IGFBP7 (insulin like growth factor binding protein 7)

2003-02-01  

Identity

HGNC
LOCATION
4q12
LOCUSID
ALIAS
AGM,FSTL2,IBP-7,IGFBP-7,IGFBP-7v,IGFBPRP1,MAC25,PSF,RAMSVPS,TAF
FUSION GENES

Other Information

Locus ID:

NCBI: 3490
MIM: 602867
HGNC: 5476
Ensembl: ENSG00000163453

Variants:

dbSNP: 3490
ClinVar: 3490
TCGA: ENSG00000163453
COSMIC: IGFBP7

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000163453ENST00000295666Q16270
ENSG00000163453ENST00000514062Q16270

Expression (GTEx)

0
1000
2000
3000
4000
5000
6000

Pathways

PathwaySourceExternal ID
Cellular responses to stressREACTOMER-HSA-2262752
Cellular SenescenceREACTOMER-HSA-2559583
Senescence-Associated Secretory Phenotype (SASP)REACTOMER-HSA-2559582

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
182670692008Oncogenic BRAF induces senescence and apoptosis through pathways mediated by the secreted protein IGFBP7.315
233886122013Discovery and validation of cell cycle arrest biomarkers in human acute kidney injury.267
246757172014Urinary TIMP-2 and IGFBP7 as early biomarkers of acute kidney injury and renal recovery following cardiac surgery.88
240674382014Identification of IGFBP-7 by urinary proteomics as a novel prognostic marker in early acute kidney injury.43
232503962012IGFBP7 binds to the IGF-1 receptor and blocks its activation by insulin-like growth factors.40
173123902007IGFBP7 plays a potential tumor suppressor role in colorectal carcinogenesis.39
246326182015IGFBP7, a novel tumor stroma marker, with growth-promoting effects in colon cancer through a paracrine tumor-stroma interaction.36
187114012008Glioblastoma-secreted factors induce IGFBP7 and angiogenesis by modulating Smad-2-dependent TGF-beta signaling.33
196384262010IGFBP7 is a p53-responsive gene specifically silenced in colorectal cancer with CpG island methylator phenotype.31
219085792011Insulin-like growth factor-binding protein-7 functions as a potential tumor suppressor in hepatocellular carcinoma.29

Citation

Dessen P

IGFBP7 (insulin like growth factor binding protein 7)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40934/igfbp7