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IL12B (interleukin 12B)

Identity

Other namesCLMF
CLMF2
IL-12B
NKSF
NKSF2
HGNC (Hugo) IL12B
LocusID (NCBI) 3593
Location 5q33.3
Location_base_pair Starts at 158741791 and ends at 158757481 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)IL12B   5970
Cards
Entrez_Gene (NCBI)IL12B  3593  interleukin 12B
GeneCards (Weizmann)IL12B
Ensembl hg19 (Hinxton)ENSG00000113302 [Gene_View]  chr5:158741791-158757481 [Contig_View]  IL12B [Vega]
Ensembl hg38 (Hinxton)ENSG00000113302 [Gene_View]  chr5:158741791-158757481 [Contig_View]  IL12B [Vega]
ICGC DataPortalENSG00000113302
cBioPortalIL12B
AceView (NCBI)IL12B
Genatlas (Paris)IL12B
WikiGenes3593
SOURCE (Princeton)IL12B
Genomic and cartography
GoldenPath hg19 (UCSC)IL12B  -     chr5:158741791-158757481 -  5q33.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)IL12B  -     5q33.3   [Description]    (hg38-Dec_2013)
EnsemblIL12B - 5q33.3 [CytoView hg19]  IL12B - 5q33.3 [CytoView hg38]
Mapping of homologs : NCBIIL12B [Mapview hg19]  IL12B [Mapview hg38]
OMIM161561   209950   600807   
Gene and transcription
Genbank (Entrez)AF180563 AY046592 AY046593 BC067498 BC067499
RefSeq transcript (Entrez)NM_002187
RefSeq genomic (Entrez)AC_000137 NC_000005 NC_018916 NG_009618 NT_023133 NW_001838954 NW_004929325
Consensus coding sequences : CCDS (NCBI)IL12B
Cluster EST : UnigeneHs.674 [ NCBI ]
CGAP (NCI)Hs.674
Alternative Splicing : Fast-db (Paris)GSHG0025225
Alternative Splicing GalleryENSG00000113302
Gene ExpressionIL12B [ NCBI-GEO ]     IL12B [ SEEK ]   IL12B [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP29460 (Uniprot)
NextProtP29460  [Medical]
With graphics : InterProP29460
Splice isoforms : SwissVarP29460 (Swissvar)
Domaine pattern : Prosite (Expaxy)FN3 (PS50853)    HEMATOPO_REC_L_F3 (PS01354)    IG_LIKE (PS50835)   
Domains : Interpro (EBI)Fibronectin_type3    Hematopoietin_rcpt_L_F3_CS    Ig-like_dom    Ig-like_fold    Ig_sub2    IL-12_beta    IL-12_beta_cen-dom   
Related proteins : CluSTrP29460
Domain families : Pfam (Sanger)IL12p40_C (PF10420)   
Domain families : Pfam (NCBI)pfam10420   
Domain families : Smart (EMBL)IGc2 (SM00408)  
DMDM Disease mutations3593
Blocks (Seattle)P29460
PDB (SRS)1F42    1F45    3D85    3D87    3DUH    3HMX    3QWR    4GRW   
PDB (PDBSum)1F42    1F45    3D85    3D87    3DUH    3HMX    3QWR    4GRW   
PDB (IMB)1F42    1F45    3D85    3D87    3DUH    3HMX    3QWR    4GRW   
PDB (RSDB)1F42    1F45    3D85    3D87    3DUH    3HMX    3QWR    4GRW   
Human Protein AtlasENSG00000113302
Peptide AtlasP29460
HPRD01194
IPIIPI00021798   
Protein Interaction databases
DIP (DOE-UCLA)P29460
IntAct (EBI)P29460
FunCoupENSG00000113302
BioGRIDIL12B
IntegromeDBIL12B
STRING (EMBL)IL12B
Ontologies - Pathways
QuickGOP29460
Ontology : AmiGOpositive regulation of T cell mediated cytotoxicity  positive regulation of defense response to virus by host  positive regulation of defense response to virus by host  natural killer cell activation involved in immune response  positive regulation of T-helper 1 type immune response  positive regulation of T-helper 1 type immune response  positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target  negative regulation of inflammatory response to antigenic stimulus  cytokine receptor activity  cytokine activity  interleukin-12 receptor binding  interleukin-12 receptor binding  protein binding  extracellular space  cytoplasm  cell cycle arrest  growth factor activity  response to UV-B  positive regulation of activation of JAK2 kinase activity  membrane  cell migration  cytokine-mediated signaling pathway  sensory perception of pain  sexual reproduction  natural killer cell activation  negative regulation of interleukin-10 production  negative regulation of interleukin-17 production  positive regulation of granulocyte macrophage colony-stimulating factor production  positive regulation of interferon-gamma