Atlas of Genetics and Cytogenetics in Oncology and Haematology


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IL12RB2 (interleukin 12 receptor subunit beta 2)

Identity

Alias_namesinterleukin 12 receptor
Other alias-
HGNC (Hugo) IL12RB2
LocusID (NCBI) 3595
Atlas_Id 45862
Location 1p31.3  [Link to chromosome band 1p31]
Location_base_pair Starts at 67307364 and ends at 67396900 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
IL12RB2 (1p31.3) / ANKRD11 (16q24.3)IL12RB2 (1p31.3) / DAB1 (1p32.2)IL12RB2 (1p31.3) / PDE4B (1p31.3)
IL12RB2 1p31.3 / DAB1 1p32.2IL12RB2 1p31.3 / PDE4B 1p31.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)IL12RB2   5972
Cards
Entrez_Gene (NCBI)IL12RB2  3595  interleukin 12 receptor subunit beta 2
Aliases
GeneCards (Weizmann)IL12RB2
Ensembl hg19 (Hinxton)ENSG00000081985 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000081985 [Gene_View]  chr1:67307364-67396900 [Contig_View]  IL12RB2 [Vega]
ICGC DataPortalENSG00000081985
TCGA cBioPortalIL12RB2
AceView (NCBI)IL12RB2
Genatlas (Paris)IL12RB2
WikiGenes3595
SOURCE (Princeton)IL12RB2
Genetics Home Reference (NIH)IL12RB2
Genomic and cartography
GoldenPath hg38 (UCSC)IL12RB2  -     chr1:67307364-67396900 +  1p31.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)IL12RB2  -     1p31.3   [Description]    (hg19-Feb_2009)
EnsemblIL12RB2 - 1p31.3 [CytoView hg19]  IL12RB2 - 1p31.3 [CytoView hg38]
Mapping of homologs : NCBIIL12RB2 [Mapview hg19]  IL12RB2 [Mapview hg38]
OMIM601642   
Gene and transcription
Genbank (Entrez)AK294494 AK300020 AK310837 AK316525 BC104772
RefSeq transcript (Entrez)NM_001258214 NM_001258215 NM_001258216 NM_001319233 NM_001559
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)IL12RB2
Cluster EST : UnigeneHs.479347 [ NCBI ]
CGAP (NCI)Hs.479347
Alternative Splicing GalleryENSG00000081985
Gene ExpressionIL12RB2 [ NCBI-GEO ]   IL12RB2 [ EBI - ARRAY_EXPRESS ]   IL12RB2 [ SEEK ]   IL12RB2 [ MEM ]
Gene Expression Viewer (FireBrowse)IL12RB2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3595
GTEX Portal (Tissue expression)IL12RB2
Human Protein AtlasENSG00000081985-IL12RB2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ99665   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ99665  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ99665
Splice isoforms : SwissVarQ99665
PhosPhoSitePlusQ99665
Domaine pattern : Prosite (Expaxy)FN3 (PS50853)    HEMATOPO_REC_L_F2 (PS01353)   
Domains : Interpro (EBI)FN3_dom    Hematopoietin_rcpt_Gp130_CS    Ig-like_fold    IgC2-like_lig-bd   
Domain families : Pfam (Sanger)fn3 (PF00041)    Lep_receptor_Ig (PF06328)   
Domain families : Pfam (NCBI)pfam00041    pfam06328   
Domain families : Smart (EMBL)FN3 (SM00060)  
Conserved Domain (NCBI)IL12RB2
DMDM Disease mutations3595
Blocks (Seattle)IL12RB2
SuperfamilyQ99665
Human Protein Atlas [tissue]ENSG00000081985-IL12RB2 [tissue]
Peptide AtlasQ99665
HPRD03383
IPIIPI00438855   IPI00438856   IPI01011400   IPI00479253   
Protein Interaction databases
DIP (DOE-UCLA)Q99665
IntAct (EBI)Q99665
FunCoupENSG00000081985
BioGRIDIL12RB2
STRING (EMBL)IL12RB2
ZODIACIL12RB2
Ontologies - Pathways
QuickGOQ99665
