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IGF2 (insulin-like growth factor 2 (somatomedin A))

Identity

Other namesC11orf43
IGF-II
PP9974
HGNC (Hugo) IGF2
LocusID (NCBI) 3481
Location 11p15.5
Location_base_pair Starts at 2150347 and ends at 2160204 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas)

Solid Tumors ProstateOverviewID5041 ProstateOverviewID5041 ProstateOverviewID5041 ProstateOverviewID5041 ProstateOverviewID5041

External links

Nomenclature
HGNC (Hugo)IGF2   5466
Cards
Entrez_Gene (NCBI)IGF2  3481  insulin-like growth factor 2 (somatomedin A)
GeneCards (Weizmann)IGF2
Ensembl (Hinxton)ENSG00000167244 [Gene_View]  chr11:2150347-2160204 [Contig_View]  IGF2 [Vega]
ICGC DataPortalENSG00000167244
cBioPortalIGF2
AceView (NCBI)IGF2
Genatlas (Paris)IGF2
WikiGenes3481
SOURCE (Princeton)NM_000612 NM_001007139 NM_001127598
Genomic and cartography
GoldenPath (UCSC)IGF2  -  11p15.5   chr11:2150347-2160204 -  11p15.5   [Description]    (hg19-Feb_2009)
EnsemblIGF2 - 11p15.5 [CytoView]
Mapping of homologs : NCBIIGF2 [Mapview]
OMIM147470   
Gene and transcription
Genbank (Entrez)AF318382 AK025719 AK126688 AK313938 AY971350
RefSeq transcript (Entrez)NM_000612 NM_001007139 NM_001127598
RefSeq genomic (Entrez)AC_000143 NC_000011 NC_018922 NG_008849 NT_009237 NW_001838018 NW_004929378
Consensus coding sequences : CCDS (NCBI)IGF2
Cluster EST : UnigeneHs.272259 [ NCBI ]
CGAP (NCI)Hs.272259
Alternative Splicing : Fast-db (Paris)GSHG0005467
Alternative Splicing GalleryENSG00000167244
Gene ExpressionIGF2 [ NCBI-GEO ]     IGF2 [ SEEK ]   IGF2 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP01344 (Uniprot)
NextProtP01344  [Medical]
With graphics : InterProP01344
Splice isoforms : SwissVarP01344 (Swissvar)
Domaine pattern : Prosite (Expaxy)INSULIN (PS00262)   
Domains : Interpro (EBI)IGF2 [organisation]   IGF2_C [organisation]   Insulin-like [organisation]   Insulin-like_growth_factor [organisation]   Insulin_CS [organisation]   Insulin_family [organisation]  
Related proteins : CluSTrP01344
Domain families : Pfam (Sanger)IGF2_C (PF08365)    Insulin (PF00049)   
Domain families : Pfam (NCBI)pfam08365    pfam00049   
Domain families : Smart (EMBL)IlGF (SM00078)  
Domain structure : Prodom (Prabi Lyon)IGF2_C (PD005188)   
DMDM Disease mutations3481
Blocks (Seattle)P01344
PDB (SRS)1GF2    1IGL    2L29    2V5P    3E4Z    3KR3   
PDB (PDBSum)1GF2    1IGL    2L29    2V5P    3E4Z    3KR3   
PDB (IMB)1GF2    1IGL    2L29    2V5P    3E4Z    3KR3   
PDB (RSDB)1GF2    1IGL    2L29    2V5P    3E4Z    3KR3   
Human Protein AtlasENSG00000167244 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasP01344
HPRD00939
IPIIPI00001508   IPI00001611   IPI00940065   IPI00215977   IPI00853573   IPI00894133   IPI00853225   
Protein Interaction databases
DIP (DOE-UCLA)P01344
IntAct (EBI)P01344
FunCoupENSG00000167244
BioGRIDIGF2
InParanoidP01344
Interologous Interaction database P01344
IntegromeDBIGF2
STRING (EMBL)IGF2
Ontologies - Pathways
