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IGKC (immunoglobulin kappa constant)

Identity

Alias (NCBI)HCAK1
IGKCD
Km
HGNC (Hugo) IGKC
HGNC Alias symbHCAK1
LocusID (NCBI) 3514
Atlas_Id 52874
Location 2p11.2  [Link to chromosome band 2p11]
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
HLA-B (6p21.33) / IGKC (2p11.2)IGHV3-30 (14q32.33) / IGKC (2p11.2)IGKC (2p11.2) / IGHA2 (14q32.33)
IGKC (2p11.2) / IGHG1 (14q32.33)IGKC (2p11.2) / IGHG2 (14q32.33)IGKC (2p11.2) / IGHG3 (14q32.33)
IGKC (2p11.2) / IGHG4 (14q32.33)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute



External links

 

Nomenclature
HGNC (Hugo)IGKC   5716
Cards
Entrez_Gene (NCBI)IGKC    immunoglobulin kappa constant
AliasesHCAK1; IGKCD; Km
GeneCards (Weizmann)IGKC
Ensembl hg19 (Hinxton)ENSG00000211592 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000211592 [Gene_View]  ENSG00000211592 [Sequence]  - [Contig_View]  IGKC [Vega]
ICGC DataPortalENSG00000211592
TCGA cBioPortalIGKC
AceView (NCBI)IGKC
Genatlas (Paris)IGKC
SOURCE (Princeton)IGKC
Genetics Home Reference (NIH)IGKC
Genomic and cartography
GoldenPath hg38 (UCSC)IGKC  -  
GoldenPath hg19 (UCSC)IGKC  -  
GoldenPathIGKC - [CytoView hg19]  IGKC - [CytoView hg38]
ImmunoBaseENSG00000211592
Genome Data Viewer NCBIIGKC [Mapview hg19]  
OMIM147200   614102   
Gene and transcription
Genbank (Entrez)AB245096 AF113887 AY894991 BC029444 BC034141
RefSeq transcript (Entrez)
Consensus coding sequences : CCDS (NCBI)IGKC
Gene ExpressionIGKC [ NCBI-GEO ]   IGKC [ EBI - ARRAY_EXPRESS ]   IGKC [ SEEK ]   IGKC [ MEM ]
Gene Expression Viewer (FireBrowse)IGKC [ Firebrowse - Broad ]
GenevisibleExpression of IGKC in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3514
GTEX Portal (Tissue expression)IGKC
Human Protein AtlasENSG00000211592-IGKC [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP01834   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP01834  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP01834
PhosPhoSitePlusP01834
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)    IG_MHC (PS00290)   
Domains : Interpro (EBI)Ig-like_dom    Ig-like_dom_sf    Ig-like_fold    Ig/MHC_CS    Ig_C1-set   
Domain families : Pfam (Sanger)C1-set (PF07654)   
Domain families : Pfam (NCBI)pfam07654   
Domain families : Smart (EMBL)IGc1 (SM00407)  
Conserved Domain (NCBI)IGKC
PDB (RSDB)1A4J    1A4K    1CLY    1D5B    1D5I    1D6V    1DFB    1GAF    1HEZ    1HKL    1HZH    1I7Z    1MIM    1N0X    1UCB    2NY7    2O5X    2O5Y    2O5Z    2QQK    2QQL    2QQN    2QSC    2R56    2RFX    2VXQ    3B2U    3B2V    3BDY    3BE1    3BKY    3BN9    3BQU    3C08    3C09    3CFJ    3CFK    3CSY    3D0L    3D85    3DVG    3DVN    3EYF    3EYO    3EYQ    3IU3    3O11    3QCT    3QCU    3QCV    3RU8    3U0W    3U7W    3U7Y    3VH8    3WUW    3X11    3X12    4D3C    4D9R    4HIX    4NM4    4NM8    4XMP    4XNY    4XNZ    4XXD    4YDV    5B38    5B39    5ESV    5ESZ    5VEB    5VIY    6AU5    6AXP    6AYN    6AZK    6AZL    6B9Y    6B9Z    6BAE    6BAH    6DCV    6DCW    6N2X    6N32    6N35    6OGE    6OKP   
PDB Europe1A4J    1A4K    1CLY    1D5B    1D5I    1D6V    1DFB    1GAF    1HEZ    1HKL    1HZH    1I7Z    1MIM    1N0X    1UCB    2NY7    2O5X    2O5Y    2O5Z    2QQK    2QQL    2QQN    2QSC    2R56    2RFX    2VXQ    3B2U    3B2V    3BDY    3BE1    3BKY    3BN9    3BQU    3C08    3C09    3CFJ    3CFK    3CSY    3D0L    3D85    3DVG    3DVN    3EYF    3EYO    3EYQ    3IU3    3O11    3QCT    3QCU    3QCV    3RU8    3U0W    3U7W    3U7Y    3VH8    3WUW    3X11    3X12    4D3C    4D9R    4HIX    4NM4    4NM8    4XMP    4XNY    4XNZ    4XXD    4YDV    5B38    5B39    5ESV    5ESZ    5VEB    5VIY    6AU5    6AXP    6AYN    6AZK    6AZL    6B9Y    6B9Z    6BAE    6BAH    6DCV    6DCW    6N2X    6N32    6N35    6OGE    6OKP   
