IL12A (interleukin 12A)

2003-08-01  

Identity

HGNC
LOCATION
3q25.33
LOCUSID
ALIAS
CLMF,IL-12A,NFSK,NKSF1,P35

Other Information

Locus ID:

NCBI: 3592
MIM: 161560
HGNC: 5969
Ensembl: ENSG00000168811

Variants:

dbSNP: 3592
ClinVar: 3592
TCGA: ENSG00000168811
COSMIC: IL12A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000168811ENST00000305579P29459
ENSG00000168811ENST00000305579O60595
ENSG00000168811ENST00000466512E9PGR3
ENSG00000168811ENST00000480787E7ENE1

Expression (GTEx)

0
1
2
3
4
5
6
7
8

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Toll-like receptor signaling pathwayKEGGko04620
Jak-STAT signaling pathwayKEGGko04630
Type I diabetes mellitusKEGGko04940
Allograft rejectionKEGGko05330
Cytokine-cytokine receptor interactionKEGGhsa04060
Toll-like receptor signaling pathwayKEGGhsa04620
Jak-STAT signaling pathwayKEGGhsa04630
Type I diabetes mellitusKEGGhsa04940
Allograft rejectionKEGGhsa05330
RIG-I-like receptor signaling pathwayKEGGko04622
RIG-I-like receptor signaling pathwayKEGGhsa04622
LeishmaniasisKEGGko05140
LeishmaniasisKEGGhsa05140
Chagas disease (American trypanosomiasis)KEGGko05142
Chagas disease (American trypanosomiasis)KEGGhsa05142
MalariaKEGGko05144
MalariaKEGGhsa05144
AmoebiasisKEGGko05146
AmoebiasisKEGGhsa05146
ToxoplasmosisKEGGko05145
ToxoplasmosisKEGGhsa05145
African trypanosomiasisKEGGko05143
African trypanosomiasisKEGGhsa05143
MeaslesKEGGko05162
MeaslesKEGGhsa05162
TuberculosisKEGGko05152
TuberculosisKEGGhsa05152
Influenza AKEGGko05164
Influenza AKEGGhsa05164
PertussisKEGGko05133
PertussisKEGGhsa05133
Herpes simplex infectionKEGGko05168
Herpes simplex infectionKEGGhsa05168
LegionellosisKEGGko05134
LegionellosisKEGGhsa05134
Inflammatory bowel disease (IBD)KEGGhsa05321
Inflammatory bowel disease (IBD)KEGGko05321
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Interleukin-6 family signalingREACTOMER-HSA-6783589
IL-6-type cytokine receptor ligand interactionsREACTOMER-HSA-6788467
Interleukin-12 signalingREACTOMER-HSA-447115
Th1 and Th2 cell differentiationKEGGko04658
Th1 and Th2 cell differentiationKEGGhsa04658
Interleukin-4 and 13 signalingREACTOMER-HSA-6785807
Interleukin-10 signalingREACTOMER-HSA-6783783

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA165817016Kidney TransplantationDiseaseClinicalAnnotationassociatedPD21107304
PA166048654ustekinumabChemicalLabelAnnotationassociated
PA450566mycophenolate mofetilChemicalClinicalAnnotationassociatedPD21107304

References

Pubmed IDYearTitleCitations
172361322007A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes.285
190739672008Shared and distinct genetic variants in type 1 diabetes and celiac disease.249
183111402008Newly identified genetic risk variants for celiac disease related to the immune response.231
254468962014Macrophage IL-10 blocks CD8+ T cell-dependent responses to chemotherapy by suppressing IL-12 expression in intratumoral dendritic cells.195
194583522009Primary biliary cirrhosis associated with HLA, IL12A, and IL12RB2 variants.183
194583522009Primary biliary cirrhosis associated with HLA, IL12A, and IL12RB2 variants.183
206398802010Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis.124
177034122007Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.100
271111452016IL-1β, IL-4 and IL-12 control the fate of group 2 innate lymphoid cells in human airway inflammation in the lungs.100
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85

Citation

Dessen P

IL12A (interleukin 12A)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/40940/il12a