IL18 (interleukin 18)

2003-08-01  

Identity

HGNC
LOCATION
11q23.1
LOCUSID
ALIAS
IGIF,IL-18,IL-1g,IL1F4
FUSION GENES

Other Information

Locus ID:

NCBI: 3606
MIM: 600953
HGNC: 5986
Ensembl: ENSG00000150782

Variants:

dbSNP: 3606
ClinVar: 3606
TCGA: ENSG00000150782
COSMIC: IL18

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000150782ENST00000280357Q14116
ENSG00000150782ENST00000524595Q14116
ENSG00000150782ENST00000524595A0A024R3E0
ENSG00000150782ENST00000528832Q14116

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Cytokine-cytokine receptor interactionKEGGhsa04060
NOD-like receptor signaling pathwayKEGGko04621
NOD-like receptor signaling pathwayKEGGhsa04621
Cytosolic DNA-sensing pathwayKEGGko04623
Cytosolic DNA-sensing pathwayKEGGhsa04623
MalariaKEGGko05144
MalariaKEGGhsa05144
African trypanosomiasisKEGGko05143
African trypanosomiasisKEGGhsa05143
Rheumatoid arthritisKEGGko05323
Rheumatoid arthritisKEGGhsa05323
TuberculosisKEGGko05152
TuberculosisKEGGhsa05152
Influenza AKEGGko05164
Influenza AKEGGhsa05164
Salmonella infectionKEGGko05132
Salmonella infectionKEGGhsa05132
LegionellosisKEGGko05134
LegionellosisKEGGhsa05134
Inflammatory bowel disease (IBD)KEGGhsa05321
Inflammatory bowel disease (IBD)KEGGko05321
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Interleukin-1 processingREACTOMER-HSA-448706
Interleukin-4 and 13 signalingREACTOMER-HSA-6785807
Interleukin-10 signalingREACTOMER-HSA-6783783

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA134850491TransplantationDiseaseClinicalAnnotationassociatedPK25712187
PA165817016Kidney TransplantationDiseaseClinicalAnnotationassociatedPK25487141
PA166114457lung transplantationDiseaseClinicalAnnotationassociatedPK25487141
PA446863Hepatitis C, ChronicDiseaseClinicalAnnotationassociatedPD19455410
PA451241ribavirinChemicalClinicalAnnotationassociatedPD19455410
PA451578tacrolimusChemicalClinicalAnnotationassociatedPK25487141, 25712187
PA451999interferonsChemicalClinicalAnnotationassociatedPD19455410

References

Pubmed IDYearTitleCitations
237029782013Activation and regulation of the inflammasomes.736
276696502016Mechanism and Regulation of NLRP3 Inflammasome Activation.330
218361432011Postoperative biomarkers predict acute kidney injury and poor outcomes after adult cardiac surgery.186
184649132008A genome-wide association study identifies protein quantitative trait loci (pQTLs).184
185230122008ATP is released by monocytes stimulated with pathogen-sensing receptor ligands and induces IL-1beta and IL-18 secretion in an autocrine way.162
168278652006Urine NGAL and IL-18 are predictive biomarkers for delayed graft function following kidney transplantation.132
218361472011Postoperative biomarkers predict acute kidney injury and poor outcomes after pediatric cardiac surgery.111
158025342005NK/iDC interaction results in IL-18 secretion by DCs at the synaptic cleft followed by NK cell activation and release of the DC maturation factor HMGB1.109
223073262012DC-derived IL-18 drives Treg differentiation, murine Helicobacter pylori-specific immune tolerance, and asthma protection.102
177034122007Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.100

Citation

Dessen P

IL18 (interleukin 18)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/40947/il18