PDB (PDBSum)1A4J    1A4K    1CLY    1D5B    1D5I    1D6V    1DFB    1GAF    1HEZ    1HKL    1HZH    1I7Z    1MIM    1N0X    1UCB    2NY7    2O5X    2O5Y    2O5Z    2QQK    2QQL    2QQN    2QSC    2R56    2RFX    2VXQ    3B2U    3B2V    3BDY    3BE1    3BKY    3BN9    3BQU    3C08    3C09    3CFJ    3CFK    3CSY    3D0L    3D85    3DVG    3DVN    3EYF    3EYO    3EYQ    3IU3    3O11    3QCT    3QCU    3QCV    3RU8    3U0W    3U7W    3U7Y    3VH8    3WUW    3X11    3X12    4D3C    4D9R    4HIX    4NM4    4NM8    4XMP    4XNY    4XNZ    4XXD    4YDV    5B38    5B39    5ESV    5ESZ    5VEB    5VIY    6AU5    6AXP    6AYN    6AZK    6AZL    6B9Y    6B9Z    6BAE    6BAH    6DCV    6DCW    6N2X    6N32    6N35    6OGE    6OKP   
PDB (IMB)1A4J    1A4K    1CLY    1D5B    1D5I    1D6V    1DFB    1GAF    1HEZ    1HKL    1HZH    1I7Z    1MIM    1N0X    1UCB    2NY7    2O5X    2O5Y    2O5Z    2QQK    2QQL    2QQN    2QSC    2R56    2RFX    2VXQ    3B2U    3B2V    3BDY    3BE1    3BKY    3BN9    3BQU    3C08    3C09    3CFJ    3CFK    3CSY    3D0L    3D85    3DVG    3DVN    3EYF    3EYO    3EYQ    3IU3    3O11    3QCT    3QCU    3QCV    3RU8    3U0W    3U7W    3U7Y    3VH8    3WUW    3X11    3X12    4D3C    4D9R    4HIX    4NM4    4NM8    4XMP    4XNY    4XNZ    4XXD    4YDV    5B38    5B39    5ESV    5ESZ    5VEB    5VIY    6AU5    6AXP    6AYN    6AZK    6AZL    6B9Y    6B9Z    6BAE    6BAH    6DCV    6DCW    6N2X    6N32    6N35    6OGE    6OKP   
Structural Biology KnowledgeBase1A4J    1A4K    1CLY    1D5B    1D5I    1D6V    1DFB    1GAF    1HEZ    1HKL    1HZH    1I7Z    1MIM    1N0X    1UCB    2NY7    2O5X    2O5Y    2O5Z    2QQK    2QQL    2QQN    2QSC    2R56    2RFX    2VXQ    3B2U    3B2V    3BDY    3BE1    3BKY    3BN9    3BQU    3C08    3C09    3CFJ    3CFK    3CSY    3D0L    3D85    3DVG    3DVN    3EYF    3EYO    3EYQ    3IU3    3O11    3QCT    3QCU    3QCV    3RU8    3U0W    3U7W    3U7Y    3VH8    3WUW    3X11    3X12    4D3C    4D9R    4HIX    4NM4    4NM8    4XMP    4XNY    4XNZ    4XXD    4YDV    5B38    5B39    5ESV    5ESZ    5VEB    5VIY    6AU5    6AXP    6AYN    6AZK    6AZL    6B9Y    6B9Z    6BAE    6BAH    6DCV    6DCW    6N2X    6N32    6N35    6OGE    6OKP   
SCOP (Structural Classification of Proteins)1A4J    1A4K    1CLY    1D5B    1D5I    1D6V    1DFB    1GAF    1HEZ    1HKL    1HZH    1I7Z    1MIM    1N0X    1UCB    2NY7    2O5X    2O5Y    2O5Z    2QQK    2QQL    2QQN    2QSC    2R56    2RFX    2VXQ    3B2U    3B2V    3BDY    3BE1    3BKY    3BN9    3BQU    3C08    3C09    3CFJ    3CFK    3CSY    3D0L    3D85    3DVG    3DVN    3EYF    3EYO    3EYQ    3IU3    3O11    3QCT    3QCU    3QCV    3RU8    3U0W    3U7W    3U7Y    3VH8    3WUW    3X11    3X12    4D3C    4D9R    4HIX    4NM4    4NM8    4XMP    4XNY    4XNZ    4XXD    4YDV    5B38    5B39    5ESV    5ESZ    5VEB    5VIY    6AU5    6AXP    6AYN    6AZK    6AZL    6B9Y    6B9Z    6BAE    6BAH    6DCV    6DCW    6N2X    6N32    6N35    6OGE    6OKP   
CATH (Classification of proteins structures)1A4J    1A4K    1CLY    1D5B    1D5I    1D6V    1DFB    1GAF    1HEZ    1HKL    1HZH    1I7Z    1MIM    1N0X    1UCB    2NY7    2O5X    2O5Y    2O5Z    2QQK    2QQL    2QQN    2QSC    2R56    2RFX    2VXQ    3B2U    3B2V    3BDY    3BE1    3BKY    3BN9    3BQU    3C08    3C09    3CFJ    3CFK    3CSY    3D0L    3D85    3DVG    3DVN    3EYF    3EYO    3EYQ    3IU3    3O11    3QCT    3QCU    3QCV    3RU8    3U0W    3U7W    3U7Y    3VH8    3WUW    3X11    3X12    4D3C    4D9R    4HIX    4NM4    4NM8    4XMP    4XNY    4XNZ    4XXD    4YDV    5B38    5B39    5ESV    5ESZ    5VEB    5VIY    6AU5    6AXP    6AYN    6AZK    6AZL    6B9Y    6B9Z    6BAE    6BAH    6DCV    6DCW    6N2X    6N32    6N35    6OGE    6OKP   
SuperfamilyP01834
AlphaFold pdb e-kbP01834   
Human Protein Atlas [tissue]ENSG00000211592-IGKC [tissue]
Protein Interaction databases
DIP (DOE-UCLA)P01834
IntAct (EBI)P01834
