IL2 (interleukin 2)

Identity

Other names	IL-2
	TCGF
	lymphokine
HGNC	IL2
Location	4q26-q27
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	IL2   6001
Entrez_Gene	IL2  3558  interleukin 2
	Cards
GeneCards	IL2
Ensembl	IL2 [Search_View]   ENSG00000109471 [Gene_View]
Genatlas	IL2
GeneLynx	IL2
eGenome	IL2
euGene	3558
	Genomic and cartography
GoldenPath	IL2  -     chr4:123592076-123597100 -  4q27   [Description]    (hg18-March_2006)
Ensembl	IL2 - 4q27 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	IL2
	Gene and transcription
Genbank	A14844 [ ENTREZ ]
Genbank	AF228636 [ ENTREZ ]
Genbank	AF532913 [ ENTREZ ]
Genbank	AY283686 [ ENTREZ ]
Genbank	AY523040 [ ENTREZ ]
RefSeq	NM_000586 [ SRS ]    NM_000586 [ ENTREZ ]
RefSeq	AC_000047 [ SRS ]    AC_000047 [ ENTREZ ]
RefSeq	AC_000136 [ SRS ]    AC_000136 [ ENTREZ ]
RefSeq	NC_000004 [ SRS ]    NC_000004 [ ENTREZ ]
RefSeq	NT_016354 [ SRS ]    NT_016354 [ ENTREZ ]
RefSeq	NW_001838920 [ SRS ]    NW_001838920 [ ENTREZ ]
RefSeq	NW_922217 [ SRS ]    NW_922217 [ ENTREZ ]
AceView	IL2 AceView - NCBI
Unigene	Hs.89679 [ SRS ]    Hs.89679 [ NCBI ]     HS89679 [ spliceNest ]
Fast-db	9240 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	P60568 [ SRS]    P60568 [ EXPASY ]     P60568 [ INTERPRO ]     P60568 [ UNIPROT ]
Prosite	PS00424 INTERLEUKIN_2 [ SRS ]    PS00424 INTERLEUKIN_2 [ Expasy ]
Interpro	IPR012351 4_helix_cytokine_core [ SRS ]    IPR012351 4_helix_cytokine_core [ EBI ]
Interpro	IPR000779 Interleukin-2 [ SRS ]    IPR000779 Interleukin-2 [ EBI ]
CluSTr	P60568
Pfam	PF00715 IL2 [ SRS ]    PF00715 IL2 [ Sanger ]    pfam00715 [ NCBI-CDD ]
Smart	SM00189 IL2 [EMBL]
Prodom	PD003649 Interleukin-2[INRA-Toulouse]
Prodom	P60568 IL2_HUMAN [ Domain structure ]   P60568 IL2_HUMAN  [ sequences sharing at least 1 domain ]
Blocks	P60568
PDB	1ILM [ SRS ]    1ILM [ PdbSum ],   1ILM [ IMB ]   1ILM [ RSDB ]
PDB	1ILN [ SRS ]    1ILN [ PdbSum ],   1ILN [ IMB ]   1ILN [ RSDB ]
PDB	1IRL [ SRS ]    1IRL [ PdbSum ],   1IRL [ IMB ]   1IRL [ RSDB ]
PDB	1M47 [ SRS ]    1M47 [ PdbSum ],   1M47 [ IMB ]   1M47 [ RSDB ]
PDB	1M48 [ SRS ]    1M48 [ PdbSum ],   1M48 [ IMB ]   1M48 [ RSDB ]
PDB	1M49 [ SRS ]    1M49 [ PdbSum ],   1M49 [ IMB ]   1M49 [ RSDB ]
PDB	1M4A [ SRS ]    1M4A [ PdbSum ],   1M4A [ IMB ]   1M4A [ RSDB ]
PDB	1M4B [ SRS ]    1M4B [ PdbSum ],   1M4B [ IMB ]   1M4B [ RSDB ]
PDB	1M4C [ SRS ]    1M4C [ PdbSum ],   1M4C [ IMB ]   1M4C [ RSDB ]
PDB	1NBP [ SRS ]    1NBP [ PdbSum ],   1NBP [ IMB ]   1NBP [ RSDB ]
PDB	1PW6 [ SRS ]    1PW6 [ PdbSum ],   1PW6 [ IMB ]   1PW6 [ RSDB ]
PDB	1PY2 [ SRS ]    1PY2 [ PdbSum ],   1PY2 [ IMB ]   1PY2 [ RSDB ]
