IGHD (immunoglobulin heavy constant delta)

2007-02-01  

Identity

HGNC
IGHD
LOCATION
14q32.33
LOCUSID
3495
ALIAS
-

Other Information

Locus ID:

NCBI: 3495
MIM: 147170
HGNC: 5480
Ensembl: ENSG00000211898
IMGT/GENE-DB:

Variants:

dbSNP: 3495
ClinVar: 3495
TCGA: ENSG00000211898
COSMIC: IGHD

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000211898ENST00000390556A0A0A0MS09
ENSG00000211898ENST00000613640P01880

Expression (GTEx)

0
50
100
150
200
250
300
350
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

References

Pubmed IDYearTitleCitations
84182081993Immunoglobulin D (IgD)-deficient mice reveal an auxiliary receptor function for IgD in antigen-mediated recruitment of B cells.50
120239682002The role of constant region carbohydrate in the assembly and secretion of human IgD and IgA1.15
18380071991Cell autonomous expression of IgD is not essential for the maturation of conventional B cells.7
164022152006Reconsidering the human immunoglobulin heavy-chain locus: 1. An evaluation of the expressed human IGHD gene repertoire.7
302910282018Secreted IgD Amplifies Humoral T Helper 2 Cell Responses by Binding Basophils via Galectin-9 and CD44.6
119021412002Role of surface IgM and IgD on survival of the cells from B-cell chronic lymphocytic leukemia.5
171694232007Use of IGHJ and IGHD gene mutations in analysis of immunoglobulin sequences for the prognosis of chronic lymphocytic leukemia.5
174758602007Characterization of the IgD binding site of encapsulated Haemophilus influenzae serotype b.3
289583732017Expression of immunoglobulin D is increased in chronic rhinosinusitis.1

Citation

Dessen P

IGHD (immunoglobulin heavy constant delta)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45806/ighd