IL20RA (interleukin 20 receptor subunit alpha)

2010-02-01  

Identity

HGNC
LOCATION
6q23.3
LOCUSID
ALIAS
CRF2-8,IL-20R-alpha,IL-20R1,IL-20RA
FUSION GENES

Other Information

Locus ID:

NCBI: 53832
MIM: 605620
HGNC: 6003
Ensembl: ENSG00000016402

Variants:

dbSNP: 53832
ClinVar: 53832
TCGA: ENSG00000016402
COSMIC: IL20RA

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000016402ENST00000316649Q9UHF4
ENSG00000016402ENST00000367746Q96SH7
ENSG00000016402ENST00000367748Q9UHF4
ENSG00000016402ENST00000460306A0A0U1RQS0
ENSG00000016402ENST00000468393A0A0U1RQU9
ENSG00000016402ENST00000541547Q9UHF4
ENSG00000016402ENST00000635289A0A0U1RRA1

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Jak-STAT signaling pathwayKEGGko04630
Cytokine-cytokine receptor interactionKEGGhsa04060
Jak-STAT signaling pathwayKEGGhsa04630
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Interleukin-19, 20, 22, 24REACTOMER-HSA-8854691

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
334565602021IL20RA signaling enhances stemness and promotes the formation of an immunosuppressive microenvironment in breast cancer.32
342832512021MicroRNA 452 regulates IL20RA-mediated JAK1/STAT3 pathway in inflammatory colitis and colorectal cancer.11
334565602021IL20RA signaling enhances stemness and promotes the formation of an immunosuppressive microenvironment in breast cancer.32
342832512021MicroRNA 452 regulates IL20RA-mediated JAK1/STAT3 pathway in inflammatory colitis and colorectal cancer.11
294836152019CRISPR/cas9 mediated knockout of an intergenic variant rs6927172 identified IL-20RA as a new risk gene for multiple autoimmune diseases.14
311526792019Flexible regions govern promiscuous binding of IL-24 to receptors IL-20R1 and IL-22R1.9
294836152019CRISPR/cas9 mediated knockout of an intergenic variant rs6927172 identified IL-20RA as a new risk gene for multiple autoimmune diseases.14
311526792019Flexible regions govern promiscuous binding of IL-24 to receptors IL-20R1 and IL-22R1.9
269770112016IL24 and its Receptors Regulate Growth and Migration of Pancreatic Cancer Cells and Are Potential Biomarkers for IL24 Molecular Therapy.7
277990702016Capture Hi-C identifies a novel causal gene, IL20RA, in the pan-autoimmune genetic susceptibility region 6q23.45
269770112016IL24 and its Receptors Regulate Growth and Migration of Pancreatic Cancer Cells and Are Potential Biomarkers for IL24 Molecular Therapy.7
277990702016Capture Hi-C identifies a novel causal gene, IL20RA, in the pan-autoimmune genetic susceptibility region 6q23.45
222321812012Purification, crystallization and preliminary X-ray diffraction analysis of the IL-20-IL-20R1-IL-20R2 complex.0
222321812012Purification, crystallization and preliminary X-ray diffraction analysis of the IL-20-IL-20R1-IL-20R2 complex.0
199264562010Further association analysis of chr 6q22-24 suggests a role of IL-20RA polymorphisms in psoriasis.4

Citation

Dessen P

IL20RA (interleukin 20 receptor subunit alpha)

Atlas Genet Cytogenet Oncol Haematol. 2010-02-01

Online version: http://atlasgeneticsoncology.org/gene/51317/il20ra