Atlas of Genetics and Cytogenetics in Oncology and Haematology

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IL1R2 (interleukin 1 receptor type 2)

Identity

Alias (NCBI)CD121b
CDw121b
IL-1R-2
IL-1RT-2
IL-1RT2
IL1R2c
IL1RB
HGNC (Hugo) IL1R2
HGNC Alias symbCD121b
HGNC Previous nameIL1RB
HGNC Previous nameinterleukin 1 receptor, type II
LocusID (NCBI) 7850
Atlas_Id 43854
Location 2q11.2  [Link to chromosome band 2q11]
Location_base_pair Starts at 101991960 and ends at 102028544 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CANX (5q35.3) / IL1R2 (2q11.2)IL1R1 (2q12.1) / IL1R2 (2q11.2)IL1RL2 (2q12.1) / IL1R2 (2q11.2)
CANX 5q35.3 / IL1R2 2q11.2IL1R1 2q12.1 / IL1R2 2q11.2IL1RL2 2q12.1 / IL1R2 2q11.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 3 ]
  IL1R1/IL1R2 (2q11)
t(2;2)(q11;q12) IL1RL2/IL1R2
t(2;5)(q11;q35) CANX/IL1R2

External links

Nomenclature
HGNC (Hugo)IL1R2   5994
Cards
Entrez_Gene (NCBI)IL1R2    interleukin 1 receptor type 2
AliasesCD121b; CDw121b; IL-1R-2; IL-1RT-2; 
IL-1RT2; IL1R2c; IL1RB
GeneCards (Weizmann)IL1R2
Ensembl hg19 (Hinxton)ENSG00000115590 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000115590 [Gene_View]  ENSG00000115590 [Sequence]  chr2:101991960-102028544 [Contig_View]  IL1R2 [Vega]
ICGC DataPortalENSG00000115590
TCGA cBioPortalIL1R2
AceView (NCBI)IL1R2
Genatlas (Paris)IL1R2
SOURCE (Princeton)IL1R2
Genetics Home Reference (NIH)IL1R2
Genomic and cartography
GoldenPath hg38 (UCSC)IL1R2  -     chr2:101991960-102028544 +  2q11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)IL1R2  -     2q11.2   [Description]    (hg19-Feb_2009)
GoldenPathIL1R2 - 2q11.2 [CytoView hg19]  IL1R2 - 2q11.2 [CytoView hg38]
ImmunoBaseENSG00000115590
genome Data Viewer NCBIIL1R2 [Mapview hg19]  
OMIM147811   
Gene and transcription
Genbank (Entrez)AK130412 AK309161 BC012346 BC027733 BC039031
RefSeq transcript (Entrez)NM_001261419 NM_004633 NM_173343
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)IL1R2
Alternative Splicing GalleryENSG00000115590
Gene ExpressionIL1R2 [ NCBI-GEO ]   IL1R2 [ EBI - ARRAY_EXPRESS ]   IL1R2 [ SEEK ]   IL1R2 [ MEM ]
Gene Expression Viewer (FireBrowse)IL1R2 [ Firebrowse - Broad ]
GenevisibleExpression of IL1R2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7850
GTEX Portal (Tissue expression)IL1R2
Human Protein AtlasENSG00000115590-IL1R2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP27930   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP27930  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP27930
Splice isoforms : SwissVarP27930
PhosPhoSitePlusP27930
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)   
Domains : Interpro (EBI)Ig-like_dom    Ig-like_dom_sf    Ig-like_fold    Ig_6    Ig_sub    Ig_sub2    IL-1_rcpt_fam    IL-1_rcpt_I/II-typ    IL-1_rcpt_II-typ    Immunoglobulin   
Domain families : Pfam (Sanger)ig (PF00047)    Ig_6 (PF18452)   
Domain families : Pfam (NCBI)pfam00047    pfam18452   
Domain families : Smart (EMBL)IG (SM00409)  IGc2 (SM00408)  
Conserved Domain (NCBI)IL1R2
Blocks (Seattle)IL1R2
PDB (RSDB)3O4O   
PDB Europe3O4O   
PDB (PDBSum)3O4O   
PDB (IMB)3O4O   
Structural Biology KnowledgeBase3O4O   
SCOP (Structural Classification of Proteins)3O4O   
CATH (Classification of proteins structures)3O4O   
SuperfamilyP27930
Human Protein Atlas [tissue]ENSG00000115590-IL1R2 [tissue]
Peptide AtlasP27930
HPRD00995
IPIIPI00021382   IPI00924851   IPI00924548   
Protein Interaction databases
DIP (DOE-UCLA)P27930
IntAct (EBI)P27930
