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IL23R (interleukin 23 receptor)

Identity

Other names-
HGNC (Hugo) IL23R
LocusID (NCBI) 149233
Location 1p31.3
Location_base_pair Starts at 67632169 and ends at 67725650 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)IL23R   19100
Cards
Entrez_Gene (NCBI)IL23R  149233  interleukin 23 receptor
GeneCards (Weizmann)IL23R
Ensembl hg19 (Hinxton)ENSG00000162594 [Gene_View]  chr1:67632169-67725650 [Contig_View]  IL23R [Vega]
Ensembl hg38 (Hinxton)ENSG00000162594 [Gene_View]  chr1:67632169-67725650 [Contig_View]  IL23R [Vega]
ICGC DataPortalENSG00000162594
cBioPortalIL23R
AceView (NCBI)IL23R
Genatlas (Paris)IL23R
WikiGenes149233
SOURCE (Princeton)IL23R
Genomic and cartography
GoldenPath hg19 (UCSC)IL23R  -     chr1:67632169-67725650 +  1p31.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)IL23R  -     1p31.3   [Description]    (hg38-Dec_2013)
EnsemblIL23R - 1p31.3 [CytoView hg19]  IL23R - 1p31.3 [CytoView hg38]
Mapping of homologs : NCBIIL23R [Mapview hg19]  IL23R [Mapview hg38]
OMIM605606   607562   612261   
Gene and transcription
Genbank (Entrez)AF461422 AM990313 AM990314 AM990315 AM990316
RefSeq transcript (Entrez)NM_144701
RefSeq genomic (Entrez)AC_000133 NC_000001 NC_018912 NG_011498 NT_032977 NW_001838579 NW_004929290
Consensus coding sequences : CCDS (NCBI)IL23R
Cluster EST : UnigeneHs.677426 [ NCBI ]
CGAP (NCI)Hs.677426
Alternative Splicing : Fast-db (Paris)GSHG0000610
Alternative Splicing GalleryENSG00000162594
Gene ExpressionIL23R [ NCBI-GEO ]     IL23R [ SEEK ]   IL23R [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ5VWK5 (Uniprot)
NextProtQ5VWK5  [Medical]
With graphics : InterProQ5VWK5
Splice isoforms : SwissVarQ5VWK5 (Swissvar)
Domaine pattern : Prosite (Expaxy)FN3 (PS50853)   
Domains : Interpro (EBI)Fibronectin_type3    Ig-like_fold   
Related proteins : CluSTrQ5VWK5
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Domain families : Smart (EMBL)FN3 (SM00060)  
DMDM Disease mutations149233
Blocks (Seattle)Q5VWK5
Human Protein AtlasENSG00000162594
Peptide AtlasQ5VWK5
HPRD16249
IPIIPI00303045   IPI00816175   IPI00815647   IPI00816048   IPI00479853   IPI00816154   IPI00816507   IPI00942620   IPI00915346   IPI01008736   IPI00915430   IPI01012722   IPI01011369   
Protein Interaction databases
DIP (DOE-UCLA)Q5VWK5
IntAct (EBI)Q5VWK5
FunCoupENSG00000162594
BioGRIDIL23R
IntegromeDBIL23R
STRING (EMBL)IL23R
Ontologies - Pathways
QuickGOQ5VWK5
Ontology : AmiGOpositive regulation of T cell mediated cytotoxicity  positive regulation of defense response to virus by host  positive regulation of defense response to virus by host  positive regulation of T-helper 1 type immune response  positive regulation of T-helper 1 type immune response  interleukin-12 receptor binding  inflammatory response  positive regulation of activation of JAK2 kinase activity  response to lipopolysaccharide  negative regulation of interleukin-10 production  positive regulation of granulocyte macrophage colony-stimulating factor production  positive regulation of interferon-gamma production  positive regulation of interferon-gamma production  positive regulation of interferon-gamma production  positive regulation of interleukin-12 production  positive regulation of interleukin-17 production  positive regulation of natural killer cell proliferation  response to interferon-gamma  interleukin-23-mediated signaling pathway  interleukin-23 binding  interleukin-23 receptor activity  positive regulation of T cell proliferation  positive regulation of activated T cell proliferation  regulation of tyrosine phosphorylation of Stat1 protein  positive regulation of tyrosine phosphorylation of Stat3 protein  positive regulation of tyrosine phosphorylation of Stat4 protein  positive regulation of tyrosine phosphorylation of Stat5 protein  receptor complex  positive regulation of memory T cell differentiation  positive regulation of osteoclast differentiation  defense response to Gram-negative bacterium  positive regulation of NK T cell activation  interleukin-23 receptor complex  positive regulation of T-helper 17 type immune response  positive regulation of T-helper 17 cell lineage commitment  
