Atlas of Genetics and Cytogenetics in Oncology and Haematology

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IL18 (interleukin 18)

Identity

Alias (NCBI)IGIF
IL-18
IL-1g
IL1F4
HGNC (Hugo) IL18
HGNC Alias symbIGIF
IL1F4
IL-1g
IL-18
HGNC Alias nameinterferon-gamma-inducing factor
HGNC Previous nameinterleukin 18 (interferon-gamma-inducing factor)
LocusID (NCBI) 3606
Atlas_Id 40947
Location 11q23.1  [Link to chromosome band 11q23]
Location_base_pair Starts at 112143260 and ends at 112164094 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
EGF (4q25)::IL18 (11q23.1)IL18 (11q23.1)::EGF (4q25)TERT (5p15.33)::IL18 (11q23.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

 

Nomenclature
HGNC (Hugo)IL18   5986
Cards
Entrez_Gene (NCBI)IL18    interleukin 18
AliasesIGIF; IL-18; IL-1g; IL1F4
GeneCards (Weizmann)IL18
Ensembl hg19 (Hinxton)ENSG00000150782 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000150782 [Gene_View]  ENSG00000150782 [Sequence]  chr11:112143260-112164094 [Contig_View]  IL18 [Vega]
ICGC DataPortalENSG00000150782
TCGA cBioPortalIL18
AceView (NCBI)IL18
Genatlas (Paris)IL18
SOURCE (Princeton)IL18
Genetics Home Reference (NIH)IL18
Genomic and cartography
GoldenPath hg38 (UCSC)IL18  -     chr11:112143260-112164094 -  11q23.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)IL18  -     11q23.1   [Description]    (hg19-Feb_2009)
GoldenPathIL18 - 11q23.1 [CytoView hg19]  IL18 - 11q23.1 [CytoView hg38]
ImmunoBaseENSG00000150782
Genome Data Viewer NCBIIL18 [Mapview hg19]  
OMIM600953   
Gene and transcription
Genbank (Entrez)AF077611 AF380360 AK311301 AY044641 AY266351
RefSeq transcript (Entrez)NM_001243211 NM_001386420 NM_001562
Consensus coding sequences : CCDS (NCBI)IL18
Gene ExpressionIL18 [ NCBI-GEO ]   IL18 [ EBI - ARRAY_EXPRESS ]   IL18 [ SEEK ]   IL18 [ MEM ]
Gene Expression Viewer (FireBrowse)IL18 [ Firebrowse - Broad ]
GenevisibleExpression of IL18 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3606
GTEX Portal (Tissue expression)IL18
Human Protein AtlasENSG00000150782-IL18 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ14116   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ14116  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ14116
PhosPhoSitePlusQ14116
Domains : Interpro (EBI)IL-18    IL-1_fam    IL1/FGF   
Domain families : Pfam (Sanger)IL1 (PF00340)   
Domain families : Pfam (NCBI)pfam00340   
Conserved Domain (NCBI)IL18
PDB (RSDB)1J0S    2VXT    3F62    3WO2    3WO3    3WO4    4EEE    4EKX    4HJJ    4R6U    4XFS    4XFT    4XFU   
PDB Europe1J0S    2VXT    3F62    3WO2    3WO3    3WO4    4EEE    4EKX    4HJJ    4R6U    4XFS    4XFT    4XFU   
PDB (PDBSum)1J0S    2VXT    3F62    3WO2    3WO3    3WO4    4EEE    4EKX    4HJJ    4R6U    4XFS    4XFT    4XFU   
PDB (IMB)1J0S    2VXT    3F62    3WO2    3WO3    3WO4    4EEE    4EKX    4HJJ    4R6U    4XFS    4XFT    4XFU   
Structural Biology KnowledgeBase1J0S    2VXT    3F62    3WO2    3WO3    3WO4    4EEE    4EKX    4HJJ    4R6U    4XFS    4XFT    4XFU   
SCOP (Structural Classification of Proteins)1J0S    2VXT    3F62    3WO2    3WO3    3WO4    4EEE    4EKX    4HJJ    4R6U    4XFS    4XFT    4XFU   
CATH (Classification of proteins structures)1J0S    2VXT    3F62    3WO2    3WO3    3WO4    4EEE    4EKX    4HJJ    4R6U    4XFS    4XFT    4XFU   
SuperfamilyQ14116
AlphaFold pdb e-kbQ14116   
Human Protein Atlas [tissue]ENSG00000150782-IL18 [tissue]
HPRD02976
Protein Interaction databases
DIP (DOE-UCLA)Q14116
IntAct (EBI)Q14116
BioGRIDIL18
STRING (EMBL)IL18
ZODIACIL18
Ontologies - Pathways
QuickGOQ14116
Ontology : AmiGOMAPK cascade  angiogenesis  cytokine activity  cytokine activity  cytokine activity  protein binding  extracellular region  extracellular space  cytosol  inflammatory response  cell-cell signaling  cell population proliferation  positive regulation of macrophage derived foam cell differentiation  positive regulation of phosphatidylinositol 3-kinase signaling  natural killer cell activation  regulation of cell adhesion  sleep  lipopolysaccharide-mediated signaling pathway  activation of protein kinase B activity  positive regulation of chemokine production  positive regulation of granulocyte macrophage colony-stimulating factor production  positive regulation of interferon-gamma production  positive regulation of interferon-gamma production  positive regulation of interleukin-13 production  positive regulation of interleukin-17 production  positive regulation of natural killer cell proliferation  positive regulation of tissue remodeling  interleukin-18-mediated signaling pathway  T-helper 1 type immune response  type 2 immune response  positive regulation of activated T cell proliferation  neutrophil activation  natural killer cell mediated cytotoxicity  positive regulation of tyrosine phosphorylation of STAT protein  cholesterol