Identity
HGNC
LOCATION
7p15.3
LOCUSID
ALIAS
CT98,IMP-3,IMP3,KOC,KOC1,VICKZ3
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 10643
MIM: 608259
HGNC: 28868
Ensembl: ENSG00000136231
Variants:
dbSNP: 10643
ClinVar: 10643
TCGA: ENSG00000136231
COSMIC: IGF2BP3
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000136231 | ENST00000258729 | O00425 |
| ENSG00000136231 | ENST00000421467 | F8WD15 |
| ENSG00000136231 | ENST00000619562 | O00425 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Gene Expression | REACTOME | R-HSA-74160 |
| Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA | REACTOME | R-HSA-428359 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37861451 | 2024 | Association of the m(6) A reader IGF2BP3 with tumor progression and brain-specific metastasis in breast cancer. | 0 |
| 38271139 | 2024 | Knockdown of RNA-binding protein IMP3 suppresses oral squamous cell carcinoma proliferation by destabilizing E2F5 transcript. | 0 |
| 38284203 | 2024 | Insulin-like growth factor 2 mRNA-binding protein 3 enhanced melanoma migration through regulation of AKT1 and RELA expression. | 0 |
| 38286802 | 2024 | Regulation of ULK1 by WTAP/IGF2BP3 axis enhances mitophagy and progression in epithelial ovarian cancer. | 2 |
| 38329630 | 2024 | Hypoxia increases the biogenesis of IGF2BP3-bound circular RNAs. | 0 |
| 38341127 | 2024 | NONO promotes gallbladder cancer cell proliferation by enhancing oncogenic RNA splicing of DLG1 through interaction with IGF2BP3/RBM14. | 1 |
| 38355626 | 2024 | IGF2BP3 enhances lipid metabolism in cervical cancer by upregulating the expression of SCD. | 1 |
| 38429265 | 2024 | Depletion of the N(6)-Methyladenosine (m6A) reader protein IGF2BP3 induces ferroptosis in glioma by modulating the expression of GPX4. | 0 |
| 38448411 | 2024 | The RNA m(6)A reader IGF2BP3 regulates NFAT1/IRF1 axis-mediated anti-tumor activity in gastric cancer. | 1 |
| 38459420 | 2024 | Circ_0098823 binding with IGF2BP3 regulates DNM1L stability to promote metastasis of hepatocellular carcinoma via mitochondrial fission. | 2 |
| 38460759 | 2024 | IGF2BP3 stabilizes SESN1 mRNA to mitigate oxidized low-density lipoprotein-induced oxidative stress and endothelial dysfunction in human umbilical vein endothelial cells by activating Nrf2 signaling. | 0 |
| 38565412 | 2024 | Hsa_circ_0005320 affects cell proliferation and the cell cycle via the IGF2BP3/CDK2 axis in bladder cancer. | 0 |
| 38572589 | 2024 | m(6)A-dependent upregulation of DDX21 by super-enhancer-driven IGF2BP2 and IGF2BP3 facilitates progression of acute myeloid leukaemia. | 1 |
| 38679464 | 2024 | N6-methyladenosine methylation on FSCN1 mediated by METTL14/IGF2BP3 contributes to human papillomavirus type 16-infected cervical squamous cell carcinoma. | 0 |
| 38820515 | 2024 | IGF2BP3 regulates the expression of RRM2 and promotes the progression of rheumatoid arthritis via RRM2/Akt/MMP-9 pathway. | 0 |
Citation
Dessen P
IGF2BP3 (insulin like growth factor 2 mRNA binding protein 3)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/40970/igf2bp3
