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IGFBP1 (insulin like growth factor binding protein 1)

Identity

Alias (NCBI)AFBP
IBP1
IGF-BP25
PP12
hIGFBP-1
HGNC (Hugo) IGFBP1
HGNC Alias symbIGF-BP25
AFBP
hIGFBP-1
PP12
HGNC Alias nameplacental protein 12
 amniotic fluid binding protein
 alpha-pregnancy-associated endometrial globulin
 growth hormone independent-binding protein
 binding protein-28
 binding protein-26
 binding protein-25
 IGF-binding protein 1
HGNC Previous nameIBP1
HGNC Previous nameinsulin-like growth factor binding protein 1
LocusID (NCBI) 3484
Atlas_Id 40930
Location 7p12.3  [Link to chromosome band 7p12]
Location_base_pair Starts at 45888488 and ends at 45893659 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)IGFBP1   5469
Cards
Entrez_Gene (NCBI)IGFBP1    insulin like growth factor binding protein 1
AliasesAFBP; IBP1; IGF-BP25; PP12; 
hIGFBP-1
GeneCards (Weizmann)IGFBP1
Ensembl hg19 (Hinxton)ENSG00000146678 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000146678 [Gene_View]  ENSG00000146678 [Sequence]  chr7:45888488-45893659 [Contig_View]  IGFBP1 [Vega]
ICGC DataPortalENSG00000146678
TCGA cBioPortalIGFBP1
AceView (NCBI)IGFBP1
Genatlas (Paris)IGFBP1
SOURCE (Princeton)IGFBP1
Genetics Home Reference (NIH)IGFBP1
Genomic and cartography
GoldenPath hg38 (UCSC)IGFBP1  -     chr7:45888488-45893659 +  7p12.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)IGFBP1  -     7p12.3   [Description]    (hg19-Feb_2009)
GoldenPathIGFBP1 - 7p12.3 [CytoView hg19]  IGFBP1 - 7p12.3 [CytoView hg38]
ImmunoBaseENSG00000146678
Genome Data Viewer NCBIIGFBP1 [Mapview hg19]  
OMIM146730   
Gene and transcription
Genbank (Entrez)AF042356 AK314925 AV695706 BC035263 BC057806
RefSeq transcript (Entrez)NM_000596 NM_001013029
Consensus coding sequences : CCDS (NCBI)IGFBP1
Gene ExpressionIGFBP1 [ NCBI-GEO ]   IGFBP1 [ EBI - ARRAY_EXPRESS ]   IGFBP1 [ SEEK ]   IGFBP1 [ MEM ]
Gene Expression Viewer (FireBrowse)IGFBP1 [ Firebrowse - Broad ]
GenevisibleExpression of IGFBP1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3484
GTEX Portal (Tissue expression)IGFBP1
Human Protein AtlasENSG00000146678-IGFBP1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP08833   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP08833  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP08833
PhosPhoSitePlusP08833
Domaine pattern : Prosite (Expaxy)IGFBP_N_1 (PS00222)    IGFBP_N_2 (PS51323)    THYROGLOBULIN_1_1 (PS00484)    THYROGLOBULIN_1_2 (PS51162)   
Domains : Interpro (EBI)Growth_fac_rcpt_cys_sf    IGFBP-like    IGFBP1    IGFBP_1-6_chordata    Insulin_GF-bd_Cys-rich_CS    Thyroglobulin_1    Thyroglobulin_1_sf   
Domain families : Pfam (Sanger)IGFBP (PF00219)    Thyroglobulin_1 (PF00086)   
Domain families : Pfam (NCBI)pfam00219    pfam00086   
Domain families : Smart (EMBL)IB (SM00121)  TY (SM00211)  
Conserved Domain (NCBI)IGFBP1
PDB (RSDB)1ZT3    1ZT5    2DSQ   
PDB Europe1ZT3    1ZT5    2DSQ   
PDB (PDBSum)1ZT3    1ZT5    2DSQ   
PDB (IMB)1ZT3    1ZT5    2DSQ   
Structural Biology KnowledgeBase1ZT3    1ZT5    2DSQ   
SCOP (Structural Classification of Proteins)1ZT3    1ZT5    2DSQ   
CATH (Classification of proteins structures)1ZT3    1ZT5    2DSQ   
SuperfamilyP08833
AlphaFold pdb e-kbP08833   
Human Protein Atlas [tissue]ENSG00000146678-IGFBP1 [tissue]