production  positive regulation of interleukin-10 production  positive regulation of interleukin-10 production  positive regulation of interleukin-12 production  positive regulation of interleukin-17 production  positive regulation of tumor necrosis factor production  positive regulation of natural killer cell activation  positive regulation of natural killer cell activation  positive regulation of natural killer cell proliferation  positive regulation of mononuclear cell proliferation  positive regulation of tissue remodeling  positive regulation of smooth muscle cell apoptotic process  regulation of cytokine biosynthetic process  T-helper 1 type immune response  T-helper cell differentiation  interferon-gamma biosynthetic process  positive regulation of T cell proliferation  positive regulation of activated T cell proliferation  interleukin-12 alpha subunit binding  positive regulation of NF-kappaB import into nucleus  regulation of tyrosine phosphorylation of Stat1 protein  positive regulation of tyrosine phosphorylation of Stat3 protein  positive regulation of tyrosine phosphorylation of Stat4 protein  positive regulation of tyrosine phosphorylation of Stat5 protein  identical protein binding  protein homodimerization activity  defense response to protozoan  positive regulation of memory T cell differentiation  interleukin-12 complex  negative regulation of growth of symbiont in host  positive regulation of interferon-gamma biosynthetic process  interleukin-23 receptor binding  positive regulation of osteoclast differentiation  positive regulation of cell adhesion  protein heterodimerization activity  negative regulation of smooth muscle cell proliferation  positive regulation of lymphocyte proliferation  positive regulation of inflammatory response  defense response to Gram-negative bacterium  positive regulation of NK T cell activation  positive regulation of NK T cell activation  positive regulation of NK T cell proliferation  defense response to virus  interleukin-23 complex  cellular response to lipopolysaccharide  cellular response to interferon-gamma  positive regulation of T-helper 17 type immune response  positive regulation of T-helper 17 cell lineage commitment  
Ontology : EGO-EBIpositive regulation of T cell mediated cytotoxicity  positive regulation of defense response to virus by host  positive regulation of defense response to virus by host  natural killer cell activation involved in immune response  positive regulation of T-helper 1 type immune response  positive regulation of T-helper 1 type immune response  positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target  negative regulation of inflammatory response to antigenic stimulus  cytokine receptor activity  cytokine activity  interleukin-12 receptor binding  interleukin-12 receptor binding  protein binding  extracellular space  cytoplasm  cell cycle arrest  growth factor activity  response to UV-B  positive regulation of activation of JAK2 kinase activity  membrane  cell migration  cytokine-mediated signaling pathway  sensory perception of pain  sexual reproduction  natural killer cell activation  negative regulation of interleukin-10 production  negative regulation of interleukin-17 production  positive regulation of granulocyte macrophage colony-stimulating factor production  positive regulation of interferon-gamma production  positive regulation of interleukin-10 production  positive regulation of interleukin-10 production  positive regulation of interleukin-12 production  positive regulation of interleukin-17 production  positive regulation of tumor necrosis factor production  positive regulation of natural killer cell activation  positive regulation of natural killer cell activation  positive regulation of natural killer cell proliferation  positive regulation of mononuclear cell proliferation  positive regulation of tissue remodeling  positive regulation of