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IKBKE (inhibitor of nuclear factor kappa B kinase subunit epsilon)

Identity

Alias_symbol (synonym)IKKE
IKK-i
KIAA0151
Other aliasIKK-E
IKKI
HGNC (Hugo) IKBKE
LocusID (NCBI) 9641
Atlas_Id 43315
Location 1q32.1  [Link to chromosome band 1q32]
Location_base_pair Starts at 206470243 and ends at 206496890 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
IKBKE (1q32.1) / ACSM1 (16p12.3)IKBKE (1q32.1) / STX8 (17p13.1)RASSF5 (1q32.1) / IKBKE (1q32.1)
RNASEK-C17orf49 (17p13.1) / IKBKE (1q32.1)IKBKE 1q32.1 / ACSM1 16p12.3RASSF5 1q32.1 / IKBKE 1q32.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)IKBKE   14552
Cards
Entrez_Gene (NCBI)IKBKE  9641  inhibitor of nuclear factor kappa B kinase subunit epsilon
AliasesIKK-E; IKK-i; IKKE; IKKI
GeneCards (Weizmann)IKBKE
Ensembl hg19 (Hinxton)ENSG00000263528 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000263528 [Gene_View]  chr1:206470243-206496890 [Contig_View]  IKBKE [Vega]
ICGC DataPortalENSG00000263528
TCGA cBioPortalIKBKE
AceView (NCBI)IKBKE
Genatlas (Paris)IKBKE
WikiGenes9641
SOURCE (Princeton)IKBKE
Genetics Home Reference (NIH)IKBKE
Genomic and cartography
GoldenPath hg38 (UCSC)IKBKE  -     chr1:206470243-206496890 +  1q32.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)IKBKE  -     1q32.1   [Description]    (hg19-Feb_2009)
EnsemblIKBKE - 1q32.1 [CytoView hg19]  IKBKE - 1q32.1 [CytoView hg38]
Mapping of homologs : NCBIIKBKE [Mapview hg19]  IKBKE [Mapview hg38]
OMIM605048   
Gene and transcription
Genbank (Entrez)AB016590 AF241789 AK093798 AK310737 AL706097
RefSeq transcript (Entrez)NM_001193321 NM_001193322 NM_014002
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)IKBKE
Cluster EST : UnigeneHs.321045 [ NCBI ]
CGAP (NCI)Hs.321045
Alternative Splicing GalleryENSG00000263528
Gene ExpressionIKBKE [ NCBI-GEO ]   IKBKE [ EBI - ARRAY_EXPRESS ]   IKBKE [ SEEK ]   IKBKE [ MEM ]
Gene Expression Viewer (FireBrowse)IKBKE [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9641
GTEX Portal (Tissue expression)IKBKE
Human Protein AtlasENSG00000263528-IKBKE [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ14164   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ14164  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ14164
Splice isoforms : SwissVarQ14164
Catalytic activity : Enzyme2.7.11.10 [ Enzyme-Expasy ]   2.7.11.102.7.11.10 [ IntEnz-EBI ]   2.7.11.10 [ BRENDA ]   2.7.11.10 [ KEGG ]   
PhosPhoSitePlusQ14164
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)   
Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)IKBKE
DMDM Disease mutations9641
Blocks (Seattle)IKBKE
SuperfamilyQ14164
Human Protein Atlas [tissue]ENSG00000263528-IKBKE [tissue]
Peptide AtlasQ14164
HPRD05442
IPIIPI00029045   IPI00981235   IPI00982350   
Protein Interaction databases
DIP (DOE-UCLA)Q14164
IntAct (EBI)Q14164
FunCoupENSG00000263528
BioGRIDIKBKE
STRING (EMBL)IKBKE
ZODIACIKBKE
Ontologies - Pathways
QuickGOQ14164
Ontology : AmiGOprotein kinase activity  NF-kappaB-inducing kinase activity  protein binding  ATP binding  nucleus  cytoplasm  cytosol  protein phosphorylation  immune response  I-kappaB phosphorylation  IkappaB kinase activity  intrinsic apoptotic signaling pathway in response to DNA damage  endosome membrane  positive regulation of lipid storage  PML body  peptidyl-serine phosphorylation  ubiquitin protein ligase binding  mitochondrial membrane  negative regulation of type I interferon production  response to type I interferon  response to interferon-beta  TRIF-dependent toll-like receptor signaling pathway  K48-linked polyubiquitin binding  NIK/NF-kappaB signaling  positive regulation of I-kappaB kinase/NF-kappaB signaling  innate immune response  protein homooligomerization  K63-linked polyubiquitin binding  cellular response to virus  
