Atlas of Genetics and Cytogenetics in Oncology and Haematology

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IGF2BP3 (insulin like growth factor 2 mRNA binding protein 3)

Identity

Alias_namesinsulin-like growth factor 2 mRNA binding protein 3
Alias_symbol (synonym)IMP-3
CT98
IMP3
Other aliasKOC
KOC1
VICKZ3
HGNC (Hugo) IGF2BP3
LocusID (NCBI) 10643
Atlas_Id 40970
Location 7p15.3  [Link to chromosome band 7p15]
Location_base_pair Starts at 23310209 and ends at 23470376 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
IGF2BP3 (7p15.3) / ACSM1 (16p12.3)IGF2BP3 (7p15.3) / POLR2B (4q12)IGF2BP3 (7p15.3) / PRKCA (17q24.2)
IGF2BP3 (7p15.3) / SSR2 (1q22)IGF2BP3 (7p15.3) / THADA (2p21)POLR2B (4q12) / IGF2BP3 (7p15.3)
THADA (2p21) / IGF2BP3 (7p15.3)IGF2BP3 7p15.3 / ACSM1 16p12.3THADA 2p21 / IGF2BP3 7p15.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 4 ]
  t(2;7)(p21;p15) IGF2BP3/THADA
t(2;7)(p21;p15) THADA/IGF2BP3
t(7;16)(p15;p12) IGF2BP3/ACSM1
t(7;17)(p15;q24) IGF2BP3/PRKCA

