IL22RA2 (interleukin 22 receptor subunit alpha 2)

2014-11-01  

Identity

HGNC
IL22RA2
LOCATION
6q23.3
LOCUSID
116379
ALIAS
CRF2-10,CRF2-S1,CRF2X,IL-22BP,IL-22R-alpha-2,IL-22RA2,ZCYTOR16
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 116379
MIM: 606648
HGNC: 14901
Ensembl: ENSG00000164485

Variants:

dbSNP: 116379
ClinVar: 116379
TCGA: ENSG00000164485
COSMIC: IL22RA2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000164485ENST00000296980Q969J5
ENSG00000164485ENST00000339602Q969J5
ENSG00000164485ENST00000349184Q969J5

Expression (GTEx)

0
1
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Jak-STAT signaling pathwayKEGGko04630
Cytokine-cytokine receptor interactionKEGGhsa04060
Jak-STAT signaling pathwayKEGGhsa04630
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Interleukin-19, 20, 22, 24REACTOMER-HSA-8854691

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
192400612009Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.75
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
263294272016IL-22BP is produced by eosinophils in human gut and blocks IL-22 protective actions during colitis.24
210417312010IL-22RA2 associates with multiple sclerosis and macrophage effector mechanisms in experimental neuroinflammation.22
192850802009Crystal structure of a soluble decoy receptor IL-22BP bound to interleukin-22.17
186758242008IL-22R, IL-10R2, and IL-22BP binding sites are topologically juxtaposed on adjacent and overlapping surfaces of IL-22.16
283563822017Limited Presence of IL-22 Binding Protein, a Natural IL-22 Inhibitor, Strengthens Psoriatic Skin Inflammation.16
193934222009Polymorphisms in the interleukin-22 receptor alpha-1 gene are associated with severe chronic rhinosinusitis.15
276782202016Human IL-22 binding protein isoforms act as a rheostat for IL-22 signaling.9
269317842016Deletion of the entire interferon-γ receptor 1 gene causing complete deficiency in three related patients.5

Citation

Dessen P

IL22RA2 (interleukin 22 receptor subunit alpha 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/64597/il22ra2