IL17RA (interleukin 17 receptor A)

2013-08-01 Affiliation

Identity

HGNC

IL17RA

LOCATION

22q11.1

LOCUSID

23765

ALIAS

CANDF5,CD217,CDw217,IL-17RA,IL17R,IMD51,hIL-17R

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 23765
MIM: 605461
HGNC: 5985
Ensembl: ENSG00000177663

Variants:

dbSNP: 23765
ClinVar: 23765
TCGA: ENSG00000177663
COSMIC: IL17RA

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000177663	ENST00000319363	Q96F46
ENSG00000177663	ENST00000612619	Q96F46

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Cytokine-cytokine receptor interaction	KEGG	ko04060
Cytokine-cytokine receptor interaction	KEGG	hsa04060
Immune System	REACTOME	R-HSA-168256
Cytokine Signaling in Immune system	REACTOME	R-HSA-1280215
Signaling by Interleukins	REACTOME	R-HSA-449147
Interleukin-17 signaling	REACTOME	R-HSA-448424
IL-17 signaling pathway	KEGG	ko04657
IL-17 signaling pathway	KEGG	hsa04657

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA164713366	Tumor necrosis factor alpha (TNF-alpha) inhibitors	Chemical	ClinicalAnnotation	associated		PD	27670766
PA445451	Psoriasis	Disease	ClinicalAnnotation	associated		PD	27670766

References

Pubmed ID	Year	Title	Citations
16785495	2006	Cutting edge: interleukin 17 signals through a heteromeric receptor complex.	182
15972674	2005	Role of IL-17A, IL-17F, and the IL-17 receptor in regulating growth-related oncogene-alpha and granulocyte colony-stimulating factor in bronchial epithelium: implications for airway inflammation in cystic fibrosis.	145
18768888	2008	Identification of functional roles for both IL-17RB and IL-17RA in mediating IL-25-induced activities.	104
17703412	2007	Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.	100
18684971	2008	The human IL-17F/IL-17A heterodimeric cytokine signals through the IL-17RA/IL-17RC receptor complex.	77
17456598	2007	Distinct functional motifs within the IL-17 receptor regulate signal transduction and target gene expression.	73
19244213	2009	IL-17 receptor signaling inhibits C/EBPbeta by sequential phosphorylation of the regulatory 2 domain.	62
18097068	2008	IL-17RA and IL-17RC receptors are essential for IL-17A-induced ELR+ CXC chemokine expression in synoviocytes and are overexpressed in rheumatoid blood.	45
21894442	2012	IL-17 receptor and its functional significance in psoriatic arthritis.	44
22898922	2012	Th17-associated cytokines promote human airway smooth muscle cell proliferation.	44

Citation

Dessen P

IL17RA (interleukin 17 receptor A)

Atlas Genet Cytogenet Oncol Haematol. 2013-08-01

Online version: http://atlasgeneticsoncology.org/gene/53729/il17ra