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IL1A (interleukin 1, alpha)

Identity

Other namesIL-1A
IL1
IL1-ALPHA
IL1F1
HGNC (Hugo) IL1A
LocusID (NCBI) 3552
Location 2q13
Location_base_pair Starts at 113531492 and ends at 113542971 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)IL1A   5991
Entrez_Gene (NCBI)IL1A  3552  interleukin 1, alpha
Cards
GeneCards (Weizmann)IL1A
Ensembl (Hinxton)ENSG00000115008 [Gene_View]  chr2:113531492-113542971 [Contig_View]  IL1A [Vega]
AceView (NCBI)IL1A
Genatlas (Paris)IL1A
SOURCE (Stanford)NM_000575
Genomic and cartography
GoldenPath (UCSC)IL1A  -  2q13   chr2:113531492-113542971 -  2q13   [Description]    (hg19-Feb_2009)
EnsemblIL1A - 2q13 [CytoView]
Mapping of homologs : NCBIIL1A [Mapview]
OMIM147760   
Gene and transcription
Genbank (Entrez)AK314850 BC013142 BC035169 BT007014 CA307202
RefSeq transcript (SRS)NM_000575
RefSeq transcript (Entrez)NM_000575
RefSeq genomic (SRS)AC_000134 NC_000002 NC_018913 NG_008850 NT_022135 NW_001838841 NW_004078008
RefSeq genomic (Entrez)AC_000134 NC_000002 NC_018913 NG_008850 NT_022135 NW_001838841 NW_004078008
Consensus coding sequences : CCDS (NCBI)IL1A
Cluster EST : UnigeneHs.1722 [ SRS ] Hs.1722 [ NCBI ]
CGAP (NCI)Hs.1722
Alternative Splicing : Fast-db (Paris)GSHG0017931
Alternative Splicing GalleryENSG00000115008
Gene ExpressionIL1A [ NCBI-GEO ]   IL1A [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP01583 (SRS) P01583 (Uniprot)
NextProtP01583
With graphics : InterProP01583
Splice isoforms : SwissVarP01583(Swissvar)
Domaine pattern : Prosite (SRS)INTERLEUKIN_1 (PS00253)   
Domaine pattern : Prosite (Expaxy)INTERLEUKIN_1 (PS00253)   
Domains : Interpro (SRS)Cytokine_IL1-like    IL1_propep    Interleukin-1_CS    Interleukin_1    InterleukinIL1A    InterleukinIL1AB   
Domains : Interpro (EBI)Cytokine_IL1-like    IL1_propep    Interleukin-1_CS    Interleukin_1    InterleukinIL1A    InterleukinIL1AB   
Related proteins : CluSTrP01583
Domain families : Pfam (SRS)IL1 (PF00340)    IL1_propep (PF02394)   
Domain families : Pfam (Sanger)IL1 (PF00340)    IL1_propep (PF02394)   
Domain families : Pfam (NCBI)pfam00340    pfam02394   
Domain families : Smart (EMBL)IL1 (SM00125)  
DMDM3552
Blocks (Seattle)P01583
PDB (SRS)1ITA    2ILA    2KKI    2L5X   
PDB (PDBSum)1ITA    2ILA    2KKI    2L5X   
PDB (IMB)1ITA    2ILA    2KKI    2L5X   
PDB (RSDB)1ITA    2ILA    2KKI    2L5X   
Human Protein AtlasENSG00000115008
HPRD00988
IPIIPI00003096   
Protein Interaction databases
DIP (DOE-UCLA)P01583
IntAct (EBI)P01583
FunCoupENSG00000115008
REACTOMEIL1A
Protein Interaction Database3552
BioGRIDIL1A
InParanoidP01583
Interologous Interaction database P01583
IntegromeDBIL1A
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)IL1A
SNP (GeneSNP Utah)IL1A
SNP : HGBaseIL1A
Genetic variants : HAPMAPIL1A
Somatic Mutations in Cancer : COSMICIL1A 
CONAN: Copy Number AnalysisIL1A 
Mutations and Diseases : HGMDIL1A
OMIM147760   
GENETests147760   
Disease Genetic AssociationIL1A
Huge Navigator IL1A [HugePedia]  IL1A [HugeCancerGEM]
Genomic VariantsIL1A  IL1A [DGVbeta]
snp3D : Map Gene to Disease3552
General knowledge
Homologs : HomoloGeneIL1A
Homology/Alignments : Family Browser (UCSC)IL1A
Phylogenetic Trees/Animal Genes : TreeFamIL1A
Chemical/Protein Interactions : CTD3552
Chemical/Pharm GKB GenePA29807
Clinical trialIL1A
Cancer Resource (Charite)ENSG00000115008
