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IL1A (interleukin 1 alpha)

Identity

Other namesIL-1A
IL1
IL1-ALPHA
IL1F1
HGNC (Hugo) IL1A
LocusID (NCBI) 3552
Atlas_Id 40949
Location 2q13  [Link to chromosome band 2q13]
Location_base_pair Starts at 113531492 and ends at 113542975 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
IL1A (2q13) / IL1A (2q13)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)IL1A   5991
Cards
Entrez_Gene (NCBI)IL1A  3552  interleukin 1 alpha
AliasesIL-1A; IL1; IL1-ALPHA; IL1F1
GeneCards (Weizmann)IL1A
Ensembl hg19 (Hinxton)ENSG00000115008 [Gene_View]  chr2:113531492-113542975 [Contig_View]  IL1A [Vega]
Ensembl hg38 (Hinxton)ENSG00000115008 [Gene_View]  chr2:113531492-113542975 [Contig_View]  IL1A [Vega]
ICGC DataPortalENSG00000115008
TCGA cBioPortalIL1A
AceView (NCBI)IL1A
Genatlas (Paris)IL1A
WikiGenes3552
SOURCE (Princeton)IL1A
Genomic and cartography
GoldenPath hg19 (UCSC)IL1A  -     chr2:113531492-113542975 -  2q13   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)IL1A  -     2q13   [Description]    (hg38-Dec_2013)
EnsemblIL1A - 2q13 [CytoView hg19]  IL1A - 2q13 [CytoView hg38]
Mapping of homologs : NCBIIL1A [Mapview hg19]  IL1A [Mapview hg38]
OMIM147760   
Gene and transcription
Genbank (Entrez)AA856674 AK314850 BC013142 BC035169 BT007014
RefSeq transcript (Entrez)NM_000575
RefSeq genomic (Entrez)NC_000002 NC_018913 NG_008850 NT_005403 NW_004929304
Consensus coding sequences : CCDS (NCBI)IL1A
Cluster EST : UnigeneHs.1722 [ NCBI ]
CGAP (NCI)Hs.1722
Alternative Splicing GalleryENSG00000115008
Gene ExpressionIL1A [ NCBI-GEO ]   IL1A [ EBI - ARRAY_EXPRESS ]   IL1A [ SEEK ]   IL1A [ MEM ]
Gene Expression Viewer (FireBrowse)IL1A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3552
GTEX Portal (Tissue expression)IL1A
Protein : pattern, domain, 3D structure
UniProt/SwissProtP01583 (Uniprot)
NextProtP01583  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP01583
Splice isoforms : SwissVarP01583 (Swissvar)
PhosPhoSitePlusP01583
Domaine pattern : Prosite (Expaxy)INTERLEUKIN_1 (PS00253)   
Domains : Interpro (EBI)Cytokine_IL1-like    IL-1_alpha    IL-1_alpha/beta    IL-1_CS    IL-1_fam    IL-1_propep   
Domain families : Pfam (Sanger)IL1 (PF00340)    IL1_propep (PF02394)   
Domain families : Pfam (NCBI)pfam00340    pfam02394   
DMDM Disease mutations3552
Blocks (Seattle)IL1A
PDB (SRS)1ITA    2ILA    2KKI    2L5X   
PDB (PDBSum)1ITA    2ILA    2KKI    2L5X   
PDB (IMB)1ITA    2ILA    2KKI    2L5X   
PDB (RSDB)1ITA    2ILA    2KKI    2L5X   
Structural Biology KnowledgeBase1ITA    2ILA    2KKI    2L5X   
SCOP (Structural Classification of Proteins)1ITA    2ILA    2KKI    2L5X   
CATH (Classification of proteins structures)1ITA    2ILA    2KKI    2L5X   
SuperfamilyP01583
Human Protein AtlasENSG00000115008
Peptide AtlasP01583
HPRD00988
IPIIPI00003096   
Protein Interaction databases
DIP (DOE-UCLA)P01583
IntAct (EBI)P01583
FunCoupENSG00000115008
BioGRIDIL1A
STRING (EMBL)IL1A
ZODIACIL1A
Ontologies - Pathways
QuickGOP01583
Ontology : AmiGOfever generation  connective tissue replacement involved in inflammatory response wound healing  cytokine activity  interleukin-1 receptor binding  copper ion binding  protein binding  extracellular region  extracellular space  extracellular space  cytosol  apoptotic process  inflammatory response  immune response  cell proliferation  negative regulation of cell proliferation  positive regulation of vascular endothelial growth factor production  positive regulation of gene expression  cytokine-mediated signaling pathway  cellular response to heat  ectopic germ cell programmed cell death  positive regulation of I-kappaB kinase/NF-kappaB signaling  positive regulation of interleukin-2 biosynthetic process  positive regulation of angiogenesis  positive regulation of mitotic nuclear division  positive regulation of transcription from RNA polymerase II promoter  positive regulation of JNK cascade  response to copper ion  positive regulation of protein secretion  positive regulation of cytokine secretion  extrinsic apoptotic signaling pathway in absence of ligand  negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  