homeostasis  interleukin-18 receptor binding  positive regulation of T-helper 2 cell differentiation  negative regulation of myoblast differentiation  positive regulation of transcription by RNA polymerase II  positive regulation of smooth muscle cell proliferation  positive regulation of inflammatory response  positive regulation of NF-kappaB transcription factor activity  positive regulation of NK T cell proliferation  positive regulation of protein kinase B signaling  triglyceride homeostasis  cellular response to organic cyclic compound  positive regulation of cold-induced thermogenesis  positive regulation of neuroinflammatory response  positive regulation of NIK/NF-kappaB signaling  positive regulation of T-helper 1 cell cytokine production  
Ontology : EGO-EBIMAPK cascade  angiogenesis  cytokine activity  cytokine activity  cytokine activity  protein binding  extracellular region  extracellular space  cytosol  inflammatory response  cell-cell signaling  cell population proliferation  positive regulation of macrophage derived foam cell differentiation  positive regulation of phosphatidylinositol 3-kinase signaling  natural killer cell activation  regulation of cell adhesion  sleep  lipopolysaccharide-mediated signaling pathway  activation of protein kinase B activity  positive regulation of chemokine production  positive regulation of granulocyte macrophage colony-stimulating factor production  positive regulation of interferon-gamma production  positive regulation of interferon-gamma production  positive regulation of interleukin-13 production  positive regulation of interleukin-17 production  positive regulation of natural killer cell proliferation  positive regulation of tissue remodeling  interleukin-18-mediated signaling pathway  T-helper 1 type immune response  type 2 immune response  positive regulation of activated T cell proliferation  neutrophil activation  natural killer cell mediated cytotoxicity  positive regulation of tyrosine phosphorylation of STAT protein  cholesterol homeostasis  interleukin-18 receptor binding  positive regulation of T-helper 2 cell differentiation  negative regulation of myoblast differentiation  positive regulation of transcription by RNA polymerase II  positive regulation of smooth muscle cell proliferation  positive regulation of inflammatory response  positive regulation of NF-kappaB transcription factor activity  positive regulation of NK T cell proliferation  positive regulation of protein kinase B signaling  triglyceride homeostasis  cellular response to organic cyclic compound  positive regulation of cold-induced thermogenesis  positive regulation of neuroinflammatory response  positive regulation of NIK/NF-kappaB signaling  positive regulation of T-helper 1 cell cytokine production  
Pathways : BIOCARTABIOCARTA_CYTOKINEPATHWAY    BIOCARTA_IL12PATHWAY    BIOCARTA_NKCELLSPATHWAY    BIOCARTA_TH1TH2PATHWAY   
Pathways : KEGGKEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION    KEGG_NOD_LIKE_RECEPTOR_SIGNALING    KEGG_CYTOSOLIC_DNA_SENSING   
NDEx NetworkIL18
Atlas of Cancer Signalling NetworkIL18
Wikipedia pathwaysIL18
Orthology - Evolution
OrthoDB3606
GeneTree (enSembl)ENSG00000150782
Phylogenetic Trees/Animal Genes : TreeFamIL18
Homologs : HomoloGeneIL18
Homology/Alignments : Family Browser (UCSC)IL18
Gene fusions - Rearrangements
Fusion : QuiverIL18
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIL18 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IL18
dbVarIL18
ClinVarIL18
MonarchIL18
1000_GenomesIL18 
Exome Variant ServerIL18
GNOMAD BrowserENSG00000150782
Varsome BrowserIL18
ACMGIL18 variants
VarityQ14116
Genomic Variants (DGV)IL18 [DGVbeta]
DECIPHERIL18 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisIL18 
Mutations
ICGC Data PortalIL18 
TCGA Data PortalIL18 
Broad Tumor PortalIL18
OASIS PortalIL18 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIL18  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DIL18
Mutations and Diseases : HGMDIL18
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaIL18
DgiDB (Drug Gene Interaction Database)IL18
DoCM (Curated mutations)IL18
CIViC (Clinical Interpretations of Variants in Cancer)IL18
Cancer3DIL18
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600953   
Orphanet
DisGeNETIL18
MedgenIL18
Genetic Testing Registry IL18
NextProtQ14116 [Medical]
GENETestsIL18
Target ValidationIL18
Huge Navigator IL18 [HugePedia]
ClinGenIL18
Clinical trials, drugs, therapy
MyCancerGenomeIL18
Protein Interactions : CTDIL18
Pharm GKB GenePA29802
PharosQ14116
Clinical trialIL18
Miscellaneous
canSAR (ICR)IL18
HarmonizomeIL18
ARCHS4IL18
DataMed IndexIL18
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXIL18
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Jan 20 12:38:26 CET 2022
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