Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

IL2 (interleukin 2)

Identity

Alias (NCBI)IL-2
TCGF
lymphokine
HGNC (Hugo) IL2
HGNC Alias symbIL-2
TCGF
HGNC Alias nameT cell growth factor
LocusID (NCBI) 3558
Atlas_Id 438
Location 4q27  [Link to chromosome band 4q27]
Location_base_pair Starts at 122451471 and ends at 122456725 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DEXI (16p13.13) / IL2 (4q27)IL2 (4q27) / TNF (6p21.33)IL2 (4q27) / TNFRSF17 (16p13.13)
TNFRSF17 (16p13.13) / IL2 (4q27)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 7 ]
  Adult T-cell leukemia/lymphoma (ATLL)
Breast implant-associated anaplastic large cell lymphoma
del(18)(p11)
i(18)(q10)
Mycosis fungoides/Sezary's syndrome
t(1;19)(q22;p13.2) MEF2D/DAZAP1
t(4;16)(q26;p13) IL2/TNFRSF17


External links

 

Nomenclature
HGNC (Hugo)IL2   6001
Cards
Entrez_Gene (NCBI)IL2    interleukin 2
AliasesIL-2; TCGF; lymphokine
GeneCards (Weizmann)IL2
Ensembl hg19 (Hinxton)ENSG00000109471 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000109471 [Gene_View]  ENSG00000109471 [Sequence]  chr4:122451471-122456725 [Contig_View]  IL2 [Vega]
ICGC DataPortalENSG00000109471
TCGA cBioPortalIL2
AceView (NCBI)IL2
Genatlas (Paris)IL2
SOURCE (Princeton)IL2
Genetics Home Reference (NIH)IL2
Genomic and cartography
GoldenPath hg38 (UCSC)IL2  -     chr4:122451471-122456725 -  4q27   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)IL2  -     4q27   [Description]    (hg19-Feb_2009)
GoldenPathIL2 - 4q27 [CytoView hg19]  IL2 - 4q27 [CytoView hg38]
ImmunoBaseENSG00000109471
Genome Data Viewer NCBIIL2 [Mapview hg19]  
OMIM147680   
Gene and transcription
Genbank (Entrez)A14844 AB451325 AB451454 AF228636 AF532913
RefSeq transcript (Entrez)NM_000586
Consensus coding sequences : CCDS (NCBI)IL2
Gene ExpressionIL2 [ NCBI-GEO ]   IL2 [ EBI - ARRAY_EXPRESS ]   IL2 [ SEEK ]   IL2 [ MEM ]
Gene Expression Viewer (FireBrowse)IL2 [ Firebrowse - Broad ]
GenevisibleExpression of IL2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3558
GTEX Portal (Tissue expression)IL2
Human Protein AtlasENSG00000109471-IL2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP60568   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP60568  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP60568
PhosPhoSitePlusP60568
Domaine pattern : Prosite (Expaxy)INTERLEUKIN_2 (PS00424)   
Domains : Interpro (EBI)4_helix_cytokine-like_core    IL-2    IL-2_CS   
Domain families : Pfam (Sanger)IL2 (PF00715)   
Domain families : Pfam (NCBI)pfam00715   
Domain families : Smart (EMBL)IL2 (SM00189)  
Conserved Domain (NCBI)IL2
PDB (RSDB)1ILM    1ILN    1IRL    1M47    1M48    1M49    1M4A    1M4B    1M4C    1NBP    1PW6    1PY2    1QVN    1Z92    2B5I    2ERJ    3INK    3QAZ    3QB1    4NEJ    4NEM    5LQB    5M5E    5UTZ    6LX3    6LXW    6VWU   
PDB Europe1ILM    1ILN    1IRL    1M47    1M48    1M49    1M4A    1M4B    1M4C    1NBP    1PW6    1PY2    1QVN    1Z92    2B5I    2ERJ    3INK    3QAZ    3QB1    4NEJ    4NEM    5LQB    5M5E    5UTZ    6LX3    6LXW    6VWU   
PDB (PDBSum)1ILM    1ILN    1IRL    1M47    1M48    1M49    1M4A    1M4B    1M4C    1NBP    1PW6    1PY2    1QVN    1Z92    2B5I    2ERJ    3INK    3QAZ    3QB1    4NEJ    4NEM    5LQB    5M5E    5UTZ    6LX3    6LXW    6VWU   
PDB (IMB)1ILM    1ILN    1IRL    1M47    1M48    1M49    1M4A    1M4B    1M4C    1NBP    1PW6    1PY2    1QVN    1Z92    2B5I    2ERJ    3INK    3QAZ    3QB1    4NEJ    4NEM    5LQB    5M5E    5UTZ    6LX3    6LXW    6VWU   
Structural Biology KnowledgeBase1ILM    1ILN    1IRL    1M47    1M48    1M49    1M4A    1M4B    1M4C    1NBP    1PW6    1PY2    1QVN    1Z92    2B5I    2ERJ    3INK    3QAZ    3QB1    4NEJ    4NEM    5LQB    5M5E    5UTZ    6LX3    6LXW    6VWU   
