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IL10RB (interleukin 10 receptor subunit beta)

Identity

Alias_namesCRFB4
D21S58
D21S66
interleukin 10 receptor
Alias_symbol (synonym)CRF2-4
CDW210B
IL-10R2
Other alias
HGNC (Hugo) IL10RB
LocusID (NCBI) 3588
Atlas_Id 53793
Location 21q22.11  [Link to chromosome band 21q22]
Location_base_pair Starts at 33266360 and ends at 33297234 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
GOLT1A (1q32.1) / IL10RB (21q22.11)HIST1H3B (6p22.2) / IL10RB (21q22.11)IL10RB (21q22.11) / AFF1 (4q21.3)
RAB7A (3q21.3) / IL10RB (21q22.11)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)IL10RB   5965
LRG (Locus Reference Genomic)LRG_152
Cards
Entrez_Gene (NCBI)IL10RB  3588  interleukin 10 receptor subunit beta
AliasesCDW210B; CRF2-4; CRFB4; D21S58; 
D21S66; IL-10R2
GeneCards (Weizmann)IL10RB
Ensembl hg19 (Hinxton)ENSG00000243646 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000243646 [Gene_View]  chr21:33266360-33297234 [Contig_View]  IL10RB [Vega]
ICGC DataPortalENSG00000243646
TCGA cBioPortalIL10RB
AceView (NCBI)IL10RB
Genatlas (Paris)IL10RB
WikiGenes3588
SOURCE (Princeton)IL10RB
Genetics Home Reference (NIH)IL10RB
Genomic and cartography
GoldenPath hg38 (UCSC)IL10RB  -     chr21:33266360-33297234 +  21q22.11   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)IL10RB  -     21q22.11   [Description]    (hg19-Feb_2009)
EnsemblIL10RB - 21q22.11 [CytoView hg19]  IL10RB - 21q22.11 [CytoView hg38]
Mapping of homologs : NCBIIL10RB [Mapview hg19]  IL10RB [Mapview hg38]
OMIM123889   610424   612567   
Gene and transcription
Genbank (Entrez)AI025402 AK124057 AK299961 AK313348 AU133530
RefSeq transcript (Entrez)NM_000628
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)IL10RB
Cluster EST : UnigeneHs.654593 [ NCBI ]
CGAP (NCI)Hs.654593
Alternative Splicing GalleryENSG00000243646
Gene ExpressionIL10RB [ NCBI-GEO ]   IL10RB [ EBI - ARRAY_EXPRESS ]   IL10RB [ SEEK ]   IL10RB [ MEM ]
Gene Expression Viewer (FireBrowse)IL10RB [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3588
GTEX Portal (Tissue expression)IL10RB
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ08334   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ08334  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ08334
Splice isoforms : SwissVarQ08334
PhosPhoSitePlusQ08334
Domaine pattern : Prosite (Expaxy)FN3 (PS50853)   
Domains : Interpro (EBI)FN3_dom    Ig-like_fold    Interferon/interleukin_rcp_dom   
Domain families : Pfam (Sanger)Interfer-bind (PF09294)    Tissue_fac (PF01108)   
Domain families : Pfam (NCBI)pfam09294    pfam01108   
Conserved Domain (NCBI)IL10RB
DMDM Disease mutations3588
Blocks (Seattle)IL10RB
PDB (SRS)3LQM   
PDB (PDBSum)3LQM   
PDB (IMB)3LQM   
PDB (RSDB)3LQM   
Structural Biology KnowledgeBase3LQM   
SCOP (Structural Classification of Proteins)3LQM   
CATH (Classification of proteins structures)3LQM   
SuperfamilyQ08334
Human Protein AtlasENSG00000243646
Peptide AtlasQ08334
HPRD00473
IPIIPI01014391   IPI00646217   IPI00893917   IPI00892611   
Protein Interaction databases
DIP (DOE-UCLA)Q08334
IntAct (EBI)Q08334
FunCoupENSG00000243646
BioGRIDIL10RB
STRING (EMBL)IL10RB
ZODIACIL10RB
Ontologies - Pathways
QuickGOQ08334
Ontology : AmiGOreceptor activity  interleukin-10 receptor activity  protein binding  plasma membrane  plasma membrane  inflammatory response  immune response  signal transduction  integral component of membrane  cytokine-mediated signaling pathway  interleukin-28 receptor complex  defense response to virus  extracellular exosome  
Ontology : EGO-EBIreceptor activity  interleukin-10 receptor activity  protein binding  plasma membrane  plasma membrane  inflammatory response  immune response  signal transduction  integral component of membrane  cytokine-mediated signaling pathway  interleukin-28 receptor complex  defense response to virus  extracellular exosome  
Pathways : BIOCARTAIL-10 Anti-inflammatory Signaling Pathway [Genes]   
Pathways : KEGGCytokine-cytokine receptor interaction    Jak-STAT signaling pathway    Toxoplasmosis    Tuberculosis    Epstein-Barr virus infection   
NDEx NetworkIL10RB
Atlas of Cancer Signalling NetworkIL10RB
Wikipedia pathwaysIL10RB
Orthology - Evolution
OrthoDB3588
GeneTree (enSembl)ENSG00000243646
Phylogenetic Trees/Animal Genes : TreeFamIL10RB
HOVERGENQ08334
HOGENOMQ08334
Homologs : HomoloGeneIL10RB
Homology/Alignments : Family Browser (UCSC)IL10RB
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIL10RB [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IL10RB
dbVarIL10RB
ClinVarIL10RB
1000_GenomesIL10RB 
Exome Variant ServerIL10RB
ExAC (Exome Aggregation Consortium)IL10RB (select the gene name)
Genetic variants : HAPMAP3588
Genomic Variants (DGV)IL10RB [DGVbeta]
DECIPHERIL10RB [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisIL10RB 
Mutations
ICGC Data PortalIL10RB 
TCGA Data PortalIL10RB 
Broad Tumor PortalIL10RB
OASIS PortalIL10RB [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIL10RB  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDIL10RB
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)**PUBLIC** CCHMC Molecular Genetics Laboratory Mutation Database
BioMutasearch IL10RB
DgiDB (Drug Gene Interaction Database)IL10RB
DoCM (Curated mutations)IL10RB (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)IL10RB (select a term)
intoGenIL10RB
Cancer3DIL10RB(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM123889    610424    612567   
Orphanet19277   
MedgenIL10RB
Genetic Testing Registry IL10RB
NextProtQ08334 [Medical]
TSGene3588
GENETestsIL10RB
Target ValidationIL10RB
Huge Navigator IL10RB [HugePedia]
snp3D : Map Gene to Disease3588
BioCentury BCIQIL10RB
ClinGenIL10RB
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3588
Chemical/Pharm GKB GenePA29780
Clinical trialIL10RB
Miscellaneous
canSAR (ICR)IL10RB (select the gene name)
Probes
Litterature
PubMed73 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineIL10RB
EVEXIL10RB
GoPubMedIL10RB
iHOPIL10RB
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 17:03:52 CEST 2017

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