Atlas of Genetics and Cytogenetics in Oncology and Haematology

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IL20RB (interleukin 20 receptor subunit beta)

Identity

Alias_namesFNDC6
fibronectin type III domain containing 6
interleukin 20 receptor beta
interleukin 20 receptor beta subunit
Alias_symbol (synonym)DIRS1
IL-20R2
MGC34923
Other alias
HGNC (Hugo) IL20RB
LocusID (NCBI) 53833
Atlas_Id 51327
Location 3q22.3  [Link to chromosome band 3q22]
Location_base_pair Starts at 136957865 and ends at 137011084 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CRYBG3 (3q11.2) / IL20RB (3q22.3)IL20RB (3q22.3) / NCK1 (3q22.3)IL20RB (3q22.3) / NR4A1 (12q13.13)
IL20RB (3q22.3) / RASSF8 (12p12.1)NCK1 (3q22.3) / IL20RB (3q22.3)NR4A1 (12q13.13) / IL20RB (3q22.3)
CRYBG3 3q11.2 / IL20RB 3q22.3IL20RB 3q22.3 / NCK1 3q22.3IL20RB 3q22.3 / NR4A1 12q13.13
NR4A1 12q13.13 / IL20RB 3q22.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 5 ]
  t(3;3)(q11;q22) CRYBG3/IL20RB
IL20RB/NCK1 (3q22)
t(3;12)(q22;p12) IL20RB/RASSF8
t(3;12)(q22;q13) IL20RB/NR4A1
t(3;12)(q22;q13) NR4A1/IL20RB

