Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

IL1A (interleukin 1 alpha)

Identity

Alias (NCBI)IL-1 alpha
IL-1A
IL1
IL1-ALPHA
IL1F1
HGNC (Hugo) IL1A
HGNC Alias symbIL1F1
IL-1A
IL1-ALPHA
HGNC Alias namepreinterleukin 1 alpha
 hematopoietin-1
 pro-interleukin-1-alpha
HGNC Previous nameIL1
LocusID (NCBI) 3552
Atlas_Id 40949
Location 2q14.1  [Link to chromosome band 2q14]
Location_base_pair Starts at 112773926 and ends at 112784400 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
IL1A (2q13) / IL1A (2q13)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)IL1A   5991
Cards
Entrez_Gene (NCBI)IL1A    interleukin 1 alpha
AliasesIL-1; IL-1A; IL1; IL1-ALPHA; 
IL1F1
GeneCards (Weizmann)IL1A
Ensembl hg19 (Hinxton)ENSG00000115008 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000115008 [Gene_View]  ENSG00000115008 [Sequence]  chr2:112773926-112784400 [Contig_View]  IL1A [Vega]
ICGC DataPortalENSG00000115008
TCGA cBioPortalIL1A
AceView (NCBI)IL1A
Genatlas (Paris)IL1A
SOURCE (Princeton)IL1A
Genetics Home Reference (NIH)IL1A
Genomic and cartography
GoldenPath hg38 (UCSC)IL1A  -     chr2:112773926-112784400 -  2q14.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)IL1A  -     2q14.1   [Description]    (hg19-Feb_2009)
GoldenPathIL1A - 2q14.1 [CytoView hg19]  IL1A - 2q14.1 [CytoView hg38]
ImmunoBaseENSG00000115008
Genome Data Viewer NCBIIL1A [Mapview hg19]  
OMIM147760   
Gene and transcription
Genbank (Entrez)AA856674 AK314850 BC013142 BC035169 BT007014
RefSeq transcript (Entrez)NM_000575 NM_001371554
Consensus coding sequences : CCDS (NCBI)IL1A
Gene ExpressionIL1A [ NCBI-GEO ]   IL1A [ EBI - ARRAY_EXPRESS ]   IL1A [ SEEK ]   IL1A [ MEM ]
Gene Expression Viewer (FireBrowse)IL1A [ Firebrowse - Broad ]
GenevisibleExpression of IL1A in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3552
GTEX Portal (Tissue expression)IL1A
Human Protein AtlasENSG00000115008-IL1A [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP01583   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP01583  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP01583
PhosPhoSitePlusP01583
Domaine pattern : Prosite (Expaxy)INTERLEUKIN_1 (PS00253)   
Domains : Interpro (EBI)IL-1_alpha    IL-1_CS    IL-1_fam    IL-1_propep    IL1/FGF   
Domain families : Pfam (Sanger)IL1 (PF00340)    IL1_propep (PF02394)   
Domain families : Pfam (NCBI)pfam00340    pfam02394   
Conserved Domain (NCBI)IL1A
PDB (RSDB)1ITA    2ILA    2KKI    2L5X    5UC6   
PDB Europe1ITA    2ILA    2KKI    2L5X    5UC6   
PDB (PDBSum)1ITA    2ILA    2KKI    2L5X    5UC6   
PDB (IMB)1ITA    2ILA    2KKI    2L5X    5UC6   
Structural Biology KnowledgeBase1ITA    2ILA    2KKI    2L5X    5UC6   
SCOP (Structural Classification of Proteins)1ITA    2ILA    2KKI    2L5X    5UC6   
CATH (Classification of proteins structures)1ITA    2ILA    2KKI    2L5X    5UC6   
SuperfamilyP01583
AlphaFold pdb e-kbP01583   
Human Protein Atlas [tissue]ENSG00000115008-IL1A [tissue]
HPRD00988
Protein Interaction databases
DIP (DOE-UCLA)P01583
IntAct (EBI)P01583
BioGRIDIL1A
STRING (EMBL)IL1A
ZODIACIL1A
Ontologies - Pathways
QuickGOP01583
Ontology : AmiGOfever generation  positive regulation of cytokine production  connective tissue replacement involved in inflammatory response wound healing  cytokine activity  interleukin-1 receptor binding  copper ion binding  protein binding  extracellular region  extracellular space  extracellular space  extracellular space  cytosol  cellular sodium ion homeostasis  apoptotic process  inflammatory response  immune response  negative regulation of cell population proliferation  positive regulation of vascular endothelial growth factor production  positive regulation of gene expression  positive regulation of gene expression  cytokine-mediated signaling pathway  cytokine-mediated signaling pathway  cytokine-mediated signaling pathway  positive regulation of interleukin-2 production  positive regulation of interleukin-2 production  positive regulation of interleukin-6 production  positive regulation of tumor necrosis factor production  positive regulation of immature T cell proliferation in thymus  cellular response to heat  ectopic germ cell programmed cell death  positive regulation of angiogenesis  positive regulation of mitotic nuclear division  positive regulation of transcription by RNA polymerase II  response to copper ion  positive regulation of protein secretion  regulation of nitric-oxide synthase activity  positive regulation of cell division  interleukin-1-mediated signaling pathway  cellular response to lipopolysaccharide  extrinsic apoptotic signaling pathway in absence of ligand  negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  