HPRD00897
Protein Interaction databases
DIP (DOE-UCLA)P08833
IntAct (EBI)P08833
BioGRIDIGFBP1
STRING (EMBL)IGFBP1
ZODIACIGFBP1
Ontologies - Pathways
QuickGOP08833
Ontology : AmiGOsignaling receptor binding  protein binding  insulin-like growth factor binding  extracellular region  extracellular space  endoplasmic reticulum lumen  Golgi apparatus  signal transduction  aging  insulin receptor signaling pathway  positive regulation of cell growth  insulin-like growth factor I binding  insulin-like growth factor I binding  insulin-like growth factor II binding  insulin-like growth factor II binding  tissue regeneration  regulation of insulin-like growth factor receptor signaling pathway  negative regulation of canonical Wnt signaling pathway  
Ontology : EGO-EBIsignaling receptor binding  protein binding  insulin-like growth factor binding  extracellular region  extracellular space  endoplasmic reticulum lumen  Golgi apparatus  signal transduction  aging  insulin receptor signaling pathway  positive regulation of cell growth  insulin-like growth factor I binding  insulin-like growth factor I binding  insulin-like growth factor II binding  insulin-like growth factor II binding  tissue regeneration  regulation of insulin-like growth factor receptor signaling pathway  negative regulation of canonical Wnt signaling pathway  
Pathways : BIOCARTABIOCARTA_GHRELINPATHWAY   
NDEx NetworkIGFBP1
Atlas of Cancer Signalling NetworkIGFBP1
Wikipedia pathwaysIGFBP1
Orthology - Evolution
OrthoDB3484
GeneTree (enSembl)ENSG00000146678
Phylogenetic Trees/Animal Genes : TreeFamIGFBP1
Homologs : HomoloGeneIGFBP1
Homology/Alignments : Family Browser (UCSC)IGFBP1
Gene fusions - Rearrangements
Fusion : QuiverIGFBP1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIGFBP1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IGFBP1
dbVarIGFBP1
ClinVarIGFBP1
MonarchIGFBP1
1000_GenomesIGFBP1 
Exome Variant ServerIGFBP1
GNOMAD BrowserENSG00000146678
Varsome BrowserIGFBP1
ACMGIGFBP1 variants
VarityP08833
Genomic Variants (DGV)IGFBP1 [DGVbeta]
DECIPHERIGFBP1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisIGFBP1 
Mutations
ICGC Data PortalIGFBP1 
TCGA Data PortalIGFBP1 
Broad Tumor PortalIGFBP1
OASIS PortalIGFBP1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIGFBP1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DIGFBP1
Mutations and Diseases : HGMDIGFBP1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaIGFBP1
DgiDB (Drug Gene Interaction Database)IGFBP1
DoCM (Curated mutations)IGFBP1
CIViC (Clinical Interpretations of Variants in Cancer)IGFBP1
Cancer3DIGFBP1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM146730   
Orphanet
DisGeNETIGFBP1
MedgenIGFBP1
Genetic Testing Registry IGFBP1
NextProtP08833 [Medical]
GENETestsIGFBP1
Target ValidationIGFBP1
Huge Navigator IGFBP1 [HugePedia]
ClinGenIGFBP1
Clinical trials, drugs, therapy
MyCancerGenomeIGFBP1
Protein Interactions : CTDIGFBP1
Pharm GKB GenePA29703
PharosP08833
Clinical trialIGFBP1
Miscellaneous
canSAR (ICR)IGFBP1
HarmonizomeIGFBP1
ARCHS4IGFBP1
DataMed IndexIGFBP1
Probes
Litterature
PubMed305 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXIGFBP1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Thu Jan 20 12:38:13 CET 2022

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