Atlas of Genetics and Cytogenetics in Oncology and Haematology


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IGKC (immunoglobulin kappa constant)

Identity

Alias_symbol (synonym)HCAK1
Other aliasIGKCD
Km
HGNC (Hugo) IGKC
LocusID (NCBI) 3514
Atlas_Id 52874
Location 2p11.2  [Link to chromosome band 2p11]
Location_base_pair Starts at 88857364 and ends at 89245076 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
HLA-B (6p21.33) / IGKC (2p11.2)IGHV3-30 (14q32.33) / IGKC (2p11.2)IGKC (2p11.2) / IGHA2 (14q32.33)
IGKC (2p11.2) / IGHG1 (14q32.33)IGKC (2p11.2) / IGHG2 (14q32.33)IGKC (2p11.2) / IGHG3 (14q32.33)
IGKC (2p11.2) / IGHG4 (14q32.33)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute


External links

Nomenclature
HGNC (Hugo)IGKC   5716
Cards
Entrez_Gene (NCBI)IGKC  3514  immunoglobulin kappa constant
AliasesHCAK1; IGKCD; Km
GeneCards (Weizmann)IGKC
Ensembl hg19 (Hinxton) [Gene_View]
Ensembl hg38 (Hinxton) [Gene_View]  chr2:88857364-89245076 [Contig_View]  IGKC [Vega]
TCGA cBioPortalIGKC
AceView (NCBI)IGKC
Genatlas (Paris)IGKC
WikiGenes3514
SOURCE (Princeton)IGKC
Genetics Home Reference (NIH)IGKC
Genomic and cartography
GoldenPath hg38 (UCSC)IGKC  -     chr2:88857364-89245076 -  2p11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)IGKC  -     2p11.2   [Description]    (hg19-Feb_2009)
EnsemblIGKC - 2p11.2 [CytoView hg19]  IGKC - 2p11.2 [CytoView hg38]
Mapping of homologs : NCBIIGKC [Mapview hg19]  IGKC [Mapview hg38]
OMIM147200   614102   
Gene and transcription
Genbank (Entrez)AB245096 AF113887 AY894991 BC029444 BC034141
RefSeq transcript (Entrez)
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)IGKC
Cluster EST : UnigeneHs.449609 [ NCBI ]
CGAP (NCI)Hs.449609
Gene ExpressionIGKC [ NCBI-GEO ]   IGKC [ EBI - ARRAY_EXPRESS ]   IGKC [ SEEK ]   IGKC [ MEM ]
Gene Expression Viewer (FireBrowse)IGKC [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3514
GTEX Portal (Tissue expression)IGKC
Protein : pattern, domain, 3D structure
UniProt/SwissProtP01834   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP01834  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP01834
Splice isoforms : SwissVarP01834
PhosPhoSitePlusP01834
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)    IG_MHC (PS00290)   
Domains : Interpro (EBI)Ig-like_dom    Ig-like_fold    Ig/MHC_CS    Ig_C1-set   
Domain families : Pfam (Sanger)C1-set (PF07654)   
Domain families : Pfam (NCBI)pfam07654   
Domain families : Smart (EMBL)IGc1 (SM00407)  
Conserved Domain (NCBI)IGKC
DMDM Disease mutations3514
Blocks (Seattle)IGKC
PDB (SRS)###############################################################################################################################################################################################################################################################   
PDB (PDBSum)###############################################################################################################################################################################################################################################################   
PDB (IMB)###############################################################################################################################################################################################################################################################   
PDB (RSDB)###############################################################################################################################################################################################################################################################   
Structural Biology KnowledgeBase###############################################################################################################################################################################################################################################################   
SCOP (Structural Classification of Proteins)###############################################################################################################################################################################################################################################################   
CATH (Classification of proteins structures)###############################################################################################################################################################################################################################################################   
SuperfamilyP01834
Peptide AtlasP01834
IPIIPI00829699   IPI00024134   IPI00922330   IPI00853045   IPI00969456   IPI00979250   
Protein Interaction databases
DIP (DOE-UCLA)P01834
IntAct (EBI)P01834
BioGRIDIGKC
STRING (EMBL)IGKC
ZODIACIGKC
Ontologies - Pathways
QuickGOP01834
Ontology : AmiGOretina homeostasis  immunoglobulin production  antigen binding  antigen binding  serine-type endopeptidase activity  extracellular region  extracellular region  extracellular space  extracellular space  plasma membrane  proteolysis  receptor-mediated endocytosis  phagocytosis, recognition  phagocytosis, engulfment  immune response  immune response  complement activation  complement activation, classical pathway  complement activation, classical pathway  external side of plasma membrane  immunoglobulin receptor binding  Fc-epsilon receptor signaling pathway  Fc-gamma receptor signaling pathway involved in phagocytosis  immunoglobulin complex, circulating  defense response to bacterium  innate immune response  regulation of immune response  B cell receptor signaling pathway  positive regulation of B cell activation  leukocyte migration  extracellular exosome  blood microparticle  
Ontology : EGO-EBIretina homeostasis  immunoglobulin production  antigen binding  antigen binding  serine-type endopeptidase activity  extracellular region  extracellular region  extracellular space  extracellular space  plasma membrane  proteolysis  receptor-mediated endocytosis  phagocytosis, recognition  phagocytosis, engulfment  immune response  immune response  complement activation  complement activation, classical pathway  complement activation, classical pathway  external side of plasma membrane  immunoglobulin receptor binding  Fc-epsilon receptor signaling pathway  Fc-gamma receptor signaling pathway involved in phagocytosis  immunoglobulin complex, circulating  defense response to bacterium  innate immune response  regulation of immune response  B cell receptor signaling pathway  positive regulation of B cell activation  leukocyte migration  extracellular exosome  blood microparticle  
NDEx NetworkIGKC
Atlas of Cancer Signalling NetworkIGKC
Wikipedia pathwaysIGKC
Orthology - Evolution
OrthoDB3514
Phylogenetic Trees/Animal Genes : TreeFamIGKC
HOVERGENP01834
HOGENOMP01834
Homologs : HomoloGeneIGKC
Homology/Alignments : Family Browser (UCSC)IGKC
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIGKC [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IGKC
dbVarIGKC
ClinVarIGKC
1000_GenomesIGKC 
Exome Variant ServerIGKC
ExAC (Exome Aggregation Consortium)IGKC (select the gene name)
Genetic variants : HAPMAP3514
Genomic Variants (DGV)IGKC [DGVbeta]
DECIPHERIGKC [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisIGKC 
Mutations
ICGC Data PortalIGKC 
TCGA Data PortalIGKC 
Broad Tumor PortalIGKC
OASIS PortalIGKC [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDIGKC
BioMutasearch IGKC
DgiDB (Drug Gene Interaction Database)IGKC
DoCM (Curated mutations)IGKC (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)IGKC (select a term)
intoGenIGKC
Cancer3DIGKC(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM147200    614102   
Orphanet18308   
MedgenIGKC
Genetic Testing Registry IGKC
NextProtP01834 [Medical]
TSGene3514
GENETestsIGKC
Target ValidationIGKC
Huge Navigator IGKC [HugePedia]
snp3D : Map Gene to Disease3514
BioCentury BCIQIGKC
ClinGenIGKC
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3514
Chemical/Pharm GKB GenePA29735
Clinical trialIGKC
Miscellaneous
canSAR (ICR)IGKC (select the gene name)
Probes
Litterature
PubMed61 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineIGKC
EVEXIGKC
GoPubMedIGKC
iHOPIGKC
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 25 19:13:00 CEST 2017

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