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IKBKE (inhibitor of nuclear factor kappa B kinase subunit epsilon)

Identity

Alias (NCBI)IKK-E
IKK-i
IKKE
IKKI
HGNC (Hugo) IKBKE
HGNC Alias symbIKKE
IKK-i
KIAA0151
HGNC Previous nameinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
LocusID (NCBI) 9641
Atlas_Id 43315
Location 1q32.1  [Link to chromosome band 1q32]
Location_base_pair Starts at 206470476 and ends at 206496889 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
IKBKE (1q32.1) / ACSM1 (16p12.3)IKBKE (1q32.1) / STX8 (17p13.1)RASSF5 (1q32.1) / IKBKE (1q32.1)
RNASEK-C17orf49 (17p13.1) / IKBKE (1q32.1)IKBKE 1q32.1 / ACSM1 16p12.3RASSF5 1q32.1 / IKBKE 1q32.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  Burkitt's lymphoma (BL)


External links

 

Nomenclature
HGNC (Hugo)IKBKE   14552
Cards
Entrez_Gene (NCBI)IKBKE    inhibitor of nuclear factor kappa B kinase subunit epsilon
AliasesIKK-E; IKK-i; IKKE; IKKI
GeneCards (Weizmann)IKBKE
Ensembl hg19 (Hinxton)ENSG00000263528 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000263528 [Gene_View]  ENSG00000263528 [Sequence]  chr1:206470476-206496889 [Contig_View]  IKBKE [Vega]
ICGC DataPortalENSG00000263528
TCGA cBioPortalIKBKE
AceView (NCBI)IKBKE
Genatlas (Paris)IKBKE
SOURCE (Princeton)IKBKE
Genetics Home Reference (NIH)IKBKE
Genomic and cartography
GoldenPath hg38 (UCSC)IKBKE  -     chr1:206470476-206496889 +  1q32.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)IKBKE  -     1q32.1   [Description]    (hg19-Feb_2009)
GoldenPathIKBKE - 1q32.1 [CytoView hg19]  IKBKE - 1q32.1 [CytoView hg38]
ImmunoBaseENSG00000263528
Genome Data Viewer NCBIIKBKE [Mapview hg19]  
OMIM605048   
Gene and transcription
Genbank (Entrez)AB016590 AF241789 AK093798 AK310737 AL706097
RefSeq transcript (Entrez)NM_001193321 NM_001193322 NM_014002
Consensus coding sequences : CCDS (NCBI)IKBKE
Gene ExpressionIKBKE [ NCBI-GEO ]   IKBKE [ EBI - ARRAY_EXPRESS ]   IKBKE [ SEEK ]   IKBKE [ MEM ]
Gene Expression Viewer (FireBrowse)IKBKE [ Firebrowse - Broad ]
GenevisibleExpression of IKBKE in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9641
GTEX Portal (Tissue expression)IKBKE
Human Protein AtlasENSG00000263528-IKBKE [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ14164   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ14164  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ14164
Catalytic activity : Enzyme2.7.11.10 [ Enzyme-Expasy ]   2.7.11.102.7.11.10 [ IntEnz-EBI ]   2.7.11.10 [ BRENDA ]   2.7.11.10 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ14164
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)   
Domains : Interpro (EBI)Kinase-like_dom_sf    Prot_kinase_dom    Protein_kinase_ATP_BS    TBK1_CCD1    TBK1_ULD   
Domain families : Pfam (Sanger)Pkinase (PF00069)    TBK1_CCD1 (PF18394)    TBK1_ULD (PF18396)   
Domain families : Pfam (NCBI)pfam00069    pfam18394    pfam18396   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)IKBKE
SuperfamilyQ14164
AlphaFold pdb e-kbQ14164   
Human Protein Atlas [tissue]ENSG00000263528-IKBKE [tissue]
HPRD05442
Protein Interaction databases
DIP (DOE-UCLA)Q14164
IntAct (EBI)Q14164
BioGRIDIKBKE
STRING (EMBL)IKBKE
ZODIACIKBKE
Ontologies - Pathways
QuickGOQ14164
Ontology : AmiGOactivation of MAPK activity  protein serine/threonine kinase activity  NF-kappaB-inducing kinase activity  protein binding  ATP binding  nucleus  nucleoplasm  cytoplasm  cytoplasm  cytosol  protein phosphorylation  immune response  I-kappaB phosphorylation  IkappaB kinase activity  intrinsic apoptotic signaling pathway in response to DNA damage  gene expression  positive regulation of lipid storage  PML body  peptidyl-serine phosphorylation  protein phosphatase binding  ubiquitin protein ligase binding  mitochondrial membrane  negative regulation of type I interferon production  response to type I interferon  response to interferon-beta  TRIF-dependent toll-like receptor signaling pathway  K48-linked polyubiquitin modification-dependent protein binding  NIK/NF-kappaB signaling  identical protein binding  positive regulation of I-kappaB kinase/NF-kappaB signaling  regulation of protein-containing complex assembly  mRNA stabilization  positive regulation of DNA-binding transcription factor activity  positive regulation of type I interferon-mediated signaling pathway  K63-linked polyubiquitin modification-dependent protein binding  interleukin-17-mediated signaling pathway  cellular response to virus  
