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IL2 (interleukin 2)

Identity

Other namesIL-2
TCGF
lymphokine
HGNC (Hugo) IL2
LocusID (NCBI) 3558
Location 4q27
Location_base_pair Starts at 123372626 and ends at 123377650 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas)

Leukemias 11q23ChildAMLID1615 11q23ID1030 11q23secondLeukID1131

External links

Nomenclature
HGNC (Hugo)IL2   6001
Cards
Entrez_Gene (NCBI)IL2  3558  interleukin 2
GeneCards (Weizmann)IL2
Ensembl (Hinxton) [Gene_View]  chr4:123372626-123377650 [Contig_View]  IL2 [Vega]
cBioPortalIL2
AceView (NCBI)IL2
Genatlas (Paris)IL2
WikiGenes3558
SOURCE (Princeton)NM_000586
Genomic and cartography
GoldenPath (UCSC)IL2  -  4q27   chr4:123372626-123377650 -  4q27   [Description]    (hg19-Feb_2009)
EnsemblIL2 - 4q27 [CytoView]
Mapping of homologs : NCBIIL2 [Mapview]
OMIM147680   
Gene and transcription
Genbank (Entrez)A14844 AB451325 AB451454 AF228636 AF532913
RefSeq transcript (Entrez)NM_000586
RefSeq genomic (Entrez)AC_000136 NC_000004 NC_018915 NG_016779 NT_016354 NW_001838920 NW_004929320
Consensus coding sequences : CCDS (NCBI)IL2
Cluster EST : UnigeneHs.89679 [ NCBI ]
CGAP (NCI)Hs.89679
Alternative Splicing : Fast-db (Paris)GSHG0023509
Gene ExpressionIL2 [ NCBI-GEO ]     IL2 [ SEEK ]   IL2 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP60568 (Uniprot)
NextProtP60568  [Medical]
With graphics : InterProP60568
Splice isoforms : SwissVarP60568 (Swissvar)
Domaine pattern : Prosite (Expaxy)INTERLEUKIN_2 (PS00424)   
Domains : Interpro (EBI)4_helix_cytokine-like_core [organisation]   4_helix_cytokine_core [organisation]   IL-2 [organisation]  
Related proteins : CluSTrP60568
Domain families : Pfam (Sanger)IL2 (PF00715)   
Domain families : Pfam (NCBI)pfam00715   
Domain families : Smart (EMBL)IL2 (SM00189)  
Domain structure : Prodom (Prabi Lyon)Interleukin-2 (PD003649)   
DMDM Disease mutations3558
Blocks (Seattle)P60568
PDB (SRS)1ILM    1ILN    1IRL    1M47    1M48    1M49    1M4A    1M4B    1M4C    1NBP    1PW6    1PY2    1QVN    1Z92    2B5I    2ERJ    3INK    3QAZ    3QB1   
PDB (PDBSum)1ILM    1ILN    1IRL    1M47    1M48    1M49    1M4A    1M4B    1M4C    1NBP    1PW6    1PY2    1QVN    1Z92    2B5I    2ERJ    3INK    3QAZ    3QB1   
PDB (IMB)1ILM    1ILN    1IRL    1M47    1M48    1M49    1M4A    1M4B    1M4C    1NBP    1PW6    1PY2    1QVN    1Z92    2B5I    2ERJ    3INK    3QAZ    3QB1   
PDB (RSDB)1ILM    1ILN    1IRL    1M47    1M48    1M49    1M4A    1M4B    1M4C    1NBP    1PW6    1PY2    1QVN    1Z92    2B5I    2ERJ    3INK    3QAZ    3QB1   
Peptide AtlasP60568
HPRD00979
IPIIPI00003099   
Protein Interaction databases
DIP (DOE-UCLA)P60568
IntAct (EBI)P60568
BioGRIDIL2
InParanoidP60568
Interologous Interaction database P60568
IntegromeDBIL2
STRING (EMBL)IL2
Ontologies - Pathways
Ontology : AmiGOnegative regulation of protein phosphorylation  negative regulation of B cell apoptotic process  cytokine activity  interleukin-2 receptor binding  interleukin-2 receptor binding  extracellular region  extracellular space  immune response  cell adhesion  positive regulation of cytosolic calcium ion concentration  protein kinase C-activating G-protein coupled receptor signaling pathway  cell-cell signaling  growth factor activity  positive regulation of cell proliferation  kinase activator activity  natural killer cell activation  T cell differentiation  carbohydrate binding  positive regulation of cell growth  positive regulation of B cell proliferation  kappa-type opioid receptor binding  positive regulation of interferon-gamma production  positive regulation of interleukin-17 production  positive regulation of tissue remodeling  positive regulation of activated T cell proliferation  positive regulation of tyrosine phosphorylation of Stat5 protein  negative regulation of apoptotic process  glycosphingolipid binding  positive regulation of regulatory T cell differentiation  negative regulation of heart contraction  positive regulation of transcription from RNA polymerase II promoter  regulation of T cell homeostatic proliferation  positive regulation of isotype switching to IgG isotypes  negative regulation of lymphocyte proliferation  negative regulation of inflammatory response  positive regulation of inflammatory response  positive regulation of immunoglobulin secretion  positive regulation of dendritic spine development  extrinsic apoptotic signaling pathway in absence of ligand  
