Atlas of Genetics and Cytogenetics in Oncology and Haematology


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IGHA1 (immunoglobulin heavy constant alpha 1)

Identity

Other aliasIgA1
HGNC (Hugo) IGHA1
LocusID (NCBI) 3493
Atlas_Id 53263
Location 14_KI270846v1_alt  [Link to chromosome band 14]
Location_base_pair Starts at 174891 and ends at 1149925 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
IGHA1 (14q32.33) / MTATP8P1 ()IGHA1 (14q32.33) / NFKB2 (10q24.32)IGHV3OR16-13 () / IGHA1 (14q32.33)
IGHV3OR16-9 () / IGHA1 (14q32.33)IGLC3 () / IGHA1 (14q32.33)NFKB2 (10q24.32) / IGHA1 (14q32.33)
RNA28S5 () / IGHA1 (14q32.33)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute


External links

Nomenclature
HGNC (Hugo)IGHA1   5478
Cards
Entrez_Gene (NCBI)IGHA1  3493  immunoglobulin heavy constant alpha 1
AliasesIgA1
GeneCards (Weizmann)IGHA1
Ensembl hg19 (Hinxton) [Gene_View]
Ensembl hg38 (Hinxton) [Gene_View]  chr14_KI270846v1_alt:174891-1149925 [Contig_View]  IGHA1 [Vega]
TCGA cBioPortalIGHA1
AceView (NCBI)IGHA1
Genatlas (Paris)IGHA1
WikiGenes3493
SOURCE (Princeton)IGHA1
Genetics Home Reference (NIH)IGHA1
Genomic and cartography
GoldenPath hg38 (UCSC)IGHA1  -     chr14_KI270846v1_alt:174891-1149925 -  14_KI270846v1_alt   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)IGHA1  -     14_KI270846v1_alt   [Description]    (hg19-Feb_2009)
EnsemblIGHA1 - 14_KI270846v1_alt [CytoView hg19]  IGHA1 - 14_KI270846v1_alt [CytoView hg38]
Mapping of homologs : NCBIIGHA1 [Mapview hg19]  IGHA1 [Mapview hg38]
OMIM146900   
Gene and transcription
Genbank (Entrez)###############################################################################################################################################################################################################################################################
RefSeq transcript (Entrez)
RefSeq genomic (Entrez)NC_000014 NG_001019 NT_187600
Consensus coding sequences : CCDS (NCBI)IGHA1
Cluster EST : UnigeneHs.699841 [ NCBI ]
CGAP (NCI)Hs.699841
Gene ExpressionIGHA1 [ NCBI-GEO ]   IGHA1 [ EBI - ARRAY_EXPRESS ]   IGHA1 [ SEEK ]   IGHA1 [ MEM ]
Gene Expression Viewer (FireBrowse)IGHA1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3493
GTEX Portal (Tissue expression)IGHA1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP01876   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP01876  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP01876
Splice isoforms : SwissVarP01876
PhosPhoSitePlusP01876
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)    IG_MHC (PS00290)   
Domains : Interpro (EBI)Ig-like_dom    Ig-like_fold    Ig/MHC_CS    Ig_C1-set   
Domain families : Pfam (Sanger)C1-set (PF07654)   
Domain families : Pfam (NCBI)pfam07654   
Domain families : Smart (EMBL)IGc1 (SM00407)  
Conserved Domain (NCBI)IGHA1
DMDM Disease mutations3493
Blocks (Seattle)IGHA1
PDB (SRS)1IGA    1OW0    2QEJ    3CHN   
PDB (PDBSum)1IGA    1OW0    2QEJ    3CHN   
PDB (IMB)1IGA    1OW0    2QEJ    3CHN   
PDB (RSDB)1IGA    1OW0    2QEJ    3CHN   
Structural Biology KnowledgeBase1IGA    1OW0    2QEJ    3CHN   
SCOP (Structural Classification of Proteins)1IGA    1OW0    2QEJ    3CHN   
CATH (Classification of proteins structures)1IGA    1OW0    2QEJ    3CHN   
SuperfamilyP01876
Peptide AtlasP01876
IPIIPI00426060   IPI00423460   IPI00423462   IPI00647704   IPI00446505   IPI00449920   IPI00383164   IPI00386524   IPI00386879   