External links

Nomenclature
HGNC (Hugo)IL20RB   6004
Cards
Entrez_Gene (NCBI)IL20RB  53833  interleukin 20 receptor subunit beta
AliasesDIRS1; FNDC6; IL-20R2
GeneCards (Weizmann)IL20RB
Ensembl hg19 (Hinxton)ENSG00000174564 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000174564 [Gene_View]  ENSG00000174564 [Sequence]  chr3:136957865-137011084 [Contig_View]  IL20RB [Vega]
ICGC DataPortalENSG00000174564
TCGA cBioPortalIL20RB
AceView (NCBI)IL20RB
Genatlas (Paris)IL20RB
WikiGenes53833
SOURCE (Princeton)IL20RB
Genetics Home Reference (NIH)IL20RB
Genomic and cartography
GoldenPath hg38 (UCSC)IL20RB  -     chr3:136957865-137011084 +  3q22.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)IL20RB  -     3q22.3   [Description]    (hg19-Feb_2009)
EnsemblIL20RB - 3q22.3 [CytoView hg19]  IL20RB - 3q22.3 [CytoView hg38]
Mapping of homologs : NCBIIL20RB [Mapview hg19]  IL20RB [Mapview hg38]
OMIM605621   
Gene and transcription
Genbank (Entrez)AK296832 AK316084 AY358305 BC027449 BC033292
RefSeq transcript (Entrez)NM_144717
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)IL20RB
Cluster EST : UnigeneHs.61232 [ NCBI ]
CGAP (NCI)Hs.61232
Alternative Splicing GalleryENSG00000174564
Gene ExpressionIL20RB [ NCBI-GEO ]   IL20RB [ EBI - ARRAY_EXPRESS ]   IL20RB [ SEEK ]   IL20RB [ MEM ]
Gene Expression Viewer (FireBrowse)IL20RB [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)53833
GTEX Portal (Tissue expression)IL20RB
Human Protein AtlasENSG00000174564-IL20RB [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6UXL0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6UXL0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6UXL0
Splice isoforms : SwissVarQ6UXL0
PhosPhoSitePlusQ6UXL0
Domaine pattern : Prosite (Expaxy)FN3 (PS50853)   
Domains : Interpro (EBI)FN3_dom    FN3_sf    Ig-like_fold    Interferon/interleukin_rcp_dom   
Domain families : Pfam (Sanger)Interfer-bind (PF09294)    Tissue_fac (PF01108)   
Domain families : Pfam (NCBI)pfam09294    pfam01108   
Conserved Domain (NCBI)IL20RB
DMDM Disease mutations53833
Blocks (Seattle)IL20RB
PDB (SRS)4DOH   
PDB (PDBSum)4DOH   
PDB (IMB)4DOH   
PDB (RSDB)4DOH   
Structural Biology KnowledgeBase4DOH   
SCOP (Structural Classification of Proteins)4DOH   
CATH (Classification of proteins structures)4DOH   
SuperfamilyQ6UXL0
Human Protein Atlas [tissue]ENSG00000174564-IL20RB [tissue]
Peptide AtlasQ6UXL0
HPRD14594
IPIIPI00097434   IPI00217924   IPI00944975   IPI00945701   IPI00946106   
Protein Interaction databases
DIP (DOE-UCLA)Q6UXL0
IntAct (EBI)Q6UXL0
FunCoupENSG00000174564
BioGRIDIL20RB
STRING (EMBL)IL20RB
ZODIACIL20RB
Ontologies - Pathways
QuickGOQ6UXL0
Ontology : AmiGOnegative regulation of type IV hypersensitivity  inflammatory response to antigenic stimulus  immune response-inhibiting signal transduction  protein binding  plasma membrane  plasma membrane  integral component of membrane  cytokine-mediated signaling pathway  cytokine-mediated signaling pathway  negative regulation of interferon-gamma production  negative regulation of interleukin-2 production  positive regulation of interleukin-10 production  positive regulation of interleukin-4 production  interleukin-20 binding  negative regulation of T cell proliferation  homeostasis of number of cells within a tissue  
Ontology : EGO-EBInegative regulation of type IV hypersensitivity  inflammatory response to antigenic stimulus  immune response-inhibiting signal transduction  protein binding  plasma membrane  plasma membrane  integral component of membrane  cytokine-mediated signaling pathway  cytokine-mediated signaling pathway  negative regulation of interferon-gamma production  negative regulation of interleukin-2 production  positive regulation of interleukin-10 production  positive regulation of interleukin-4 production  interleukin-20 binding  negative regulation of T cell proliferation  homeostasis of number of cells within a tissue  
Pathways : KEGGCytokine-cytokine receptor interaction    Jak-STAT signaling pathway   
NDEx NetworkIL20RB
Atlas of Cancer Signalling NetworkIL20RB
Wikipedia pathwaysIL20RB
Orthology - Evolution
OrthoDB53833
GeneTree (enSembl)ENSG00000174564
Phylogenetic Trees/Animal Genes : TreeFamIL20RB
HOVERGENQ6UXL0
HOGENOMQ6UXL0
Homologs : HomoloGeneIL20RB
Homology/Alignments : Family Browser (UCSC)IL20RB
Gene fusions - Rearrangements
Fusion : MitelmanCRYBG3/IL20RB [3q11.2/3q22.3]  [t(3;3)(q11;q22)]  
Fusion : MitelmanIL20RB/NCK1 [3q22.3/3q22.3]  [t(3;3)(q22;q22)]  
Fusion : MitelmanIL20RB/NR4A1 [3q22.3/12q13.13]  [t(3;12)(q22;q13)]  
Fusion : MitelmanIL20RB/RASSF8 [3q22.3/12p12.1]  [t(3;12)(q22;p12)]  
Fusion : MitelmanNR4A1/IL20RB [12q13.13/3q22.3]  [t(3;12)(q22;q13)]  
Fusion PortalCRYBG3 3q11.2 IL20RB 3q22.3 LUSC
Fusion PortalIL20RB 3q22.3 NCK1 3q22.3 HNSC
Fusion PortalIL20RB 3q22.3 NR4A1 12q13.13 HNSC
Fusion PortalNR4A1 12q13.13 IL20RB 3q22.3 HNSC
Fusion : QuiverIL20RB
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIL20RB [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IL20RB
dbVarIL20RB
ClinVarIL20RB
1000_GenomesIL20RB 
Exome Variant ServerIL20RB
ExAC (Exome Aggregation Consortium)ENSG00000174564
GNOMAD BrowserENSG00000174564
Varsome BrowserIL20RB
Genetic variants : HAPMAP53833
Genomic Variants (DGV)IL20RB [DGVbeta]
DECIPHERIL20RB [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisIL20RB 
Mutations
ICGC Data PortalIL20RB 
TCGA Data PortalIL20RB 
Broad Tumor PortalIL20RB
OASIS PortalIL20RB [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIL20RB  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDIL20RB
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch IL20RB
DgiDB (Drug Gene Interaction Database)IL20RB
DoCM (Curated mutations)IL20RB (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)IL20RB (select a term)
intoGenIL20RB
Cancer3DIL20RB(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605621   
Orphanet
DisGeNETIL20RB
MedgenIL20RB
Genetic Testing Registry IL20RB
NextProtQ6UXL0 [Medical]
TSGene53833
GENETestsIL20RB
Target ValidationIL20RB
Huge Navigator IL20RB [HugePedia]
snp3D : Map Gene to Disease53833
BioCentury BCIQIL20RB
ClinGenIL20RB
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD53833
Chemical/Pharm GKB GenePA29819
Clinical trialIL20RB
Miscellaneous
canSAR (ICR)IL20RB (select the gene name)
Probes
Litterature
PubMed23 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineIL20RB
EVEXIL20RB
GoPubMedIL20RB
iHOPIL20RB
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 6 11:13:16 CET 2018
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