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IL2 (interleukin 2)

Identity

Other namesIL-2
TCGF
lymphokine
HGNC (Hugo) IL2
LocusID (NCBI) 3558
Atlas_Id 438
Location 4q27  [Link to chromosome band 4q27]
Location_base_pair Starts at 123372626 and ends at 123377650 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
DEXI (16p13.13) / IL2 (4q27)IL2 (4q27) / TNF (6p21.33)IL2 (4q27) / TNFRSF17 (16p13.13)
TNFRSF17 (16p13.13) / IL2 (4q27)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 3 ]
  Adult T-cell leukemia/lymphoma (ATLL)
Mycosis fungoides/Sezary's syndrome
t(4;16)(q26;p13) IL2/TNFRSF17

External links

Nomenclature
HGNC (Hugo)IL2   6001
Cards
Entrez_Gene (NCBI)IL2  3558  interleukin 2
AliasesIL-2; TCGF; lymphokine
GeneCards (Weizmann)IL2
Ensembl hg19 (Hinxton)ENSG00000109471 [Gene_View]  chr4:123372626-123377650 [Contig_View]  IL2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000109471 [Gene_View]  chr4:123372626-123377650 [Contig_View]  IL2 [Vega]
ICGC DataPortalENSG00000109471
TCGA cBioPortalIL2
AceView (NCBI)IL2
Genatlas (Paris)IL2
WikiGenes3558
SOURCE (Princeton)IL2
Genomic and cartography
GoldenPath hg19 (UCSC)IL2  -     chr4:123372626-123377650 -  4q27   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)IL2  -     4q27   [Description]    (hg38-Dec_2013)
EnsemblIL2 - 4q27 [CytoView hg19]  IL2 - 4q27 [CytoView hg38]
Mapping of homologs : NCBIIL2 [Mapview hg19]  IL2 [Mapview hg38]
OMIM147680   
Gene and transcription
Genbank (Entrez)A14844 AB451325 AB451454 AF228636 AF532913
RefSeq transcript (Entrez)NM_000586
RefSeq genomic (Entrez)NC_000004 NC_018915 NG_016779 NT_016354 NW_004929320
Consensus coding sequences : CCDS (NCBI)IL2
Cluster EST : UnigeneHs.89679 [ NCBI ]
CGAP (NCI)Hs.89679
Alternative Splicing GalleryENSG00000109471
Gene ExpressionIL2 [ NCBI-GEO ]   IL2 [ EBI - ARRAY_EXPRESS ]   IL2 [ SEEK ]   IL2 [ MEM ]
Gene Expression Viewer (FireBrowse)IL2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3558
GTEX Portal (Tissue expression)IL2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP60568 (Uniprot)
NextProtP60568  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP60568
Splice isoforms : SwissVarP60568 (Swissvar)
PhosPhoSitePlusP60568
Domaine pattern : Prosite (Expaxy)INTERLEUKIN_2 (PS00424)   
Domains : Interpro (EBI)4_helix_cytokine-like_core    4_helix_cytokine_core    IL-2    IL-2_CS   
Domain families : Pfam (Sanger)IL2 (PF00715)   
Domain families : Pfam (NCBI)pfam00715   
Domain families : Smart (EMBL)IL2 (SM00189)  
Domain structure : Prodom (Prabi Lyon)Interleukin-2 (PD003649)   
DMDM Disease mutations3558
Blocks (Seattle)IL2
PDB (SRS)1ILM    1ILN    1IRL    1M47    1M48    1M49    1M4A    1M4B    1M4C    1NBP    1PW6    1PY2    1QVN    1Z92    2B5I    2ERJ    3INK    3QAZ    3QB1    4NEJ    4NEM   
PDB (PDBSum)1ILM    1ILN    1IRL    1M47    1M48    1M49    1M4A    1M4B    1M4C    1NBP    1PW6    1PY2    1QVN    1Z92    2B5I    2ERJ    3INK    3QAZ    3QB1    4NEJ    4NEM   
PDB (IMB)1ILM    1ILN    1IRL    1M47    1M48    1M49    1M4A    1M4B    1M4C    1NBP    1PW6    1PY2    1QVN    1Z92    2B5I    2ERJ    3INK    3QAZ    3QB1    4NEJ    4NEM   
PDB (RSDB)1ILM    1ILN    1IRL    1M47    1M48    1M49    1M4A    1M4B    1M4C    1NBP    1PW6    1PY2    1QVN    1Z92    2B5I    2ERJ    3INK    3QAZ    3QB1    4NEJ    4NEM   
Structural Biology KnowledgeBase1ILM    1ILN    1IRL    1M47    1M48    1M49    1M4A    1M4B    1M4C    1NBP    1PW6    1PY2    1QVN    1Z92    2B5I    2ERJ    3INK    3QAZ    3QB1    4NEJ    4NEM   
