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IL1RAP (interleukin 1 receptor accessory protein)

Identity

Alias_symbol (synonym)IL-1RAcP
IL1R3
C3orf13
Other alias
HGNC (Hugo) IL1RAP
LocusID (NCBI) 3556
Atlas_Id 40952
Location 3q28  [Link to chromosome band 3q28]
Location_base_pair Starts at 190514051 and ends at 190651519 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
IL1RAP (3q28) / TMEM207 (3q28)IL1RAP (3q28) / TP63 (3q28)IL1RAP (3q28) / TPRG1 (3q28)
IL1RAP 3q28 / TMEM207 3q28IL1RAP 3q28 / TP63 3q28IL1RAP 3q28 / TPRG1 3q28

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)IL1RAP   5995
Cards
Entrez_Gene (NCBI)IL1RAP  3556  interleukin 1 receptor accessory protein
AliasesC3orf13; IL-1RAcP; IL1R3
GeneCards (Weizmann)IL1RAP
Ensembl hg19 (Hinxton)ENSG00000196083 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000196083 [Gene_View]  chr3:190514051-190651519 [Contig_View]  IL1RAP [Vega]
ICGC DataPortalENSG00000196083
TCGA cBioPortalIL1RAP
AceView (NCBI)IL1RAP
Genatlas (Paris)IL1RAP
WikiGenes3556
SOURCE (Princeton)IL1RAP
Genetics Home Reference (NIH)IL1RAP
Genomic and cartography
GoldenPath hg38 (UCSC)IL1RAP  -     chr3:190514051-190651519 +  3q28   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)IL1RAP  -     3q28   [Description]    (hg19-Feb_2009)
EnsemblIL1RAP - 3q28 [CytoView hg19]  IL1RAP - 3q28 [CytoView hg38]
Mapping of homologs : NCBIIL1RAP [Mapview hg19]  IL1RAP [Mapview hg38]
OMIM602626   
Gene and transcription
Genbank (Entrez)AB006537 AF029213 AF167343 AF487335 AF538730
RefSeq transcript (Entrez)NM_001167928 NM_001167929 NM_001167930 NM_001167931 NM_002182 NM_134470
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)IL1RAP
Cluster EST : UnigeneHs.478673 [ NCBI ]
CGAP (NCI)Hs.478673
Alternative Splicing GalleryENSG00000196083
Gene ExpressionIL1RAP [ NCBI-GEO ]   IL1RAP [ EBI - ARRAY_EXPRESS ]   IL1RAP [ SEEK ]   IL1RAP [ MEM ]
Gene Expression Viewer (FireBrowse)IL1RAP [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3556
GTEX Portal (Tissue expression)IL1RAP
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NPH3   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NPH3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NPH3
Splice isoforms : SwissVarQ9NPH3
PhosPhoSitePlusQ9NPH3
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)    TIR (PS50104)   
Domains : Interpro (EBI)Ig-like_dom    Ig-like_fold    Ig_sub    IL-1_rcpt_fam    IL-1_rcpt_I/II-typ    TIR_dom   
Domain families : Pfam (Sanger)TIR (PF01582)   
Domain families : Pfam (NCBI)pfam01582   
Domain families : Smart (EMBL)IG (SM00409)  TIR (SM00255)  
Conserved Domain (NCBI)IL1RAP
DMDM Disease mutations3556
Blocks (Seattle)IL1RAP
PDB (SRS)3O4O    4DEP   
PDB (PDBSum)3O4O    4DEP   
PDB (IMB)3O4O    4DEP   
PDB (RSDB)3O4O    4DEP   
Structural Biology KnowledgeBase3O4O    4DEP   
SCOP (Structural Classification of Proteins)3O4O    4DEP   
CATH (Classification of proteins structures)3O4O    4DEP   
SuperfamilyQ9NPH3
Human Protein AtlasENSG00000196083
Peptide AtlasQ9NPH3
HPRD04021
IPIIPI00031789   IPI00107619   IPI00337687   IPI00925621   IPI00925851   IPI00926554   IPI00926779   IPI00927047   
Protein Interaction databases
DIP (DOE-UCLA)Q9NPH3
IntAct (EBI)Q9NPH3
FunCoupENSG00000196083
BioGRIDIL1RAP
STRING (EMBL)IL1RAP
ZODIACIL1RAP
Ontologies - Pathways
QuickGOQ9NPH3