Ontology : EGO-EBIfever generation  connective tissue replacement involved in inflammatory response wound healing  cytokine activity  interleukin-1 receptor binding  copper ion binding  protein binding  extracellular region  extracellular space  extracellular space  cytosol  apoptotic process  inflammatory response  immune response  cell proliferation  negative regulation of cell proliferation  positive regulation of vascular endothelial growth factor production  positive regulation of gene expression  cytokine-mediated signaling pathway  cellular response to heat  ectopic germ cell programmed cell death  positive regulation of I-kappaB kinase/NF-kappaB signaling  positive regulation of interleukin-2 biosynthetic process  positive regulation of angiogenesis  positive regulation of mitotic nuclear division  positive regulation of transcription from RNA polymerase II promoter  positive regulation of JNK cascade  response to copper ion  positive regulation of protein secretion  positive regulation of cytokine secretion  extrinsic apoptotic signaling pathway in absence of ligand  negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  
Pathways : BIOCARTACells and Molecules involved in local acute inflammatory response [Genes]    Cytokine Network [Genes]    IL-10 Anti-inflammatory Signaling Pathway [Genes]    Adhesion and Diapedesis of Lymphocytes [Genes]    Cytokines and Inflammatory Response [Genes]    Signal transduction through IL1R [Genes]    Erythrocyte Differentiation Pathway [Genes]    NF-kB Signaling Pathway [Genes]    Adhesion and Diapedesis of Granulocytes [Genes]    Stress Induction of HSP Regulation [Genes]   
Pathways : KEGGMAPK signaling pathway    Cytokine-cytokine receptor interaction    Apoptosis    Osteoclast differentiation    Hematopoietic cell lineage    Non-alcoholic fatty liver disease (NAFLD)    Type I diabetes mellitus    Prion diseases    Salmonella infection    Pertussis    Leishmaniasis    Tuberculosis    Measles    Influenza A    Inflammatory bowel disease (IBD)    Rheumatoid arthritis    Graft-versus-host disease   
NDEx NetworkIL1A
Atlas of Cancer Signalling NetworkIL1A
Wikipedia pathwaysIL1A
Orthology - Evolution
OrthoDB3552
GeneTree (enSembl)ENSG00000115008
Phylogenetic Trees/Animal Genes : TreeFamIL1A
Homologs : HomoloGeneIL1A
Homology/Alignments : Family Browser (UCSC)IL1A
Gene fusions - Rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerIL1A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IL1A
dbVarIL1A
ClinVarIL1A
1000_GenomesIL1A 
Exome Variant ServerIL1A
ExAC (Exome Aggregation Consortium)IL1A (select the gene name)
Genetic variants : HAPMAP3552
Genomic Variants (DGV)IL1A [DGVbeta]
Mutations
ICGC Data PortalIL1A 
TCGA Data PortalIL1A 
Broad Tumor PortalIL1A
OASIS PortalIL1A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIL1A 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)TBsLVD Tuberculosis susceptibility Locus Variation Database
BioMutasearch IL1A
DgiDB (Drug Gene Interaction Database)IL1A
DoCM (Curated mutations)IL1A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)IL1A (select a term)
intoGenIL1A
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)2:113531492-113542975  ENSG00000115008
CONAN: Copy Number AnalysisIL1A 
Mutations and Diseases : HGMDIL1A
OMIM147760   
MedgenIL1A
Genetic Testing Registry IL1A
NextProtP01583 [Medical]
TSGene3552
GENETestsIL1A
Huge Navigator IL1A [HugePedia]
snp3D : Map Gene to Disease3552
BioCentury BCIQIL1A
ClinGenIL1A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3552
Chemical/Pharm GKB GenePA29807
Clinical trialIL1A
Miscellaneous
canSAR (ICR)IL1A (select the gene name)
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineIL1A
EVEXIL1A
GoPubMedIL1A
iHOPIL1A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Oct 1 15:57:37 CEST 2016

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