Atlas of Genetics and Cytogenetics in Oncology and Haematology

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IL18 (interleukin 18)

Identity

Alias_namesinterleukin 18 (interferon-gamma-inducing factor)
Alias_symbol (synonym)IGIF
IL1F4
IL-1g
IL-18
Other alias
HGNC (Hugo) IL18
LocusID (NCBI) 3606
Atlas_Id 40947
Location 11q23.1  [Link to chromosome band 11q23]
Location_base_pair Starts at 112143251 and ends at 112164117 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
EGF (4q25) / IL18 (11q23.1)IL18 (11q23.1) / EGF (4q25)TERT (5p15.33) / IL18 (11q23.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)IL18   5986
Cards
Entrez_Gene (NCBI)IL18  3606  interleukin 18
AliasesIGIF; IL-18; IL-1g; IL1F4
GeneCards (Weizmann)IL18
Ensembl hg19 (Hinxton)ENSG00000150782 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000150782 [Gene_View]  chr11:112143251-112164117 [Contig_View]  IL18 [Vega]
ICGC DataPortalENSG00000150782
TCGA cBioPortalIL18
AceView (NCBI)IL18
Genatlas (Paris)IL18
WikiGenes3606
SOURCE (Princeton)IL18
Genetics Home Reference (NIH)IL18
Genomic and cartography
GoldenPath hg38 (UCSC)IL18  -     chr11:112143251-112164117 -  11q23.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)IL18  -     11q23.1   [Description]    (hg19-Feb_2009)
EnsemblIL18 - 11q23.1 [CytoView hg19]  IL18 - 11q23.1 [CytoView hg38]
Mapping of homologs : NCBIIL18 [Mapview hg19]  IL18 [Mapview hg38]
OMIM600953   
Gene and transcription
Genbank (Entrez)AF077611 AF380360 AK311301 AY044641 AY266351
RefSeq transcript (Entrez)NM_001243211 NM_001562
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)IL18
Cluster EST : UnigeneHs.83077 [ NCBI ]
CGAP (NCI)Hs.83077
Alternative Splicing GalleryENSG00000150782
Gene ExpressionIL18 [ NCBI-GEO ]   IL18 [ EBI - ARRAY_EXPRESS ]   IL18 [ SEEK ]   IL18 [ MEM ]
Gene Expression Viewer (FireBrowse)IL18 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3606
GTEX Portal (Tissue expression)IL18
Human Protein AtlasENSG00000150782-IL18 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ14116   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ14116  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ14116
Splice isoforms : SwissVarQ14116
PhosPhoSitePlusQ14116
Domains : Interpro (EBI)IL-18    IL-1_fam    IL1/FGF   
Domain families : Pfam (Sanger)IL1 (PF00340)   
Domain families : Pfam (NCBI)pfam00340   
Conserved Domain (NCBI)IL18
DMDM Disease mutations3606
Blocks (Seattle)IL18
PDB (SRS)1J0S    2VXT    3F62    3WO2    3WO3    3WO4    4EEE    4EKX    4HJJ    4R6U    4XFS    4XFT    4XFU   
PDB (PDBSum)1J0S    2VXT    3F62    3WO2    3WO3    3WO4    4EEE    4EKX    4HJJ    4R6U    4XFS    4XFT    4XFU   
PDB (IMB)1J0S    2VXT    3F62    3WO2    3WO3    3WO4    4EEE    4EKX    4HJJ    4R6U    4XFS    4XFT    4XFU   
PDB (RSDB)1J0S    2VXT    3F62    3WO2    3WO3    3WO4    4EEE    4EKX    4HJJ    4R6U    4XFS    4XFT    4XFU   
Structural Biology KnowledgeBase1J0S    2VXT    3F62    3WO2    3WO3    3WO4    4EEE    4EKX    4HJJ    4R6U    4XFS    4XFT    4XFU   
SCOP (Structural Classification of Proteins)1J0S    2VXT    3F62    3WO2    3WO3    3WO4    4EEE    4EKX    4HJJ    4R6U    4XFS    4XFT    4XFU   
CATH (Classification of proteins structures)1J0S    2VXT    3F62    3WO2    3WO3    3WO4    4EEE    4EKX    4HJJ    4R6U    4XFS    4XFT    4XFU   
SuperfamilyQ14116
Human Protein Atlas [tissue]ENSG00000150782-IL18 [tissue]
Peptide AtlasQ14116
HPRD02976
IPIIPI00290198   IPI00980067   
Protein Interaction databases
DIP (DOE-UCLA)Q14116
IntAct (EBI)Q14116
FunCoupENSG00000150782
BioGRIDIL18
STRING (EMBL)IL18
ZODIACIL18
Ontologies - Pathways
QuickGOQ14116
Ontology : AmiGOMAPK cascade  angiogenesis  cytokine activity  cytokine activity  protein binding  extracellular region  extracellular space  cytosol  inflammatory response  immune response  cell-cell signaling  cell proliferation  regulation of receptor activity  positive regulation of macrophage derived foam cell differentiation  positive regulation of phosphatidylinositol 3-kinase signaling  cytokine-mediated signaling pathway  natural killer cell activation  regulation of cell adhesion  sleep  lipopolysaccharide-mediated signaling pathway  activation of protein kinase B activity  interleukin-6 production  positive regulation of granulocyte macrophage colony-stimulating factor production  positive regulation of interferon-gamma production  positive regulation of interleukin-17 production  positive regulation of natural killer cell proliferation  positive regulation of tissue remodeling  interleukin-18-mediated signaling pathway  interleukin-18-mediated signaling pathway  T-helper 1 cell cytokine production  chemokine biosynthetic process  T-helper 1 type immune response  type 2 immune response  interleukin-2 biosynthetic process  interferon-gamma biosynthetic process  positive regulation of activated T cell proliferation  neutrophil activation  interleukin-13 biosynthetic process  granulocyte macrophage colony-stimulating factor biosynthetic process  natural killer cell mediated cytotoxicity  positive regulation of NF-kappaB import into nucleus  positive regulation of tyrosine phosphorylation of STAT protein  cholesterol homeostasis  positive regulation of T-helper 2 cell differentiation  negative regulation of myoblast differentiation  positive regulation of transcription by RNA polymerase II  positive regulation of smooth muscle cell proliferation  positive regulation of inflammatory response  positive regulation of NK T cell proliferation  positive regulation of protein kinase B signaling  extracellular exosome  triglyceride homeostasis  cellular response to organic cyclic compound  
