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IGFBP2 (insulin-like growth factor binding protein 2, 36kDa)

Identity

Other namesIBP2
IGF-BP53
HGNC (Hugo) IGFBP2
LocusID (NCBI) 3485
Location 2q35
Location_base_pair Starts at 217498127 and ends at 217529158 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)IGFBP2   5471
Entrez_Gene (NCBI)IGFBP2  3485  insulin-like growth factor binding protein 2, 36kDa
Cards
GeneCards (Weizmann)IGFBP2
Ensembl (Hinxton)ENSG00000115457 [Gene_View]  chr2:217498127-217529158 [Contig_View]  IGFBP2 [Vega]
AceView (NCBI)IGFBP2
Genatlas (Paris)IGFBP2
SOURCE (Stanford)NM_000597
Genomic and cartography
GoldenPath (UCSC)IGFBP2  -  2q35   chr2:217498127-217529158 +  2q35   [Description]    (hg19-Feb_2009)
EnsemblIGFBP2 - 2q35 [CytoView]
Mapping of homologs : NCBIIGFBP2 [Mapview]
OMIM146731   
Gene and transcription
Genbank (Entrez)A09809 AB209509 AL559513 BC004312 BC009902
RefSeq transcript (SRS)NM_000597
RefSeq transcript (Entrez)NM_000597
RefSeq genomic (SRS)AC_000134 NC_000002 NC_018913 NT_005403 NW_001838863 NW_004078008
RefSeq genomic (Entrez)AC_000134 NC_000002 NC_018913 NT_005403 NW_001838863 NW_004078008
Consensus coding sequences : CCDS (NCBI)IGFBP2
Cluster EST : UnigeneHs.438102 [ SRS ] Hs.438102 [ NCBI ]
CGAP (NCI)Hs.438102
Alternative Splicing : Fast-db (Paris)GSHG0017176
Alternative Splicing GalleryENSG00000115457
Gene ExpressionIGFBP2 [ NCBI-GEO ]   IGFBP2 [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP18065 (SRS) P18065 (Uniprot)
NextProtP18065
With graphics : InterProP18065
Splice isoforms : SwissVarP18065(Swissvar)
Domaine pattern : Prosite (SRS)IGFBP_N_1 (PS00222)    IGFBP_N_2 (PS51323)    THYROGLOBULIN_1_1 (PS00484)    THYROGLOBULIN_1_2 (PS51162)   
Domaine pattern : Prosite (Expaxy)IGFBP_N_1 (PS00222)    IGFBP_N_2 (PS51323)    THYROGLOBULIN_1_1 (PS00484)    THYROGLOBULIN_1_2 (PS51162)   
Domains : Interpro (SRS)Growth_fac_rcpt    IGFBP-2    IGFBP-like    IGFBP1-6    IGFBP_1-6_chordata    Insulin_GF-bd_Cys-rich_CS    Thyroglobulin_1   
Domains : Interpro (EBI)Growth_fac_rcpt    IGFBP-2    IGFBP-like    IGFBP1-6    IGFBP_1-6_chordata    Insulin_GF-bd_Cys-rich_CS    Thyroglobulin_1   
Related proteins : CluSTrP18065
Domain families : Pfam (SRS)IGFBP (PF00219)    Thyroglobulin_1 (PF00086)   
Domain families : Pfam (Sanger)IGFBP (PF00219)    Thyroglobulin_1 (PF00086)   
Domain families : Pfam (NCBI)pfam00219    pfam00086   
Domain families : Smart (EMBL)IB (SM00121)  TY (SM00211)  
DMDM3485
Blocks (Seattle)P18065
PDB (SRS)2H7T   
PDB (PDBSum)2H7T   
PDB (IMB)2H7T   
PDB (RSDB)2H7T   
Human Protein AtlasENSG00000115457
HPRD00898
IPIIPI00556442   IPI00297284   IPI00926948   IPI00927165   IPI00927386   
Protein Interaction databases
DIP (DOE-UCLA)P18065
IntAct (EBI)P18065
FunCoupENSG00000115457
REACTOMEIGFBP2
Protein Interaction Database3485
BioGRIDIGFBP2
InParanoidP18065
Interologous Interaction database P18065
IntegromeDBIGFBP2
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)IGFBP2
SNP (GeneSNP Utah)IGFBP2
SNP : HGBaseIGFBP2
Genetic variants : HAPMAPIGFBP2
Somatic Mutations in Cancer : COSMICIGFBP2 
CONAN: Copy Number AnalysisIGFBP2 
Mutations and Diseases : HGMDIGFBP2
OMIM146731   
GENETests146731   
Disease Genetic AssociationIGFBP2
Huge Navigator IGFBP2 [HugePedia]  IGFBP2 [HugeCancerGEM]
Genomic VariantsIGFBP2  IGFBP2 [DGVbeta]
ClinVarIGFBP2
snp3D : Map Gene to Disease3485
General knowledge
Homologs : HomoloGeneIGFBP2
Homology/Alignments : Family Browser (UCSC)IGFBP2
Phylogenetic Trees/Animal Genes : TreeFamIGFBP2
Chemical/Protein Interactions : CTD3485
Chemical/Pharm GKB GenePA29704
Clinical trialIGFBP2
Cancer Resource (Charite)ENSG00000115457
Ontology : AmiGOregulation of cell growth  protein binding  extracellular region  extracellular region  extracellular space  response to stress  signal transduction  female pregnancy  aging  response to nutrient  response to mechanical stimulus  response to lithium ion  apical plasma membrane  cytoplasmic vesicle  insulin-like growth factor I binding  insulin-like growth factor II binding  response to estradiol stimulus  response to retinoic acid  cellular response to hormone stimulus  positive regulation of activated T cell proliferation  response to drug  regulation of insulin-like growth factor receptor signaling pathway  regulation of insulin-like growth factor receptor signaling pathway  cellular protein metabolic process  response to glucocorticoid stimulus  
Ontology : EGO-EBIregulation of cell growth  protein binding  extracellular region  extracellular region  extracellular space  response to stress  signal transduction  female pregnancy  aging  response to nutrient  response to mechanical stimulus  response to lithium ion  apical plasma membrane  cytoplasmic vesicle  insulin-like growth factor I binding  insulin-like growth factor II binding  response to estradiol stimulus  response to retinoic acid  cellular response to hormone stimulus  positive regulation of activated T cell proliferation  response to drug  regulation of insulin-like growth factor receptor signaling pathway  regulation of insulin-like growth factor receptor signaling pathway  cellular protein metabolic process  response to glucocorticoid stimulus  
Pathways : BIOCARTAGhrelin: Regulation of Food Intake and Energy Homeostasis [Genes]   
Other databases
Probes
Litterature
PubMed145 Pubmed reference(s) in Entrez
PubGeneIGFBP2
iHOPIGFBP2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated01-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jun 14 17:31:19 CEST 2013
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