IGFBP2 (insulin like growth factor binding protein 2)

2003-08-01  

Identity

HGNC
LOCATION
2q35
LOCUSID
ALIAS
IBP2,IGF-BP53
FUSION GENES

Other Information

Locus ID:

NCBI: 3485
MIM: 146731
HGNC: 5471
Ensembl: ENSG00000115457

Variants:

dbSNP: 3485
ClinVar: 3485
TCGA: ENSG00000115457
COSMIC: IGFBP2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000115457ENST00000233809P18065
ENSG00000115457ENST00000434997C9JW52
ENSG00000115457ENST00000436812H7C1H0
ENSG00000115457ENST00000456764C9JMY1

Expression (GTEx)

0
500
1000
1500

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)REACTOMER-HSA-381426

References

Pubmed IDYearTitleCitations
178274002007Studies of association of variants near the HHEX, CDKN2A/B, and IGF2BP2 genes with type 2 diabetes and impaired insulin release in 10,705 Danish subjects: validation and extension of genome-wide association studies.97
173722102007Insulin growth factor-binding protein 2 is a candidate biomarker for PTEN status and PI3K/Akt pathway activation in glioblastoma and prostate cancer.73
198623252009PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 are associated with type 2 diabetes in a Chinese population.70
129075972003Insulin-like growth factor binding protein 2 enhances glioblastoma invasion by activating invasion-enhancing genes.65
176069272007Insulin-like growth factor binding protein 2 promotes glioma development and progression.56
184611612008Post genome-wide association studies of novel genes associated with type 2 diabetes show gene-gene interaction and high predictive value.53
151717172004Integrin-mediated action of insulin-like growth factor binding protein-2 in tumor cells.51
223455622012Insulin-like growth factor-binding protein 2-driven glioma progression is prevented by blocking a clinically significant integrin, integrin-linked kinase, and NF-κB network.46
173698472007IGF-II and IGFBP-2 differentially regulate PTEN in human breast cancer cells.44
165696422006An interaction between insulin-like growth factor-binding protein 2 (IGFBP2) and integrin alpha5 is essential for IGFBP2-induced cell mobility.43

Citation

Dessen P

IGFBP2 (insulin like growth factor binding protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/40931/igfbp2