Atlas of Genetics and Cytogenetics in Oncology and Haematology


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IL13 (interleukin 13)

Identity

Other namesIL-13
P600
HGNC (Hugo) IL13
LocusID (NCBI) 3596
Location 5q31.1
Location_base_pair Starts at 131993865 and ends at 131996801 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)IL13   5973
Cards
Entrez_Gene (NCBI)IL13  3596  interleukin 13
GeneCards (Weizmann)IL13
Ensembl (Hinxton)ENSG00000169194 [Gene_View]  chr5:131993865-131996801 [Contig_View]  IL13 [Vega]
ICGC DataPortalENSG00000169194
cBioPortalIL13
AceView (NCBI)IL13
Genatlas (Paris)IL13
WikiGenes3596
SOURCE (Princeton)NM_002188
Genomic and cartography
GoldenPath (UCSC)IL13  -  5q31.1   chr5:131993865-131996801 +  5q31.1   [Description]    (hg19-Feb_2009)
EnsemblIL13 - 5q31.1 [CytoView]
Mapping of homologs : NCBIIL13 [Mapview]
OMIM147683   600807   607154   
Gene and transcription
Genbank (Entrez)AF043334 BC096138 BC096139 BC096140 BC096141
RefSeq transcript (Entrez)NM_002188
RefSeq genomic (Entrez)AC_000137 NC_000005 NC_018916 NG_012090 NT_034772 NW_001838952 NW_004929323
Consensus coding sequences : CCDS (NCBI)IL13
Cluster EST : UnigeneHs.845 [ NCBI ]
CGAP (NCI)Hs.845
Alternative Splicing : Fast-db (Paris)GSHG0024229
Alternative Splicing GalleryENSG00000169194
Gene ExpressionIL13 [ NCBI-GEO ]     IL13 [ SEEK ]   IL13 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP35225 (Uniprot)
NextProtP35225  [Medical]
With graphics : InterProP35225
Splice isoforms : SwissVarP35225 (Swissvar)
Domaine pattern : Prosite (Expaxy)INTERLEUKIN_4_13 (PS00838)   
Domains : Interpro (EBI)4_helix_cytokine-like_core [organisation]   4_helix_cytokine_core [organisation]   IL-13 [organisation]   IL-4/IL-13 [organisation]   IL-4/IL-13_CS [organisation]  
Related proteins : CluSTrP35225
Domain families : Pfam (Sanger)IL13 (PF03487)   
Domain families : Pfam (NCBI)pfam03487   
Domain families : Smart (EMBL)IL4_13 (SM00190)  
DMDM Disease mutations3596
Blocks (Seattle)P35225
PDB (SRS)1GA3    1IJZ    1IK0    1J9U    3BPO    3G6D    3ITR    3ITS    3L5W    3L5X    3LB6    4I77    4PS4   
PDB (PDBSum)1GA3    1IJZ    1IK0    1J9U    3BPO    3G6D    3ITR    3ITS    3L5W    3L5X    3LB6    4I77    4PS4   
PDB (IMB)1GA3    1IJZ    1IK0    1J9U    3BPO    3G6D    3ITR    3ITS    3L5W    3L5X    3LB6    4I77    4PS4   
PDB (RSDB)1GA3    1IJZ    1IK0    1J9U    3BPO    3G6D    3ITR    3ITS    3L5W    3L5X    3LB6    4I77    4PS4   
Human Protein AtlasENSG00000169194 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasP35225
HPRD00981
IPIIPI00807607   
Protein Interaction databases
DIP (DOE-UCLA)P35225
IntAct (EBI)P35225
FunCoupENSG00000169194
BioGRIDIL13
InParanoidP35225
Interologous Interaction database P35225
IntegromeDBIL13
STRING (EMBL)IL13
Ontologies - Pathways
Ontology : AmiGOpositive regulation of immunoglobulin production  cytokine activity  interleukin-13 receptor binding  protein binding  extracellular region  extracellular space  cytoplasm  cellular component movement  inflammatory response  immune response  signal transduction  cell-cell signaling  external side of plasma membrane  regulation of proton transport  positive regulation of B cell proliferation  response to lipopolysaccharide  positive regulation of connective tissue growth factor production  response to nicotine  positive regulation of tyrosine phosphorylation of Stat6 protein  positive regulation of macrophage activation  response to ethanol  positive regulation of smooth muscle cell proliferation  positive regulation of protein secretion  positive regulation of release of sequestered calcium ion into cytosol  cellular response to mechanical stimulus  cellular response to cytokine stimulus  negative regulation of transforming growth factor beta production  negative regulation of lung ciliated cell differentiation  positive regulation of lung goblet cell differentiation  positive regulation of pancreatic stellate cell proliferation  
Ontology : EGO-EBIpositive regulation of immunoglobulin production  cytokine activity  interleukin-13 receptor binding  protein binding  extracellular region  extracellular space  cytoplasm  cellular component movement  inflammatory response  immune response  signal transduction  cell-cell signaling  external side of plasma membrane  regulation of proton transport  positive regulation of B cell proliferation  response to lipopolysaccharide  positive regulation of connective tissue growth factor production  response to nicotine  positive regulation of tyrosine phosphorylation of Stat6 protein  positive regulation of macrophage activation  response to ethanol  positive regulation of smooth muscle cell proliferation  positive regulation of protein secretion  positive regulation of release of sequestered calcium ion into cytosol  cellular response to mechanical stimulus  cellular response to cytokine stimulus  negative regulation of transforming growth factor beta production  negative regulation of lung ciliated cell differentiation  positive regulation of lung goblet cell differentiation  positive regulation of pancreatic stellate cell proliferation  
Pathways : BIOCARTACytokines and Inflammatory Response [Genes]    Dendritic cells in regulating TH1 and TH2 Development [Genes]    Cytokine Network [Genes]    GATA3 participate in activating the Th2 cytokine genes expression [Genes]   
Pathways : KEGGCytokine-cytokine receptor interaction    Jak-STAT signaling pathway    Fc epsilon RI signaling pathway    Measles    Asthma    Inflammatory bowel disease (IBD)   
Protein Interaction DatabaseIL13
Wikipedia pathwaysIL13
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)IL13
snp3D : Map Gene to Disease3596
SNP (GeneSNP Utah)IL13
SNP : HGBaseIL13
Genetic variants : HAPMAPIL13
Exome VariantIL13
1000_GenomesIL13 
ICGC programENSG00000169194 
Somatic Mutations in Cancer : COSMICIL13 
CONAN: Copy Number AnalysisIL13 
Mutations and Diseases : HGMDIL13
Genomic VariantsIL13  IL13 [DGVbeta]
dbVarIL13
ClinVarIL13
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM147683    600807    607154   
MedgenIL13
GENETestsIL13
Disease Genetic AssociationIL13
Huge Navigator IL13 [HugePedia]  IL13 [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneIL13
Homology/Alignments : Family Browser (UCSC)IL13
Phylogenetic Trees/Animal Genes : TreeFamIL13
Chemical/Protein Interactions : CTD3596
Chemical/Pharm GKB GenePA199
Clinical trialIL13
Cancer Resource (Charite)ENSG00000169194
Other databases
Probes
Litterature
PubMed489 Pubmed reference(s) in Entrez
CoreMineIL13
iHOPIL13
OncoSearchIL13
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jul 30 13:59:25 CEST 2014

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