Atlas of Genetics and Cytogenetics in Oncology and Haematology


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IGKC (immunoglobulin kappa constant)

Identity

Alias_symbol (synonym)HCAK1
Other aliasIGKCD
Km
HGNC (Hugo) IGKC
LocusID (NCBI) 3514
Atlas_Id 52874
Location 2p11.2  [Link to chromosome band 2p11]
Location_base_pair Starts at 89156877 and ends at 89544559 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
HLA-B (6p21.33) / IGKC (2p11.2)IGHV3-30 (14q32.33) / IGKC (2p11.2)IGKC (2p11.2) / IGHA2 (14q32.33)
IGKC (2p11.2) / IGHG1 (14q32.33)IGKC (2p11.2) / IGHG2 (14q32.33)IGKC (2p11.2) / IGHG3 (14q32.33)
IGKC (2p11.2) / IGHG4 (14q32.33)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute


External links

Nomenclature
HGNC (Hugo)IGKC   5716
Cards
Entrez_Gene (NCBI)IGKC  3514  immunoglobulin kappa constant
AliasesHCAK1; IGKCD; Km
GeneCards (Weizmann)IGKC
Ensembl hg19 (Hinxton) [Gene_View]  chr2:89156877-89544559 [Contig_View]  IGKC [Vega]
Ensembl hg38 (Hinxton) [Gene_View]  chr2:89156877-89544559 [Contig_View]  IGKC [Vega]
TCGA cBioPortalIGKC
AceView (NCBI)IGKC
Genatlas (Paris)IGKC
WikiGenes3514
SOURCE (Princeton)IGKC
Genetics Home Reference (NIH)IGKC
Genomic and cartography
GoldenPath hg19 (UCSC)IGKC  -     chr2:89156877-89544559 -  2p11.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)IGKC  -     2p11.2   [Description]    (hg38-Dec_2013)
EnsemblIGKC - 2p11.2 [CytoView hg19]  IGKC - 2p11.2 [CytoView hg38]
Mapping of homologs : NCBIIGKC [Mapview hg19]  IGKC [Mapview hg38]
OMIM147200   614102   
Gene and transcription
Genbank (Entrez)AB245096 AF113887 AY894991 BC029444 BC034141
RefSeq transcript (Entrez)
RefSeq genomic (Entrez)NC_000002 NC_018913 NG_000834 NT_022184 NW_004929300
Consensus coding sequences : CCDS (NCBI)IGKC
Cluster EST : UnigeneHs.449609 [ NCBI ]
CGAP (NCI)Hs.449609
Gene ExpressionIGKC [ NCBI-GEO ]   IGKC [ EBI - ARRAY_EXPRESS ]   IGKC [ SEEK ]   IGKC [ MEM ]
Gene Expression Viewer (FireBrowse)IGKC [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3514
GTEX Portal (Tissue expression)IGKC
Protein : pattern, domain, 3D structure
UniProt/SwissProtP01834   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP01834  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP01834
Splice isoforms : SwissVarP01834
PhosPhoSitePlusP01834
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)    IG_MHC (PS00290)   
Domains : Interpro (EBI)Ig-like_dom    Ig-like_fold    Ig/MHC_CS    Ig_C1-set   
Domain families : Pfam (Sanger)C1-set (PF07654)   
Domain families : Pfam (NCBI)pfam07654   
Domain families : Smart (EMBL)IGc1 (SM00407)  
Conserved Domain (NCBI)IGKC
DMDM Disease mutations3514
Blocks (Seattle)IGKC
PDB (SRS)1A4J    1A4K    1CLY    1D5B    1D5I    1D6V    1DFB    1GAF    1HEZ    1HKL    1HZH    1I7Z    1MIM    1N0X    1OM3    1OP3    1OP5    1UCB    2NY7    2O5X    2O5Y    2O5Z    2QQK    2QQL    2QQN    2QSC    2R56    2RFX    2VXQ    3B2U    3B2V    3BDY    3BE1    3BKY    3BN9    3BQU    3C08    3C09    3CFJ    3CFK    3CSY    3D0L    3D85    3DVG    3DVN    3EYF    3EYO    3EYQ    3IU3    3O11    3QCT    3QCU    3QCV    3RU8    3U0W    3U7W    3U7Y    3VH8    3WUW    3X11    3X12    4D3C    4D9R    4HIX    4NM4    4NM8    4XMP    4XNY    4XNZ    4XXD    4YDV    5ESV    5ESZ   