SCOP (Structural Classification of Proteins)1ILM    1ILN    1IRL    1M47    1M48    1M49    1M4A    1M4B    1M4C    1NBP    1PW6    1PY2    1QVN    1Z92    2B5I    2ERJ    3INK    3QAZ    3QB1    4NEJ    4NEM   
CATH (Classification of proteins structures)1ILM    1ILN    1IRL    1M47    1M48    1M49    1M4A    1M4B    1M4C    1NBP    1PW6    1PY2    1QVN    1Z92    2B5I    2ERJ    3INK    3QAZ    3QB1    4NEJ    4NEM   
SuperfamilyP60568
Human Protein AtlasENSG00000109471
Peptide AtlasP60568
HPRD00979
IPIIPI00003099   
Protein Interaction databases
DIP (DOE-UCLA)P60568
IntAct (EBI)P60568
FunCoupENSG00000109471
BioGRIDIL2
STRING (EMBL)IL2
ZODIACIL2
Ontologies - Pathways
QuickGOP60568
Ontology : AmiGOMAPK cascade  negative regulation of protein phosphorylation  adaptive immune response  negative regulation of B cell apoptotic process  Ras guanyl-nucleotide exchange factor activity  cytokine activity  interleukin-2 receptor binding  interleukin-2 receptor binding  extracellular region  extracellular space  cytosol  immune response  cell adhesion  positive regulation of cytosolic calcium ion concentration  protein kinase C-activating G-protein coupled receptor signaling pathway  cell-cell signaling  growth factor activity  positive regulation of cell proliferation  kinase activator activity  natural killer cell activation  T cell differentiation  carbohydrate binding  positive regulation of cell growth  positive regulation of B cell proliferation  kappa-type opioid receptor binding  positive regulation of interferon-gamma production  positive regulation of interleukin-17 production  positive regulation of tissue remodeling  positive regulation of activated T cell proliferation  positive regulation of tyrosine phosphorylation of Stat5 protein  negative regulation of apoptotic process  glycosphingolipid binding  positive regulation of GTPase activity  response to ethanol  positive regulation of regulatory T cell differentiation  negative regulation of heart contraction  positive regulation of transcription from RNA polymerase II promoter  regulation of T cell homeostatic proliferation  positive regulation of isotype switching to IgG isotypes  negative regulation of lymphocyte proliferation  negative regulation of inflammatory response  positive regulation of inflammatory response  positive regulation of immunoglobulin secretion  positive regulation of dendritic spine development  extrinsic apoptotic signaling pathway in absence of ligand  
Ontology : EGO-EBIMAPK cascade  negative regulation of protein phosphorylation  adaptive immune response  negative regulation of B cell apoptotic process  Ras guanyl-nucleotide exchange factor activity  cytokine activity  interleukin-2 receptor binding  interleukin-2 receptor binding  extracellular region  extracellular space  cytosol  immune response  cell adhesion  positive regulation of cytosolic calcium ion concentration  protein kinase C-activating G-protein coupled receptor signaling pathway  cell-cell signaling  growth factor activity  positive regulation of cell proliferation  kinase activator activity  natural killer cell activation  T cell differentiation  carbohydrate binding  positive regulation of cell growth  positive regulation of B cell proliferation  kappa-type opioid receptor binding  positive regulation of interferon-gamma production  positive regulation of interleukin-17 production  positive regulation of tissue remodeling  positive regulation of activated T cell proliferation  positive regulation of tyrosine phosphorylation of Stat5 protein  negative