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IGHA1 (immunoglobulin heavy constant alpha 1)

Identity

Alias (NCBI)IgA1
HGNC (Hugo) IGHA1
LocusID (NCBI) 3493
Atlas_Id 53263
Location 14q32.33  [Link to chromosome band 14q32]
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
IGHA1 (14q32.33) / MTATP8P1 ()IGHA1 (14q32.33) / NFKB2 (10q24.32)IGHV3OR16-13 () / IGHA1 (14q32.33)
IGHV3OR16-9 () / IGHA1 (14q32.33)IGLC3 () / IGHA1 (14q32.33)NFKB2 (10q24.32) / IGHA1 (14q32.33)
RNA28S5 () / IGHA1 (14q32.33)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute



External links

 

Nomenclature
HGNC (Hugo)IGHA1   5478
Cards
Entrez_Gene (NCBI)IGHA1    immunoglobulin heavy constant alpha 1
AliasesIgA1
GeneCards (Weizmann)IGHA1
Ensembl hg19 (Hinxton)ENSG00000211895 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000211895 [Gene_View]  ENSG00000211895 [Sequence]  - [Contig_View]  IGHA1 [Vega]
ICGC DataPortalENSG00000211895
TCGA cBioPortalIGHA1
AceView (NCBI)IGHA1
Genatlas (Paris)IGHA1
SOURCE (Princeton)IGHA1
Genetics Home Reference (NIH)IGHA1
Genomic and cartography
GoldenPath hg38 (UCSC)IGHA1  -  
GoldenPath hg19 (UCSC)IGHA1  -  
GoldenPathIGHA1 - [CytoView hg19]  IGHA1 - [CytoView hg38]
ImmunoBaseENSG00000211895
Genome Data Viewer NCBIIGHA1 [Mapview hg19]  
OMIM146900   
Gene and transcription
Genbank (Entrez)AF067420 AF283666 AJ294729 AK027379 AK058027
RefSeq transcript (Entrez)
Consensus coding sequences : CCDS (NCBI)IGHA1
Gene ExpressionIGHA1 [ NCBI-GEO ]   IGHA1 [ EBI - ARRAY_EXPRESS ]   IGHA1 [ SEEK ]   IGHA1 [ MEM ]
Gene Expression Viewer (FireBrowse)IGHA1 [ Firebrowse - Broad ]
GenevisibleExpression of IGHA1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3493
GTEX Portal (Tissue expression)IGHA1
Human Protein AtlasENSG00000211895-IGHA1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP01876   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP01876  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP01876
PhosPhoSitePlusP01876
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)    IG_MHC (PS00290)   
Domains : Interpro (EBI)Ig-like_dom    Ig-like_dom_sf    Ig-like_fold    Ig/MHC_CS    Ig_C1-set   
Domain families : Pfam (Sanger)C1-set (PF07654)   
Domain families : Pfam (NCBI)pfam07654   
Domain families : Smart (EMBL)IGc1 (SM00407)  
Conserved Domain (NCBI)IGHA1
PDB (RSDB)1IGA    1OW0    2ESG    2QEJ    3CHN    6LX3    6LXW    6UE7   
PDB Europe1IGA    1OW0    2ESG    2QEJ    3CHN    6LX3    6LXW    6UE7   
PDB (PDBSum)1IGA    1OW0    2ESG    2QEJ    3CHN    6LX3    6LXW    6UE7   
PDB (IMB)1IGA    1OW0    2ESG    2QEJ    3CHN    6LX3    6LXW    6UE7   
Structural Biology KnowledgeBase1IGA    1OW0    2ESG    2QEJ    3CHN    6LX3    6LXW    6UE7   
SCOP (Structural Classification of Proteins)1IGA    1OW0    2ESG    2QEJ    3CHN    6LX3    6LXW    6UE7   
CATH (Classification of proteins structures)1IGA    1OW0    2ESG    2QEJ    3CHN    6LX3    6LXW    6UE7   
SuperfamilyP01876
AlphaFold pdb e-kbP01876   
Human Protein Atlas [tissue]ENSG00000211895-IGHA1 [tissue]
Protein Interaction databases
DIP (DOE-UCLA)P01876
IntAct (EBI)P01876
BioGRIDIGHA1
STRING (EMBL)IGHA1
ZODIACIGHA1
Ontologies - Pathways
QuickGOP01876