Ontology : EGO-EBIprotein kinase activity  NF-kappaB-inducing kinase activity  protein binding  ATP binding  nucleus  cytoplasm  cytosol  protein phosphorylation  immune response  I-kappaB phosphorylation  IkappaB kinase activity  intrinsic apoptotic signaling pathway in response to DNA damage  endosome membrane  positive regulation of lipid storage  PML body  peptidyl-serine phosphorylation  ubiquitin protein ligase binding  mitochondrial membrane  negative regulation of type I interferon production  response to type I interferon  response to interferon-beta  TRIF-dependent toll-like receptor signaling pathway  K48-linked polyubiquitin binding  NIK/NF-kappaB signaling  positive regulation of I-kappaB kinase/NF-kappaB signaling  innate immune response  protein homooligomerization  K63-linked polyubiquitin binding  cellular response to virus  
Pathways : KEGGToll-like receptor signaling pathway    RIG-I-like receptor signaling pathway    Cytosolic DNA-sensing pathway    Hepatitis C    Hepatitis B    Measles    Influenza A    Herpes simplex infection   
NDEx NetworkIKBKE
Atlas of Cancer Signalling NetworkIKBKE
Wikipedia pathwaysIKBKE
Orthology - Evolution
OrthoDB9641
GeneTree (enSembl)ENSG00000263528
Phylogenetic Trees/Animal Genes : TreeFamIKBKE
HOVERGENQ14164
HOGENOMQ14164
Homologs : HomoloGeneIKBKE
Homology/Alignments : Family Browser (UCSC)IKBKE
Gene fusions - Rearrangements
Fusion : MitelmanIKBKE/ACSM1 [1q32.1/16p12.3]  
Fusion : MitelmanRASSF5/IKBKE [1q32.1/1q32.1]  [t(1;1)(q32;q32)]  
Fusion: TCGA_MDACCIKBKE 1q32.1 ACSM1 16p12.3 KIRC
Fusion: TCGA_MDACCRASSF5 1q32.1 IKBKE 1q32.1 HNSC
Tumor Fusion PortalIKBKE
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIKBKE [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IKBKE
dbVarIKBKE
ClinVarIKBKE
1000_GenomesIKBKE 
Exome Variant ServerIKBKE
ExAC (Exome Aggregation Consortium)ENSG00000263528
GNOMAD BrowserENSG00000263528
Genetic variants : HAPMAP9641
Genomic Variants (DGV)IKBKE [DGVbeta]
DECIPHERIKBKE [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisIKBKE 
Mutations
ICGC Data PortalIKBKE 
TCGA Data PortalIKBKE 
Broad Tumor PortalIKBKE
OASIS PortalIKBKE [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIKBKE  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDIKBKE
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch IKBKE
DgiDB (Drug Gene Interaction Database)IKBKE
DoCM (Curated mutations)IKBKE (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)IKBKE (select a term)
intoGenIKBKE
Cancer3DIKBKE(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605048   
Orphanet
DisGeNETIKBKE
MedgenIKBKE
Genetic Testing Registry IKBKE
NextProtQ14164 [Medical]
TSGene9641
GENETestsIKBKE
Target ValidationIKBKE
Huge Navigator IKBKE [HugePedia]
snp3D : Map Gene to Disease9641
BioCentury BCIQIKBKE
ClinGenIKBKE
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9641
Chemical/Pharm GKB GenePA134962294
Clinical trialIKBKE
Miscellaneous
canSAR (ICR)IKBKE (select the gene name)
Probes
Litterature
PubMed136 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineIKBKE
EVEXIKBKE
GoPubMedIKBKE
iHOPIKBKE
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:17:33 CET 2017

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