Atlas of Genetics and Cytogenetics in Oncology and Haematology

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IL23R (interleukin 23 receptor)

Identity

Alias_symbol (synonym)IL-23R
Other alias-
HGNC (Hugo) IL23R
LocusID (NCBI) 149233
Atlas_Id 43925
Location 1p31.3  [Link to chromosome band 1p31]
Location_base_pair Starts at 67166486 and ends at 67259967 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)IL23R   19100
Cards
Entrez_Gene (NCBI)IL23R  149233  interleukin 23 receptor
Aliases
GeneCards (Weizmann)IL23R
Ensembl hg19 (Hinxton)ENSG00000162594 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000162594 [Gene_View]  ENSG00000162594 [Sequence]  chr1:67166486-67259967 [Contig_View]  IL23R [Vega]
ICGC DataPortalENSG00000162594
TCGA cBioPortalIL23R
AceView (NCBI)IL23R
Genatlas (Paris)IL23R
WikiGenes149233
SOURCE (Princeton)IL23R
Genetics Home Reference (NIH)IL23R
Genomic and cartography
GoldenPath hg38 (UCSC)IL23R  -     chr1:67166486-67259967 +  1p31.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)IL23R  -     1p31.3   [Description]    (hg19-Feb_2009)
GoldenPathIL23R - 1p31.3 [CytoView hg19]  IL23R - 1p31.3 [CytoView hg38]
ImmunoBaseENSG00000162594
Mapping of homologs : NCBIIL23R [Mapview hg19]  IL23R [Mapview hg38]
OMIM605606   607562   612261   
Gene and transcription
Genbank (Entrez)AF461422 AM990313 AM990314 AM990315 AM990316
RefSeq transcript (Entrez)NM_144701
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)IL23R
Cluster EST : UnigeneHs.677426 [ NCBI ]
CGAP (NCI)Hs.677426
Alternative Splicing GalleryENSG00000162594
Gene ExpressionIL23R [ NCBI-GEO ]   IL23R [ EBI - ARRAY_EXPRESS ]   IL23R [ SEEK ]   IL23R [ MEM ]
Gene Expression Viewer (FireBrowse)IL23R [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)149233
GTEX Portal (Tissue expression)IL23R
Human Protein AtlasENSG00000162594-IL23R [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ5VWK5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ5VWK5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ5VWK5
Splice isoforms : SwissVarQ5VWK5
PhosPhoSitePlusQ5VWK5
Domaine pattern : Prosite (Expaxy)FN3 (PS50853)   
Domains : Interpro (EBI)FN3_dom    FN3_sf    Ig-like_fold   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)IL23R
DMDM Disease mutations149233
Blocks (Seattle)IL23R
PDB (RSDB)5MZV   
PDB Europe5MZV   
PDB (PDBSum)5MZV   
PDB (IMB)5MZV   
Structural Biology KnowledgeBase5MZV   
SCOP (Structural Classification of Proteins)5MZV   
CATH (Classification of proteins structures)5MZV   
SuperfamilyQ5VWK5
Human Protein Atlas [tissue]ENSG00000162594-IL23R [tissue]
Peptide AtlasQ5VWK5
HPRD16249
IPIIPI00303045   IPI00816175   IPI00815647   IPI00816048   IPI00479853   IPI00816154   IPI00816507   IPI00942620   IPI00915346   IPI01008736   IPI00915430   IPI01012722   IPI01011369   
Protein Interaction databases
DIP (DOE-UCLA)Q5VWK5
IntAct (EBI)Q5VWK5
FunCoupENSG00000162594
BioGRIDIL23R
STRING (EMBL)IL23R
ZODIACIL23R
Ontologies - Pathways
QuickGOQ5VWK5
Ontology : AmiGOpositive regulation of T cell mediated cytotoxicity  positive regulation of defense response to virus by host  positive regulation of defense response to virus by host  positive regulation of T-helper 1 type immune response  positive regulation of T-helper 1 type immune response  cytokine receptor activity  interleukin-12 receptor binding  interleukin-12 receptor binding  protein binding  plasma membrane  inflammatory response  external side of plasma membrane  positive regulation of activation of Janus kinase activity  cytokine-mediated signaling pathway  cytokine binding  response to lipopolysaccharide  negative regulation of interleukin-10 production  positive regulation of granulocyte macrophage colony-stimulating factor production  positive regulation of interferon-gamma production  positive regulation of interferon-gamma production  positive regulation of interferon-gamma production  positive regulation of interleukin-12 production  positive regulation of interleukin-17 production  positive regulation of natural killer cell proliferation  response to interferon-gamma  interleukin-23-mediated signaling pathway  interleukin-23 binding  interleukin-23 binding  interleukin-23 receptor activity  positive regulation of T cell proliferation  positive regulation of activated T cell proliferation  regulation of tyrosine phosphorylation of STAT protein  positive regulation of tyrosine phosphorylation of STAT protein  receptor complex  receptor complex  positive regulation of memory T cell differentiation  positive regulation of osteoclast differentiation  defense response to Gram-negative bacterium  positive regulation of NK T cell activation  interleukin-23 receptor complex  interleukin-23 receptor complex  positive regulation of T-helper 17 type immune response  positive regulation of T-helper 17 cell lineage commitment  