Ontology : AmiGOretina homeostasis  glomerular filtration  antigen binding  antigen binding  extracellular region  extracellular space  extracellular space  receptor-mediated endocytosis  phagocytosis, recognition  phagocytosis, engulfment  immune response  complement activation, classical pathway  external side of plasma membrane  protein-chromophore linkage  antibacterial humoral response  immunoglobulin receptor binding  immunoglobulin complex, circulating  defense response to bacterium  innate immune response  B cell receptor signaling pathway  positive regulation of B cell activation  leukocyte migration  positive regulation of respiratory burst  extracellular exosome  monomeric IgA immunoglobulin complex  secretory IgA immunoglobulin complex  secretory dimeric IgA immunoglobulin complex  blood microparticle  
Ontology : EGO-EBIretina homeostasis  glomerular filtration  antigen binding  antigen binding  extracellular region  extracellular space  extracellular space  receptor-mediated endocytosis  phagocytosis, recognition  phagocytosis, engulfment  immune response  complement activation, classical pathway  external side of plasma membrane  protein-chromophore linkage  antibacterial humoral response  immunoglobulin receptor binding  immunoglobulin complex, circulating  defense response to bacterium  innate immune response  B cell receptor signaling pathway  positive regulation of B cell activation  leukocyte migration  positive regulation of respiratory burst  extracellular exosome  monomeric IgA immunoglobulin complex  secretory IgA immunoglobulin complex  secretory dimeric IgA immunoglobulin complex  blood microparticle  
NDEx NetworkIGHA1
Atlas of Cancer Signalling NetworkIGHA1
Wikipedia pathwaysIGHA1
Orthology - Evolution
OrthoDB3493
GeneTree (enSembl)ENSG00000211895
Phylogenetic Trees/Animal Genes : TreeFamIGHA1
Homologs : HomoloGeneIGHA1
Homology/Alignments : Family Browser (UCSC)IGHA1
Gene fusions - Rearrangements
Fusion : QuiverIGHA1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIGHA1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IGHA1
dbVarIGHA1
ClinVarIGHA1
MonarchIGHA1
1000_GenomesIGHA1 
Exome Variant ServerIGHA1
GNOMAD BrowserENSG00000211895
Varsome BrowserIGHA1
ACMGIGHA1 variants
VarityP01876
Genomic Variants (DGV)IGHA1 [DGVbeta]
DECIPHERIGHA1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisIGHA1 
Mutations
ICGC Data PortalIGHA1 
TCGA Data PortalIGHA1 
Broad Tumor PortalIGHA1
OASIS PortalIGHA1 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDIGHA1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaIGHA1
DgiDB (Drug Gene Interaction Database)IGHA1
DoCM (Curated mutations)IGHA1
CIViC (Clinical Interpretations of Variants in Cancer)IGHA1
Cancer3DIGHA1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM146900   
Orphanet
DisGeNETIGHA1
MedgenIGHA1
Genetic Testing Registry IGHA1
NextProtP01876 [Medical]
GENETestsIGHA1
Target ValidationIGHA1
Huge Navigator IGHA1 [HugePedia]
ClinGenIGHA1
Clinical trials, drugs, therapy
MyCancerGenomeIGHA1
Protein Interactions : CTDIGHA1
Pharm GKB GenePA29710
PharosP01876
Clinical trialIGHA1
Miscellaneous
canSAR (ICR)IGHA1
HarmonizomeIGHA1
DataMed IndexIGHA1
Probes
Litterature
PubMed68 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXIGHA1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:13:35 CEST 2021

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