| Nomenclature |
|---|
| HGNC (Hugo) | IL1R1 5993 |
| Cards |
|---|
| Entrez_Gene (NCBI) | IL1R1 interleukin 1 receptor type 1 |
| Aliases | CD121A; D2S1473; IL-1R-alpha; IL1R; |
| IL1RA; P80 |
| GeneCards (Weizmann) | IL1R1 |
| Ensembl hg19 (Hinxton) | ENSG00000115594 [Gene_View] |
| Ensembl hg38 (Hinxton) | ENSG00000115594 [Gene_View] ENSG00000115594 [Sequence] chr2:102104604-102165370 [Contig_View] IL1R1 [Vega] |
| ICGC DataPortal | ENSG00000115594 |
| TCGA cBioPortal | IL1R1 |
| AceView (NCBI) | IL1R1 |
| Genatlas (Paris) | IL1R1 |
| SOURCE (Princeton) | IL1R1 |
| Genetics Home Reference (NIH) | IL1R1 |
| Genomic and cartography |
|---|
| GoldenPath hg38 (UCSC) | IL1R1 - chr2:102104604-102165370 + 2q12.1 [Description] (hg38-Dec_2013) |
| GoldenPath hg19 (UCSC) | IL1R1 - 2q12.1 [Description] (hg19-Feb_2009) |
| GoldenPath | IL1R1 - 2q12.1 [CytoView hg19] IL1R1 - 2q12.1 [CytoView hg38] |
| ImmunoBase | ENSG00000115594 |
| Genome Data Viewer NCBI | IL1R1 [Mapview hg19] |
| OMIM | 147810 |
| Gene and transcription |
|---|
| Genbank (Entrez) | AK026803 AK314433 AL548240 AU136426 BC067506 |
| RefSeq transcript (Entrez) | NM_000877 NM_001288706 NM_001320978 NM_001320980 NM_001320981 NM_001320982 NM_001320983 NM_001320984 NM_001320985 NM_001320986 |
| Consensus coding sequences : CCDS (NCBI) | IL1R1 |
| Gene Expression | IL1R1 [ NCBI-GEO ] IL1R1 [ EBI - ARRAY_EXPRESS ]
IL1R1 [ SEEK ] IL1R1 [ MEM ] |
| Gene Expression Viewer (FireBrowse) | IL1R1 [ Firebrowse - Broad ] |
| Genevisible | Expression of IL1R1 in : [tissues] [cell-lines] [cancer] [perturbations] |
| BioGPS (Tissue expression) | 3554 |
| GTEX Portal (Tissue expression) | IL1R1 |
| Human Protein Atlas | ENSG00000115594-IL1R1 [pathology] [cell] [tissue] |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | P14778 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
| NextProt | P14778 [Sequence] [Exons] [Medical] [Publications] |
| With graphics : InterPro | P14778 |
| PhosPhoSitePlus | P14778 |
| Domaine pattern : Prosite (Expaxy) | IG_LIKE (PS50835) TIR (PS50104) |
| Domains : Interpro (EBI) | Ig-like_dom Ig-like_dom_sf Ig-like_fold Ig_sub IL-1_rcpt_fam IL-1_rcpt_I-typ IL-1_rcpt_I/II-typ IL-1RAcP-like_ig TIR_dom Toll_tir_struct_dom_sf |
| Domain families : Pfam (Sanger) | Ig_2 (PF13895) Ig_6 (PF18452) TIR (PF01582) |
| Domain families : Pfam (NCBI) | pfam13895 pfam18452 pfam01582 |
| Domain families : Smart (EMBL) | IG (SM00409) TIR (SM00255) |
| Conserved Domain (NCBI) | IL1R1 |
| PDB (RSDB) | 1G0Y 1IRA 1ITB 4DEP 4GAF |
| PDB Europe | 1G0Y 1IRA 1ITB 4DEP 4GAF |
| PDB (PDBSum) | 1G0Y 1IRA 1ITB 4DEP 4GAF |
| PDB (IMB) | 1G0Y 1IRA 1ITB 4DEP 4GAF |
| Structural Biology KnowledgeBase | 1G0Y 1IRA 1ITB 4DEP 4GAF |
| SCOP (Structural Classification of Proteins) | 1G0Y 1IRA 1ITB 4DEP 4GAF |
| CATH (Classification of proteins structures) | 1G0Y 1IRA 1ITB 4DEP 4GAF |
| Superfamily | P14778 |
| AlphaFold pdb e-kb | P14778 |
| Human Protein Atlas [tissue] | ENSG00000115594-IL1R1 [tissue] |
| HPRD | 00994 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | P14778 |
| IntAct (EBI) | P14778 |
| BioGRID | IL1R1 |
| STRING (EMBL) | IL1R1 |
| ZODIAC | IL1R1 |
| Ontologies - Pathways |
|---|
| QuickGO | P14778 |
| Ontology : AmiGO | protease binding transmembrane signaling receptor activity interleukin-1 receptor activity interleukin-1 receptor activity interleukin-1, type I, activating receptor activity platelet-derived growth factor receptor binding protein binding extracellular region plasma membrane integral component of plasma membrane inflammatory response immune response cell surface receptor signaling pathway external side of plasma membrane membrane cytokine-mediated signaling pathway interleukin-1 binding positive regulation of interferon-gamma production NAD(P)+ nucleosidase activity regulation of inflammatory response NAD+ nucleotidase, cyclic ADP-ribose generating interleukin-1-mediated signaling pathway interleukin-1-mediated signaling pathway interleukin-1-mediated signaling pathway response to interleukin-1 positive regulation of neutrophil extravasation positive regulation of T-helper 1 cell cytokine production positive regulation of interleukin-1-mediated signaling pathway |
