Atlas of Genetics and Cytogenetics in Oncology and Haematology


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IL10RB (interleukin 10 receptor subunit beta)

Identity

Alias (NCBI)CDW210B
CRF2-4
CRFB4
D21S58
D21S66
IL-10R2
HGNC (Hugo) IL10RB
HGNC Alias symbCRF2-4
CDW210B
IL-10R2
HGNC Previous nameCRFB4
 D21S58
 D21S66
HGNC Previous nameinterleukin 10 receptor, beta
LocusID (NCBI) 3588
Atlas_Id 53793
Location 21q22.11  [Link to chromosome band 21q22]
Location_base_pair Starts at 33266367 and ends at 33297221 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
GOLT1A (1q32.1) / IL10RB (21q22.11)HIST1H3B (6p22.2) / IL10RB (21q22.11)IL10RB (21q22.11) / AFF1 (4q21.3)
RAB7A (3q21.3) / IL10RB (21q22.11)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)IL10RB   5965
LRG (Locus Reference Genomic)LRG_152
Cards
Entrez_Gene (NCBI)IL10RB    interleukin 10 receptor subunit beta
AliasesCDW210B; CRF2-4; CRFB4; D21S58; 
D21S66; IL-10R2
GeneCards (Weizmann)IL10RB
Ensembl hg19 (Hinxton)ENSG00000243646 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000243646 [Gene_View]  ENSG00000243646 [Sequence]  chr21:33266367-33297221 [Contig_View]  IL10RB [Vega]
ICGC DataPortalENSG00000243646
TCGA cBioPortalIL10RB
AceView (NCBI)IL10RB
Genatlas (Paris)IL10RB
SOURCE (Princeton)IL10RB
Genetics Home Reference (NIH)IL10RB
Genomic and cartography
GoldenPath hg38 (UCSC)IL10RB  -     chr21:33266367-33297221 +  21q22.11   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)IL10RB  -     21q22.11   [Description]    (hg19-Feb_2009)
GoldenPathIL10RB - 21q22.11 [CytoView hg19]  IL10RB - 21q22.11 [CytoView hg38]
ImmunoBaseENSG00000243646
Genome Data Viewer NCBIIL10RB [Mapview hg19]  
OMIM123889   610424   612567   
Gene and transcription
Genbank (Entrez)AI025402 AK124057 AK299961 AK313348 AU133530
RefSeq transcript (Entrez)NM_000628
Consensus coding sequences : CCDS (NCBI)IL10RB
Gene ExpressionIL10RB [ NCBI-GEO ]   IL10RB [ EBI - ARRAY_EXPRESS ]   IL10RB [ SEEK ]   IL10RB [ MEM ]
Gene Expression Viewer (FireBrowse)IL10RB [ Firebrowse - Broad ]
GenevisibleExpression of IL10RB in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3588
GTEX Portal (Tissue expression)IL10RB
Human Protein AtlasENSG00000243646-IL10RB [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ08334   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ08334  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ08334
PhosPhoSitePlusQ08334
Domaine pattern : Prosite (Expaxy)FN3 (PS50853)   
Domains : Interpro (EBI)FN3_dom    FN3_sf    Ig-like_fold    Interferon/interleukin_rcp_dom   
Domain families : Pfam (Sanger)Interfer-bind (PF09294)    Tissue_fac (PF01108)   
Domain families : Pfam (NCBI)pfam09294    pfam01108   
Conserved Domain (NCBI)IL10RB
PDB (RSDB)3LQM    5T5W   
PDB Europe3LQM    5T5W   
PDB (PDBSum)3LQM    5T5W   
PDB (IMB)3LQM    5T5W   
Structural Biology KnowledgeBase3LQM    5T5W   
SCOP (Structural Classification of Proteins)3LQM    5T5W   
CATH (Classification of proteins structures)3LQM    5T5W   
SuperfamilyQ08334
AlphaFold pdb e-kbQ08334   
Human Protein Atlas [tissue]ENSG00000243646-IL10RB [tissue]
HPRD00473
Protein Interaction databases
DIP (DOE-UCLA)Q08334
IntAct (EBI)Q08334
BioGRIDIL10RB
STRING (EMBL)IL10RB
ZODIACIL10RB
Ontologies - Pathways
QuickGOQ08334
Ontology : AmiGOcytokine receptor activity  interleukin-10 receptor activity  interleukin-10 receptor activity  protein binding  plasma membrane  plasma membrane  inflammatory response  immune response  signal transduction  integral component of membrane  cytokine-mediated signaling pathway  cytokine-mediated signaling pathway  interleukin-28 receptor complex  signaling receptor activity  positive regulation of receptor signaling pathway via JAK-STAT  defense response to virus  positive regulation of cellular respiration  
Ontology : EGO-EBIcytokine receptor activity  interleukin-10 receptor activity  interleukin-10 receptor activity  protein binding  plasma membrane  plasma membrane  inflammatory response  immune response  signal transduction  integral component of membrane  cytokine-mediated signaling pathway  cytokine-mediated signaling pathway  interleukin-28 receptor complex  signaling receptor activity  positive regulation of receptor signaling pathway via JAK-STAT  defense response to virus  positive regulation of cellular respiration  
Pathways : BIOCARTAIL-10 Anti-inflammatory Signaling Pathway [Genes]   
Pathways : KEGGCytokine-cytokine receptor interaction    Jak-STAT signaling pathway    Toxoplasmosis    Tuberculosis    Epstein-Barr virus infection   
NDEx NetworkIL10RB
Atlas of Cancer Signalling NetworkIL10RB
Wikipedia pathwaysIL10RB
Orthology - Evolution
OrthoDB3588
GeneTree (enSembl)ENSG00000243646
Phylogenetic Trees/Animal Genes : TreeFamIL10RB
Homologs : HomoloGeneIL10RB
Homology/Alignments : Family Browser (UCSC)IL10RB
Gene fusions - Rearrangements
Fusion : QuiverIL10RB
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIL10RB [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IL10RB
dbVarIL10RB
ClinVarIL10RB
MonarchIL10RB
1000_GenomesIL10RB 
Exome Variant ServerIL10RB
GNOMAD BrowserENSG00000243646
Varsome BrowserIL10RB
ACMGIL10RB variants
VarityQ08334
Genomic Variants (DGV)IL10RB [DGVbeta]
DECIPHERIL10RB [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisIL10RB 
Mutations
ICGC Data PortalIL10RB 
TCGA Data PortalIL10RB 
Broad Tumor PortalIL10RB
OASIS PortalIL10RB [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIL10RB  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DIL10RB
Mutations and Diseases : HGMDIL10RB
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaIL10RB
DgiDB (Drug Gene Interaction Database)IL10RB
DoCM (Curated mutations)IL10RB
CIViC (Clinical Interpretations of Variants in Cancer)IL10RB
Cancer3DIL10RB
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM123889    610424    612567   
Orphanet19277   
DisGeNETIL10RB
MedgenIL10RB
Genetic Testing Registry IL10RB
NextProtQ08334 [Medical]
GENETestsIL10RB
Target ValidationIL10RB
Huge Navigator IL10RB [HugePedia]
ClinGenIL10RB
Clinical trials, drugs, therapy
MyCancerGenomeIL10RB
Protein Interactions : CTDIL10RB
Pharm GKB GenePA29780
Pharm GKB PathwaysPA166126086   
PharosQ08334
Clinical trialIL10RB
Miscellaneous
canSAR (ICR)IL10RB
HarmonizomeIL10RB
DataMed IndexIL10RB
Probes
Litterature
PubMed87 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXIL10RB
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 15:13:41 CEST 2021

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