Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

IKZF4 (IKAROS family zinc finger 4)

Identity

Alias_namesZNFN1A4
zinc finger protein, subfamily 1A, 4 (Eos)
IKAROS family zinc finger 4 (Eos)
Alias_symbol (synonym)Eos
Other aliasEOS
HGNC (Hugo) IKZF4
LocusID (NCBI) 64375
Atlas_Id 64585
Location 12q13.2  [Link to chromosome band 12q13]
Location_base_pair Starts at 56020905 and ends at 56038435 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)IKZF4   13179
Cards
Entrez_Gene (NCBI)IKZF4  64375  IKAROS family zinc finger 4
AliasesEOS; ZNFN1A4
GeneCards (Weizmann)IKZF4
Ensembl hg19 (Hinxton)ENSG00000123411 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000123411 [Gene_View]  chr12:56020905-56038435 [Contig_View]  IKZF4 [Vega]
ICGC DataPortalENSG00000123411
TCGA cBioPortalIKZF4
AceView (NCBI)IKZF4
Genatlas (Paris)IKZF4
WikiGenes64375
SOURCE (Princeton)IKZF4
Genetics Home Reference (NIH)IKZF4
Genomic and cartography
GoldenPath hg38 (UCSC)IKZF4  -     chr12:56020905-56038435 +  12q13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)IKZF4  -     12q13.2   [Description]    (hg19-Feb_2009)
EnsemblIKZF4 - 12q13.2 [CytoView hg19]  IKZF4 - 12q13.2 [CytoView hg38]
Mapping of homologs : NCBIIKZF4 [Mapview hg19]  IKZF4 [Mapview hg38]
OMIM606239   
Gene and transcription
Genbank (Entrez)AB058685 AF230809 AK055063 AK122880 AK314543
RefSeq transcript (Entrez)NM_001351089 NM_001351090 NM_001351091 NM_001351092 NM_022465
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)IKZF4
Cluster EST : UnigeneHs.553221 [ NCBI ]
CGAP (NCI)Hs.553221
Alternative Splicing GalleryENSG00000123411
Gene ExpressionIKZF4 [ NCBI-GEO ]   IKZF4 [ EBI - ARRAY_EXPRESS ]   IKZF4 [ SEEK ]   IKZF4 [ MEM ]
Gene Expression Viewer (FireBrowse)IKZF4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)64375
GTEX Portal (Tissue expression)IKZF4
Human Protein AtlasENSG00000123411-IKZF4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9H2S9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9H2S9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9H2S9
Splice isoforms : SwissVarQ9H2S9
PhosPhoSitePlusQ9H2S9
Domaine pattern : Prosite (Expaxy)ZINC_FINGER_C2H2_1 (PS00028)    ZINC_FINGER_C2H2_2 (PS50157)   
Domains : Interpro (EBI)Znf_C2H2    Znf_C2H2-like    Znf_C2H2/integrase_DNA-bd   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Domain families : Smart (EMBL)ZnF_C2H2 (SM00355)  
Conserved Domain (NCBI)IKZF4
DMDM Disease mutations64375
Blocks (Seattle)IKZF4
PDB (SRS)2MA7   
PDB (PDBSum)2MA7   
PDB (IMB)2MA7   
PDB (RSDB)2MA7   
Structural Biology KnowledgeBase2MA7   
SCOP (Structural Classification of Proteins)2MA7   
CATH (Classification of proteins structures)2MA7   
SuperfamilyQ9H2S9
Human Protein Atlas [tissue]ENSG00000123411-IKZF4 [tissue]
Peptide AtlasQ9H2S9
HPRD05874
IPIIPI00064241   IPI00797730   IPI01022246   IPI01022084   IPI01025994   IPI01022621   
Protein Interaction databases
DIP (DOE-UCLA)Q9H2S9
IntAct (EBI)Q9H2S9
FunCoupENSG00000123411
BioGRIDIKZF4
STRING (EMBL)IKZF4
ZODIACIKZF4
Ontologies - Pathways
QuickGOQ9H2S9
Ontology : AmiGOtranscription factor activity, sequence-specific DNA binding  nucleus  nucleoplasm  transcription, DNA-templated  zinc ion binding  nuclear body  protein domain specific binding  protein homodimerization activity  protein complex  bHLH transcription factor binding  sequence-specific DNA binding  transcription regulatory region DNA binding  negative regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  protein heterodimerization activity  protein homooligomerization  protein heterooligomerization  
Ontology : EGO-EBItranscription factor activity, sequence-specific DNA binding  nucleus  nucleoplasm  transcription, DNA-templated  zinc ion binding  nuclear body  protein domain specific binding  protein homodimerization activity  protein complex  bHLH transcription factor binding  sequence-specific DNA binding  transcription regulatory region DNA binding  negative regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  protein heterodimerization activity  protein homooligomerization  protein heterooligomerization  
NDEx NetworkIKZF4
Atlas of Cancer Signalling NetworkIKZF4
Wikipedia pathwaysIKZF4
Orthology - Evolution
OrthoDB64375
GeneTree (enSembl)ENSG00000123411
Phylogenetic Trees/Animal Genes : TreeFamIKZF4
HOVERGENQ9H2S9
HOGENOMQ9H2S9
Homologs : HomoloGeneIKZF4
Homology/Alignments : Family Browser (UCSC)IKZF4
Gene fusions - Rearrangements
Tumor Fusion PortalIKZF4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIKZF4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IKZF4
dbVarIKZF4
ClinVarIKZF4
1000_GenomesIKZF4 
Exome Variant ServerIKZF4
ExAC (Exome Aggregation Consortium)ENSG00000123411
GNOMAD BrowserENSG00000123411
Genetic variants : HAPMAP64375
Genomic Variants (DGV)IKZF4 [DGVbeta]
DECIPHERIKZF4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisIKZF4 
Mutations
ICGC Data PortalIKZF4 
TCGA Data PortalIKZF4 
Broad Tumor PortalIKZF4
OASIS PortalIKZF4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIKZF4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDIKZF4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch IKZF4
DgiDB (Drug Gene Interaction Database)IKZF4
DoCM (Curated mutations)IKZF4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)IKZF4 (select a term)
intoGenIKZF4
Cancer3DIKZF4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606239   
Orphanet
DisGeNETIKZF4
MedgenIKZF4
Genetic Testing Registry IKZF4
NextProtQ9H2S9 [Medical]
TSGene64375
GENETestsIKZF4
Target ValidationIKZF4
Huge Navigator IKZF4 [HugePedia]
snp3D : Map Gene to Disease64375
BioCentury BCIQIKZF4
ClinGenIKZF4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD64375
Chemical/Pharm GKB GenePA162391948
Clinical trialIKZF4
Miscellaneous
canSAR (ICR)IKZF4 (select the gene name)
Probes
Litterature
PubMed19 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineIKZF4
EVEXIKZF4
GoPubMedIKZF4
iHOPIKZF4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 13:26:17 CET 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.