PDB (PDBSum)1A4J    1A4K    1CLY    1D5B    1D5I    1D6V    1DFB    1GAF    1HEZ    1HKL    1HZH    1I7Z    1MIM    1N0X    1OM3    1OP3    1OP5    1UCB    2NY7    2O5X    2O5Y    2O5Z    2QQK    2QQL    2QQN    2QSC    2R56    2RFX    2VXQ    3B2U    3B2V    3BDY    3BE1    3BKY    3BN9    3BQU    3C08    3C09    3CFJ    3CFK    3CSY    3D0L    3D85    3DVG    3DVN    3EYF    3EYO    3EYQ    3IU3    3O11    3QCT    3QCU    3QCV    3RU8    3U0W    3U7W    3U7Y    3VH8    3WUW    3X11    3X12    4D3C    4D9R    4HIX    4NM4    4NM8    4XMP    4XNY    4XNZ    4XXD    4YDV    5ESV    5ESZ   
PDB (IMB)1A4J    1A4K    1CLY    1D5B    1D5I    1D6V    1DFB    1GAF    1HEZ    1HKL    1HZH    1I7Z    1MIM    1N0X    1OM3    1OP3    1OP5    1UCB    2NY7    2O5X    2O5Y    2O5Z    2QQK    2QQL    2QQN    2QSC    2R56    2RFX    2VXQ    3B2U    3B2V    3BDY    3BE1    3BKY    3BN9    3BQU    3C08    3C09    3CFJ    3CFK    3CSY    3D0L    3D85    3DVG    3DVN    3EYF    3EYO    3EYQ    3IU3    3O11    3QCT    3QCU    3QCV    3RU8    3U0W    3U7W    3U7Y    3VH8    3WUW    3X11    3X12    4D3C    4D9R    4HIX    4NM4    4NM8    4XMP    4XNY    4XNZ    4XXD    4YDV    5ESV    5ESZ   
PDB (RSDB)1A4J    1A4K    1CLY    1D5B    1D5I    1D6V    1DFB    1GAF    1HEZ    1HKL    1HZH    1I7Z    1MIM    1N0X    1OM3    1OP3    1OP5    1UCB    2NY7    2O5X    2O5Y    2O5Z    2QQK    2QQL    2QQN    2QSC    2R56    2RFX    2VXQ    3B2U    3B2V    3BDY    3BE1    3BKY    3BN9    3BQU    3C08    3C09    3CFJ    3CFK    3CSY    3D0L    3D85    3DVG    3DVN    3EYF    3EYO    3EYQ    3IU3    3O11    3QCT    3QCU    3QCV    3RU8    3U0W    3U7W    3U7Y    3VH8    3WUW    3X11    3X12    4D3C    4D9R    4HIX    4NM4    4NM8    4XMP    4XNY    4XNZ    4XXD    4YDV    5ESV    5ESZ   
Structural Biology KnowledgeBase1A4J    1A4K    1CLY    1D5B    1D5I    1D6V    1DFB    1GAF    1HEZ    1HKL    1HZH    1I7Z    1MIM    1N0X    1OM3    1OP3    1OP5    1UCB    2NY7    2O5X    2O5Y    2O5Z    2QQK    2QQL    2QQN    2QSC    2R56    2RFX    2VXQ    3B2U    3B2V    3BDY    3BE1    3BKY    3BN9    3BQU    3C08    3C09    3CFJ    3CFK    3CSY    3D0L    3D85    3DVG    3DVN    3EYF    3EYO    3EYQ    3IU3    3O11    3QCT    3QCU    3QCV    3RU8    3U0W    3U7W    3U7Y    3VH8    3WUW    3X11    3X12    4D3C    4D9R    4HIX    4NM4    4NM8    4XMP    4XNY    4XNZ    4XXD    4YDV    5ESV    5ESZ   
SCOP (Structural Classification of Proteins)1A4J    1A4K    1CLY    1D5B    1D5I    1D6V    1DFB    1GAF    1HEZ    1HKL    1HZH    1I7Z    1MIM    1N0X    1OM3    1OP3    1OP5    1UCB    2NY7    2O5X    2O5Y    2O5Z    2QQK    2QQL    2QQN    2QSC    2R56    2RFX    2VXQ    3B2U    3B2V    3BDY    3BE1    3BKY    3BN9    3BQU    3C08    3C09    3CFJ    3CFK    3CSY    3D0L    3D85    3DVG    3DVN    3EYF    3EYO    3EYQ    3IU3    3O11    3QCT    3QCU    3QCV    3RU8    3U0W    3U7W    3U7Y    3VH8    3WUW    3X11    3X12    4D3C    4D9R    4HIX    4NM4    4NM8    4XMP    4XNY    4XNZ    4XXD    4YDV    5ESV    5ESZ   
CATH (Classification of proteins structures)1A4J    1A4K    1CLY    1D5B    1D5I    1D6V    1DFB    1GAF    1HEZ    1HKL    1HZH    1I7Z    1MIM    1N0X    1OM3    1OP3    1OP5    1UCB    2NY7    2O5X    2O5Y    2O5Z    2QQK    2QQL    2QQN    2QSC    2R56    2RFX    2VXQ    3B2U    3B2V    3BDY    3BE1    3BKY    3BN9    3BQU    3C08    3C09    3CFJ    3CFK    3CSY    3D0L    3D85    3DVG    3DVN    3EYF    3EYO    3EYQ    3IU3    3O11    3QCT    3QCU    3QCV    3RU8    3U0W    3U7W    3U7Y    3VH8    3WUW    3X11    3X12    4D3C    4D9R    4HIX    4NM4    4NM8    4XMP    4XNY    4XNZ    4XXD    4YDV    5ESV    5ESZ   
SuperfamilyP01834
Peptide AtlasP01834