Ontology : EGO-EBIfever generation  positive regulation of cytokine production  connective tissue replacement involved in inflammatory response wound healing  cytokine activity  interleukin-1 receptor binding  copper ion binding  protein binding  extracellular region  extracellular space  extracellular space  extracellular space  cytosol  cellular sodium ion homeostasis  apoptotic process  inflammatory response  immune response  negative regulation of cell population proliferation  positive regulation of vascular endothelial growth factor production  positive regulation of gene expression  positive regulation of gene expression  cytokine-mediated signaling pathway  cytokine-mediated signaling pathway  cytokine-mediated signaling pathway  positive regulation of interleukin-2 production  positive regulation of interleukin-2 production  positive regulation of interleukin-6 production  positive regulation of tumor necrosis factor production  positive regulation of immature T cell proliferation in thymus  cellular response to heat  ectopic germ cell programmed cell death  positive regulation of angiogenesis  positive regulation of mitotic nuclear division  positive regulation of transcription by RNA polymerase II  response to copper ion  positive regulation of protein secretion  regulation of nitric-oxide synthase activity  positive regulation of cell division  interleukin-1-mediated signaling pathway  cellular response to lipopolysaccharide  extrinsic apoptotic signaling pathway in absence of ligand  negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  
Pathways : BIOCARTACells and Molecules involved in local acute inflammatory response [Genes]    Cytokine Network [Genes]    IL-10 Anti-inflammatory Signaling Pathway [Genes]    Adhesion and Diapedesis of Lymphocytes [Genes]    Cytokines and Inflammatory Response [Genes]    Signal transduction through IL1R [Genes]    Erythrocyte Differentiation Pathway [Genes]    NF-kB Signaling Pathway [Genes]    Adhesion and Diapedesis of Granulocytes [Genes]    Stress Induction of HSP Regulation [Genes]   
Pathways : KEGGMAPK signaling pathway    Cytokine-cytokine receptor interaction    Apoptosis    Osteoclast differentiation    Hematopoietic cell lineage    Non-alcoholic fatty liver disease (NAFLD)    Type I diabetes mellitus    Prion diseases    Salmonella infection    Pertussis    Leishmaniasis    Tuberculosis    Measles    Influenza A    Inflammatory bowel disease (IBD)    Rheumatoid arthritis    Graft-versus-host disease   
NDEx NetworkIL1A
Atlas of Cancer Signalling NetworkIL1A
Wikipedia pathwaysIL1A
Orthology - Evolution
OrthoDB3552
GeneTree (enSembl)ENSG00000115008
Phylogenetic Trees/Animal Genes : TreeFamIL1A
Homologs : HomoloGeneIL1A
Homology/Alignments : Family Browser (UCSC)IL1A
Gene fusions - Rearrangements
Fusion : QuiverIL1A
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIL1A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IL1A
dbVarIL1A
ClinVarIL1A
MonarchIL1A
1000_GenomesIL1A 
Exome Variant ServerIL1A
GNOMAD BrowserENSG00000115008
Varsome BrowserIL1A
ACMGIL1A variants
VarityP01583
Genomic Variants (DGV)IL1A [DGVbeta]
DECIPHERIL1A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisIL1A 
Mutations
ICGC Data PortalIL1A 
TCGA Data PortalIL1A 
Broad Tumor PortalIL1A
OASIS PortalIL1A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIL1A  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DIL1A
Mutations and Diseases : HGMDIL1A
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaIL1A
DgiDB (Drug Gene Interaction Database)IL1A
DoCM (Curated mutations)IL1A
CIViC (Clinical Interpretations of Variants in Cancer)IL1A
Cancer3DIL1A
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM147760   
Orphanet
DisGeNETIL1A
MedgenIL1A
Genetic Testing Registry IL1A
NextProtP01583 [Medical]
GENETestsIL1A
Target ValidationIL1A
Huge Navigator IL1A [HugePedia]
ClinGenIL1A
Clinical trials, drugs, therapy
MyCancerGenomeIL1A
Protein Interactions : CTDIL1A
Pharm GKB GenePA29807
PharosP01583
Clinical trialIL1A
Miscellaneous
canSAR (ICR)IL1A
HarmonizomeIL1A
DataMed IndexIL1A
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXIL1A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 15:13:46 CEST 2021

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.