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IGLL5 (immunoglobulin lambda like polypeptide 5)

Identity

Alias_namesimmunoglobulin lambda-like polypeptide 5
Other aliasIGL
IGLV
VL-MAR
HGNC (Hugo) IGLL5
LocusID (NCBI) 100423062
Atlas_Id 54374
Location 22q11.22  [Link to chromosome band 22q11]
Location_base_pair Starts at 22887780 and ends at 22895833 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
IGHG1 (14q32.33) / IGLL5 (22q11.22)IGLL5 (22q11.22) / DAZAP1 (19p13.3)IGLL5 (22q11.22) / EEF1D (8q24.3)
IGLV1-36 () / IGLL5 (22q11.22)IGLV1-40 () / IGLL5 (22q11.22)IGLV1-44 (22q11.22) / IGLL5 (22q11.22)
IGLV1-47 () / IGLL5 (22q11.22)IGLV2-14 () / IGLL5 (22q11.22)IGLV3-21 (22q11.22) / IGLL5 (22q11.22)
IGLV3-27 () / IGLL5 (22q11.22)IGLV6-57 (22q11.22) / IGLL5 (22q11.22)LOC96610 () / IGLL5 (22q11.22)
SFTPC (8p21.3) / IGLL5 (22q11.22)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)IGLL5   38476
Cards
Entrez_Gene (NCBI)IGLL5  100423062  immunoglobulin lambda like polypeptide 5
AliasesIGL; IGLV; VL-MAR
GeneCards (Weizmann)IGLL5
Ensembl hg19 (Hinxton)ENSG00000254709 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000254709 [Gene_View]  chr22:22887780-22895833 [Contig_View]  IGLL5 [Vega]
ICGC DataPortalENSG00000254709
TCGA cBioPortalIGLL5
AceView (NCBI)IGLL5
Genatlas (Paris)IGLL5
WikiGenes100423062
SOURCE (Princeton)IGLL5
Genetics Home Reference (NIH)IGLL5
Genomic and cartography
GoldenPath hg38 (UCSC)IGLL5  -     chr22:22887780-22895833 +  22q11.22   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)IGLL5  -     22q11.22   [Description]    (hg19-Feb_2009)
EnsemblIGLL5 - 22q11.22 [CytoView hg19]  IGLL5 - 22q11.22 [CytoView hg38]
Mapping of homologs : NCBIIGLL5 [Mapview hg19]  IGLL5 [Mapview hg38]
Gene and transcription
Genbank (Entrez)###############################################################################################################################################################################################################################################################
RefSeq transcript (Entrez)NM_001178126 NM_001256296
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)IGLL5
Cluster EST : UnigeneHs.731137 [ NCBI ]
CGAP (NCI)Hs.731137
Alternative Splicing GalleryENSG00000254709
Gene ExpressionIGLL5 [ NCBI-GEO ]   IGLL5 [ EBI - ARRAY_EXPRESS ]   IGLL5 [ SEEK ]   IGLL5 [ MEM ]
Gene Expression Viewer (FireBrowse)IGLL5 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)100423062
GTEX Portal (Tissue expression)IGLL5
Protein : pattern, domain, 3D structure
UniProt/SwissProtB9A064   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtB9A064  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProB9A064
Splice isoforms : SwissVarB9A064
PhosPhoSitePlusB9A064
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)    IG_MHC (PS00290)   
Domains : Interpro (EBI)Ig-like_dom    Ig-like_fold    Ig/MHC_CS    Ig_C1-set   
Domain families : Pfam (Sanger)C1-set (PF07654)   
Domain families : Pfam (NCBI)pfam07654   
Domain families : Smart (EMBL)IGc1 (SM00407)  
Conserved Domain (NCBI)IGLL5
DMDM Disease mutations100423062
Blocks (Seattle)IGLL5
SuperfamilyB9A064
Human Protein AtlasENSG00000254709
Peptide AtlasB9A064
IPIIPI00977041   IPI00893175   IPI00893178   
Protein Interaction databases
DIP (DOE-UCLA)B9A064
IntAct (EBI)B9A064
FunCoupENSG00000254709
BioGRIDIGLL5
STRING (EMBL)IGLL5
ZODIACIGLL5
Ontologies - Pathways
QuickGOB9A064
Ontology : AmiGOantigen binding  phagocytosis, recognition  phagocytosis, engulfment  complement activation, classical pathway  external side of plasma membrane  immunoglobulin receptor binding  immunoglobulin complex, circulating  defense response to bacterium  innate immune response  B cell receptor signaling pathway  positive regulation of B cell activation  extracellular exosome  blood microparticle  
