IGFBP1 (insulin like growth factor binding protein 1)

2003-11-01  

Identity

HGNC
LOCATION
7p12.3
LOCUSID
ALIAS
AFBP,IBP1,IGF-BP25,PP12,hIGFBP-1

Other Information

Locus ID:

NCBI: 3484
MIM: 146730
HGNC: 5469
Ensembl: ENSG00000146678

Variants:

dbSNP: 3484
ClinVar: 3484
TCGA: ENSG00000146678
COSMIC: IGFBP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000146678ENST00000275525P08833
ENSG00000146678ENST00000457280C9JXF9
ENSG00000146678ENST00000468955C9J6H2

Expression (GTEx)

0
50
100
150
200
250
300
350
400

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)REACTOMER-HSA-381426
Unfolded Protein Response (UPR)REACTOMER-HSA-381119
PERK regulates gene expressionREACTOMER-HSA-381042
ATF4 activates genesREACTOMER-HSA-380994

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
147158372004The prospective association of serum insulin-like growth factor I (IGF-I) and IGF-binding protein-1 levels with all cause and cardiovascular disease mortality in older adults: the Rancho Bernardo Study.77
197306832009The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors.59
185969092008IGF-1, IGFBP-1, and IGFBP-3 polymorphisms predict circulating IGF levels but not breast cancer risk: findings from the Breast and Prostate Cancer Cohort Consortium (BPC3).50
185969092008IGF-1, IGFBP-1, and IGFBP-3 polymorphisms predict circulating IGF levels but not breast cancer risk: findings from the Breast and Prostate Cancer Cohort Consortium (BPC3).50
157974612005Insulin-like growth factor signaling in fish.48
159878202005Role of FOXO1A in the regulation of insulin-like growth factor-binding protein-1 in human endometrial cells: interaction with progesterone receptor.41
164044262006Polymorphisms of genes coding for insulin-like growth factor 1 and its major binding proteins, circulating levels of IGF-I and IGFBP-3 and breast cancer risk: results from the EPIC study.41
186657842008IGF-1 and IGF-binding proteins and bone mass, geometry, and strength: relation to metabolic control in adolescent girls with type 1 diabetes.38
207340642010A large-scale candidate gene association study of age at menarche and age at natural menopause.38

Citation

Dessen P

IGFBP1 (insulin like growth factor binding protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/40930/igfbp1