Ontology : EGO-EBIpositive regulation of T cell mediated cytotoxicity  positive regulation of defense response to virus by host  positive regulation of defense response to virus by host  positive regulation of T-helper 1 type immune response  positive regulation of T-helper 1 type immune response  cytokine receptor activity  interleukin-12 receptor binding  interleukin-12 receptor binding  protein binding  plasma membrane  inflammatory response  external side of plasma membrane  positive regulation of activation of Janus kinase activity  cytokine-mediated signaling pathway  cytokine binding  response to lipopolysaccharide  negative regulation of interleukin-10 production  positive regulation of granulocyte macrophage colony-stimulating factor production  positive regulation of interferon-gamma production  positive regulation of interferon-gamma production  positive regulation of interferon-gamma production  positive regulation of interleukin-12 production  positive regulation of interleukin-17 production  positive regulation of natural killer cell proliferation  response to interferon-gamma  interleukin-23-mediated signaling pathway  interleukin-23 binding  interleukin-23 binding  interleukin-23 receptor activity  positive regulation of T cell proliferation  positive regulation of activated T cell proliferation  regulation of tyrosine phosphorylation of STAT protein  positive regulation of tyrosine phosphorylation of STAT protein  receptor complex  receptor complex  positive regulation of memory T cell differentiation  positive regulation of osteoclast differentiation  defense response to Gram-negative bacterium  positive regulation of NK T cell activation  interleukin-23 receptor complex  interleukin-23 receptor complex  positive regulation of T-helper 17 type immune response  positive regulation of T-helper 17 cell lineage commitment  
Pathways : KEGGCytokine-cytokine receptor interaction    Jak-STAT signaling pathway    Inflammatory bowel disease (IBD)   
NDEx NetworkIL23R
Atlas of Cancer Signalling NetworkIL23R
Wikipedia pathwaysIL23R
Orthology - Evolution
OrthoDB149233
GeneTree (enSembl)ENSG00000162594
Phylogenetic Trees/Animal Genes : TreeFamIL23R
HOGENOMQ5VWK5
Homologs : HomoloGeneIL23R
Homology/Alignments : Family Browser (UCSC)IL23R
Gene fusions - Rearrangements
Fusion : QuiverIL23R
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIL23R [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IL23R
dbVarIL23R
ClinVarIL23R
1000_GenomesIL23R 
Exome Variant ServerIL23R
ExAC (Exome Aggregation Consortium)ENSG00000162594
GNOMAD BrowserENSG00000162594
Varsome BrowserIL23R
Genetic variants : HAPMAP149233
Genomic Variants (DGV)IL23R [DGVbeta]
DECIPHERIL23R [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisIL23R 
Mutations
ICGC Data PortalIL23R 
TCGA Data PortalIL23R 
Broad Tumor PortalIL23R
OASIS PortalIL23R [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIL23R  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DIL23R
Mutations and Diseases : HGMDIL23R
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch IL23R
DgiDB (Drug Gene Interaction Database)IL23R
DoCM (Curated mutations)IL23R (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)IL23R (select a term)
intoGenIL23R
Cancer3DIL23R(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605606    607562    612261   
Orphanet703   
DisGeNETIL23R
MedgenIL23R
Genetic Testing Registry IL23R
NextProtQ5VWK5 [Medical]
TSGene149233
GENETestsIL23R
Target ValidationIL23R
Huge Navigator IL23R [HugePedia]
snp3D : Map Gene to Disease149233
BioCentury BCIQIL23R
ClinGenIL23R
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD149233
Chemical/Pharm GKB GenePA134935109
Clinical trialIL23R
Miscellaneous
canSAR (ICR)IL23R (select the gene name)
DataMed IndexIL23R
Probes
Litterature
PubMed344 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineIL23R
EVEXIL23R
GoPubMedIL23R
iHOPIL23R
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Nov 13 17:48:18 CET 2019
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