IL13 (interleukin 13)

2003-11-01  

Identity

HGNC
LOCATION
5q31.1
LOCUSID
ALIAS
IL-13,P600
FUSION GENES

Other Information

Locus ID:

NCBI: 3596
MIM: 147683
HGNC: 5973
Ensembl: ENSG00000169194

Variants:

dbSNP: 3596
ClinVar: 3596
TCGA: ENSG00000169194
COSMIC: IL13

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000169194ENST00000304506P35225
ENSG00000169194ENST00000617259A0A087WW07

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Jak-STAT signaling pathwayKEGGko04630
Fc epsilon RI signaling pathwayKEGGko04664
AsthmaKEGGko05310
Cytokine-cytokine receptor interactionKEGGhsa04060
Jak-STAT signaling pathwayKEGGhsa04630
Fc epsilon RI signaling pathwayKEGGhsa04664
AsthmaKEGGhsa05310
MeaslesKEGGko05162
MeaslesKEGGhsa05162
Inflammatory bowel disease (IBD)KEGGhsa05321
Inflammatory bowel disease (IBD)KEGGko05321
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Th1 and Th2 cell differentiationKEGGko04658
Th1 and Th2 cell differentiationKEGGhsa04658
Interleukin-4 and 13 signalingREACTOMER-HSA-6785807
Interleukin-10 signalingREACTOMER-HSA-6783783
IL-17 signaling pathwayKEGGko04657
IL-17 signaling pathwayKEGGhsa04657

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA162372840sunitinibChemicalClinicalAnnotationassociatedPD26387812
PA164712789Hepatitis vaccinesChemicalClinicalAnnotationassociatedPD21111021
PA443624Carcinoma, Renal CellDiseaseClinicalAnnotationassociatedPD26387812

References

Pubmed IDYearTitleCitations
191692542009Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways.410
163278022006IL-13 signaling through the IL-13alpha2 receptor is involved in induction of TGF-beta1 production and fibrosis.281
151462472004Nonclassical CD1d-restricted NK T cells that produce IL-13 characterize an atypical Th2 response in ulcerative colitis.237
176236482007Soluble ST2 blocks interleukin-33 signaling in allergic airway inflammation.158
182431012008Molecular and structural basis of cytokine receptor pleiotropy in the interleukin-4/13 system.158
180731242007IL-13 involvement in eosinophilic esophagitis: transcriptome analysis and reversibility with glucocorticoids.149
238107662013IL-33 is more potent than IL-25 in provoking IL-13-producing nuocytes (type 2 innate lymphoid cells) and airway contraction.131
179116232007IL-13 induces disease-promoting type 2 cytokines, alternatively activated macrophages and allergic inflammation during pulmonary infection of mice with Cryptococcus neoformans.127
201592422010Genome-wide association study of asthma identifies RAD50-IL13 and HLA-DR/DQ regions.112
201592422010Genome-wide association study of asthma identifies RAD50-IL13 and HLA-DR/DQ regions.112

Citation

Dessen P

IL13 (interleukin 13)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/40942/il13