Identity
HGNC
LOCATION
4q27
LOCUSID
ALIAS
IL-2,TCGF,lymphokine
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 3558
MIM: 147680
HGNC: 6001
Ensembl: ENSG00000109471
Variants:
dbSNP: 3558
ClinVar: 3558
TCGA: ENSG00000109471
COSMIC: IL2
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000109471 | ENST00000226730 | P60568 |
| ENSG00000109471 | ENST00000226730 | Q0GK43 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA444822 | Lupus Erythematosus, Systemic | Disease | ClinicalAnnotation | associated | PD | 23645042 | |
| PA451261 | rituximab | Chemical | ClinicalAnnotation | associated | PD | 23645042 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37086778 | 2024 | Tumor-infiltrating mast cells stimulate ICOS(+) regulatory T cells through an IL-33 and IL-2 axis to promote gastric cancer progression. | 7 |
| 37843874 | 2024 | IL2RA rs2104286 and IL2 rs2069762 polymorphisms may be associated with bipolar disorder and its clinical findings. | 0 |
| 38037265 | 2024 | The soluble IL-2 receptor α/CD25 as a modulator of IL-2 function. | 1 |
| 38195135 | 2024 | Evaluation of gene-gene interaction between the interleukin (IL)-2 and IL-2RA gene polymorphisms in schizophrenia patients in the Turkish Population. | 0 |
| 38374693 | 2024 | Differential requirement for IL-2 and IL-23 in the differentiation and effector functions of Th17/ILC3-like cells in a human T cell line. | 0 |
| 38378682 | 2024 | Regulatory T cells use heparanase to access IL-2 bound to extracellular matrix in inflamed tissue. | 0 |
| 38658764 | 2024 | PGE(2) inhibits TIL expansion by disrupting IL-2 signalling and mitochondrial function. | 4 |
| 38904818 | 2024 | Plasma Levels of Interleukin 2 (IL-2) Associated with Hearing Loss Evaluation in the Elderly. | 0 |
| 37086778 | 2024 | Tumor-infiltrating mast cells stimulate ICOS(+) regulatory T cells through an IL-33 and IL-2 axis to promote gastric cancer progression. | 7 |
| 37843874 | 2024 | IL2RA rs2104286 and IL2 rs2069762 polymorphisms may be associated with bipolar disorder and its clinical findings. | 0 |
| 38037265 | 2024 | The soluble IL-2 receptor α/CD25 as a modulator of IL-2 function. | 1 |
| 38195135 | 2024 | Evaluation of gene-gene interaction between the interleukin (IL)-2 and IL-2RA gene polymorphisms in schizophrenia patients in the Turkish Population. | 0 |
| 38374693 | 2024 | Differential requirement for IL-2 and IL-23 in the differentiation and effector functions of Th17/ILC3-like cells in a human T cell line. | 0 |
| 38378682 | 2024 | Regulatory T cells use heparanase to access IL-2 bound to extracellular matrix in inflamed tissue. | 0 |
| 38658764 | 2024 | PGE(2) inhibits TIL expansion by disrupting IL-2 signalling and mitochondrial function. | 4 |
Citation
Dessen P
IL2 (interleukin 2)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/438/il2
