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IL18RAP (interleukin 18 receptor accessory protein)

Identity

Other aliasACPL
CD218b
CDw218b
IL-18R-beta
IL-18RAcP
IL-18Rbeta
IL-1R-7
IL-1R7
IL-1RAcPL
IL18RB
HGNC (Hugo) IL18RAP
LocusID (NCBI) 8807
Atlas_Id 57158
Location 2q12.1  [Link to chromosome band 2q12]
Location_base_pair Starts at 102418794 and ends at 102452565 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

CIViC (Clinical Interpretations of Variants in Cancer)
Nomenclature
HGNC (Hugo)IL18RAP   5989
Cards
Entrez_Gene (NCBI)IL18RAP  8807  interleukin 18 receptor accessory protein
AliasesACPL; CD218b; CDw218b; IL-18R-beta; 
IL-18RAcP; IL-18Rbeta; IL-1R-7; IL-1R7; IL-1RAcPL; IL18RB
GeneCards (Weizmann)IL18RAP
Ensembl hg19 (Hinxton) [Gene_View]
Ensembl hg38 (Hinxton) [Gene_View]  chr2:102418794-102452565 [Contig_View]  IL18RAP [Vega]
TCGA cBioPortalIL18RAP
AceView (NCBI)IL18RAP
Genatlas (Paris)IL18RAP
WikiGenes8807
SOURCE (Princeton)IL18RAP
Genetics Home Reference (NIH)IL18RAP
Genomic and cartography
GoldenPath hg38 (UCSC)IL18RAP  -     chr2:102418794-102452565 +  2q12.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)IL18RAP  -     2q12.1   [Description]    (hg19-Feb_2009)
EnsemblIL18RAP - 2q12.1 [CytoView hg19]  IL18RAP - 2q12.1 [CytoView hg38]
Mapping of homologs : NCBIIL18RAP [Mapview hg19]  IL18RAP [Mapview hg38]
OMIM604509   
Gene and transcription
Genbank (Entrez)AF077346 AK300026 BC069630 BC106764 BC106765
RefSeq transcript (Entrez)NM_003853
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)IL18RAP
Cluster EST : UnigeneHs.158315 [ NCBI ]
CGAP (NCI)Hs.158315
Gene ExpressionIL18RAP [ NCBI-GEO ]   IL18RAP [ EBI - ARRAY_EXPRESS ]   IL18RAP [ SEEK ]   IL18RAP [ MEM ]
Gene Expression Viewer (FireBrowse)IL18RAP [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8807
GTEX Portal (Tissue expression)IL18RAP
Protein : pattern, domain, 3D structure
UniProt/SwissProtO95256   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO95256  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO95256
Splice isoforms : SwissVarO95256
PhosPhoSitePlusO95256
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)    TIR (PS50104)   
Domains : Interpro (EBI)Ig-like_dom    Ig-like_fold    Ig_sub    IL-1_rcpt_fam    TIR_dom   
Domain families : Pfam (Sanger)Ig_2 (PF13895)    TIR (PF01582)   
Domain families : Pfam (NCBI)pfam13895    pfam01582   
Domain families : Smart (EMBL)IG (SM00409)  TIR (SM00255)  
Conserved Domain (NCBI)IL18RAP
DMDM Disease mutations8807
Blocks (Seattle)IL18RAP
PDB (SRS)3WO4   
PDB (PDBSum)3WO4   
PDB (IMB)3WO4   
PDB (RSDB)3WO4   
Structural Biology KnowledgeBase3WO4   
SCOP (Structural Classification of Proteins)3WO4   
CATH (Classification of proteins structures)3WO4   
SuperfamilyO95256
Peptide AtlasO95256
IPIIPI00021998   IPI00718857   IPI00916288   
Protein Interaction databases
DIP (DOE-UCLA)O95256
IntAct (EBI)O95256
BioGRIDIL18RAP
STRING (EMBL)IL18RAP
ZODIACIL18RAP
Ontologies - Pathways
QuickGOO95256
Ontology : AmiGOreceptor activity  plasma membrane  inflammatory response  immune response  cell surface receptor signaling pathway  cell proliferation  integral component of membrane  interferon-gamma production  interleukin-6 production  interleukin-18-mediated signaling pathway  T-helper 1 cell cytokine production  neutrophil activation  positive regulation of natural killer cell mediated cytotoxicity  cellular response to hydrogen peroxide  
Ontology : EGO-EBIreceptor activity  plasma membrane  inflammatory response  immune response  cell surface receptor signaling pathway  cell proliferation  integral component of membrane  interferon-gamma production  interleukin-6 production  interleukin-18-mediated signaling pathway  T-helper 1 cell cytokine production  neutrophil activation  positive regulation of natural killer cell mediated cytotoxicity  cellular response to hydrogen peroxide  
Pathways : KEGGCytokine-cytokine receptor interaction    Inflammatory bowel disease (IBD)   
NDEx NetworkIL18RAP
Atlas of Cancer Signalling NetworkIL18RAP
Wikipedia pathwaysIL18RAP
Orthology - Evolution
OrthoDB8807
Phylogenetic Trees/Animal Genes : TreeFamIL18RAP
HOVERGENO95256
HOGENOMO95256
Homologs : HomoloGeneIL18RAP
Homology/Alignments : Family Browser (UCSC)IL18RAP
Gene fusions - Rearrangements
Fusion: Tumor Portal IL18RAP
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIL18RAP [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IL18RAP
dbVarIL18RAP
ClinVarIL18RAP
1000_GenomesIL18RAP 
Exome Variant ServerIL18RAP
ExAC (Exome Aggregation Consortium)
Genetic variants : HAPMAP8807
Genomic Variants (DGV)IL18RAP [DGVbeta]
DECIPHERIL18RAP [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisIL18RAP 
Mutations
ICGC Data PortalIL18RAP 
TCGA Data PortalIL18RAP 
Broad Tumor PortalIL18RAP
OASIS PortalIL18RAP [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIL18RAP  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDIL18RAP
BioMutasearch IL18RAP
DgiDB (Drug Gene Interaction Database)IL18RAP
DoCM (Curated mutations)IL18RAP (select the gene name)
IL18RAP (select a term)
intoGenIL18RAP
Cancer3DIL18RAP(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604509   
Orphanet
MedgenIL18RAP
Genetic Testing Registry IL18RAP
NextProtO95256 [Medical]
TSGene8807
GENETestsIL18RAP
Target ValidationIL18RAP
Huge Navigator IL18RAP [HugePedia]
snp3D : Map Gene to Disease8807
BioCentury BCIQIL18RAP
ClinGenIL18RAP
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8807
Chemical/Pharm GKB GenePA29805
Clinical trialIL18RAP
Miscellaneous
canSAR (ICR)IL18RAP (select the gene name)
Probes
Litterature
PubMed47 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineIL18RAP
EVEXIL18RAP
GoPubMedIL18RAP
iHOPIL18RAP
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Nov 9 12:54:15 CET 2017

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