External links

Nomenclature
HGNC (Hugo)IGF2BP3   28868
Cards
Entrez_Gene (NCBI)IGF2BP3  10643  insulin like growth factor 2 mRNA binding protein 3
AliasesCT98; IMP-3; IMP3; KOC; 
KOC1; VICKZ3
GeneCards (Weizmann)IGF2BP3
Ensembl hg19 (Hinxton)ENSG00000136231 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000136231 [Gene_View]  ENSG00000136231 [Sequence]  chr7:23310209-23470376 [Contig_View]  IGF2BP3 [Vega]
ICGC DataPortalENSG00000136231
TCGA cBioPortalIGF2BP3
AceView (NCBI)IGF2BP3
Genatlas (Paris)IGF2BP3
WikiGenes10643
SOURCE (Princeton)IGF2BP3
Genetics Home Reference (NIH)IGF2BP3
Genomic and cartography
GoldenPath hg38 (UCSC)IGF2BP3  -     chr7:23310209-23470376 -  7p15.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)IGF2BP3  -     7p15.3   [Description]    (hg19-Feb_2009)
EnsemblIGF2BP3 - 7p15.3 [CytoView hg19]  IGF2BP3 - 7p15.3 [CytoView hg38]
Mapping of homologs : NCBIIGF2BP3 [Mapview hg19]  IGF2BP3 [Mapview hg38]
OMIM608259   
Gene and transcription
Genbank (Entrez)AF117108 BC019258 BC051296 BC065269 BX640800
RefSeq transcript (Entrez)NM_006547
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)IGF2BP3
Cluster EST : UnigeneHs.700696 [ NCBI ]
CGAP (NCI)Hs.700696
Alternative Splicing GalleryENSG00000136231
Gene ExpressionIGF2BP3 [ NCBI-GEO ]   IGF2BP3 [ EBI - ARRAY_EXPRESS ]   IGF2BP3 [ SEEK ]   IGF2BP3 [ MEM ]
Gene Expression Viewer (FireBrowse)IGF2BP3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10643
GTEX Portal (Tissue expression)IGF2BP3
Human Protein AtlasENSG00000136231-IGF2BP3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO00425   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO00425  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO00425
Splice isoforms : SwissVarO00425
PhosPhoSitePlusO00425
Domaine pattern : Prosite (Expaxy)KH_TYPE_1 (PS50084)    RRM (PS50102)   
Domains : Interpro (EBI)IGF2BP3_RRM2    KH_dom    KH_dom_type_1    KH_dom_type_1_sf    Nucleotide-bd_a/b_plait_sf    RBD_domain_sf    RRM_dom   
Domain families : Pfam (Sanger)KH_1 (PF00013)    RRM_1 (PF00076)   
Domain families : Pfam (NCBI)pfam00013    pfam00076   
Domain families : Smart (EMBL)KH (SM00322)  RRM (SM00360)  
Conserved Domain (NCBI)IGF2BP3
DMDM Disease mutations10643
Blocks (Seattle)IGF2BP3
PDB (SRS)2E+44   
PDB (PDBSum)2E+44   
PDB (IMB)2E+44   
PDB (RSDB)2E+44   
Structural Biology KnowledgeBase2E+44   
SCOP (Structural Classification of Proteins)2E+44   
CATH (Classification of proteins structures)2E+44   
SuperfamilyO00425
Human Protein Atlas [tissue]ENSG00000136231-IGF2BP3 [tissue]
Peptide AtlasO00425
HPRD16306
IPIIPI00658000   IPI00165467   IPI00953668   
Protein Interaction databases
DIP (DOE-UCLA)O00425
IntAct (EBI)O00425
FunCoupENSG00000136231
BioGRIDIGF2BP3
STRING (EMBL)IGF2BP3
ZODIACIGF2BP3
Ontologies - Pathways
QuickGOO00425
Ontology : AmiGORNA binding  mRNA 3'-UTR binding  protein binding  nucleus  cytoplasm  cytosol  cytosol  translation  anatomical structure morphogenesis  negative regulation of translation  regulation of cytokine biosynthetic process  regulation of mRNA stability  translation regulator activity  mRNA 5'-UTR binding  mRNA transport  
Ontology : EGO-EBIRNA binding  mRNA 3'-UTR binding  protein binding  nucleus  cytoplasm  cytosol  cytosol  translation  anatomical structure morphogenesis  negative regulation of translation  regulation of cytokine biosynthetic process  regulation of mRNA stability  translation regulator activity  mRNA 5'-UTR binding  mRNA transport  
NDEx NetworkIGF2BP3
Atlas of Cancer Signalling NetworkIGF2BP3
Wikipedia pathwaysIGF2BP3
Orthology - Evolution
OrthoDB10643
GeneTree (enSembl)ENSG00000136231
Phylogenetic Trees/Animal Genes : TreeFamIGF2BP3
HOVERGENO00425
HOGENOMO00425
Homologs : HomoloGeneIGF2BP3
Homology/Alignments : Family Browser (UCSC)IGF2BP3
Gene fusions - Rearrangements
Fusion : MitelmanIGF2BP3/ACSM1 [7p15.3/16p12.3]  
Fusion : MitelmanIGF2BP3/THADA [7p15.3/2p21]  [t(2;7)(p21;p15)]  
Fusion : MitelmanTHADA/IGF2BP3 [2p21/7p15.3]  [t(2;7)(p21;p15)]  
Fusion PortalIGF2BP3 7p15.3 ACSM1 16p12.3 BRCA
Fusion PortalTHADA 2p21 IGF2BP3 7p15.3 THCA
Fusion : QuiverIGF2BP3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIGF2BP3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IGF2BP3
dbVarIGF2BP3
ClinVarIGF2BP3
1000_GenomesIGF2BP3 
Exome Variant ServerIGF2BP3
ExAC (Exome Aggregation Consortium)ENSG00000136231
GNOMAD BrowserENSG00000136231
Varsome BrowserIGF2BP3
Genetic variants : HAPMAP10643
Genomic Variants (DGV)IGF2BP3 [DGVbeta]
DECIPHERIGF2BP3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisIGF2BP3 
Mutations
ICGC Data PortalIGF2BP3 
TCGA Data PortalIGF2BP3 
Broad Tumor PortalIGF2BP3
OASIS PortalIGF2BP3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIGF2BP3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDIGF2BP3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch IGF2BP3
DgiDB (Drug Gene Interaction Database)IGF2BP3
DoCM (Curated mutations)IGF2BP3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)IGF2BP3 (select a term)
intoGenIGF2BP3
Cancer3DIGF2BP3(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608259   
Orphanet
DisGeNETIGF2BP3
MedgenIGF2BP3
Genetic Testing Registry IGF2BP3
NextProtO00425 [Medical]
TSGene10643
GENETestsIGF2BP3
Target ValidationIGF2BP3
Huge Navigator IGF2BP3 [HugePedia]
snp3D : Map Gene to Disease10643
BioCentury BCIQIGF2BP3
ClinGenIGF2BP3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10643
Chemical/Pharm GKB GenePA128394576
Clinical trialIGF2BP3
Miscellaneous
canSAR (ICR)IGF2BP3 (select the gene name)
Probes
Litterature
PubMed224 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineIGF2BP3
EVEXIGF2BP3
GoPubMedIGF2BP3
iHOPIGF2BP3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:12:53 CET 2018
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