Ontology : AmiGOinterleukin-33 receptor activity  signal transducer activity  interleukin-1 receptor activity  extracellular space  plasma membrane  integral component of plasma membrane  protein complex assembly  inflammatory response  immune response  membrane  positive regulation of interleukin-13 production  positive regulation of interleukin-5 production  interleukin-33-mediated signaling pathway  interleukin-2 biosynthetic process  innate immune response  positive regulation of NF-kappaB transcription factor activity  positive regulation of synapse assembly  interleukin-4 secretion  positive regulation of dendrite development  protein tyrosine kinase binding  positive regulation of interleukin-6 secretion  
Ontology : EGO-EBIinterleukin-33 receptor activity  signal transducer activity  interleukin-1 receptor activity  extracellular space  plasma membrane  integral component of plasma membrane  protein complex assembly  inflammatory response  immune response  membrane  positive regulation of interleukin-13 production  positive regulation of interleukin-5 production  interleukin-33-mediated signaling pathway  interleukin-2 biosynthetic process  innate immune response  positive regulation of NF-kappaB transcription factor activity  positive regulation of synapse assembly  interleukin-4 secretion  positive regulation of dendrite development  protein tyrosine kinase binding  positive regulation of interleukin-6 secretion  
Pathways : BIOCARTASignal transduction through IL1R [Genes]   
Pathways : KEGGCytokine-cytokine receptor interaction    Apoptosis   
NDEx NetworkIL1RAP
Atlas of Cancer Signalling NetworkIL1RAP
Wikipedia pathwaysIL1RAP
Orthology - Evolution
OrthoDB3556
GeneTree (enSembl)ENSG00000196083
Phylogenetic Trees/Animal Genes : TreeFamIL1RAP
HOVERGENQ9NPH3
HOGENOMQ9NPH3
Homologs : HomoloGeneIL1RAP
Homology/Alignments : Family Browser (UCSC)IL1RAP
Gene fusions - Rearrangements
Fusion: TCGAIL1RAP 3q28 TMEM207 3q28 LUSC
Fusion: TCGAIL1RAP 3q28 TP63 3q28 LUSC
Fusion: TCGAIL1RAP 3q28 TPRG1 3q28 LUSC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIL1RAP [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IL1RAP
dbVarIL1RAP
ClinVarIL1RAP
1000_GenomesIL1RAP 
Exome Variant ServerIL1RAP
ExAC (Exome Aggregation Consortium)IL1RAP (select the gene name)
Genetic variants : HAPMAP3556
Genomic Variants (DGV)IL1RAP [DGVbeta]
DECIPHERIL1RAP [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisIL1RAP 
Mutations
ICGC Data PortalIL1RAP 
TCGA Data PortalIL1RAP 
Broad Tumor PortalIL1RAP
OASIS PortalIL1RAP [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIL1RAP  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDIL1RAP
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch IL1RAP
DgiDB (Drug Gene Interaction Database)IL1RAP
DoCM (Curated mutations)IL1RAP (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)IL1RAP (select a term)
intoGenIL1RAP
Cancer3DIL1RAP(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602626   
Orphanet
MedgenIL1RAP
Genetic Testing Registry IL1RAP
NextProtQ9NPH3 [Medical]
TSGene3556
GENETestsIL1RAP
Target ValidationIL1RAP
Huge Navigator IL1RAP [HugePedia]
snp3D : Map Gene to Disease3556
BioCentury BCIQIL1RAP
ClinGenIL1RAP
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3556
Chemical/Pharm GKB GenePA29811
Clinical trialIL1RAP
Miscellaneous
canSAR (ICR)IL1RAP (select the gene name)
Probes
Litterature
PubMed69 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineIL1RAP
EVEXIL1RAP
GoPubMedIL1RAP
iHOPIL1RAP
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 17:03:56 CEST 2017

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