SCOP (Structural Classification of Proteins)1ILM    1ILN    1IRL    1M47    1M48    1M49    1M4A    1M4B    1M4C    1NBP    1PW6    1PY2    1QVN    1Z92    2B5I    2ERJ    3INK    3QAZ    3QB1    4NEJ    4NEM    5LQB    5M5E    5UTZ    6LX3    6LXW    6VWU   
CATH (Classification of proteins structures)1ILM    1ILN    1IRL    1M47    1M48    1M49    1M4A    1M4B    1M4C    1NBP    1PW6    1PY2    1QVN    1Z92    2B5I    2ERJ    3INK    3QAZ    3QB1    4NEJ    4NEM    5LQB    5M5E    5UTZ    6LX3    6LXW    6VWU   
SuperfamilyP60568
AlphaFold pdb e-kbP60568   
Human Protein Atlas [tissue]ENSG00000109471-IL2 [tissue]
HPRD00979
Protein Interaction databases
DIP (DOE-UCLA)P60568
IntAct (EBI)P60568
BioGRIDIL2
STRING (EMBL)IL2
ZODIACIL2
Ontologies - Pathways
QuickGOP60568
Ontology : AmiGOMAPK cascade  negative regulation of protein phosphorylation  adaptive immune response  leukocyte activation involved in immune response  positive regulation of immunoglobulin production  negative regulation of B cell apoptotic process  cytokine activity  interleukin-2 receptor binding  interleukin-2 receptor binding  protein binding  extracellular region  extracellular space  immune response  cell adhesion  positive regulation of cytosolic calcium ion concentration  protein kinase C-activating G protein-coupled receptor signaling pathway  cell-cell signaling  growth factor activity  positive regulation of cell population proliferation  gene expression  kinase activator activity  cytokine-mediated signaling pathway  natural killer cell activation  T cell differentiation  carbohydrate binding  positive regulation of cell growth  positive regulation of B cell proliferation  kappa-type opioid receptor binding  positive regulation of interferon-gamma production  positive regulation of interleukin-17 production  positive regulation of kinase activity  positive regulation of tissue remodeling  interleukin-2-mediated signaling pathway  positive regulation of activated T cell proliferation  positive regulation of tyrosine phosphorylation of STAT protein  negative regulation of apoptotic process  glycosphingolipid binding  response to ethanol  regulation of regulatory T cell differentiation  positive regulation of regulatory T cell differentiation  negative regulation of heart contraction  positive regulation of transcription by RNA polymerase II  regulation of T cell homeostatic proliferation  positive regulation of isotype switching to IgG isotypes  negative regulation of lymphocyte proliferation  negative regulation of inflammatory response  positive regulation of inflammatory response  positive regulation of dendritic spine development  extrinsic apoptotic signaling pathway in absence of ligand  positive regulation of plasma cell differentiation  negative regulation of T-helper 17 cell differentiation  
Ontology : EGO-EBIMAPK cascade  negative regulation of protein phosphorylation  adaptive immune response  leukocyte activation involved in immune response  positive regulation of immunoglobulin production  negative regulation of B cell apoptotic process  cytokine activity  interleukin-2 receptor binding  interleukin-2 receptor binding  protein binding  extracellular region  extracellular space  immune response  cell adhesion  positive regulation of cytosolic calcium ion concentration  protein kinase C-activating G protein-coupled receptor signaling pathway  cell-cell signaling  growth factor activity  positive regulation of cell population proliferation  gene expression  kinase activator activity  cytokine-mediated signaling pathway  natural killer cell activation  T cell differentiation  carbohydrate binding  positive regulation of cell growth  positive regulation of B cell proliferation  kappa-type opioid receptor binding  positive regulation of interferon-gamma production  positive regulation of interleukin-17 production  positive regulation