| Ontology : EGO-EBI | protease binding transmembrane signaling receptor activity interleukin-1 receptor activity interleukin-1 receptor activity interleukin-1, type I, activating receptor activity platelet-derived growth factor receptor binding protein binding extracellular region plasma membrane integral component of plasma membrane inflammatory response immune response cell surface receptor signaling pathway external side of plasma membrane membrane cytokine-mediated signaling pathway interleukin-1 binding positive regulation of interferon-gamma production NAD(P)+ nucleosidase activity regulation of inflammatory response NAD+ nucleotidase, cyclic ADP-ribose generating interleukin-1-mediated signaling pathway interleukin-1-mediated signaling pathway interleukin-1-mediated signaling pathway response to interleukin-1 positive regulation of neutrophil extravasation positive regulation of T-helper 1 cell cytokine production positive regulation of interleukin-1-mediated signaling pathway |
| Pathways : BIOCARTA | Signal transduction through IL1R [Genes] NF-kB Signaling Pathway [Genes] |
| Pathways : KEGG | MAPK signaling pathway Cytokine-cytokine receptor interaction NF-kappa B signaling pathway Apoptosis Osteoclast differentiation Hematopoietic cell lineage Amoebiasis HTLV-I infection |
| NDEx Network | IL1R1 |
| Atlas of Cancer Signalling Network | IL1R1 |
| Wikipedia pathways | IL1R1 |
| Orthology - Evolution |
|---|
| OrthoDB | 3554 |
| GeneTree (enSembl) | ENSG00000115594 |
| Phylogenetic Trees/Animal Genes : TreeFam | IL1R1 |
| Homologs : HomoloGene | IL1R1 |
| Homology/Alignments : Family Browser (UCSC) | IL1R1 |
| Gene fusions - Rearrangements |
|---|
| Fusion : Mitelman | IL1R1::IL1R2 [2q12.1/2q11.2] |
| Fusion : Quiver | IL1R1 |
| Polymorphisms : SNP and Copy number variants |
|---|
| NCBI Variation Viewer | IL1R1 [hg38] |
| dbSNP Single Nucleotide Polymorphism (NCBI) | IL1R1 |
| dbVar | IL1R1 |
| ClinVar | IL1R1 |
| Monarch | IL1R1 |
| 1000_Genomes | IL1R1 |
| Exome Variant Server | IL1R1 |
| GNOMAD Browser | ENSG00000115594 |
| Varsome Browser | IL1R1 |
| ACMG | IL1R1 variants |
| Varity | P14778 |
| Genomic Variants (DGV) | IL1R1 [DGVbeta] |
| DECIPHER | IL1R1 [patients] [syndromes] [variants] [genes] |
| CONAN: Copy Number Analysis | IL1R1 |
| Mutations |
|---|
| ICGC Data Portal | IL1R1 |
| TCGA Data Portal | IL1R1 |
| Broad Tumor Portal | IL1R1 |
| OASIS Portal | IL1R1 [ Somatic mutations - Copy number] |
| Somatic Mutations in Cancer : COSMIC | IL1R1 [overview] [genome browser] [tissue] [distribution] |
| Somatic Mutations in Cancer : COSMIC3D | IL1R1 |
| Mutations and Diseases : HGMD | IL1R1 |
| LOVD (Leiden Open Variation Database) | [gene] [transcripts] [variants] |
| BioMuta | IL1R1 |
| DgiDB (Drug Gene Interaction Database) | IL1R1 |
| DoCM (Curated mutations) | IL1R1 |
| CIViC (Clinical Interpretations of Variants in Cancer) | IL1R1 |
| Cancer3D | IL1R1 |
| Impact of mutations | [PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
|---|
| OMIM | 147810 |
| Orphanet | |
| DisGeNET | IL1R1 |
| Medgen | IL1R1 |
| Genetic Testing Registry | IL1R1
|
| NextProt | P14778 [Medical] |
| GENETests | IL1R1 |
| Target Validation | IL1R1 |
| Huge Navigator |
IL1R1 [HugePedia] |
| ClinGen | IL1R1 |
| Clinical trials, drugs, therapy |
|---|
| MyCancerGenome | IL1R1 |
| Protein Interactions : CTD | IL1R1 |
| Pharm GKB Gene | PA29809 |
| Pharos | P14778 |
| Clinical trial | IL1R1 |
| Miscellaneous |
|---|
| canSAR (ICR) | IL1R1 |
| Harmonizome | IL1R1 |
| ARCHS4 | IL1R1 |
| DataMed Index | IL1R1 |
| Probes |
|---|
| Litterature |
|---|
| PubMed | 303 Pubmed reference(s) in Entrez |
| GeneRIFs | Gene References Into Functions (Entrez) |
| EVEX | IL1R1 |
