Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

IGFBP2 (insulin like growth factor binding protein 2)

Identity

Alias (NCBI)IBP2
IGF-BP53
HGNC (Hugo) IGFBP2
HGNC Previous nameIBP2
HGNC Previous nameinsulin-like growth factor binding protein 2 (36kD)
 insulin-like growth factor binding protein 2, 36kDa
 insulin-like growth factor binding protein 2
LocusID (NCBI) 3485
Atlas_Id 40931
Location 2q35  [Link to chromosome band 2q35]
Location_base_pair Starts at 216632828 and ends at 216664435 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
IGFBP2 (2q35) / DNMT3L (21q22.3)IGFBP2 (2q35) / FXR1 (3q26.33)RPL37A (2q35) / IGFBP2 (2q35)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)IGFBP2   5471
Cards
Entrez_Gene (NCBI)IGFBP2    insulin like growth factor binding protein 2
AliasesIBP2; IGF-BP53
GeneCards (Weizmann)IGFBP2
Ensembl hg19 (Hinxton)ENSG00000115457 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000115457 [Gene_View]  ENSG00000115457 [Sequence]  chr2:216632828-216664435 [Contig_View]  IGFBP2 [Vega]
ICGC DataPortalENSG00000115457
TCGA cBioPortalIGFBP2
AceView (NCBI)IGFBP2
Genatlas (Paris)IGFBP2
SOURCE (Princeton)IGFBP2
Genetics Home Reference (NIH)IGFBP2
Genomic and cartography
GoldenPath hg38 (UCSC)IGFBP2  -     chr2:216632828-216664435 +  2q35   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)IGFBP2  -     2q35   [Description]    (hg19-Feb_2009)
GoldenPathIGFBP2 - 2q35 [CytoView hg19]  IGFBP2 - 2q35 [CytoView hg38]
ImmunoBaseENSG00000115457
Genome Data Viewer NCBIIGFBP2 [Mapview hg19]  
OMIM146731   
Gene and transcription
Genbank (Entrez)A09809 AB209509 AL559513 BC004312 BC009902
RefSeq transcript (Entrez)NM_000597 NM_001313990 NM_001313992 NM_001313993
Consensus coding sequences : CCDS (NCBI)IGFBP2
Gene ExpressionIGFBP2 [ NCBI-GEO ]   IGFBP2 [ EBI - ARRAY_EXPRESS ]   IGFBP2 [ SEEK ]   IGFBP2 [ MEM ]
Gene Expression Viewer (FireBrowse)IGFBP2 [ Firebrowse - Broad ]
GenevisibleExpression of IGFBP2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3485
GTEX Portal (Tissue expression)IGFBP2
Human Protein AtlasENSG00000115457-IGFBP2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP18065   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP18065  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP18065
PhosPhoSitePlusP18065
Domaine pattern : Prosite (Expaxy)IGFBP_N_1 (PS00222)    IGFBP_N_2 (PS51323)    THYROGLOBULIN_1_1 (PS00484)    THYROGLOBULIN_1_2 (PS51162)   
Domains : Interpro (EBI)Growth_fac_rcpt_cys_sf    IGFBP-2    IGFBP-like    IGFBP_1-6_chordata    Insulin_GF-bd_Cys-rich_CS    Thyroglobulin_1    Thyroglobulin_1_sf   
Domain families : Pfam (Sanger)IGFBP (PF00219)    Thyroglobulin_1 (PF00086)   
Domain families : Pfam (NCBI)pfam00219    pfam00086   
Domain families : Smart (EMBL)IB (SM00121)  TY (SM00211)  
Conserved Domain (NCBI)IGFBP2
PDB (RSDB)2H7T   
PDB Europe2H7T   
PDB (PDBSum)2H7T   
PDB (IMB)2H7T   
Structural Biology KnowledgeBase2H7T   
SCOP (Structural Classification of Proteins)2H7T   
CATH (Classification of proteins structures)2H7T   
SuperfamilyP18065
AlphaFold pdb e-kbP18065   
Human Protein Atlas [tissue]ENSG00000115457-IGFBP2 [tissue]
HPRD00898
Protein Interaction databases
DIP (DOE-UCLA)P18065
IntAct (EBI)P18065
BioGRIDIGFBP2
STRING (EMBL)IGFBP2
ZODIACIGFBP2
Ontologies - Pathways
QuickGOP18065