PDB	1QVN [ SRS ]    1QVN [ PdbSum ],   1QVN [ IMB ]   1QVN [ RSDB ]
PDB	1Z92 [ SRS ]    1Z92 [ PdbSum ],   1Z92 [ IMB ]   1Z92 [ RSDB ]
PDB	2B5I [ SRS ]    2B5I [ PdbSum ],   2B5I [ IMB ]   2B5I [ RSDB ]
PDB	2ERJ [ SRS ]    2ERJ [ PdbSum ],   2ERJ [ IMB ]   2ERJ [ RSDB ]
PDB	3INK [ SRS ]    3INK [ PdbSum ],   3INK [ IMB ]   3INK [ RSDB ]
HPRD	00979
	Protein Interaction databases
DIP	P60568
IntAct	P60568
	Polymorphism : SNP, mutations, diseases
OMIM	147680    [ map ]
GENECLINICS	147680
SNP	IL2 [dbSNP-NCBI]
SNP	NM_000586 [SNP-NCI]
SNP	IL2 [GeneSNPs - Utah]  IL2] [HGBASE - SRS]
HAPMAP	IL2 [HAPMAP]
COSMIC	IL2 [Somatic mutation (COSMIC-CGP-Sanger)]
TICdb	interleukin-2 [Translocation breakpoints In Cancer]
HGMD	IL2
	General knowledge
Family Browser	IL2 [UCSC Family Browser]
SOURCE	NM_000586
SMD	Hs.89679
SAGE	Hs.89679
GO	interleukin-2 receptor binding [Amigo]  interleukin-2 receptor binding
GO	extracellular region [Amigo]  extracellular region
GO	anti-apoptosis [Amigo]  anti-apoptosis
GO	immune response [Amigo]  immune response
GO	cell-cell signaling [Amigo]  cell-cell signaling
GO	positive regulation of cell proliferation [Amigo]  positive regulation of cell proliferation
GO	kinase activator activity [Amigo]  kinase activator activity
GO	natural killer cell activation [Amigo]  natural killer cell activation
GO	T cell differentiation [Amigo]  T cell differentiation
GO	positive regulation of cell growth [Amigo]  positive regulation of cell growth
BIOCARTA	The 4-1BB-dependent immune response    [Genes]
BIOCARTA	Antigen Dependent B Cell Activation    [Genes]
BIOCARTA	The Co-Stimulatory Signal During T-cell Activation    [Genes]
BIOCARTA	Cytokine Network    [Genes]
BIOCARTA	IL 18 Signaling Pathway    [Genes]
BIOCARTA	IL 2 signaling pathway    [Genes]
BIOCARTA	Cytokines and Inflammatory Response    [Genes]
BIOCARTA	Selective expression of chemokine receptors during T-cell polarization    [Genes]
BIOCARTA	OX40 Signaling Pathway    [Genes]
BIOCARTA	Regulation of hematopoiesis by cytokines    [Genes]
BIOCARTA	Th1/Th2 Differentiation    [Genes]
BIOCARTA	Role of Tob in T-cell activation    [Genes]
KEGG	Cytokine-cytokine receptor interaction
KEGG	Jak-STAT signaling pathway
KEGG	T cell receptor signaling pathway
KEGG	Type I diabetes mellitus
PubGene	IL2
TreeFam	IL2
CTD	3558 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	IL2 Related clones (RZPD - Berlin)
	PubMed
PubMed	319 Pubmed reference(s) in LocusLink

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

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Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Mon Aug 11 20:15:55 2008