Ontology : EGO-EBIpositive regulation of T cell mediated cytotoxicity  positive regulation of defense response to virus by host  positive regulation of defense response to virus by host  positive regulation of T-helper 1 type immune response  positive regulation of T-helper 1 type immune response  interleukin-12 receptor binding  inflammatory response  positive regulation of activation of JAK2 kinase activity  response to lipopolysaccharide  negative regulation of interleukin-10 production  positive regulation of granulocyte macrophage colony-stimulating factor production  positive regulation of interferon-gamma production  positive regulation of interferon-gamma production  positive regulation of interferon-gamma production  positive regulation of interleukin-12 production  positive regulation of interleukin-17 production  positive regulation of natural killer cell proliferation  response to interferon-gamma  interleukin-23-mediated signaling pathway  interleukin-23 binding  interleukin-23 receptor activity  positive regulation of T cell proliferation  positive regulation of activated T cell proliferation  regulation of tyrosine phosphorylation of Stat1 protein  positive regulation of tyrosine phosphorylation of Stat3 protein  positive regulation of tyrosine phosphorylation of Stat4 protein  positive regulation of tyrosine phosphorylation of Stat5 protein  receptor complex  positive regulation of memory T cell differentiation  positive regulation of osteoclast differentiation  defense response to Gram-negative bacterium  positive regulation of NK T cell activation  interleukin-23 receptor complex  positive regulation of T-helper 17 type immune response  positive regulation of T-helper 17 cell lineage commitment  
Pathways : KEGGCytokine-cytokine receptor interaction    Jak-STAT signaling pathway    Inflammatory bowel disease (IBD)   
Protein Interaction DatabaseIL23R
DoCM (Curated mutations)IL23R
Wikipedia pathwaysIL23R
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerIL23R [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IL23R
dbVarIL23R
ClinVarIL23R
1000_GenomesIL23R 
Exome Variant ServerIL23R
SNP (GeneSNP Utah)IL23R
SNP : HGBaseIL23R
Genetic variants : HAPMAPIL23R
Genomic VariantsIL23R  IL23R [DGVbeta]
Mutations
ICGC Data PortalENSG00000162594 
Somatic Mutations in Cancer : COSMICIL23R 
CONAN: Copy Number AnalysisIL23R 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)1:67632169-67725650
Mutations and Diseases : HGMDIL23R
OMIM605606    607562    612261   
MedgenIL23R
NextProtQ5VWK5 [Medical]
GENETestsIL23R
Disease Genetic AssociationIL23R
Huge Navigator IL23R [HugePedia]  IL23R [HugeCancerGEM]
snp3D : Map Gene to Disease149233
DGIdb (Drug Gene Interaction db)IL23R
General knowledge
Homologs : HomoloGeneIL23R
Homology/Alignments : Family Browser (UCSC)IL23R
Phylogenetic Trees/Animal Genes : TreeFamIL23R
Chemical/Protein Interactions : CTD149233
Chemical/Pharm GKB GenePA134935109
Clinical trialIL23R
Cancer Resource (Charite)ENSG00000162594
Other databases
Probes
Litterature
PubMed237 Pubmed reference(s) in Entrez
CoreMineIL23R
GoPubMedIL23R
iHOPIL23R
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2014Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Dec 20 22:09:27 CET 2014
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