Ontology : EGO-EBInegative regulation of protein phosphorylation  negative regulation of B cell apoptotic process  cytokine activity  interleukin-2 receptor binding  interleukin-2 receptor binding  extracellular region  extracellular space  immune response  cell adhesion  positive regulation of cytosolic calcium ion concentration  protein kinase C-activating G-protein coupled receptor signaling pathway  cell-cell signaling  growth factor activity  positive regulation of cell proliferation  kinase activator activity  natural killer cell activation  T cell differentiation  carbohydrate binding  positive regulation of cell growth  positive regulation of B cell proliferation  kappa-type opioid receptor binding  positive regulation of interferon-gamma production  positive regulation of interleukin-17 production  positive regulation of tissue remodeling  positive regulation of activated T cell proliferation  positive regulation of tyrosine phosphorylation of Stat5 protein  negative regulation of apoptotic process  glycosphingolipid binding  positive regulation of regulatory T cell differentiation  negative regulation of heart contraction  positive regulation of transcription from RNA polymerase II promoter  regulation of T cell homeostatic proliferation  positive regulation of isotype switching to IgG isotypes  negative regulation of lymphocyte proliferation  negative regulation of inflammatory response  positive regulation of inflammatory response  positive regulation of immunoglobulin secretion  positive regulation of dendritic spine development  extrinsic apoptotic signaling pathway in absence of ligand  
Pathways : BIOCARTAThe 4-1BB-dependent immune response [Genes]    Antigen Dependent B Cell Activation [Genes]    The Co-Stimulatory Signal During T-cell Activation [Genes]    Cytokine Network [Genes]    IL 2 signaling pathway [Genes]    Th1/Th2 Differentiation [Genes]    IL 18 Signaling Pathway [Genes]    Selective expression of chemokine receptors during T-cell polarization [Genes]    Regulation of hematopoiesis by cytokines [Genes]    Role of Tob in T-cell activation [Genes]    Cytokines and Inflammatory Response [Genes]    OX40 Signaling Pathway [Genes]   
Pathways : KEGGCytokine-cytokine receptor interaction    PI3K-Akt signaling pathway    Jak-STAT signaling pathway    T cell receptor signaling pathway    Intestinal immune network for IgA production    Type I diabetes mellitus    Chagas disease (American trypanosomiasis)    Measles    HTLV-I infection    Autoimmune thyroid disease    Inflammatory bowel disease (IBD)    Allograft rejection    Graft-versus-host disease   
Protein Interaction DatabaseIL2
Wikipedia pathwaysIL2
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)IL2
snp3D : Map Gene to Disease3558
SNP (GeneSNP Utah)IL2
SNP : HGBaseIL2
Genetic variants : HAPMAPIL2
Exome VariantIL2
1000_GenomesIL2 
Cancer Gene: CensusIL2 
Somatic Mutations in Cancer : COSMICIL2 
CONAN: Copy Number AnalysisIL2 
Mutations and Diseases : HGMDIL2
Mutations and Diseases : intOGenIL2
Genomic VariantsIL2  IL2 [DGVbeta]
dbVarIL2
ClinVarIL2
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM147680   
MedgenIL2
GENETestsIL2
Disease Genetic AssociationIL2
Huge Navigator IL2 [HugePedia]  IL2 [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneIL2
Homology/Alignments : Family Browser (UCSC)IL2
Phylogenetic Trees/Animal Genes : TreeFamIL2
Chemical/Protein Interactions : CTD3558
Chemical/Pharm GKB GenePA195
Clinical trialIL2
Other databases
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
CoreMineIL2
iHOPIL2
OncoSearchIL2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 26 16:50:50 CEST 2014

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