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IGFBP2 (insulin like growth factor binding protein 2)

Identity

Other namesIBP2
IGF-BP53
HGNC (Hugo) IGFBP2
LocusID (NCBI) 3485
Atlas_Id 40931
Location 2q35  [Link to chromosome band 2q35]
Location_base_pair Starts at 217498127 and ends at 217529158 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
IGFBP2 (2q35) / DNMT3L (21q22.3)IGFBP2 (2q35) / FXR1 (3q26.33)RPL37A (2q35) / IGFBP2 (2q35)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)IGFBP2   5471
Cards
Entrez_Gene (NCBI)IGFBP2  3485  insulin like growth factor binding protein 2
AliasesIBP2; IGF-BP53
GeneCards (Weizmann)IGFBP2
Ensembl hg19 (Hinxton)ENSG00000115457 [Gene_View]  chr2:217498127-217529158 [Contig_View]  IGFBP2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000115457 [Gene_View]  chr2:217498127-217529158 [Contig_View]  IGFBP2 [Vega]
ICGC DataPortalENSG00000115457
TCGA cBioPortalIGFBP2
AceView (NCBI)IGFBP2
Genatlas (Paris)IGFBP2
WikiGenes3485
SOURCE (Princeton)IGFBP2
Genomic and cartography
GoldenPath hg19 (UCSC)IGFBP2  -     chr2:217498127-217529158 +  2q35   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)IGFBP2  -     2q35   [Description]    (hg38-Dec_2013)
EnsemblIGFBP2 - 2q35 [CytoView hg19]  IGFBP2 - 2q35 [CytoView hg38]
Mapping of homologs : NCBIIGFBP2 [Mapview hg19]  IGFBP2 [Mapview hg38]
OMIM146731   
Gene and transcription
Genbank (Entrez)A09809 AB209509 AL559513 BC004312 BC009902
RefSeq transcript (Entrez)NM_000597 NM_001313990 NM_001313992 NM_001313993
RefSeq genomic (Entrez)NC_000002 NC_018913 NT_005403 NW_004929305
Consensus coding sequences : CCDS (NCBI)IGFBP2
Cluster EST : UnigeneHs.438102 [ NCBI ]
CGAP (NCI)Hs.438102
Alternative Splicing GalleryENSG00000115457
Gene ExpressionIGFBP2 [ NCBI-GEO ]   IGFBP2 [ EBI - ARRAY_EXPRESS ]   IGFBP2 [ SEEK ]   IGFBP2 [ MEM ]
Gene Expression Viewer (FireBrowse)IGFBP2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3485
GTEX Portal (Tissue expression)IGFBP2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP18065 (Uniprot)
NextProtP18065  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP18065
Splice isoforms : SwissVarP18065 (Swissvar)
PhosPhoSitePlusP18065
Domaine pattern : Prosite (Expaxy)IGFBP_N_1 (PS00222)    IGFBP_N_2 (PS51323)    THYROGLOBULIN_1_1 (PS00484)    THYROGLOBULIN_1_2 (PS51162)   
Domains : Interpro (EBI)Growth_fac_rcpt_    IGFBP-2    IGFBP-like    IGFBP1-6    IGFBP_1-6_chordata    Insulin_GF-bd_Cys-rich_CS    Thyroglobulin_1   
Domain families : Pfam (Sanger)IGFBP (PF00219)    Thyroglobulin_1 (PF00086)   
Domain families : Pfam (NCBI)pfam00219    pfam00086   
Domain families : Smart (EMBL)IB (SM00121)  TY (SM00211)  
DMDM Disease mutations3485
Blocks (Seattle)IGFBP2
PDB (SRS)2H7T   
PDB (PDBSum)2H7T   
PDB (IMB)2H7T   
PDB (RSDB)2H7T   
Structural Biology KnowledgeBase2H7T   
SCOP (Structural Classification of Proteins)2H7T   
CATH (Classification of proteins structures)2H7T   
SuperfamilyP18065
Human Protein AtlasENSG00000115457
Peptide AtlasP18065
HPRD00898
IPIIPI00556442   IPI00297284   IPI00926948   IPI00927165   IPI00927386   
Protein Interaction databases
DIP (DOE-UCLA)P18065
IntAct (EBI)P18065
FunCoupENSG00000115457
BioGRIDIGFBP2
STRING (EMBL)IGFBP2
ZODIACIGFBP2
Ontologies - Pathways
QuickGOP18065
