IL18RAP (interleukin 18 receptor accessory protein)

2017-10-01  

Identity

HGNC
IL18RAP
LOCATION
2q12.1
LOCUSID
8807
ALIAS
ACPL,CD218b,CDw218b,IL-18R-beta,IL-18RAcP,IL-18Rbeta,IL-1R-7,IL-1R7,IL-1RAcPL,IL18RB

Other Information

Locus ID:

NCBI: 8807
MIM: 604509
HGNC: 5989
Ensembl: ENSG00000115607

Variants:

dbSNP: 8807
ClinVar: 8807
TCGA: ENSG00000115607
COSMIC: IL18RAP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000115607ENST00000264260O95256
ENSG00000115607ENST00000409369O95256
ENSG00000115607ENST00000450855C9JLE2

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Cytokine-cytokine receptor interactionKEGGhsa04060
Inflammatory bowel disease (IBD)KEGGhsa05321
Inflammatory bowel disease (IBD)KEGGko05321
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
190739672008Shared and distinct genetic variants in type 1 diabetes and celiac disease.249
183111402008Newly identified genetic risk variants for celiac disease related to the immune response.231
183111402008Newly identified genetic risk variants for celiac disease related to the immune response.231
184395502008Genetic analysis of innate immunity in Crohn's disease and ulcerative colitis identifies two susceptibility loci harboring CARD9 and IL18RAP.93
184395502008Genetic analysis of innate immunity in Crohn's disease and ulcerative colitis identifies two susceptibility loci harboring CARD9 and IL18RAP.93
201767342010Comparative genetic analysis of inflammatory bowel disease and type 1 diabetes implicates multiple loci with opposite effects.66
160436442005Genetic analysis of the interleukin-18 system highlights the role of the interleukin-18 gene in cardiovascular disease.49
191805182009Associations of 25 structural, degradative, and inflammatory candidate genes with lumbar disc desiccation, bulging, and height narrowing.29
193364752009Integrated associations of genotypes with multiple blood biomarkers linked to coronary heart disease risk.27
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27

Citation

Dessen P

IL18RAP (interleukin 18 receptor accessory protein)

Atlas Genet Cytogenet Oncol Haematol. 2017-10-01

Online version: http://atlasgeneticsoncology.org/gene/57158/il18rap