Ontology : AmiGOfever generation  response to hypoxia  cytokine activity  interleukin-1 receptor binding  copper ion binding  protein binding  extracellular region  extracellular space  extracellular space  cytosol  apoptotic process  inflammatory response  immune response  cell proliferation  negative regulation of cell proliferation  cell surface  response to ozone  response to organic nitrogen  response to gamma radiation  positive regulation vascular endothelial growth factor production  positive regulation of steroid biosynthetic process  response to organic cyclic compound  cytokine-mediated signaling pathway  keratinization  response to lipopolysaccharide  positive regulation of interleukin-6 production  response to L-ascorbic acid  cellular response to heat  wound healing  negative regulation of apoptotic process  positive regulation of I-kappaB kinase/NF-kappaB cascade  positive regulation of interleukin-2 biosynthetic process  positive regulation of angiogenesis  positive regulation of mitosis  positive regulation of transcription from RNA polymerase II promoter  positive regulation of JNK cascade  response to copper ion  positive regulation of cytokine secretion  positive regulation of cell division  regulation of sensory perception of pain  positive regulation of ERK1 and ERK2 cascade  
Ontology : EGO-EBIfever generation  response to hypoxia  cytokine activity  interleukin-1 receptor binding  copper ion binding  protein binding  extracellular region  extracellular space  extracellular space  cytosol  apoptotic process  inflammatory response  immune response  cell proliferation  negative regulation of cell proliferation  cell surface  response to ozone  response to organic nitrogen  response to gamma radiation  positive regulation vascular endothelial growth factor production  positive regulation of steroid biosynthetic process  response to organic cyclic compound  cytokine-mediated signaling pathway  keratinization  response to lipopolysaccharide  positive regulation of interleukin-6 production  response to L-ascorbic acid  cellular response to heat  wound healing  negative regulation of apoptotic process  positive regulation of I-kappaB kinase/NF-kappaB cascade  positive regulation of interleukin-2 biosynthetic process  positive regulation of angiogenesis  positive regulation of mitosis  positive regulation of transcription from RNA polymerase II promoter  positive regulation of JNK cascade  response to copper ion  positive regulation of cytokine secretion  positive regulation of cell division  regulation of sensory perception of pain  positive regulation of ERK1 and ERK2 cascade  
Pathways : BIOCARTACells and Molecules involved in local acute inflammatory response [Genes]    Cytokine Network [Genes]    IL-10 Anti-inflammatory Signaling Pathway [Genes]    Adhesion and Diapedesis of Lymphocytes [Genes]    Cytokines and Inflammatory Response [Genes]    Signal transduction through IL1R [Genes]    Erythrocyte Differentiation Pathway [Genes]    NF-kB Signaling Pathway [Genes]    Adhesion and Diapedesis of Granulocytes [Genes]    Stress Induction of HSP Regulation [Genes]   
Pathways : KEGGType I diabetes mellitusApoptosisMAPK signaling pathwayCytokine-cytokine receptor interactionHematopoietic cell lineage
Other databases
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
PubGeneIL1A
iHOPIL1A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated01-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed May 1 12:19:53 CEST 2013
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