Ontology : AmiGOsignaling receptor binding  protein binding  extracellular region  extracellular region  extracellular space  extracellular space  signal transduction  female pregnancy  aging  response to nutrient  response to mechanical stimulus  response to lithium ion  apical plasma membrane  cytoplasmic vesicle  insulin-like growth factor I binding  insulin-like growth factor I binding  insulin-like growth factor II binding  insulin-like growth factor II binding  response to estradiol  response to retinoic acid  cellular response to hormone stimulus  regulation of growth  positive regulation of activated T cell proliferation  response to drug  regulation of insulin-like growth factor receptor signaling pathway  regulation of insulin-like growth factor receptor signaling pathway  regulation of insulin-like growth factor receptor signaling pathway  response to estrogen  cellular protein metabolic process  response to glucocorticoid  extracellular exosome  negative regulation of canonical Wnt signaling pathway  
Ontology : EGO-EBIsignaling receptor binding  protein binding  extracellular region  extracellular region  extracellular space  extracellular space  signal transduction  female pregnancy  aging  response to nutrient  response to mechanical stimulus  response to lithium ion  apical plasma membrane  cytoplasmic vesicle  insulin-like growth factor I binding  insulin-like growth factor I binding  insulin-like growth factor II binding  insulin-like growth factor II binding  response to estradiol  response to retinoic acid  cellular response to hormone stimulus  regulation of growth  positive regulation of activated T cell proliferation  response to drug  regulation of insulin-like growth factor receptor signaling pathway  regulation of insulin-like growth factor receptor signaling pathway  regulation of insulin-like growth factor receptor signaling pathway  response to estrogen  cellular protein metabolic process  response to glucocorticoid  extracellular exosome  negative regulation of canonical Wnt signaling pathway  
Pathways : BIOCARTAGhrelin: Regulation of Food Intake and Energy Homeostasis [Genes]   
NDEx NetworkIGFBP2
Atlas of Cancer Signalling NetworkIGFBP2
Wikipedia pathwaysIGFBP2
Orthology - Evolution
OrthoDB3485
GeneTree (enSembl)ENSG00000115457
Phylogenetic Trees/Animal Genes : TreeFamIGFBP2
Homologs : HomoloGeneIGFBP2
Homology/Alignments : Family Browser (UCSC)IGFBP2
Gene fusions - Rearrangements
Fusion : QuiverIGFBP2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIGFBP2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IGFBP2
dbVarIGFBP2
ClinVarIGFBP2
MonarchIGFBP2
1000_GenomesIGFBP2 
Exome Variant ServerIGFBP2
GNOMAD BrowserENSG00000115457
Varsome BrowserIGFBP2
ACMGIGFBP2 variants
VarityP18065
Genomic Variants (DGV)IGFBP2 [DGVbeta]
DECIPHERIGFBP2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisIGFBP2 
Mutations
ICGC Data PortalIGFBP2 
TCGA Data PortalIGFBP2 
Broad Tumor PortalIGFBP2
OASIS PortalIGFBP2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIGFBP2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DIGFBP2
Mutations and Diseases : HGMDIGFBP2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaIGFBP2
DgiDB (Drug Gene Interaction Database)IGFBP2
DoCM (Curated mutations)IGFBP2
CIViC (Clinical Interpretations of Variants in Cancer)IGFBP2
Cancer3DIGFBP2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM146731   
Orphanet
DisGeNETIGFBP2
MedgenIGFBP2
Genetic Testing Registry IGFBP2
NextProtP18065 [Medical]
GENETestsIGFBP2
Target ValidationIGFBP2
Huge Navigator IGFBP2 [HugePedia]
ClinGenIGFBP2
Clinical trials, drugs, therapy
MyCancerGenomeIGFBP2
Protein Interactions : CTDIGFBP2
Pharm GKB GenePA29704
PharosP18065
Clinical trialIGFBP2
Miscellaneous
canSAR (ICR)IGFBP2
HarmonizomeIGFBP2
DataMed IndexIGFBP2
Probes
Litterature
PubMed253 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXIGFBP2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 15:13:33 CEST 2021

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.