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IL18R1 (interleukin 18 receptor 1)

Identity

Alias (NCBI)CD218a
CDw218a
IL-18R-alpha
IL-18Ralpha
IL-1Rrp
IL18RA
IL18Ralpha2
IL1RRP
HGNC (Hugo) IL18R1
HGNC Alias symbIL1RRP
IL-1Rrp
CD218a
LocusID (NCBI) 8809
Atlas_Id 40948
Location 2q12.1  [Link to chromosome band 2q12]
Location_base_pair Starts at 102355796 and ends at 102398776 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
IL18R1 (2q12.1) / MCOLN2 (1p22.3)IL18R1 2q12.1 / MCOLN2 1p22.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)IL18R1   5988
Cards
Entrez_Gene (NCBI)IL18R1    interleukin 18 receptor 1
AliasesCD218a; CDw218a; IL-18R-alpha; IL-18Ralpha; 
IL-1Rrp; IL18RA; IL18Ralpha2; IL1RRP
GeneCards (Weizmann)IL18R1
Ensembl hg19 (Hinxton)ENSG00000115604 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000115604 [Gene_View]  ENSG00000115604 [Sequence]  chr2:102355796-102398776 [Contig_View]  IL18R1 [Vega]
ICGC DataPortalENSG00000115604
TCGA cBioPortalIL18R1
AceView (NCBI)IL18R1
Genatlas (Paris)IL18R1
SOURCE (Princeton)IL18R1
Genetics Home Reference (NIH)IL18R1
Genomic and cartography
GoldenPath hg38 (UCSC)IL18R1  -     chr2:102355796-102398776 +  2q12.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)IL18R1  -     2q12.1   [Description]    (hg19-Feb_2009)
GoldenPathIL18R1 - 2q12.1 [CytoView hg19]  IL18R1 - 2q12.1 [CytoView hg38]
ImmunoBaseENSG00000115604
Genome Data Viewer NCBIIL18R1 [Mapview hg19]  
OMIM604494   
Gene and transcription
Genbank (Entrez)AI803942 AY192162 BC069575 BC093975 BC093977
RefSeq transcript (Entrez)NM_001282399 NM_001371418 NM_001371419 NM_001371420 NM_001371421 NM_001371422 NM_001371423 NM_001371424 NM_003855
Consensus coding sequences : CCDS (NCBI)IL18R1
Gene ExpressionIL18R1 [ NCBI-GEO ]   IL18R1 [ EBI - ARRAY_EXPRESS ]   IL18R1 [ SEEK ]   IL18R1 [ MEM ]
Gene Expression Viewer (FireBrowse)IL18R1 [ Firebrowse - Broad ]
GenevisibleExpression of IL18R1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8809
GTEX Portal (Tissue expression)IL18R1
Human Protein AtlasENSG00000115604-IL18R1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13478   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13478  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13478
PhosPhoSitePlusQ13478
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)    TIR (PS50104)   
Domains : Interpro (EBI)Ig-like_dom    Ig-like_dom_sf    Ig-like_fold    Ig_sub    IL-1_rcpt_fam    IL-1_rcpt_I/II-typ    TIR_dom    Toll_tir_struct_dom_sf   
Domain families : Pfam (Sanger)TIR (PF01582)   
Domain families : Pfam (NCBI)pfam01582   
Domain families : Smart (EMBL)IG (SM00409)  TIR (SM00255)  
Conserved Domain (NCBI)IL18R1
PDB (RSDB)3WO3    3WO4    4R6U   
PDB Europe3WO3    3WO4    4R6U   
PDB (PDBSum)3WO3    3WO4    4R6U   
PDB (IMB)3WO3    3WO4    4R6U   
Structural Biology KnowledgeBase3WO3    3WO4    4R6U   
SCOP (Structural Classification of Proteins)3WO3    3WO4    4R6U   
CATH (Classification of proteins structures)3WO3    3WO4    4R6U   
SuperfamilyQ13478
AlphaFold pdb e-kbQ13478   
Human Protein Atlas [tissue]ENSG00000115604-IL18R1 [tissue]
HPRD05138
Protein Interaction databases
DIP (DOE-UCLA)Q13478
IntAct (EBI)Q13478
BioGRIDIL18R1
STRING (EMBL)IL18R1
ZODIACIL18R1
Ontologies - Pathways
QuickGOQ13478
