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IGFBP4 (insulin like growth factor binding protein 4)

Identity

Alias_namesinsulin-like growth factor-binding protein 4
insulin-like growth factor binding protein 4
Alias_symbol (synonym)IBP4
BP-4
HT29-IGFBP
IGFBP-4
Other alias
HGNC (Hugo) IGFBP4
LocusID (NCBI) 3487
Atlas_Id 43990
Location 17q21.2  [Link to chromosome band 17q21]
Location_base_pair Starts at 38599676 and ends at 38613982 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
IGFBP4 (17q21.2) / DCN (12q21.33)IGFBP4 (17q21.2) / IGFBP4 (17q21.2)IGFBP4 (17q21.2) / INS-IGF2 (11p15.5)
IGFBP4 (17q21.2) / TNKS1BP1 (11q12.1)LAMA4 (6q21) / IGFBP4 (17q21.2)SGK1 (6q23.2) / IGFBP4 (17q21.2)
SLC35B1 (17q21.33) / IGFBP4 (17q21.2)UBQLN1 (9q21.32) / IGFBP4 (17q21.2)SLC35B1 17q21.33 / IGFBP4 17q21.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)IGFBP4   5473
Cards
Entrez_Gene (NCBI)IGFBP4  3487  insulin like growth factor binding protein 4
AliasesBP-4; HT29-IGFBP; IBP4; IGFBP-4
GeneCards (Weizmann)IGFBP4
Ensembl hg19 (Hinxton)ENSG00000141753 [Gene_View]  chr17:38599676-38613982 [Contig_View]  IGFBP4 [Vega]
Ensembl hg38 (Hinxton)ENSG00000141753 [Gene_View]  chr17:38599676-38613982 [Contig_View]  IGFBP4 [Vega]
ICGC DataPortalENSG00000141753
TCGA cBioPortalIGFBP4
AceView (NCBI)IGFBP4
Genatlas (Paris)IGFBP4
WikiGenes3487
SOURCE (Princeton)IGFBP4
Genetics Home Reference (NIH)IGFBP4
Genomic and cartography
GoldenPath hg19 (UCSC)IGFBP4  -     chr17:38599676-38613982 +  17q21.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)IGFBP4  -     17q21.2   [Description]    (hg38-Dec_2013)
EnsemblIGFBP4 - 17q21.2 [CytoView hg19]  IGFBP4 - 17q21.2 [CytoView hg38]
Mapping of homologs : NCBIIGFBP4 [Mapview hg19]  IGFBP4 [Mapview hg38]
OMIM146733   
Gene and transcription
Genbank (Entrez)AK290810 AK304572 BC016041 BT019891 BT019892
RefSeq transcript (Entrez)NM_001552
RefSeq genomic (Entrez)NC_000017 NC_018928 NT_010783 NW_004929407
Consensus coding sequences : CCDS (NCBI)IGFBP4
Cluster EST : UnigeneHs.462998 [ NCBI ]
CGAP (NCI)Hs.462998
Alternative Splicing GalleryENSG00000141753
Gene ExpressionIGFBP4 [ NCBI-GEO ]   IGFBP4 [ EBI - ARRAY_EXPRESS ]   IGFBP4 [ SEEK ]   IGFBP4 [ MEM ]
Gene Expression Viewer (FireBrowse)IGFBP4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3487
GTEX Portal (Tissue expression)IGFBP4
Protein : pattern, domain, 3D structure
UniProt/SwissProtP22692   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP22692  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP22692
Splice isoforms : SwissVarP22692
PhosPhoSitePlusP22692
Domaine pattern : Prosite (Expaxy)IGFBP_N_1 (PS00222)    IGFBP_N_2 (PS51323)    THYROGLOBULIN_1_1 (PS00484)    THYROGLOBULIN_1_2 (PS51162)   
Domains : Interpro (EBI)Growth_fac_rcpt_    IGFBP-4    IGFBP-like    IGFBP1-6    IGFBP_1-6_chordata    Insulin_GF-bd_Cys-rich_CS    Thyroglobulin_1   
Domain families : Pfam (Sanger)IGFBP (PF00219)    Thyroglobulin_1 (PF00086)   
Domain families : Pfam (NCBI)pfam00219    pfam00086   
Domain families : Smart (EMBL)IB (SM00121)  TY (SM00211)  
Conserved Domain (NCBI)IGFBP4
DMDM Disease mutations3487
Blocks (Seattle)IGFBP4
PDB (SRS)1WQJ    2DSP    2DSQ    2DSR   
PDB (PDBSum)1WQJ    2DSP    2DSQ    2DSR   
PDB (IMB)1WQJ    2DSP    2DSQ    2DSR   
PDB (RSDB)1WQJ    2DSP    2DSQ    2DSR   
Structural Biology KnowledgeBase1WQJ    2DSP    2DSQ    2DSR   
SCOP (Structural Classification of Proteins)1WQJ    2DSP    2DSQ    2DSR   
CATH (Classification of proteins structures)1WQJ    2DSP    2DSQ    2DSR   
SuperfamilyP22692
Human Protein AtlasENSG00000141753
Peptide AtlasP22692
HPRD00900