smooth muscle cell apoptotic process  regulation of cytokine biosynthetic process  T-helper 1 type immune response  T-helper cell differentiation  interferon-gamma biosynthetic process  positive regulation of T cell proliferation  positive regulation of activated T cell proliferation  interleukin-12 alpha subunit binding  positive regulation of NF-kappaB import into nucleus  regulation of tyrosine phosphorylation of Stat1 protein  positive regulation of tyrosine phosphorylation of Stat3 protein  positive regulation of tyrosine phosphorylation of Stat4 protein  positive regulation of tyrosine phosphorylation of Stat5 protein  identical protein binding  protein homodimerization activity  defense response to protozoan  positive regulation of memory T cell differentiation  interleukin-12 complex  negative regulation of growth of symbiont in host  positive regulation of interferon-gamma biosynthetic process  interleukin-23 receptor binding  positive regulation of osteoclast differentiation  positive regulation of cell adhesion  protein heterodimerization activity  negative regulation of smooth muscle cell proliferation  positive regulation of lymphocyte proliferation  positive regulation of inflammatory response  defense response to Gram-negative bacterium  positive regulation of NK T cell activation  positive regulation of NK T cell activation  positive regulation of NK T cell proliferation  defense response to virus  interleukin-23 complex  cellular response to lipopolysaccharide  cellular response to interferon-gamma  positive regulation of T-helper 17 type immune response  positive regulation of T-helper 17 cell lineage commitment  
Pathways : BIOCARTATh1/Th2 Differentiation [Genes]   
Pathways : KEGGCytokine-cytokine receptor interaction    Toll-like receptor signaling pathway    RIG-I-like receptor signaling pathway    Jak-STAT signaling pathway    Type I diabetes mellitus    Pertussis    Legionellosis    Leishmaniasis    Chagas disease (American trypanosomiasis)    African trypanosomiasis    Toxoplasmosis    Amoebiasis    Tuberculosis    Measles    Influenza A    Herpes simplex infection    Proteoglycans in cancer    Inflammatory bowel disease (IBD)    Allograft rejection   
Protein Interaction DatabaseIL12B
DoCM (Curated mutations)IL12B
Wikipedia pathwaysIL12B
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerIL12B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IL12B
dbVarIL12B
ClinVarIL12B
1000_GenomesIL12B 
Exome Variant ServerIL12B
SNP (GeneSNP Utah)IL12B
SNP : HGBaseIL12B
Genetic variants : HAPMAPIL12B
Genomic VariantsIL12B  IL12B [DGVbeta]
Mutations
ICGC Data PortalENSG00000113302 
Somatic Mutations in Cancer : COSMICIL12B 
CONAN: Copy Number AnalysisIL12B 
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)Mendelian genes
LOVD (Leiden Open Variation Database)**PUBLIC** CCHMC Molecular Genetics Laboratory Mutation Database
LOVD (Leiden Open Variation Database)TBsLVD Tuberculosis susceptibility Locus Variation Database
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)5:158741791-158757481
Mutations and Diseases : HGMDIL12B
OMIM161561    209950    600807   
MedgenIL12B
NextProtP29460 [Medical]
GENETestsIL12B
Disease Genetic AssociationIL12B
Huge Navigator IL12B [HugePedia]  IL12B [HugeCancerGEM]
snp3D : Map Gene to Disease3593
DGIdb (Drug Gene Interaction db)IL12B
General knowledge
Homologs : HomoloGeneIL12B
Homology/Alignments : Family Browser (UCSC)IL12B
Phylogenetic Trees/Animal Genes : TreeFamIL12B
Chemical/Protein Interactions : CTD3593
Chemical/Pharm GKB GenePA29785
Clinical trialIL12B
Cancer Resource (Charite)ENSG00000113302
Other databases
Probes
Litterature
PubMed406 Pubmed reference(s) in Entrez
CoreMineIL12B
GoPubMedIL12B
iHOPIL12B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2014Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Dec 20 22:08:50 CET 2014

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