Ontology : AmiGOcytokine receptor activity  plasma membrane  integral component of plasma membrane  cell surface receptor signaling pathway  positive regulation of cell proliferation  external side of plasma membrane  peptidyl-tyrosine phosphorylation  cytokine-mediated signaling pathway  protein kinase binding  response to lipopolysaccharide  interferon-gamma production  positive regulation of interferon-gamma production  
Ontology : EGO-EBIcytokine receptor activity  plasma membrane  integral component of plasma membrane  cell surface receptor signaling pathway  positive regulation of cell proliferation  external side of plasma membrane  peptidyl-tyrosine phosphorylation  cytokine-mediated signaling pathway  protein kinase binding  response to lipopolysaccharide  interferon-gamma production  positive regulation of interferon-gamma production  
Pathways : BIOCARTASelective expression of chemokine receptors during T-cell polarization [Genes]    IL12 and Stat4 Dependent Signaling Pathway in Th1 Development [Genes]    Th1/Th2 Differentiation [Genes]    NO2-dependent IL 12 Pathway in NK cells [Genes]   
Pathways : KEGGCytokine-cytokine receptor interaction    Jak-STAT signaling pathway    Inflammatory bowel disease (IBD)   
NDEx NetworkIL12RB2
Atlas of Cancer Signalling NetworkIL12RB2
Wikipedia pathwaysIL12RB2
Orthology - Evolution
OrthoDB3595
GeneTree (enSembl)ENSG00000081985
Phylogenetic Trees/Animal Genes : TreeFamIL12RB2
HOVERGENQ99665
HOGENOMQ99665
Homologs : HomoloGeneIL12RB2
Homology/Alignments : Family Browser (UCSC)IL12RB2
Gene fusions - Rearrangements
Fusion : MitelmanIL12RB2/DAB1 [1p31.3/1p32.2]  
Fusion : MitelmanIL12RB2/PDE4B [1p31.3/1p31.3]  [t(1;1)(p31;p31)]  
Fusion: TCGA_MDACCIL12RB2 1p31.3 DAB1 1p32.2 BRCA
Fusion: TCGA_MDACCIL12RB2 1p31.3 PDE4B 1p31.3 BRCA
Tumor Fusion PortalIL12RB2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIL12RB2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IL12RB2
dbVarIL12RB2
ClinVarIL12RB2
1000_GenomesIL12RB2 
Exome Variant ServerIL12RB2
ExAC (Exome Aggregation Consortium)ENSG00000081985
GNOMAD BrowserENSG00000081985
Genetic variants : HAPMAP3595
Genomic Variants (DGV)IL12RB2 [DGVbeta]
DECIPHERIL12RB2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisIL12RB2 
Mutations
ICGC Data PortalIL12RB2 
TCGA Data PortalIL12RB2 
Broad Tumor PortalIL12RB2
OASIS PortalIL12RB2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIL12RB2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDIL12RB2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Mendelian genes
BioMutasearch IL12RB2
DgiDB (Drug Gene Interaction Database)IL12RB2
DoCM (Curated mutations)IL12RB2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)IL12RB2 (select a term)
intoGenIL12RB2
Cancer3DIL12RB2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601642   
Orphanet703   
DisGeNETIL12RB2
MedgenIL12RB2
Genetic Testing Registry IL12RB2
NextProtQ99665 [Medical]
TSGene3595
GENETestsIL12RB2
Target ValidationIL12RB2
Huge Navigator IL12RB2 [HugePedia]
snp3D : Map Gene to Disease3595
BioCentury BCIQIL12RB2
ClinGenIL12RB2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3595
Chemical/Pharm GKB GenePA29787
Clinical trialIL12RB2
Miscellaneous
canSAR (ICR)IL12RB2 (select the gene name)
Probes
Litterature
PubMed83 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineIL12RB2
EVEXIL12RB2
GoPubMedIL12RB2
iHOPIL12RB2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:17:35 CET 2017

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