IPIIPI00829699   IPI00024134   IPI00922330   IPI00853045   IPI00969456   IPI00979250   
Protein Interaction databases
DIP (DOE-UCLA)P01834
IntAct (EBI)P01834
BioGRIDIGKC
STRING (EMBL)IGKC
ZODIACIGKC
Ontologies - Pathways
QuickGOP01834
Ontology : AmiGOretina homeostasis  antigen binding  antigen binding  serine-type endopeptidase activity  extracellular region  extracellular region  extracellular space  plasma membrane  proteolysis  receptor-mediated endocytosis  phagocytosis, recognition  phagocytosis, engulfment  immune response  complement activation  complement activation, classical pathway  complement activation, classical pathway  external side of plasma membrane  immunoglobulin receptor binding  Fc-epsilon receptor signaling pathway  Fc-gamma receptor signaling pathway involved in phagocytosis  immunoglobulin complex, circulating  defense response to bacterium  innate immune response  regulation of immune response  B cell receptor signaling pathway  positive regulation of B cell activation  extracellular exosome  blood microparticle  
Ontology : EGO-EBIretina homeostasis  antigen binding  antigen binding  serine-type endopeptidase activity  extracellular region  extracellular region  extracellular space  plasma membrane  proteolysis  receptor-mediated endocytosis  phagocytosis, recognition  phagocytosis, engulfment  immune response  complement activation  complement activation, classical pathway  complement activation, classical pathway  external side of plasma membrane  immunoglobulin receptor binding  Fc-epsilon receptor signaling pathway  Fc-gamma receptor signaling pathway involved in phagocytosis  immunoglobulin complex, circulating  defense response to bacterium  innate immune response  regulation of immune response  B cell receptor signaling pathway  positive regulation of B cell activation  extracellular exosome  blood microparticle  
NDEx NetworkIGKC
Atlas of Cancer Signalling NetworkIGKC
Wikipedia pathwaysIGKC
Orthology - Evolution
OrthoDB3514
Phylogenetic Trees/Animal Genes : TreeFamIGKC
HOVERGENP01834
HOGENOMP01834
Homologs : HomoloGeneIGKC
Homology/Alignments : Family Browser (UCSC)IGKC
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIGKC [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IGKC
dbVarIGKC
ClinVarIGKC
1000_GenomesIGKC 
Exome Variant ServerIGKC
ExAC (Exome Aggregation Consortium)IGKC (select the gene name)
Genetic variants : HAPMAP3514
Genomic Variants (DGV)IGKC [DGVbeta]
DECIPHER (Syndromes)2:89156877-89544559  
CONAN: Copy Number AnalysisIGKC 
Mutations
ICGC Data PortalIGKC 
TCGA Data PortalIGKC 
Broad Tumor PortalIGKC
OASIS PortalIGKC [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDIGKC
BioMutasearch IGKC
DgiDB (Drug Gene Interaction Database)IGKC
DoCM (Curated mutations)IGKC (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)IGKC (select a term)
intoGenIGKC
Cancer3DIGKC(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM147200    614102   
Orphanet18308   
MedgenIGKC
Genetic Testing Registry IGKC
NextProtP01834 [Medical]
TSGene3514
GENETestsIGKC
Huge Navigator IGKC [HugePedia]
snp3D : Map Gene to Disease3514
BioCentury BCIQIGKC
ClinGenIGKC
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3514
Chemical/Pharm GKB GenePA29735
Clinical trialIGKC
Miscellaneous
canSAR (ICR)IGKC (select the gene name)
Probes
Litterature
PubMed59 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineIGKC
EVEXIGKC
GoPubMedIGKC
iHOPIGKC
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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