IL1R2 (interleukin 1 receptor type 2)

2007-02-01 Affiliation

Identity

HGNC

IL1R2

LOCATION

2q11.2

LOCUSID

7850

ALIAS

CD121b,CDw121b,IL-1R-2,IL-1RT-2,IL-1RT2,IL1R2c,IL1RB

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 7850
MIM: 147811
HGNC: 5994
Ensembl: ENSG00000115590

Variants:

dbSNP: 7850
ClinVar: 7850
TCGA: ENSG00000115590
COSMIC: IL1R2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000115590	ENST00000332549	P27930
ENSG00000115590	ENST00000393414	P27930
ENSG00000115590	ENST00000441002	P27930
ENSG00000115590	ENST00000457817	C9JNR0

Expression (GTEx)

100

150

200

250

300

350

400

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
MAPK signaling pathway	KEGG	ko04010
Cytokine-cytokine receptor interaction	KEGG	ko04060
Hematopoietic cell lineage	KEGG	ko04640
MAPK signaling pathway	KEGG	hsa04010
Cytokine-cytokine receptor interaction	KEGG	hsa04060
Hematopoietic cell lineage	KEGG	hsa04640
Amoebiasis	KEGG	ko05146
Amoebiasis	KEGG	hsa05146
HTLV-I infection	KEGG	ko05166
HTLV-I infection	KEGG	hsa05166
Transcriptional misregulation in cancer	KEGG	ko05202
Transcriptional misregulation in cancer	KEGG	hsa05202
Immune System	REACTOME	R-HSA-168256
Cytokine Signaling in Immune system	REACTOME	R-HSA-1280215
Signaling by Interleukins	REACTOME	R-HSA-449147
Interleukin-1 signaling	REACTOME	R-HSA-446652
Interleukin-10 signaling	REACTOME	R-HSA-6783783
Fluid shear stress and atherosclerosis	KEGG	ko05418
Fluid shear stress and atherosclerosis	KEGG	hsa05418

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
20062062	2010	Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci.	162
17703412	2007	Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.	100
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
23395675	2013	Intracellular interleukin-1 receptor 2 binding prevents cleavage and activity of interleukin-1α, controlling necrosis-induced sterile inflammation.	67
12363051	2002	Susceptibility to dengue hemorrhagic fever in vietnam: evidence of an association with variation in the vitamin d receptor and Fc gamma receptor IIa genes.	55
17307738	2007	Regulated intramembrane proteolysis of the interleukin-1 receptor II by alpha-, beta-, and gamma-secretase.	51
12530978	2003	The soluble form of IL-1 receptor accessory protein enhances the ability of soluble type II IL-1 receptor to inhibit IL-1 action.	45
20673868	2010	A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM).	36
18818748	2008	Preterm birth in Caucasians is associated with coagulation and inflammation pathway gene variants.	31
19527514	2009	Racial disparity in pathophysiologic pathways of preterm birth based on genetic variants.	31

Citation

Dessen P

IL1R2 (interleukin 1 receptor type 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43854/il1r2