of kinase activity  positive regulation of tissue remodeling  interleukin-2-mediated signaling pathway  positive regulation of activated T cell proliferation  positive regulation of tyrosine phosphorylation of STAT protein  negative regulation of apoptotic process  glycosphingolipid binding  response to ethanol  regulation of regulatory T cell differentiation  positive regulation of regulatory T cell differentiation  negative regulation of heart contraction  positive regulation of transcription by RNA polymerase II  regulation of T cell homeostatic proliferation  positive regulation of isotype switching to IgG isotypes  negative regulation of lymphocyte proliferation  negative regulation of inflammatory response  positive regulation of inflammatory response  positive regulation of dendritic spine development  extrinsic apoptotic signaling pathway in absence of ligand  positive regulation of plasma cell differentiation  negative regulation of T-helper 17 cell differentiation  
Pathways : BIOCARTAThe 4-1BB-dependent immune response [Genes]    Antigen Dependent B Cell Activation [Genes]    The Co-Stimulatory Signal During T-cell Activation [Genes]    Cytokine Network [Genes]    IL 2 signaling pathway [Genes]    Th1/Th2 Differentiation [Genes]    IL 18 Signaling Pathway [Genes]    Selective expression of chemokine receptors during T-cell polarization [Genes]    Regulation of hematopoiesis by cytokines [Genes]    Role of Tob in T-cell activation [Genes]    Cytokines and Inflammatory Response [Genes]    OX40 Signaling Pathway [Genes]   
Pathways : KEGGCytokine-cytokine receptor interaction    PI3K-Akt signaling pathway    Jak-STAT signaling pathway    T cell receptor signaling pathway    Intestinal immune network for IgA production    Type I diabetes mellitus    Chagas disease (American trypanosomiasis)    Measles    HTLV-I infection    Autoimmune thyroid disease    Inflammatory bowel disease (IBD)    Allograft rejection    Graft-versus-host disease   
NDEx NetworkIL2
Atlas of Cancer Signalling NetworkIL2
Wikipedia pathwaysIL2
Orthology - Evolution
OrthoDB3558
GeneTree (enSembl)ENSG00000109471
Phylogenetic Trees/Animal Genes : TreeFamIL2
Homologs : HomoloGeneIL2
Homology/Alignments : Family Browser (UCSC)IL2
Gene fusions - Rearrangements
Fusion : MitelmanIL2/TNFRSF17 [4q27/16p13.13]  
Fusion : QuiverIL2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIL2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IL2
dbVarIL2
ClinVarIL2
MonarchIL2
1000_GenomesIL2 
Exome Variant ServerIL2
GNOMAD BrowserENSG00000109471
Varsome BrowserIL2
ACMGIL2 variants
VarityP60568
Genomic Variants (DGV)IL2 [DGVbeta]
DECIPHERIL2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisIL2 
Mutations
ICGC Data PortalIL2 
TCGA Data PortalIL2 
Broad Tumor PortalIL2
OASIS PortalIL2 [ Somatic mutations - Copy number]
Cancer Gene: CensusIL2 
Somatic Mutations in Cancer : COSMICIL2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DIL2
Mutations and Diseases : HGMDIL2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaIL2
DgiDB (Drug Gene Interaction Database)IL2
DoCM (Curated mutations)IL2
CIViC (Clinical Interpretations of Variants in Cancer)IL2
Cancer3DIL2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM147680   
Orphanet
DisGeNETIL2
MedgenIL2
Genetic Testing Registry IL2
NextProtP60568 [Medical]
GENETestsIL2
Target ValidationIL2
Huge Navigator IL2 [HugePedia]
ClinGenIL2
Clinical trials, drugs, therapy
MyCancerGenomeIL2
Protein Interactions : CTDIL2
Pharm GKB GenePA195
Pharm GKB PathwaysPA165985892   
PharosP60568
Clinical trialIL2
Miscellaneous
canSAR (ICR)IL2
HarmonizomeIL2
DataMed IndexIL2
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXIL2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 15:13:47 CEST 2021

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.