Ontology : AmiGOregulation of cell growth  receptor binding  protein binding  extracellular region  extracellular region  extracellular space  signal transduction  female pregnancy  aging  response to nutrient  response to mechanical stimulus  response to lithium ion  apical plasma membrane  cytoplasmic vesicle  insulin-like growth factor I binding  insulin-like growth factor II binding  insulin-like growth factor II binding  response to estradiol  response to retinoic acid  cellular response to hormone stimulus  positive regulation of activated T cell proliferation  response to drug  regulation of insulin-like growth factor receptor signaling pathway  regulation of insulin-like growth factor receptor signaling pathway  regulation of insulin-like growth factor receptor signaling pathway  cellular protein metabolic process  response to glucocorticoid  extracellular exosome  negative regulation of canonical Wnt signaling pathway  
Ontology : EGO-EBIregulation of cell growth  receptor binding  protein binding  extracellular region  extracellular region  extracellular space  signal transduction  female pregnancy  aging  response to nutrient  response to mechanical stimulus  response to lithium ion  apical plasma membrane  cytoplasmic vesicle  insulin-like growth factor I binding  insulin-like growth factor II binding  insulin-like growth factor II binding  response to estradiol  response to retinoic acid  cellular response to hormone stimulus  positive regulation of activated T cell proliferation  response to drug  regulation of insulin-like growth factor receptor signaling pathway  regulation of insulin-like growth factor receptor signaling pathway  regulation of insulin-like growth factor receptor signaling pathway  cellular protein metabolic process  response to glucocorticoid  extracellular exosome  negative regulation of canonical Wnt signaling pathway  
Pathways : BIOCARTAGhrelin: Regulation of Food Intake and Energy Homeostasis [Genes]   
NDEx NetworkIGFBP2
Atlas of Cancer Signalling NetworkIGFBP2
Wikipedia pathwaysIGFBP2
Orthology - Evolution
OrthoDB3485
GeneTree (enSembl)ENSG00000115457
Phylogenetic Trees/Animal Genes : TreeFamIGFBP2
Homologs : HomoloGeneIGFBP2
Homology/Alignments : Family Browser (UCSC)IGFBP2
Gene fusions - Rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerIGFBP2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IGFBP2
dbVarIGFBP2
ClinVarIGFBP2
1000_GenomesIGFBP2 
Exome Variant ServerIGFBP2
ExAC (Exome Aggregation Consortium)IGFBP2 (select the gene name)
Genetic variants : HAPMAP3485
Genomic Variants (DGV)IGFBP2 [DGVbeta]
Mutations
ICGC Data PortalIGFBP2 
TCGA Data PortalIGFBP2 
Broad Tumor PortalIGFBP2
OASIS PortalIGFBP2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIGFBP2 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch IGFBP2
DgiDB (Drug Gene Interaction Database)IGFBP2
DoCM (Curated mutations)IGFBP2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)IGFBP2 (select a term)
intoGenIGFBP2
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)2:217498127-217529158  ENSG00000115457
CONAN: Copy Number AnalysisIGFBP2 
Mutations and Diseases : HGMDIGFBP2
OMIM146731   
MedgenIGFBP2
Genetic Testing Registry IGFBP2
NextProtP18065 [Medical]
TSGene3485
GENETestsIGFBP2
Huge Navigator IGFBP2 [HugePedia]
snp3D : Map Gene to Disease3485
BioCentury BCIQIGFBP2
ClinGenIGFBP2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3485
Chemical/Pharm GKB GenePA29704
Clinical trialIGFBP2
Miscellaneous
canSAR (ICR)IGFBP2 (select the gene name)
Probes
Litterature
PubMed201 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineIGFBP2
EVEXIGFBP2
GoPubMedIGFBP2
iHOPIGFBP2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 19 18:54:26 CEST 2016

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