Protein Interaction databases
DIP (DOE-UCLA)P01876
IntAct (EBI)P01876
BioGRIDIGHA1
STRING (EMBL)IGHA1
ZODIACIGHA1
Ontologies - Pathways
QuickGOP01876
Ontology : AmiGOretina homeostasis  glomerular filtration  antigen binding  antigen binding  extracellular region  extracellular space  receptor-mediated endocytosis  phagocytosis, recognition  phagocytosis, engulfment  immune response  complement activation, classical pathway  external side of plasma membrane  protein-chromophore linkage  antibacterial humoral response  immunoglobulin receptor binding  innate immune response  B cell receptor signaling pathway  positive regulation of B cell activation  leukocyte migration  positive regulation of respiratory burst  extracellular exosome  monomeric IgA immunoglobulin complex  secretory IgA immunoglobulin complex  secretory dimeric IgA immunoglobulin complex  blood microparticle  
Ontology : EGO-EBIretina homeostasis  glomerular filtration  antigen binding  antigen binding  extracellular region  extracellular space  receptor-mediated endocytosis  phagocytosis, recognition  phagocytosis, engulfment  immune response  complement activation, classical pathway  external side of plasma membrane  protein-chromophore linkage  antibacterial humoral response  immunoglobulin receptor binding  innate immune response  B cell receptor signaling pathway  positive regulation of B cell activation  leukocyte migration  positive regulation of respiratory burst  extracellular exosome  monomeric IgA immunoglobulin complex  secretory IgA immunoglobulin complex  secretory dimeric IgA immunoglobulin complex  blood microparticle  
NDEx NetworkIGHA1
Atlas of Cancer Signalling NetworkIGHA1
Wikipedia pathwaysIGHA1
Orthology - Evolution
OrthoDB3493
Phylogenetic Trees/Animal Genes : TreeFamIGHA1
HOVERGENP01876
HOGENOMP01876
Homologs : HomoloGeneIGHA1
Homology/Alignments : Family Browser (UCSC)IGHA1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIGHA1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IGHA1
dbVarIGHA1
ClinVarIGHA1
1000_GenomesIGHA1 
Exome Variant ServerIGHA1
ExAC (Exome Aggregation Consortium)IGHA1 (select the gene name)
Genetic variants : HAPMAP3493
Genomic Variants (DGV)IGHA1 [DGVbeta]
DECIPHERIGHA1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisIGHA1 
Mutations
ICGC Data PortalIGHA1 
TCGA Data PortalIGHA1 
Broad Tumor PortalIGHA1
OASIS PortalIGHA1 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDIGHA1
BioMutasearch IGHA1
DgiDB (Drug Gene Interaction Database)IGHA1
DoCM (Curated mutations)IGHA1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)IGHA1 (select a term)
intoGenIGHA1
Cancer3DIGHA1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM146900   
Orphanet
MedgenIGHA1
Genetic Testing Registry IGHA1
NextProtP01876 [Medical]
TSGene3493
GENETestsIGHA1
Target ValidationIGHA1
Huge Navigator IGHA1 [HugePedia]
snp3D : Map Gene to Disease3493
BioCentury BCIQIGHA1
ClinGenIGHA1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3493
Chemical/Pharm GKB GenePA29710
Clinical trialIGHA1
Miscellaneous
canSAR (ICR)IGHA1 (select the gene name)
Probes
Litterature
PubMed49 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineIGHA1
EVEXIGHA1
GoPubMedIGHA1
iHOPIGHA1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 25 19:12:57 CEST 2017

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