BioGRIDIL1R2
STRING (EMBL)IL1R2
ZODIACIL1R2
Ontologies - Pathways
QuickGOP27930
Ontology : AmiGOinterleukin-1 receptor activity  interleukin-1, type II, blocking receptor activity  protein binding  extracellular region  cytoplasm  plasma membrane  immune response  negative regulation of protein processing  integral component of membrane  cytokine-mediated signaling pathway  interleukin-1 binding  negative regulation of interleukin-1 alpha secretion  interleukin-1-mediated signaling pathway  negative regulation of cytokine production involved in inflammatory response  negative regulation of interleukin-1-mediated signaling pathway  
Ontology : EGO-EBIinterleukin-1 receptor activity  interleukin-1, type II, blocking receptor activity  protein binding  extracellular region  cytoplasm  plasma membrane  immune response  negative regulation of protein processing  integral component of membrane  cytokine-mediated signaling pathway  interleukin-1 binding  negative regulation of interleukin-1 alpha secretion  interleukin-1-mediated signaling pathway  negative regulation of cytokine production involved in inflammatory response  negative regulation of interleukin-1-mediated signaling pathway  
Pathways : KEGGMAPK signaling pathway    Cytokine-cytokine receptor interaction    Hematopoietic cell lineage    Amoebiasis    HTLV-I infection    Transcriptional misregulation in cancer   
NDEx NetworkIL1R2
Atlas of Cancer Signalling NetworkIL1R2
Wikipedia pathwaysIL1R2
Orthology - Evolution
OrthoDB7850
GeneTree (enSembl)ENSG00000115590
Phylogenetic Trees/Animal Genes : TreeFamIL1R2
HOGENOMP27930
Homologs : HomoloGeneIL1R2
Homology/Alignments : Family Browser (UCSC)IL1R2
Gene fusions - Rearrangements
Fusion : MitelmanCANX/IL1R2 [5q35.3/2q11.2]  
Fusion : MitelmanIL1R1/IL1R2 [2q12.1/2q11.2]  
Fusion : MitelmanIL1RL2/IL1R2 [2q12.1/2q11.2]  
Fusion PortalCANX 5q35.3 IL1R2 2q11.2 HNSC
Fusion PortalIL1R1 2q12.1 IL1R2 2q11.2 BRCA LUAD
Fusion PortalIL1RL2 2q12.1 IL1R2 2q11.2 BRCA
Fusion : QuiverIL1R2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIL1R2 [hg38]
dbVarIL1R2
ClinVarIL1R2
MonarchIL1R2
1000_GenomesIL1R2 
Exome Variant ServerIL1R2
GNOMAD BrowserENSG00000115590
Varsome BrowserIL1R2
Genomic Variants (DGV)IL1R2 [DGVbeta]
DECIPHERIL1R2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisIL1R2 
Mutations
ICGC Data PortalIL1R2 
TCGA Data PortalIL1R2 
Broad Tumor PortalIL1R2
OASIS PortalIL1R2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIL1R2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DIL1R2
Mutations and Diseases : HGMDIL1R2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch IL1R2
DgiDB (Drug Gene Interaction Database)IL1R2
DoCM (Curated mutations)IL1R2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)IL1R2 (select a term)
intoGenIL1R2
Cancer3DIL1R2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM147811   
Orphanet
DisGeNETIL1R2
MedgenIL1R2
Genetic Testing Registry IL1R2
NextProtP27930 [Medical]
GENETestsIL1R2
Target ValidationIL1R2
Huge Navigator IL1R2 [HugePedia]
ClinGenIL1R2
Clinical trials, drugs, therapy
MyCancerGenomeIL1R2
Protein Interactions : CTD
Pharm GKB GenePA29810
PharosP27930
Clinical trialIL1R2
Miscellaneous
canSAR (ICR)IL1R2 (select the gene name)
HarmonizomeIL1R2
DataMed IndexIL1R2
Probes
Litterature
PubMed121 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXIL1R2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jan 1 18:20:08 CET 2021
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