Ontology : EGO-EBIantigen binding  phagocytosis, recognition  phagocytosis, engulfment  complement activation, classical pathway  external side of plasma membrane  immunoglobulin receptor binding  immunoglobulin complex, circulating  defense response to bacterium  innate immune response  B cell receptor signaling pathway  positive regulation of B cell activation  extracellular exosome  blood microparticle  
NDEx NetworkIGLL5
Atlas of Cancer Signalling NetworkIGLL5
Wikipedia pathwaysIGLL5
Orthology - Evolution
OrthoDB100423062
GeneTree (enSembl)ENSG00000254709
Phylogenetic Trees/Animal Genes : TreeFamIGLL5
HOVERGENB9A064
HOGENOMB9A064
Homologs : HomoloGeneIGLL5
Homology/Alignments : Family Browser (UCSC)IGLL5
Gene fusions - Rearrangements
Fusion : MitelmanSFTPC/IGLL5 [8p21.3/22q11.22]  [t(8;22)(p21;q11)]  
Fusion Cancer (Beijing)IGLV1-36 [-]  -  IGLL5 [22q11.22]  [FUSC000005]  [FUSC000005]  [FUSC000005]  [FUSC000005]  [FUSC000005]  [FUSC000005]  [FUSC000005]  [FUSC000005]  [FUSC000005]
Fusion Cancer (Beijing)IGLV1-40 [-]  -  IGLL5 [22q11.22]  [FUSC002329]  [FUSC002329]  [FUSC002329]  [FUSC002329]  [FUSC002329]  [FUSC002329]
Fusion Cancer (Beijing)IGLV1-44 [22q11.22]  -  IGLL5 [22q11.22]  [FUSC000004]  [FUSC000004]  [FUSC000004]  [FUSC000004]  [FUSC000004]  [FUSC000004]  [FUSC000004]  [FUSC000004]  [FUSC000004]  [FUSC000004]
Fusion Cancer (Beijing)IGLV1-47 [-]  -  IGLL5 [22q11.22]  [FUSC000888]  [FUSC000888]  [FUSC000888]  [FUSC000888]  [FUSC000888]
Fusion Cancer (Beijing)IGLV2-14 [-]  -  IGLL5 [22q11.22]  [FUSC000680]  [FUSC000680]  [FUSC000680]  [FUSC000680]  [FUSC000680]  [FUSC000680]  [FUSC000680]  [FUSC000680]  [FUSC000680]  [FUSC000680]  [FUSC000680]
Fusion Cancer (Beijing)IGLV3-21 [22q11.22]  -  IGLL5 [22q11.22]  [FUSC000679]  [FUSC000679]  [FUSC000679]  [FUSC000679]  [FUSC000679]  [FUSC000679]
Fusion Cancer (Beijing)IGLV3-27 [-]  -  IGLL5 [22q11.22]  [FUSC003194]
Fusion Cancer (Beijing)IGLV6-57 [22q11.22]  -  IGLL5 [22q11.22]  [FUSC002328]
Fusion Cancer (Beijing)LOC96610 [IGLL5]  -  22q11.22 [FUSC002332]  [FUSC002332]  [FUSC002332]  [FUSC002332]  [FUSC002332]  [FUSC002332]
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIGLL5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IGLL5
dbVarIGLL5
ClinVarIGLL5
1000_GenomesIGLL5 
Exome Variant ServerIGLL5
ExAC (Exome Aggregation Consortium)IGLL5 (select the gene name)
Genetic variants : HAPMAP100423062
Genomic Variants (DGV)IGLL5 [DGVbeta]
DECIPHERIGLL5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisIGLL5 
Mutations
ICGC Data PortalIGLL5 
TCGA Data PortalIGLL5 
Broad Tumor PortalIGLL5
OASIS PortalIGLL5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIGLL5  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDIGLL5
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch IGLL5
DgiDB (Drug Gene Interaction Database)IGLL5
DoCM (Curated mutations)IGLL5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)IGLL5 (select a term)
intoGenIGLL5
Cancer3DIGLL5(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
MedgenIGLL5
Genetic Testing Registry IGLL5
NextProtB9A064 [Medical]
TSGene100423062
GENETestsIGLL5
Huge Navigator IGLL5 [HugePedia]
snp3D : Map Gene to Disease100423062
BioCentury BCIQIGLL5
ClinGenIGLL5
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD100423062
Chemical/Pharm GKB GenePA165378341
Clinical trialIGLL5
Miscellaneous
canSAR (ICR)IGLL5 (select the gene name)
Probes
Litterature
PubMed15 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineIGLL5
EVEXIGLL5
GoPubMedIGLL5
iHOPIGLL5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri May 19 12:20:11 CEST 2017

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