Ontology : EGO-EBIMAPK cascade  angiogenesis  cytokine activity  cytokine activity  protein binding  extracellular region  extracellular space  cytosol  inflammatory response  immune response  cell-cell signaling  cell proliferation  regulation of receptor activity  positive regulation of macrophage derived foam cell differentiation  positive regulation of phosphatidylinositol 3-kinase signaling  cytokine-mediated signaling pathway  natural killer cell activation  regulation of cell adhesion  sleep  lipopolysaccharide-mediated signaling pathway  activation of protein kinase B activity  interleukin-6 production  positive regulation of granulocyte macrophage colony-stimulating factor production  positive regulation of interferon-gamma production  positive regulation of interleukin-17 production  positive regulation of natural killer cell proliferation  positive regulation of tissue remodeling  interleukin-18-mediated signaling pathway  interleukin-18-mediated signaling pathway  T-helper 1 cell cytokine production  chemokine biosynthetic process  T-helper 1 type immune response  type 2 immune response  interleukin-2 biosynthetic process  interferon-gamma biosynthetic process  positive regulation of activated T cell proliferation  neutrophil activation  interleukin-13 biosynthetic process  granulocyte macrophage colony-stimulating factor biosynthetic process  natural killer cell mediated cytotoxicity  positive regulation of NF-kappaB import into nucleus  positive regulation of tyrosine phosphorylation of STAT protein  cholesterol homeostasis  positive regulation of T-helper 2 cell differentiation  negative regulation of myoblast differentiation  positive regulation of transcription by RNA polymerase II  positive regulation of smooth muscle cell proliferation  positive regulation of inflammatory response  positive regulation of NK T cell proliferation  positive regulation of protein kinase B signaling  extracellular exosome  triglyceride homeostasis  cellular response to organic cyclic compound  
Pathways : BIOCARTAIL 18 Signaling Pathway [Genes]    Th1/Th2 Differentiation [Genes]    Ras-Independent pathway in NK cell-mediated cytotoxicity [Genes]    Cytokine Network [Genes]    IL12 and Stat4 Dependent Signaling Pathway in Th1 Development [Genes]   
Pathways : KEGGCytokine-cytokine receptor interaction   
NDEx NetworkIL18
Atlas of Cancer Signalling NetworkIL18
Wikipedia pathwaysIL18
Orthology - Evolution
OrthoDB3606
GeneTree (enSembl)ENSG00000150782
Phylogenetic Trees/Animal Genes : TreeFamIL18
HOVERGENQ14116
HOGENOMQ14116
Homologs : HomoloGeneIL18
Homology/Alignments : Family Browser (UCSC)IL18
Gene fusions - Rearrangements
Fusion : QuiverIL18
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIL18 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IL18
dbVarIL18
ClinVarIL18
1000_GenomesIL18 
Exome Variant ServerIL18
ExAC (Exome Aggregation Consortium)ENSG00000150782
GNOMAD BrowserENSG00000150782
Genetic variants : HAPMAP3606
Genomic Variants (DGV)IL18 [DGVbeta]
DECIPHERIL18 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisIL18 
Mutations
ICGC Data PortalIL18 
TCGA Data PortalIL18 
Broad Tumor PortalIL18
OASIS PortalIL18 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIL18  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDIL18
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch IL18
DgiDB (Drug Gene Interaction Database)IL18
DoCM (Curated mutations)IL18 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)IL18 (select a term)
intoGenIL18
Cancer3DIL18(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600953   
Orphanet
DisGeNETIL18
MedgenIL18
Genetic Testing Registry IL18
NextProtQ14116 [Medical]
TSGene3606
GENETestsIL18
Target ValidationIL18
Huge Navigator IL18 [HugePedia]
snp3D : Map Gene to Disease3606
BioCentury BCIQIL18
ClinGenIL18
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3606
Chemical/Pharm GKB GenePA29802
Clinical trialIL18
Miscellaneous
canSAR (ICR)IL18 (select the gene name)
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineIL18
EVEXIL18
GoPubMedIL18
iHOPIL18
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Feb 28 13:17:49 CET 2018
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