    2V5P    3E4Z    3KR3    5L3L    5L3M    5L3N   
PDB (RSDB)1GF2    1IGL    2L29    2V5P    3E4Z    3KR3    5L3L    5L3M    5L3N   
Structural Biology KnowledgeBase1GF2    1IGL    2L29    2V5P    3E4Z    3KR3    5L3L    5L3M    5L3N   
SCOP (Structural Classification of Proteins)1GF2    1IGL    2L29    2V5P    3E4Z    3KR3    5L3L    5L3M    5L3N   
CATH (Classification of proteins structures)1GF2    1IGL    2L29    2V5P    3E4Z    3KR3    5L3L    5L3M    5L3N   
SuperfamilyP01344
Human Protein Atlas [tissue]ENSG00000167244-IGF2 [tissue]
Peptide AtlasP01344
HPRD00939
IPIIPI00001508   IPI00001611   IPI00940065   IPI00215977   IPI00853573   IPI00894133   IPI00853225   
Protein Interaction databases
DIP (DOE-UCLA)P01344
IntAct (EBI)P01344
FunCoupENSG00000167244
BioGRIDIGF2
STRING (EMBL)IGF2
ZODIACIGF2
Ontologies - Pathways
QuickGOP01344
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  skeletal system development  osteoblast differentiation  in utero embryonic development  embryonic placenta development  positive regulation of protein phosphorylation  platelet degranulation  insulin receptor binding  insulin-like growth factor receptor binding  integrin binding  hormone activity  protein binding  extracellular region  extracellular space  glucose metabolic process  regulation of gene expression by genetic imprinting  regulation of transcription, DNA-templated  multicellular organism development  growth factor activity  positive regulation of cell proliferation  positive regulation of cell proliferation  insulin receptor signaling pathway  animal organ morphogenesis  regulation of signaling receptor activity  exocrine pancreas development  regulation of histone modification  platelet alpha granule lumen  insulin receptor signaling pathway via phosphatidylinositol 3-kinase  positive regulation of multicellular organism growth  positive regulation of activated T cell proliferation  positive regulation of catalytic activity  positive regulation of MAPK cascade  protein serine/threonine kinase activator activity  cellular protein metabolic process  positive regulation of glycogen biosynthetic process  positive regulation of mitotic nuclear division  positive regulation of transcription by RNA polymerase II  positive regulation of insulin receptor signaling pathway  receptor ligand activity  positive regulation of peptidyl-tyrosine phosphorylation  striated muscle cell differentiation  regulation of muscle cell differentiation  positive regulation of cell division  positive regulation of protein kinase B signaling  embryonic placenta morphogenesis  positive regulation of protein serine/threonine kinase activity  positive regulation of glycogen (starch) synthase activity  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  skeletal system development  osteoblast differentiation  in utero embryonic development  embryonic placenta development  positive regulation of protein phosphorylation  platelet degranulation  insulin receptor binding  insulin-like growth factor receptor binding  integrin binding  hormone activity  protein binding  extracellular region  extracellular space  glucose metabolic process  regulation of gene expression by genetic imprinting  regulation of transcription, DNA-templated  multicellular organism development  growth factor activity  positive regulation of cell proliferation  positive regulation of cell proliferation  insulin receptor signaling pathway  animal organ morphogenesis  regulation of signaling receptor activity  exocrine pancreas development  regulation of histone modification  platelet alpha granule lumen  insulin receptor signaling pathway via phosphatidylinositol 3-kinase  positive regulation of multicellular organism growth  positive regulation of activated T cell proliferation  positive regulation of catalytic activity  positive regulation of MAPK cascade  protein serine/threonine kinase activator activity  cellular protein metabolic process  positive regulation of glycogen biosynthetic process  positive regulation of mitotic nuclear division  positive regulation of transcription by RNA polymerase II  positive regulation of insulin receptor signaling pathway  receptor ligand activity  positive regulation of peptidyl-tyrosine phosphorylation  striated muscle cell differentiation  regulation of muscle cell differentiation  positive regulation of cell division  positive regulation of protein kinase B signaling  embryonic placenta morphogenesis  positive regulation of protein serine/threonine kinase activity  positive regulation of glycogen (starch) synthase activity  
Pathways : KEGGProteoglycans in cancer   
NDEx NetworkIGF2
Atlas of Cancer Signalling NetworkIGF2
Wikipedia pathwaysIGF2
Orthology - Evolution
OrthoDB3481
GeneTree (enSembl)ENSG00000167244
Phylogenetic Trees/Animal Genes : TreeFamIGF2
HOVERGENP01344
HOGENOMP01344
Homologs : HomoloGeneIGF2
Homology/Alignments : Family Browser (UCSC)IGF2
Gene fusions - Rearrangements
Fusion : MitelmanCTNNA3/IGF2 [10q21.3/11p15.5]  [t(10;11)(q21;p15)]  
Fusion : MitelmanIGF2/AP1G2 [11p15.5/14q11.2]  [t(11;14)(p15;q11)]  
Fusion : MitelmanIGF2/CTNNA3 [11p15.5/10q21.3]  [t(10;11)(q21;p15)]  
Fusion : MitelmanIGF2/MCM8 [11p15.5/20p12.3]  [t(11;20)(p15;p12)]  
Fusion : MitelmanIGF2/SNW1 [11p15.5/14q24.3]  [t(11;14)(p15;q24)]  
Fusion : MitelmanMALAT1/IGF2 [11q13.1/11p15.5]  [t(11;11)(p15;q13)]  
Fusion PortalIGF2 11p15.5 AP1G2 14q11.2 BLCA
Fusion PortalIGF2 11p15.5 MCM8 20p12.3 LUAD
Fusion PortalIGF2 11p15.5 SNW1 14q24.3 THCA
Fusion : QuiverIGF2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIGF2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IGF2
dbVarIGF2
ClinVarIGF2
1000_GenomesIGF2 
Exome Variant ServerIGF2
ExAC (Exome Aggregation Consortium)ENSG00000167244
GNOMAD BrowserENSG00000167244
Varsome BrowserIGF2
Genetic variants : HAPMAP3481
Genomic Variants (DGV)IGF2 [DGVbeta]
DECIPHERIGF2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisIGF2 
Mutations
ICGC Data PortalIGF2 
TCGA Data PortalIGF2 
Broad Tumor PortalIGF2
OASIS PortalIGF2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIGF2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDIGF2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
BioMutasearch IGF2
DgiDB (Drug Gene Interaction Database)IGF2
DoCM (Curated mutations)IGF2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)IGF2 (select a term)
intoGenIGF2
Cancer3DIGF2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM130650    147470    180860    194070    616489   
Orphanet2033    19161    19162    19155   
DisGeNETIGF2
MedgenIGF2
Genetic Testing Registry IGF2
NextProtP01344 [Medical]
TSGene3481
GENETestsIGF2
Target ValidationIGF2
Huge Navigator IGF2 [HugePedia]
snp3D : Map Gene to Disease3481
BioCentury BCIQIGF2
ClinGenIGF2 (curated)
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3481
Chemical/Pharm GKB GenePA29699
Clinical trialIGF2
Miscellaneous
canSAR (ICR)IGF2 (select the gene name)
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineIGF2
EVEXIGF2
GoPubMedIGF2
iHOPIGF2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Aug 27 11:28:39 CEST 2018
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