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IGFBP1 (insulin like growth factor binding protein 1)

Identity

Alias_namesIBP1
insulin-like growth factor binding protein 1
Alias_symbol (synonym)IGF-BP25
AFBP
hIGFBP-1
PP12
Other alias
HGNC (Hugo) IGFBP1
LocusID (NCBI) 3484
Atlas_Id 40930
Location 7p12.3  [Link to chromosome band 7p12]
Location_base_pair Starts at 45888360 and ends at 45893668 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)IGFBP1   5469
Cards
Entrez_Gene (NCBI)IGFBP1  3484  insulin like growth factor binding protein 1
AliasesAFBP; IBP1; IGF-BP25; PP12; 
hIGFBP-1
GeneCards (Weizmann)IGFBP1
Ensembl hg19 (Hinxton)ENSG00000146678 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000146678 [Gene_View]  chr7:45888360-45893668 [Contig_View]  IGFBP1 [Vega]
ICGC DataPortalENSG00000146678
TCGA cBioPortalIGFBP1
AceView (NCBI)IGFBP1
Genatlas (Paris)IGFBP1
WikiGenes3484
SOURCE (Princeton)IGFBP1
Genetics Home Reference (NIH)IGFBP1
Genomic and cartography
GoldenPath hg38 (UCSC)IGFBP1  -     chr7:45888360-45893668 +  7p12.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)IGFBP1  -     7p12.3   [Description]    (hg19-Feb_2009)
EnsemblIGFBP1 - 7p12.3 [CytoView hg19]  IGFBP1 - 7p12.3 [CytoView hg38]
Mapping of homologs : NCBIIGFBP1 [Mapview hg19]  IGFBP1 [Mapview hg38]
OMIM146730   
Gene and transcription
Genbank (Entrez)AF042356 AK314925 AV695706 BC035263 BC057806
RefSeq transcript (Entrez)NM_000596 NM_001013029
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)IGFBP1
Cluster EST : UnigeneHs.642938 [ NCBI ]
CGAP (NCI)Hs.642938
Alternative Splicing GalleryENSG00000146678
Gene ExpressionIGFBP1 [ NCBI-GEO ]   IGFBP1 [ EBI - ARRAY_EXPRESS ]   IGFBP1 [ SEEK ]   IGFBP1 [ MEM ]
Gene Expression Viewer (FireBrowse)IGFBP1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3484
GTEX Portal (Tissue expression)IGFBP1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP08833   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP08833  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP08833
Splice isoforms : SwissVarP08833
PhosPhoSitePlusP08833
Domaine pattern : Prosite (Expaxy)IGFBP_N_1 (PS00222)    IGFBP_N_2 (PS51323)    THYROGLOBULIN_1_1 (PS00484)    THYROGLOBULIN_1_2 (PS51162)   
Domains : Interpro (EBI)Growth_fac_rcpt_    IGFBP-like    IGFBP1    IGFBP1-6    IGFBP_1-6_chordata    Insulin_GF-bd_Cys-rich_CS    Thyroglobulin_1   
Domain families : Pfam (Sanger)IGFBP (PF00219)    Thyroglobulin_1 (PF00086)   
Domain families : Pfam (NCBI)pfam00219    pfam00086   
Domain families : Smart (EMBL)IB (SM00121)  TY (SM00211)  
Conserved Domain (NCBI)IGFBP1
DMDM Disease mutations3484
Blocks (Seattle)IGFBP1
PDB (SRS)1ZT3    1ZT5    2DSQ   
PDB (PDBSum)1ZT3    1ZT5    2DSQ   
PDB (IMB)1ZT3    1ZT5    2DSQ   
PDB (RSDB)1ZT3    1ZT5    2DSQ   
Structural Biology KnowledgeBase1ZT3    1ZT5    2DSQ   
SCOP (Structural Classification of Proteins)1ZT3    1ZT5    2DSQ   
CATH (Classification of proteins structures)1ZT3    1ZT5    2DSQ   
SuperfamilyP08833
Human Protein AtlasENSG00000146678
Peptide AtlasP08833
HPRD00897
IPIIPI00031086   IPI00926019   IPI00945953   
Protein Interaction databases
DIP (DOE-UCLA)P08833
IntAct (EBI)P08833
FunCoupENSG00000146678
BioGRIDIGFBP1
STRING (EMBL)IGFBP1
ZODIACIGFBP1
Ontologies - Pathways
QuickGOP08833
Ontology : AmiGOreceptor binding  protein binding  insulin-like growth factor binding  extracellular region  extracellular space  Golgi apparatus  signal transduction  aging  insulin receptor signaling pathway  positive regulation of cell growth  insulin-like growth factor I binding  insulin-like growth factor II binding  PERK-mediated unfolded protein response  tissue regeneration  regulation of insulin-like growth factor receptor signaling pathway  cellular protein metabolic process  negative regulation of canonical Wnt signaling pathway  
Ontology : EGO-EBIreceptor binding  protein binding  insulin-like growth factor binding  extracellular region  extracellular space  Golgi apparatus  signal transduction  aging  insulin receptor signaling pathway  positive regulation of cell growth  insulin-like growth factor I binding  insulin-like growth factor II binding  PERK-mediated unfolded protein response  tissue regeneration  regulation of insulin-like growth factor receptor signaling pathway  cellular protein metabolic process  negative regulation of canonical Wnt signaling pathway  
Pathways : BIOCARTAGhrelin: Regulation of Food Intake and Energy Homeostasis [Genes]   
NDEx NetworkIGFBP1
Atlas of Cancer Signalling NetworkIGFBP1
Wikipedia pathwaysIGFBP1
Orthology - Evolution
OrthoDB3484
GeneTree (enSembl)ENSG00000146678
Phylogenetic Trees/Animal Genes : TreeFamIGFBP1
HOVERGENP08833
HOGENOMP08833
Homologs : HomoloGeneIGFBP1
Homology/Alignments : Family Browser (UCSC)IGFBP1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIGFBP1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IGFBP1
dbVarIGFBP1
ClinVarIGFBP1
1000_GenomesIGFBP1 
Exome Variant ServerIGFBP1
ExAC (Exome Aggregation Consortium)IGFBP1 (select the gene name)
Genetic variants : HAPMAP3484
Genomic Variants (DGV)IGFBP1 [DGVbeta]
DECIPHERIGFBP1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisIGFBP1 
Mutations
ICGC Data PortalIGFBP1 
TCGA Data PortalIGFBP1 
Broad Tumor PortalIGFBP1
OASIS PortalIGFBP1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIGFBP1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDIGFBP1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch IGFBP1
DgiDB (Drug Gene Interaction Database)IGFBP1
DoCM (Curated mutations)IGFBP1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)IGFBP1 (select a term)
intoGenIGFBP1
Cancer3DIGFBP1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM146730   
Orphanet
MedgenIGFBP1
Genetic Testing Registry IGFBP1
NextProtP08833 [Medical]
TSGene3484
GENETestsIGFBP1
Target ValidationIGFBP1
Huge Navigator IGFBP1 [HugePedia]
snp3D : Map Gene to Disease3484
BioCentury BCIQIGFBP1
ClinGenIGFBP1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3484
Chemical/Pharm GKB GenePA29703
Clinical trialIGFBP1
Miscellaneous
canSAR (ICR)IGFBP1 (select the gene name)
Probes
Litterature
PubMed248 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineIGFBP1
EVEXIGFBP1
GoPubMedIGFBP1
iHOPIGFBP1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:12:55 CEST 2017

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