regulation of apoptotic process  glycosphingolipid binding  positive regulation of GTPase activity  response to ethanol  positive regulation of regulatory T cell differentiation  negative regulation of heart contraction  positive regulation of transcription from RNA polymerase II promoter  regulation of T cell homeostatic proliferation  positive regulation of isotype switching to IgG isotypes  negative regulation of lymphocyte proliferation  negative regulation of inflammatory response  positive regulation of inflammatory response  positive regulation of immunoglobulin secretion  positive regulation of dendritic spine development  extrinsic apoptotic signaling pathway in absence of ligand  
Pathways : BIOCARTAThe 4-1BB-dependent immune response [Genes]    Antigen Dependent B Cell Activation [Genes]    The Co-Stimulatory Signal During T-cell Activation [Genes]    Cytokine Network [Genes]    IL 2 signaling pathway [Genes]    Th1/Th2 Differentiation [Genes]    IL 18 Signaling Pathway [Genes]    Selective expression of chemokine receptors during T-cell polarization [Genes]    Regulation of hematopoiesis by cytokines [Genes]    Role of Tob in T-cell activation [Genes]    Cytokines and Inflammatory Response [Genes]    OX40 Signaling Pathway [Genes]   
Pathways : KEGGCytokine-cytokine receptor interaction    PI3K-Akt signaling pathway    Jak-STAT signaling pathway    T cell receptor signaling pathway    Intestinal immune network for IgA production    Type I diabetes mellitus    Chagas disease (American trypanosomiasis)    Measles    HTLV-I infection    Autoimmune thyroid disease    Inflammatory bowel disease (IBD)    Allograft rejection    Graft-versus-host disease   
NDEx Network
Atlas of Cancer Signalling NetworkIL2
Wikipedia pathwaysIL2
Orthology - Evolution
OrthoDB3558
GeneTree (enSembl)ENSG00000109471
Phylogenetic Trees/Animal Genes : TreeFamIL2
Homologs : HomoloGeneIL2
Homology/Alignments : Family Browser (UCSC)IL2
Gene fusions - Rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerIL2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IL2
dbVarIL2
ClinVarIL2
1000_GenomesIL2 
Exome Variant ServerIL2
ExAC (Exome Aggregation Consortium)IL2 (select the gene name)
Genetic variants : HAPMAP3558
Genomic Variants (DGV)IL2 [DGVbeta]
Mutations
ICGC Data PortalIL2 
TCGA Data PortalIL2 
Broad Tumor PortalIL2
OASIS PortalIL2 [ Somatic mutations - Copy number]
Cancer Gene: CensusIL2 
Somatic Mutations in Cancer : COSMICIL2 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)TBsLVD Tuberculosis susceptibility Locus Variation Database
LOVD (Leiden Open Variation Database)Pharmacogenomics of Infectious Diseases (PGx_IfD )
BioMutasearch IL2
DgiDB (Drug Gene Interaction Database)IL2
DoCM (Curated mutations)IL2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)IL2 (select a term)
intoGenIL2
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)4:123372626-123377650  ENSG00000109471
CONAN: Copy Number AnalysisIL2 
Mutations and Diseases : HGMDIL2
OMIM147680   
MedgenIL2
Genetic Testing Registry IL2
NextProtP60568 [Medical]
TSGene3558
GENETestsIL2
Huge Navigator IL2 [HugePedia]
snp3D : Map Gene to Disease3558
BioCentury BCIQIL2
ClinGenIL2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3558
Chemical/Pharm GKB GenePA195
Clinical trialIL2
Miscellaneous
canSAR (ICR)IL2 (select the gene name)
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineIL2
EVEXIL2
GoPubMedIL2
iHOPIL2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 9 19:04:23 CEST 2016

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