Ontology : AmiGOskeletal system development  ossification  positive regulation of protein phosphorylation  platelet degranulation  insulin receptor binding  insulin-like growth factor receptor binding  hormone activity  protein binding  extracellular region  extracellular space  plasma membrane  glucose metabolic process  regulation of gene expression by genetic imprinting  regulation of transcription, DNA-dependent  multicellular organismal development  blood coagulation  growth factor activity  positive regulation of cell proliferation  insulin receptor signaling pathway  platelet activation  receptor activator activity  platelet alpha granule lumen  insulin receptor signaling pathway via phosphatidylinositol 3-kinase cascade  positive regulation of activated T cell proliferation  positive regulation of catalytic activity  positive regulation of MAPK cascade  protein serine/threonine kinase activator activity  cellular protein metabolic process  positive regulation of glycogen biosynthetic process  positive regulation of mitosis  positive regulation of insulin receptor signaling pathway  positive regulation of peptidyl-tyrosine phosphorylation  positive regulation of cell division  positive regulation of protein kinase B signaling cascade  positive regulation of protein serine/threonine kinase activity  positive regulation of receptor activity  positive regulation of glycogen (starch) synthase activity  
Ontology : EGO-EBIskeletal system development  ossification  positive regulation of protein phosphorylation  platelet degranulation  insulin receptor binding  insulin-like growth factor receptor binding  hormone activity  protein binding  extracellular region  extracellular space  plasma membrane  glucose metabolic process  regulation of gene expression by genetic imprinting  regulation of transcription, DNA-dependent  multicellular organismal development  blood coagulation  growth factor activity  positive regulation of cell proliferation  insulin receptor signaling pathway  platelet activation  receptor activator activity  platelet alpha granule lumen  insulin receptor signaling pathway via phosphatidylinositol 3-kinase cascade  positive regulation of activated T cell proliferation  positive regulation of catalytic activity  positive regulation of MAPK cascade  protein serine/threonine kinase activator activity  cellular protein metabolic process  positive regulation of glycogen biosynthetic process  positive regulation of mitosis  positive regulation of insulin receptor signaling pathway  positive regulation of peptidyl-tyrosine phosphorylation  positive regulation of cell division  positive regulation of protein kinase B signaling cascade  positive regulation of protein serine/threonine kinase activity  positive regulation of receptor activity  positive regulation of glycogen (starch) synthase activity  
Pathways : KEGGProteoglycans in cancer   
Protein Interaction DatabaseIGF2
Wikipedia pathwaysIGF2
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)IGF2
snp3D : Map Gene to Disease3481
SNP (GeneSNP Utah)IGF2
SNP : HGBaseIGF2
Genetic variants : HAPMAPIGF2
Exome VariantIGF2
1000_GenomesIGF2 
ICGC programENSG00000167244 
Somatic Mutations in Cancer : COSMICIGF2 
CONAN: Copy Number AnalysisIGF2 
Mutations and Diseases : HGMDIGF2
Genomic VariantsIGF2  IGF2 [DGVbeta]
dbVarIGF2
ClinVarIGF2
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM147470   
MedgenIGF2
GENETestsIGF2
Disease Genetic AssociationIGF2
Huge Navigator IGF2 [HugePedia]  IGF2 [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneIGF2
Homology/Alignments : Family Browser (UCSC)IGF2
Phylogenetic Trees/Animal Genes : TreeFamIGF2
Chemical/Protein Interactions : CTD3481
Chemical/Pharm GKB GenePA29699
Clinical trialIGF2
Cancer Resource (Charite)ENSG00000167244
Other databases
Probes
Litterature
PubMed446 Pubmed reference(s) in Entrez
CoreMineIGF2
iHOPIGF2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jul 11 16:59:52 CEST 2014

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