IL17B (interleukin 17B)

2014-08-01  

Identity

HGNC
LOCATION
5q32
LOCUSID
ALIAS
IL-17B,IL-20,NIRF,ZCYTO7

Other Information

Locus ID:

NCBI: 27190
MIM: 604627
HGNC: 5982
Ensembl: ENSG00000127743

Variants:

dbSNP: 27190
ClinVar: 27190
TCGA: ENSG00000127743
COSMIC: IL17B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000127743ENST00000261796Q9UHF5

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Cytokine-cytokine receptor interactionKEGGhsa04060
IL-17 signaling pathwayKEGGko04657
IL-17 signaling pathwayKEGGhsa04657

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
257323062015Targeting IL-17B-IL-17RB signaling with an anti-IL-17RB antibody blocks pancreatic cancer metastasis by silencing multiple chemokines.35
238515032014Autocrine/paracrine mechanism of interleukin-17B receptor promotes breast tumorigenesis through NF-κB-mediated antiapoptotic pathway.30
240565202014Neutrophils produce interleukin-17B in rheumatoid synovial tissue.15
271468812016Non-tumor tissue derived interleukin-17B activates IL-17RB/AKT/β-catenin pathway to enhance the stemness of gastric cancer.9
281607542017The role of IL17B-IL17RB signaling pathway in breast cancer.8
168053772006Expression profile of immune-associated genes in nasal polyps.6
236613352013Correlations between concentrations of interleukin (IL)-17A, IL-17B and IL-17F, and endothelial cells and proangiogenic cytokines in systemic lupus erythematosus patients.5
281458812017IL-17B activated mesenchymal stem cells enhance proliferation and migration of gastric cancer cells.5
157132132005Chromosome 5q candidate genes in coeliac disease: genetic variation at IL4, IL5, IL9, IL13, IL17B and NR3C1.3
198458952009Fine mapping of the CELIAC2 locus on chromosome 5q31-q33 in the Finnish and Hungarian populations.3

Citation

Dessen P

IL17B (interleukin 17B)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54833/il17b