Atlas of Genetics and Cytogenetics in Oncology and Haematology

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IL15 (interleukin 15)

Identity

Alias_symbol (synonym)IL-15
MGC9721
Other alias
HGNC (Hugo) IL15
LocusID (NCBI) 3600
Atlas_Id 40943
Location 4q31.21  [Link to chromosome band 4q31]
Location_base_pair Starts at 141636596 and ends at 141733987 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
FAM160A1 (4q31.3) / IL15 (4q31.21)PRR29 (17q23.3) / IL15 (4q31.21)FAM160A1 4q31.3 / IL15 4q31.21

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]

Solid Tumors TT_t0404q31q31ID106398

External links

Nomenclature
HGNC (Hugo)IL15   5977
Cards
Entrez_Gene (NCBI)IL15  3600  interleukin 15
AliasesIL-15
GeneCards (Weizmann)IL15
Ensembl hg19 (Hinxton)ENSG00000164136 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000164136 [Gene_View]  ENSG00000164136 [Sequence]  chr4:141636596-141733987 [Contig_View]  IL15 [Vega]
ICGC DataPortalENSG00000164136
TCGA cBioPortalIL15
AceView (NCBI)IL15
Genatlas (Paris)IL15
WikiGenes3600
SOURCE (Princeton)IL15
Genetics Home Reference (NIH)IL15
Genomic and cartography
GoldenPath hg38 (UCSC)IL15  -     chr4:141636596-141733987 +  4q31.21   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)IL15  -     4q31.21   [Description]    (hg19-Feb_2009)
GoldenPathIL15 - 4q31.21 [CytoView hg19]  IL15 - 4q31.21 [CytoView hg38]
ImmunoBaseENSG00000164136
Mapping of homologs : NCBIIL15 [Mapview hg19]  IL15 [Mapview hg38]
OMIM600554   
Gene and transcription
Genbank (Entrez)AA897685 AF031167 AK122993 AK290619 AY720442
RefSeq transcript (Entrez)NM_000585 NM_172174 NM_172175
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)IL15
Cluster EST : UnigeneHs.735901 [ NCBI ]
CGAP (NCI)Hs.735901
Alternative Splicing GalleryENSG00000164136
Gene ExpressionIL15 [ NCBI-GEO ]   IL15 [ EBI - ARRAY_EXPRESS ]   IL15 [ SEEK ]   IL15 [ MEM ]
Gene Expression Viewer (FireBrowse)IL15 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3600
GTEX Portal (Tissue expression)IL15
Human Protein AtlasENSG00000164136-IL15 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP40933   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP40933  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP40933
Splice isoforms : SwissVarP40933
PhosPhoSitePlusP40933
Domains : Interpro (EBI)4_helix_cytokine-like_core    IL-15    IL-15/IL-21_fam    IL-15/IL-21_sf    IL-15_mml   
Domain families : Pfam (Sanger)IL15 (PF02372)   
Domain families : Pfam (NCBI)pfam02372   
Conserved Domain (NCBI)IL15
DMDM Disease mutations3600
Blocks (Seattle)IL15
PDB (RSDB)2XQB    2Z3Q    2Z3R    4GS7   
PDB Europe2XQB    2Z3Q    2Z3R    4GS7   
PDB (PDBSum)2XQB    2Z3Q    2Z3R    4GS7   
PDB (IMB)2XQB    2Z3Q    2Z3R    4GS7   
Structural Biology KnowledgeBase2XQB    2Z3Q    2Z3R    4GS7   
SCOP (Structural Classification of Proteins)2XQB    2Z3Q    2Z3R    4GS7   
CATH (Classification of proteins structures)2XQB    2Z3Q    2Z3R    4GS7   
SuperfamilyP40933
Human Protein Atlas [tissue]ENSG00000164136-IL15 [tissue]
Peptide AtlasP40933
HPRD02776
IPIIPI00031509   IPI00220638   
Protein Interaction databases
DIP (DOE-UCLA)P40933
IntAct (EBI)P40933
FunCoupENSG00000164136
BioGRIDIL15
STRING (EMBL)IL15
ZODIACIL15
Ontologies - Pathways
QuickGOP40933
Ontology : AmiGONK T cell proliferation  cytokine activity  cytokine receptor binding  protein binding  extracellular region  extracellular region  extracellular space  nucleoplasm  cytoplasm  endosome  Golgi apparatus  cytosol  inflammatory response  immune response  signal transduction  tyrosine phosphorylation of STAT protein  cell-cell signaling  aging  positive regulation of cell proliferation  cell surface  skeletal muscle atrophy  nuclear speck  hyaluronan metabolic process  macrophage differentiation  positive regulation of interleukin-17 production  positive regulation of natural killer cell proliferation  positive regulation of natural killer cell differentiation  positive regulation of tissue remodeling  interleukin-15-mediated signaling pathway  interleukin-15-mediated signaling pathway  positive regulation of T cell proliferation  neutrophil activation  positive regulation of tyrosine phosphorylation of STAT protein  extrathymic T cell selection  regulation of T cell differentiation  cell maturation  lymph node development  negative regulation of smooth muscle cell proliferation  regulation of defense response to virus by host  positive regulation of inflammatory response  positive regulation of peptidyl-tyrosine phosphorylation  positive regulation of phagocytosis  positive regulation of immune response  cellular response to vitamin D  negative regulation of cold-induced thermogenesis  positive regulation of protein O-linked glycosylation  