Ontology : AmiGOinterleukin-1 receptor activity  protein binding  plasma membrane  inflammatory response  immune response  signal transduction  natural killer cell activation  positive regulation of interferon-gamma production  positive regulation of interferon-gamma production  interleukin-18-mediated signaling pathway  interleukin-18-mediated signaling pathway  interleukin-18-mediated signaling pathway  signaling receptor activity  interleukin-18 binding  interleukin-18 binding  interleukin-18 receptor activity  interleukin-18 receptor activity  T-helper 1 cell differentiation  interleukin-18 receptor complex  NAD(P)+ nucleosidase activity  positive regulation of NF-kappaB transcription factor activity  NAD+ nucleotidase, cyclic ADP-ribose generating  cellular response to cytokine stimulus  negative regulation of cold-induced thermogenesis  positive regulation of NIK/NF-kappaB signaling  positive regulation of T-helper 1 cell cytokine production  
Ontology : EGO-EBIinterleukin-1 receptor activity  protein binding  plasma membrane  inflammatory response  immune response  signal transduction  natural killer cell activation  positive regulation of interferon-gamma production  positive regulation of interferon-gamma production  interleukin-18-mediated signaling pathway  interleukin-18-mediated signaling pathway  interleukin-18-mediated signaling pathway  signaling receptor activity  interleukin-18 binding  interleukin-18 binding  interleukin-18 receptor activity  interleukin-18 receptor activity  T-helper 1 cell differentiation  interleukin-18 receptor complex  NAD(P)+ nucleosidase activity  positive regulation of NF-kappaB transcription factor activity  NAD+ nucleotidase, cyclic ADP-ribose generating  cellular response to cytokine stimulus  negative regulation of cold-induced thermogenesis  positive regulation of NIK/NF-kappaB signaling  positive regulation of T-helper 1 cell cytokine production  
Pathways : BIOCARTATh1/Th2 Differentiation [Genes]    Selective expression of chemokine receptors during T-cell polarization [Genes]    IL12 and Stat4 Dependent Signaling Pathway in Th1 Development [Genes]   
Pathways : KEGGCytokine-cytokine receptor interaction    TNF signaling pathway    Inflammatory bowel disease (IBD)   
NDEx NetworkIL18R1
Atlas of Cancer Signalling NetworkIL18R1
Wikipedia pathwaysIL18R1
Orthology - Evolution
OrthoDB8809
GeneTree (enSembl)ENSG00000115604
Phylogenetic Trees/Animal Genes : TreeFamIL18R1
Homologs : HomoloGeneIL18R1
Homology/Alignments : Family Browser (UCSC)IL18R1
Gene fusions - Rearrangements
Fusion : MitelmanIL18R1/MCOLN2 [2q12.1/1p22.3]  
Fusion : QuiverIL18R1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIL18R1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IL18R1
dbVarIL18R1
ClinVarIL18R1
MonarchIL18R1
1000_GenomesIL18R1 
Exome Variant ServerIL18R1
GNOMAD BrowserENSG00000115604
Varsome BrowserIL18R1
ACMGIL18R1 variants
VarityQ13478
Genomic Variants (DGV)IL18R1 [DGVbeta]
DECIPHERIL18R1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisIL18R1 
Mutations
ICGC Data PortalIL18R1 
TCGA Data PortalIL18R1 
Broad Tumor PortalIL18R1
OASIS PortalIL18R1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIL18R1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DIL18R1
Mutations and Diseases : HGMDIL18R1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaIL18R1
DgiDB (Drug Gene Interaction Database)IL18R1
DoCM (Curated mutations)IL18R1
CIViC (Clinical Interpretations of Variants in Cancer)IL18R1
Cancer3DIL18R1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604494   
Orphanet
DisGeNETIL18R1
MedgenIL18R1
Genetic Testing Registry IL18R1
NextProtQ13478 [Medical]
GENETestsIL18R1
Target ValidationIL18R1
Huge Navigator IL18R1 [HugePedia]
ClinGenIL18R1
Clinical trials, drugs, therapy
MyCancerGenomeIL18R1
Protein Interactions : CTDIL18R1
Pharm GKB GenePA29804
PharosQ13478
Clinical trialIL18R1
Miscellaneous
canSAR (ICR)IL18R1
HarmonizomeIL18R1
DataMed IndexIL18R1
Probes
Litterature
PubMed94 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXIL18R1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 15:13:45 CEST 2021

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