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IGFBP7 (insulin like growth factor binding protein 7)

Identity

Alias_namesinsulin-like growth factor binding protein 7
Alias_symbol (synonym)MAC25
IGFBP-7
PSF
FSTL2
Other aliasAGM
IBP-7
IGFBP-7v
IGFBPRP1
RAMSVPS
TAF
HGNC (Hugo) IGFBP7
LocusID (NCBI) 3490
Atlas_Id 40934
Location 4q12  [Link to chromosome band 4q12]
Location_base_pair Starts at 57898404 and ends at 57976551 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
IGFBP7 (4q12) / HYAL2 (3p21.31)IGFBP7 (4q12) / IGFBP7 (4q12)IGFBP7 (4q12) / PLXNA4 (7q32.3)
IGFBP7 (4q12) / POLR2B (4q12)IGFBP7 (4q12) / SLTM (15q22.1)IGFBP7 (4q12) / TMEM263 (12q23.3)
MAF (16q23.2) / IGFBP7 (4q12)SLTM (15q22.1) / IGFBP7 (4q12)TUBB3 (16q24.3) / IGFBP7 (4q12)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)IGFBP7   5476
Cards
Entrez_Gene (NCBI)IGFBP7  3490  insulin like growth factor binding protein 7
AliasesAGM; FSTL2; IBP-7; IGFBP-7; 
IGFBP-7v; IGFBPRP1; MAC25; PSF; RAMSVPS; TAF
GeneCards (Weizmann)IGFBP7
Ensembl hg19 (Hinxton)ENSG00000163453 [Gene_View]  chr4:57898404-57976551 [Contig_View]  IGFBP7 [Vega]
Ensembl hg38 (Hinxton)ENSG00000163453 [Gene_View]  chr4:57898404-57976551 [Contig_View]  IGFBP7 [Vega]
ICGC DataPortalENSG00000163453
TCGA cBioPortalIGFBP7
AceView (NCBI)IGFBP7
Genatlas (Paris)IGFBP7
WikiGenes3490
SOURCE (Princeton)IGFBP7
Genetics Home Reference (NIH)IGFBP7
Genomic and cartography
GoldenPath hg19 (UCSC)IGFBP7  -     chr4:57898404-57976551 -  4q12   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)IGFBP7  -     4q12   [Description]    (hg38-Dec_2013)
EnsemblIGFBP7 - 4q12 [CytoView hg19]  IGFBP7 - 4q12 [CytoView hg38]
Mapping of homologs : NCBIIGFBP7 [Mapview hg19]  IGFBP7 [Mapview hg38]
OMIM602867   614224   
Gene and transcription
Genbank (Entrez)AF540057 AI761388 AK303915 AK316082 BC017201
RefSeq transcript (Entrez)NM_001253835 NM_001553
RefSeq genomic (Entrez)NC_000004 NC_018915 NG_031877 NT_022853 NW_004929319
Consensus coding sequences : CCDS (NCBI)IGFBP7
Cluster EST : UnigeneHs.691061 [ NCBI ]
CGAP (NCI)Hs.691061
Alternative Splicing GalleryENSG00000163453
Gene ExpressionIGFBP7 [ NCBI-GEO ]   IGFBP7 [ EBI - ARRAY_EXPRESS ]   IGFBP7 [ SEEK ]   IGFBP7 [ MEM ]
Gene Expression Viewer (FireBrowse)IGFBP7 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3490
GTEX Portal (Tissue expression)IGFBP7
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ16270   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ16270  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ16270
Splice isoforms : SwissVarQ16270
PhosPhoSitePlusQ16270
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)    IGFBP_N_2 (PS51323)    KAZAL_2 (PS51465)   
Domains : Interpro (EBI)Growth_fac_rcpt_    Ig-like_dom    Ig-like_fold    Ig_I-set    Ig_sub    IGFBP-like    IGFBP_rP_mac25    Kazal_dom   
Domain families : Pfam (Sanger)I-set (PF07679)    IGFBP (PF00219)    Kazal_2 (PF07648)   
Domain families : Pfam (NCBI)pfam07679    pfam00219    pfam07648   
Domain families : Smart (EMBL)IB (SM00121)  IG (SM00409)  KAZAL (SM00280)  
Conserved Domain (NCBI)IGFBP7
DMDM Disease mutations3490
Blocks (Seattle)IGFBP7
SuperfamilyQ16270
Human Protein AtlasENSG00000163453
Peptide AtlasQ16270
HPRD04183
IPIIPI00016915   IPI01011823   
Protein Interaction databases
DIP (DOE-UCLA)Q16270
IntAct (EBI)Q16270
FunCoupENSG00000163453
BioGRIDIGFBP7
STRING (EMBL)IGFBP7
ZODIACIGFBP7
Ontologies - Pathways
QuickGOQ16270
Ontology : AmiGOregulation of cell growth  protein binding  insulin-like growth factor binding  extracellular region  extracellular space  cell adhesion  negative regulation of cell proliferation  extracellular matrix  extracellular exosome  
Ontology : EGO-EBIregulation of cell growth  protein binding  insulin-like growth factor binding  extracellular region  extracellular space  cell adhesion  negative regulation of cell proliferation  extracellular matrix  extracellular exosome  
NDEx NetworkIGFBP7
Atlas of Cancer Signalling NetworkIGFBP7
Wikipedia pathwaysIGFBP7
Orthology - Evolution
OrthoDB3490
GeneTree (enSembl)ENSG00000163453
Phylogenetic Trees/Animal Genes : TreeFamIGFBP7
HOVERGENQ16270
HOGENOMQ16270
Homologs : HomoloGeneIGFBP7
Homology/Alignments : Family Browser (UCSC)IGFBP7
Gene fusions - Rearrangements
Fusion : MitelmanMAF/IGFBP7 [16q23.2/4q12]  [t(4;16)(q12;q23)]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIGFBP7 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IGFBP7
dbVarIGFBP7
ClinVarIGFBP7
1000_GenomesIGFBP7 
Exome Variant ServerIGFBP7
ExAC (Exome Aggregation Consortium)IGFBP7 (select the gene name)
Genetic variants : HAPMAP3490
Genomic Variants (DGV)IGFBP7 [DGVbeta]
DECIPHER (Syndromes)4:57898404-57976551  ENSG00000163453
CONAN: Copy Number AnalysisIGFBP7 
Mutations
ICGC Data PortalIGFBP7 
TCGA Data PortalIGFBP7 
Broad Tumor PortalIGFBP7
OASIS PortalIGFBP7 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIGFBP7  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDIGFBP7
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch IGFBP7
DgiDB (Drug Gene Interaction Database)IGFBP7
DoCM (Curated mutations)IGFBP7 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)IGFBP7 (select a term)
intoGenIGFBP7
Cancer3DIGFBP7(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602867    614224   
Orphanet20587   
MedgenIGFBP7
Genetic Testing Registry IGFBP7
NextProtQ16270 [Medical]
TSGene3490
GENETestsIGFBP7
Huge Navigator IGFBP7 [HugePedia]
snp3D : Map Gene to Disease3490
BioCentury BCIQIGFBP7
ClinGenIGFBP7
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3490
Chemical/Pharm GKB GenePA29709
Clinical trialIGFBP7
Miscellaneous
canSAR (ICR)IGFBP7 (select the gene name)
Probes
Litterature
PubMed102 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineIGFBP7
EVEXIGFBP7
GoPubMedIGFBP7
iHOPIGFBP7
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:04:52 CEST 2017

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