IPIIPI00305380   IPI01009723   
Protein Interaction databases
DIP (DOE-UCLA)P22692
IntAct (EBI)P22692
FunCoupENSG00000141753
BioGRIDIGFBP4
STRING (EMBL)IGFBP4
ZODIACIGFBP4
Ontologies - Pathways
QuickGOP22692
Ontology : AmiGOskeletal system development  regulation of cell growth  receptor binding  extracellular region  extracellular space  DNA metabolic process  inflammatory response  signal transduction  cell proliferation  regulation of glucose metabolic process  insulin-like growth factor I binding  insulin-like growth factor II binding  positive regulation of MAPK cascade  regulation of insulin-like growth factor receptor signaling pathway  positive regulation of insulin-like growth factor receptor signaling pathway  cellular protein metabolic process  type B pancreatic cell proliferation  negative regulation of canonical Wnt signaling pathway  
Ontology : EGO-EBIskeletal system development  regulation of cell growth  receptor binding  extracellular region  extracellular space  DNA metabolic process  inflammatory response  signal transduction  cell proliferation  regulation of glucose metabolic process  insulin-like growth factor I binding  insulin-like growth factor II binding  positive regulation of MAPK cascade  regulation of insulin-like growth factor receptor signaling pathway  positive regulation of insulin-like growth factor receptor signaling pathway  cellular protein metabolic process  type B pancreatic cell proliferation  negative regulation of canonical Wnt signaling pathway  
Pathways : BIOCARTAGhrelin: Regulation of Food Intake and Energy Homeostasis [Genes]   
NDEx NetworkIGFBP4
Atlas of Cancer Signalling NetworkIGFBP4
Wikipedia pathwaysIGFBP4
Orthology - Evolution
OrthoDB3487
GeneTree (enSembl)ENSG00000141753
Phylogenetic Trees/Animal Genes : TreeFamIGFBP4
HOVERGENP22692
HOGENOMP22692
Homologs : HomoloGeneIGFBP4
Homology/Alignments : Family Browser (UCSC)IGFBP4
Gene fusions - Rearrangements
Fusion : MitelmanSLC35B1/IGFBP4 [17q21.33/17q21.2]  [t(17;17)(q21;q21)]  
Fusion: TCGASLC35B1 17q21.33 IGFBP4 17q21.2 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIGFBP4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IGFBP4
dbVarIGFBP4
ClinVarIGFBP4
1000_GenomesIGFBP4 
Exome Variant ServerIGFBP4
ExAC (Exome Aggregation Consortium)IGFBP4 (select the gene name)
Genetic variants : HAPMAP3487
Genomic Variants (DGV)IGFBP4 [DGVbeta]
DECIPHER (Syndromes)17:38599676-38613982  ENSG00000141753
CONAN: Copy Number AnalysisIGFBP4 
Mutations
ICGC Data PortalIGFBP4 
TCGA Data PortalIGFBP4 
Broad Tumor PortalIGFBP4
OASIS PortalIGFBP4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIGFBP4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDIGFBP4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch IGFBP4
DgiDB (Drug Gene Interaction Database)IGFBP4
DoCM (Curated mutations)IGFBP4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)IGFBP4 (select a term)
intoGenIGFBP4
Cancer3DIGFBP4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM146733   
Orphanet
MedgenIGFBP4
Genetic Testing Registry IGFBP4
NextProtP22692 [Medical]
TSGene3487
GENETestsIGFBP4
Huge Navigator IGFBP4 [HugePedia]
snp3D : Map Gene to Disease3487
BioCentury BCIQIGFBP4
ClinGenIGFBP4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3487
Chemical/Pharm GKB GenePA29706
Clinical trialIGFBP4
Miscellaneous
canSAR (ICR)IGFBP4 (select the gene name)
Probes
Litterature
PubMed83 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineIGFBP4
EVEXIGFBP4
GoPubMedIGFBP4
iHOPIGFBP4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:10:25 CET 2017

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