IKBKE (inhibitor of nuclear factor kappa B kinase subunit epsilon)

2006-10-01 Affiliation

Identity

HGNC

IKBKE

LOCATION

1q32.1

LOCUSID

9641

ALIAS

IKK-E,IKK-i,IKKE,IKKI

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 9641
MIM: 605048
HGNC: 14552
Ensembl: ENSG00000263528

Variants:

dbSNP: 9641
ClinVar: 9641
TCGA: ENSG00000263528
COSMIC: IKBKE

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000263528	ENST00000578328	A0A075B7B4
ENSG00000263528	ENST00000579827	A0A075B7D5
ENSG00000263528	ENST00000581977	Q14164
ENSG00000263528	ENST00000584998	Q14164
ENSG00000263528	ENST00000605726	A0A075B7C7

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Toll-like receptor signaling pathway	KEGG	ko04620
Toll-like receptor signaling pathway	KEGG	hsa04620
RIG-I-like receptor signaling pathway	KEGG	ko04622
RIG-I-like receptor signaling pathway	KEGG	hsa04622
NOD-like receptor signaling pathway	KEGG	ko04621
NOD-like receptor signaling pathway	KEGG	hsa04621
Cytosolic DNA-sensing pathway	KEGG	ko04623
Cytosolic DNA-sensing pathway	KEGG	hsa04623
Hepatitis C	KEGG	ko05160
Hepatitis C	KEGG	hsa05160
Measles	KEGG	ko05162
Measles	KEGG	hsa05162
Influenza A	KEGG	ko05164
Influenza A	KEGG	hsa05164
Herpes simplex infection	KEGG	ko05168
Herpes simplex infection	KEGG	hsa05168
Hepatitis B	KEGG	hsa05161
Immune System	REACTOME	R-HSA-168256
Innate Immune System	REACTOME	R-HSA-168249
Toll-Like Receptors Cascades	REACTOME	R-HSA-168898
Toll Like Receptor 3 (TLR3) Cascade	REACTOME	R-HSA-168164
MyD88-independent TLR3/TLR4 cascade	REACTOME	R-HSA-166166
TRIF-mediated TLR3/TLR4 signaling	REACTOME	R-HSA-937061
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon	REACTOME	R-HSA-936964
Toll Like Receptor 4 (TLR4) Cascade	REACTOME	R-HSA-166016
Activated TLR4 signalling	REACTOME	R-HSA-166054
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways	REACTOME	R-HSA-168928
TRAF3-dependent IRF activation pathway	REACTOME	R-HSA-918233
TRAF6 mediated IRF7 activation	REACTOME	R-HSA-933541
Negative regulators of RIG-I/MDA5 signaling	REACTOME	R-HSA-936440
IL-17 signaling pathway	KEGG	ko04657
IL-17 signaling pathway	KEGG	hsa04657

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PD	PMIDs
PA131301952	gefitinib	Chemical	ClinicalAnnotation	associated	PD	31664190
PA443622	Carcinoma, Non-Small-Cell Lung	Disease	ClinicalAnnotation	associated	PD	31664190
PA443899	Diarrhea	Disease	ClinicalAnnotation	associated	PD	31664190
PA444109	Exanthema	Disease	ClinicalAnnotation	associated	PD	31664190

References

Pubmed ID	Year	Title	Citations
12692549	2003	IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway.	833
17574021	2007	Integrative genomic approaches identify IKBKE as a breast cancer oncogene.	285
15489227	2004	Constitutive and interleukin-1-inducible phosphorylation of p65 NF-{kappa}B at serine 536 is mediated by multiple protein kinases including I{kappa}B kinase (IKK)-{alpha}, IKK{beta}, IKK{epsilon}, TRAF family member-associated (TANK)-binding kinase 1 (TBK1), and an unknown kinase and couples p65 to TATA-binding protein-associated factor II31-mediated interleukin-8 transcription.	131
19153231	2009	Ebola virus protein VP35 impairs the function of interferon regulatory factor-activating kinases IKKepsilon and TBK-1.	118
16731946	2006	Dissociation of a MAVS/IPS-1/VISA/Cardif-IKKepsilon molecular complex from the mitochondrial outer membrane by hepatitis C virus NS3-4A proteolytic cleavage.	107
19481526	2009	Phosphorylation of the tumor suppressor CYLD by the breast cancer oncogene IKKepsilon promotes cell transformation.	94
18353649	2008	Are the IKKs and IKK-related kinases TBK1 and IKK-epsilon similarly activated?	88
21464307	2011	IkappaB kinase epsilon and TANK-binding kinase 1 activate AKT by direct phosphorylation.	88
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
17327220	2007	Modulation of the interferon antiviral response by the TBK1/IKKi adaptor protein TANK.	83

Citation

Dessen P

IKBKE (inhibitor of nuclear factor kappa B kinase subunit epsilon)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43315/ikbke