Ontology : EGO-EBINK T cell proliferation  cytokine activity  cytokine receptor binding  protein binding  extracellular region  extracellular region  extracellular space  nucleoplasm  cytoplasm  endosome  Golgi apparatus  cytosol  inflammatory response  immune response  signal transduction  tyrosine phosphorylation of STAT protein  cell-cell signaling  aging  positive regulation of cell proliferation  cell surface  skeletal muscle atrophy  nuclear speck  hyaluronan metabolic process  macrophage differentiation  positive regulation of interleukin-17 production  positive regulation of natural killer cell proliferation  positive regulation of natural killer cell differentiation  positive regulation of tissue remodeling  interleukin-15-mediated signaling pathway  interleukin-15-mediated signaling pathway  positive regulation of T cell proliferation  neutrophil activation  positive regulation of tyrosine phosphorylation of STAT protein  extrathymic T cell selection  regulation of T cell differentiation  cell maturation  lymph node development  negative regulation of smooth muscle cell proliferation  regulation of defense response to virus by host  positive regulation of inflammatory response  positive regulation of peptidyl-tyrosine phosphorylation  positive regulation of phagocytosis  positive regulation of immune response  cellular response to vitamin D  negative regulation of cold-induced thermogenesis  positive regulation of protein O-linked glycosylation  
Pathways : KEGGCytokine-cytokine receptor interaction    Jak-STAT signaling pathway    TNF signaling pathway    Intestinal immune network for IgA production    HTLV-I infection    Herpes simplex infection    Rheumatoid arthritis   
NDEx NetworkIL15
Atlas of Cancer Signalling NetworkIL15
Wikipedia pathwaysIL15
Orthology - Evolution
OrthoDB3600
GeneTree (enSembl)ENSG00000164136
Phylogenetic Trees/Animal Genes : TreeFamIL15
HOGENOMP40933
Homologs : HomoloGeneIL15
Homology/Alignments : Family Browser (UCSC)IL15
Gene fusions - Rearrangements
Fusion : MitelmanFAM160A1/IL15 [4q31.3/4q31.21]  [t(4;4)(q31;q31)]  
Fusion PortalFAM160A1 4q31.3 IL15 4q31.21 BRCA
Fusion : QuiverIL15
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIL15 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IL15
dbVarIL15
ClinVarIL15
1000_GenomesIL15 
Exome Variant ServerIL15
ExAC (Exome Aggregation Consortium)ENSG00000164136
GNOMAD BrowserENSG00000164136
Varsome BrowserIL15
Genetic variants : HAPMAP3600
Genomic Variants (DGV)IL15 [DGVbeta]
DECIPHERIL15 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisIL15 
Mutations
ICGC Data PortalIL15 
TCGA Data PortalIL15 
Broad Tumor PortalIL15
OASIS PortalIL15 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIL15  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DIL15
Mutations and Diseases : HGMDIL15
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch IL15
DgiDB (Drug Gene Interaction Database)IL15
DoCM (Curated mutations)IL15 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)IL15 (select a term)
intoGenIL15
Cancer3DIL15(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600554   
Orphanet
DisGeNETIL15
MedgenIL15
Genetic Testing Registry IL15
NextProtP40933 [Medical]
TSGene3600
GENETestsIL15
Target ValidationIL15
Huge Navigator IL15 [HugePedia]
snp3D : Map Gene to Disease3600
BioCentury BCIQIL15
ClinGenIL15
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3600
Chemical/Pharm GKB GenePA29790
Clinical trialIL15
Miscellaneous
canSAR (ICR)IL15 (select the gene name)
DataMed IndexIL15
Probes
Litterature
PubMed428 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineIL15
EVEXIL15
GoPubMedIL15
iHOPIL15
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Aug 26 18:12:32 CEST 2019
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