BioGRIDIGKC
STRING (EMBL)IGKC
ZODIACIGKC
Ontologies - Pathways
QuickGOP01834
Ontology : AmiGOretina homeostasis  immunoglobulin production  negative regulation of inflammatory response to antigenic stimulus  antigen binding  antigen binding  extracellular region  extracellular region  extracellular space  extracellular space  plasma membrane  receptor-mediated endocytosis  phagocytosis, recognition  phagocytosis, engulfment  immune response  immune response  complement activation  complement activation, classical pathway  complement activation, classical pathway  opsonization  external side of plasma membrane  peptide cross-linking  immunoglobulin complex  regulation of complement activation  immunoglobulin receptor binding  Fc-epsilon receptor signaling pathway  Fc-gamma receptor signaling pathway involved in phagocytosis  immunoglobulin complex, circulating  defense response to bacterium  innate immune response  regulation of immune response  B cell receptor signaling pathway  positive regulation of B cell activation  leukocyte migration  extracellular exosome  blood microparticle  
Ontology : EGO-EBIretina homeostasis  immunoglobulin production  negative regulation of inflammatory response to antigenic stimulus  antigen binding  antigen binding  extracellular region  extracellular region  extracellular space  extracellular space  plasma membrane  receptor-mediated endocytosis  phagocytosis, recognition  phagocytosis, engulfment  immune response  immune response  complement activation  complement activation, classical pathway  complement activation, classical pathway  opsonization  external side of plasma membrane  peptide cross-linking  immunoglobulin complex  regulation of complement activation  immunoglobulin receptor binding  Fc-epsilon receptor signaling pathway  Fc-gamma receptor signaling pathway involved in phagocytosis  immunoglobulin complex, circulating  defense response to bacterium  innate immune response  regulation of immune response  B cell receptor signaling pathway  positive regulation of B cell activation  leukocyte migration  extracellular exosome  blood microparticle  
NDEx NetworkIGKC
Atlas of Cancer Signalling NetworkIGKC
Wikipedia pathwaysIGKC
Orthology - Evolution
OrthoDB3514
GeneTree (enSembl)ENSG00000211592
Phylogenetic Trees/Animal Genes : TreeFamIGKC
Homologs : HomoloGeneIGKC
Homology/Alignments : Family Browser (UCSC)IGKC
Gene fusions - Rearrangements
Fusion : QuiverIGKC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIGKC [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IGKC
dbVarIGKC
ClinVarIGKC
MonarchIGKC
1000_GenomesIGKC 
Exome Variant ServerIGKC
GNOMAD BrowserENSG00000211592
Varsome BrowserIGKC
ACMGIGKC variants
VarityP01834
Genomic Variants (DGV)IGKC [DGVbeta]
DECIPHERIGKC [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisIGKC 
Mutations
ICGC Data PortalIGKC 
TCGA Data PortalIGKC 
Broad Tumor PortalIGKC
OASIS PortalIGKC [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDIGKC
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaIGKC
DgiDB (Drug Gene Interaction Database)IGKC
DoCM (Curated mutations)IGKC
CIViC (Clinical Interpretations of Variants in Cancer)IGKC
Cancer3DIGKC
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM147200    614102   
Orphanet18308   
DisGeNETIGKC
MedgenIGKC
Genetic Testing Registry IGKC
NextProtP01834 [Medical]
GENETestsIGKC
Target ValidationIGKC
Huge Navigator IGKC [HugePedia]
ClinGenIGKC
Clinical trials, drugs, therapy
MyCancerGenomeIGKC
Protein Interactions : CTDIGKC
Pharm GKB GenePA29735
PharosP01834
Clinical trialIGKC
Miscellaneous
canSAR (ICR)IGKC
HarmonizomeIGKC
DataMed IndexIGKC
Probes
Litterature
PubMed80 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXIGKC
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:13:37 CEST 2021

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