IGHM (immunoglobulin heavy constant mu)

2007-02-01 Affiliation

Identity

HGNC

IGHM

LOCATION

14q32.33

LOCUSID

3507

ALIAS

AGM1,MU,VH

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 3507
MIM: 147020
HGNC: 5541
Ensembl: ENSG00000211899
IMGT/GENE-DB:

Variants:

dbSNP: 3507
ClinVar: 3507
TCGA: ENSG00000211899
COSMIC: IGHM

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000211899	ENST00000390559	P01871
ENSG00000211899	ENST00000637539	P01871

Expression (GTEx)

500

1000

1500

2000

2500

3000

3500

4000

4500

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

References

Pubmed ID	Year	Title	Citations
18174230	2008	Association of polymorphisms in complement component C3 gene with susceptibility to systemic lupus erythematosus.	18
22305633	2013	IgM-phosphorylcholine autoantibodies and outcome in acute coronary syndromes.	16
24141767	2014	Rearrangement and expression of the immunoglobulin μ-chain gene in human myeloid cells.	14
15591116	2005	Lower levels of surface B-cell-receptor expression in chronic lymphocytic leukemia are associated with glycosylation and folding defects of the mu and CD79a chains.	13
18515657	2008	S(mu) mutation patterns suggest different progression pathways in follicular lymphoma: early direct or late from FL progenitor cells.	12
11839670	2002	Intraclonal homogeneity of clonotypic immunoglobulin M and diversity of nonclinical post-switch isotypes in multiple myeloma: insights into the evolution of the myeloma clone.	5
27611867	2016	The Expression Pattern of the Pre-B Cell Receptor Components Correlates with Cellular Stage and Clinical Outcome in Acute Lymphoblastic Leukemia.	5
26910880	2016	Cohort of Iranian Patients with Congenital Agammaglobulinemia: Mutation Analysis and Novel Gene Defects.	2
28769069	2017	Autosomal recessive agammaglobulinemia due to defect in μ heavy chain caused by a novel mutation in the IGHM gene.	1
28534223	2017	Immunoglobulin M gene association with autoantibody reactivity and type 1 diabetes.	0

Citation

Dessen P

IGHM (immunoglobulin heavy constant mu)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45610/ighm