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IL18R1 (interleukin 18 receptor 1)

Identity

Alias_symbol (synonym)IL1RRP
IL-1Rrp
CD218a
Other aliasCDw218a
IL18RA
HGNC (Hugo) IL18R1
LocusID (NCBI) 8809
Atlas_Id 40948
Location 2q12.1  [Link to chromosome band 2q12]
Location_base_pair Starts at 102356283 and ends at 102398775 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
IL18R1 (2q12.1) / MCOLN2 (1p22.3)IL18R1 2q12.1 / MCOLN2 1p22.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)IL18R1   5988
Cards
Entrez_Gene (NCBI)IL18R1  8809  interleukin 18 receptor 1
AliasesCD218a; CDw218a; IL-1Rrp; IL18RA; 
IL1RRP
GeneCards (Weizmann)IL18R1
Ensembl hg19 (Hinxton)ENSG00000115604 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000115604 [Gene_View]  chr2:102356283-102398775 [Contig_View]  IL18R1 [Vega]
ICGC DataPortalENSG00000115604
TCGA cBioPortalIL18R1
AceView (NCBI)IL18R1
Genatlas (Paris)IL18R1
WikiGenes8809
SOURCE (Princeton)IL18R1
Genetics Home Reference (NIH)IL18R1
Genomic and cartography
GoldenPath hg38 (UCSC)IL18R1  -     chr2:102356283-102398775 +  2q12.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)IL18R1  -     2q12.1   [Description]    (hg19-Feb_2009)
EnsemblIL18R1 - 2q12.1 [CytoView hg19]  IL18R1 - 2q12.1 [CytoView hg38]
Mapping of homologs : NCBIIL18R1 [Mapview hg19]  IL18R1 [Mapview hg38]
OMIM604494   
Gene and transcription
Genbank (Entrez)AI803942 AY192162 BC069575 BC093975 BC093977
RefSeq transcript (Entrez)NM_001282399 NM_003855
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)IL18R1
Cluster EST : UnigeneHs.469521 [ NCBI ]
CGAP (NCI)Hs.469521
Alternative Splicing GalleryENSG00000115604
Gene ExpressionIL18R1 [ NCBI-GEO ]   IL18R1 [ EBI - ARRAY_EXPRESS ]   IL18R1 [ SEEK ]   IL18R1 [ MEM ]
Gene Expression Viewer (FireBrowse)IL18R1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8809
GTEX Portal (Tissue expression)IL18R1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13478   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13478  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13478
Splice isoforms : SwissVarQ13478
PhosPhoSitePlusQ13478
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)    TIR (PS50104)   
Domains : Interpro (EBI)Ig-like_dom    Ig-like_fold    Ig_sub    IL-1_rcpt_fam    IL-1_rcpt_I/II-typ    TIR_dom   
Domain families : Pfam (Sanger)TIR (PF01582)   
Domain families : Pfam (NCBI)pfam01582   
Domain families : Smart (EMBL)IG (SM00409)  TIR (SM00255)  
Conserved Domain (NCBI)IL18R1
DMDM Disease mutations8809
Blocks (Seattle)IL18R1
PDB (SRS)3WO3    3WO4    4R6U   
PDB (PDBSum)3WO3    3WO4    4R6U   
PDB (IMB)3WO3    3WO4    4R6U   
PDB (RSDB)3WO3    3WO4    4R6U   
Structural Biology KnowledgeBase3WO3    3WO4    4R6U   
SCOP (Structural Classification of Proteins)3WO3    3WO4    4R6U   
CATH (Classification of proteins structures)3WO3    3WO4    4R6U   
SuperfamilyQ13478
Human Protein AtlasENSG00000115604
Peptide AtlasQ13478
HPRD05138
IPIIPI00021999   IPI00384723   
Protein Interaction databases
DIP (DOE-UCLA)Q13478
IntAct (EBI)Q13478
FunCoupENSG00000115604
BioGRIDIL18R1
STRING (EMBL)IL18R1
ZODIACIL18R1
Ontologies - Pathways
QuickGOQ13478
Ontology : AmiGOreceptor activity  interleukin-1 receptor activity  protein binding  plasma membrane  immune response  signal transduction  integral component of membrane  natural killer cell activation  positive regulation of interferon-gamma production  interleukin-18-mediated signaling pathway  interleukin-18 receptor activity  positive regulation of NF-kappaB import into nucleus  T-helper 1 cell differentiation  
Ontology : EGO-EBIreceptor activity  interleukin-1 receptor activity  protein binding  plasma membrane  immune response  signal transduction  integral component of membrane  natural killer cell activation  positive regulation of interferon-gamma production  interleukin-18-mediated signaling pathway  interleukin-18 receptor activity  positive regulation of NF-kappaB import into nucleus  T-helper 1 cell differentiation  
Pathways : BIOCARTATh1/Th2 Differentiation [Genes]    Selective expression of chemokine receptors during T-cell polarization [Genes]    IL12 and Stat4 Dependent Signaling Pathway in Th1 Development [Genes]   
Pathways : KEGGCytokine-cytokine receptor interaction    TNF signaling pathway    Inflammatory bowel disease (IBD)   
NDEx NetworkIL18R1
Atlas of Cancer Signalling NetworkIL18R1
Wikipedia pathwaysIL18R1
Orthology - Evolution
OrthoDB8809
GeneTree (enSembl)ENSG00000115604
Phylogenetic Trees/Animal Genes : TreeFamIL18R1
HOVERGENQ13478
HOGENOMQ13478
Homologs : HomoloGeneIL18R1
Homology/Alignments : Family Browser (UCSC)IL18R1
Gene fusions - Rearrangements
Fusion : MitelmanIL18R1/MCOLN2 [2q12.1/1p22.3]  
Fusion: TCGAIL18R1 2q12.1 MCOLN2 1p22.3 HNSC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIL18R1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IL18R1
dbVarIL18R1
ClinVarIL18R1
1000_GenomesIL18R1 
Exome Variant ServerIL18R1
ExAC (Exome Aggregation Consortium)IL18R1 (select the gene name)
Genetic variants : HAPMAP8809
Genomic Variants (DGV)IL18R1 [DGVbeta]
DECIPHERIL18R1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisIL18R1 
Mutations
ICGC Data PortalIL18R1 
TCGA Data PortalIL18R1 
Broad Tumor PortalIL18R1
OASIS PortalIL18R1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIL18R1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDIL18R1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch IL18R1
DgiDB (Drug Gene Interaction Database)IL18R1
DoCM (Curated mutations)IL18R1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)IL18R1 (select a term)
intoGenIL18R1
Cancer3DIL18R1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604494   
Orphanet
MedgenIL18R1
Genetic Testing Registry IL18R1
NextProtQ13478 [Medical]
TSGene8809
GENETestsIL18R1
Huge Navigator IL18R1 [HugePedia]
snp3D : Map Gene to Disease8809
BioCentury BCIQIL18R1
ClinGenIL18R1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8809
Chemical/Pharm GKB GenePA29804
Clinical trialIL18R1
Miscellaneous
canSAR (ICR)IL18R1 (select the gene name)
Probes
Litterature
PubMed84 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineIL18R1
EVEXIL18R1
GoPubMedIL18R1
iHOPIL18R1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:20:19 CEST 2017

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