IGHG1 (immunoglobulin heavy constant gamma 1 (G1m marker))

2011-11-01  

Identity

HGNC
LOCATION
14q32.33
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 3500
MIM: 147100
HGNC: 5525
Ensembl: ENSG00000211896
IMGT/GENE-DB:

Variants:

dbSNP: 3500
ClinVar: 3500
TCGA: ENSG00000211896
COSMIC: IGHG1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000211896ENST00000390542A0A0A0MS07
ENSG00000211896ENST00000390548A0A0A0MS08
ENSG00000211896ENST00000390549P01857

Expression (GTEx)

0
500
1000
1500
2000
2500
3000
3500

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Complement cascadeREACTOMER-HSA-166658
Initial triggering of complementREACTOMER-HSA-166663
Creation of C4 and C2 activatorsREACTOMER-HSA-166786
Classical antibody-mediated complement activationREACTOMER-HSA-173623
Fcgamma receptor (FCGR) dependent phagocytosisREACTOMER-HSA-2029480
FCGR activationREACTOMER-HSA-2029481
Regulation of actin dynamics for phagocytic cup formationREACTOMER-HSA-2029482
Role of phospholipids in phagocytosisREACTOMER-HSA-2029485
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Interleukin-4 and 13 signalingREACTOMER-HSA-6785807

References

Pubmed IDYearTitleCitations
2594039420153D Structural Fluctuation of IgG1 Antibody Revealed by Individual Particle Electron Tomography.35
193190242009IgG1 heavy chain-coding gene polymorphism (G1m allotypes) and development of antibodies-to-infliximab.21
193190242009IgG1 heavy chain-coding gene polymorphism (G1m allotypes) and development of antibodies-to-infliximab.21
188216752008Immunoglobulin gene polymorphisms are susceptibility factors in clinical and autoantibody subgroups of the idiopathic inflammatory myopathies.13
216545442011The presence of IGHG1 in human pancreatic carcinomas is associated with immune evasion mechanisms.13
231172832013Suppression of IGHG1 gene expression by siRNA leads to growth inhibition and apoptosis induction in human prostate cancer cell.12
170448682006Immunoglobulin enhancer HS1,2 polymorphism: a new powerful anthropogenetic marker.7
120395242002TNF-alpha, IL1-beta, and immunoglobulin (GM and KM) gene polymorphisms in sarcoidosis.6
120395242002TNF-alpha, IL1-beta, and immunoglobulin (GM and KM) gene polymorphisms in sarcoidosis.6
253588682014Sleep quality, BDNF genotype and gene expression in individuals with chronic abdominal pain.6

Citation

Dessen P

IGHG1 (immunoglobulin heavy constant gamma 1 (G1m marker))

Atlas Genet Cytogenet Oncol Haematol. 2011-11-01

Online version: http://atlasgeneticsoncology.org/gene/52481/ighg1