Ontology : EGO-EBIactivation of MAPK activity  protein serine/threonine kinase activity  NF-kappaB-inducing kinase activity  protein binding  ATP binding  nucleus  nucleoplasm  cytoplasm  cytoplasm  cytosol  protein phosphorylation  immune response  I-kappaB phosphorylation  IkappaB kinase activity  intrinsic apoptotic signaling pathway in response to DNA damage  gene expression  positive regulation of lipid storage  PML body  peptidyl-serine phosphorylation  protein phosphatase binding  ubiquitin protein ligase binding  mitochondrial membrane  negative regulation of type I interferon production  response to type I interferon  response to interferon-beta  TRIF-dependent toll-like receptor signaling pathway  K48-linked polyubiquitin modification-dependent protein binding  NIK/NF-kappaB signaling  identical protein binding  positive regulation of I-kappaB kinase/NF-kappaB signaling  regulation of protein-containing complex assembly  mRNA stabilization  positive regulation of DNA-binding transcription factor activity  positive regulation of type I interferon-mediated signaling pathway  K63-linked polyubiquitin modification-dependent protein binding  interleukin-17-mediated signaling pathway  cellular response to virus  
Pathways : KEGGToll-like receptor signaling pathway    RIG-I-like receptor signaling pathway    Cytosolic DNA-sensing pathway    Hepatitis C    Hepatitis B    Measles    Influenza A    Herpes simplex infection   
NDEx NetworkIKBKE
Atlas of Cancer Signalling NetworkIKBKE
Wikipedia pathwaysIKBKE
Orthology - Evolution
OrthoDB9641
GeneTree (enSembl)ENSG00000263528
Phylogenetic Trees/Animal Genes : TreeFamIKBKE
Homologs : HomoloGeneIKBKE
Homology/Alignments : Family Browser (UCSC)IKBKE
Gene fusions - Rearrangements
Fusion : MitelmanIKBKE/ACSM1 [1q32.1/16p12.3]  
Fusion : MitelmanRASSF5/IKBKE [1q32.1/1q32.1]  
Fusion : QuiverIKBKE
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIKBKE [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IKBKE
dbVarIKBKE
ClinVarIKBKE
MonarchIKBKE
1000_GenomesIKBKE 
Exome Variant ServerIKBKE
GNOMAD BrowserENSG00000263528
Varsome BrowserIKBKE
ACMGIKBKE variants
VarityQ14164
Genomic Variants (DGV)IKBKE [DGVbeta]
DECIPHERIKBKE [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisIKBKE 
Mutations
ICGC Data PortalIKBKE 
TCGA Data PortalIKBKE 
Broad Tumor PortalIKBKE
OASIS PortalIKBKE [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIKBKE  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DIKBKE
Mutations and Diseases : HGMDIKBKE
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaIKBKE
DgiDB (Drug Gene Interaction Database)IKBKE
DoCM (Curated mutations)IKBKE
CIViC (Clinical Interpretations of Variants in Cancer)IKBKE
Cancer3DIKBKE
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605048   
Orphanet
DisGeNETIKBKE
MedgenIKBKE
Genetic Testing Registry IKBKE
NextProtQ14164 [Medical]
GENETestsIKBKE
Target ValidationIKBKE
Huge Navigator IKBKE [HugePedia]
ClinGenIKBKE
Clinical trials, drugs, therapy
MyCancerGenomeIKBKE
Protein Interactions : CTDIKBKE
Pharm GKB GenePA134962294
PharosQ14164
Clinical trialIKBKE
Miscellaneous
canSAR (ICR)IKBKE
HarmonizomeIKBKE
DataMed IndexIKBKE
Probes
Litterature
PubMed188 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXIKBKE
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 15:13:40 CEST 2021

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