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IL27RA (interleukin 27 receptor subunit alpha)

Identity

Alias_namesinterleukin 27 receptor
Alias_symbol (synonym)WSX-1
TCCR
CRL1
WSX1
zcytor1
IL-27R
Other aliasIL-27RA
IL27R
HGNC (Hugo) IL27RA
LocusID (NCBI) 9466
Atlas_Id 50022
Location 19p13.12  [Link to chromosome band 19p13]
Location_base_pair Starts at 14142552 and ends at 14163717 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CDC37 (19p13.2) / IL27RA (19p13.12)IL27RA (19p13.12) / RLN3 (19p13.12)IL27RA 19p13.12 / RLN3 19p13.12

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)IL27RA   17290
Cards
Entrez_Gene (NCBI)IL27RA  9466  interleukin 27 receptor subunit alpha
AliasesCRL1; IL-27RA; IL27R; TCCR; 
WSX1; zcytor1
GeneCards (Weizmann)IL27RA
Ensembl hg19 (Hinxton)ENSG00000104998 [Gene_View]  chr19:14142552-14163717 [Contig_View]  IL27RA [Vega]
Ensembl hg38 (Hinxton)ENSG00000104998 [Gene_View]  chr19:14142552-14163717 [Contig_View]  IL27RA [Vega]
ICGC DataPortalENSG00000104998
TCGA cBioPortalIL27RA
AceView (NCBI)IL27RA
Genatlas (Paris)IL27RA
WikiGenes9466
SOURCE (Princeton)IL27RA
Genetics Home Reference (NIH)IL27RA
Genomic and cartography
GoldenPath hg19 (UCSC)IL27RA  -     chr19:14142552-14163717 +  19p13.12   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)IL27RA  -     19p13.12   [Description]    (hg38-Dec_2013)
EnsemblIL27RA - 19p13.12 [CytoView hg19]  IL27RA - 19p13.12 [CytoView hg38]
Mapping of homologs : NCBIIL27RA [Mapview hg19]  IL27RA [Mapview hg38]
OMIM605350   
Gene and transcription
Genbank (Entrez)AF053004 AF106912 AF265242 AI983115 AW298502
RefSeq transcript (Entrez)NM_004843
RefSeq genomic (Entrez)NC_000019 NC_018930 NT_011295 NW_004929414
Consensus coding sequences : CCDS (NCBI)IL27RA
Cluster EST : UnigeneHs.352155 [ NCBI ]
CGAP (NCI)Hs.352155
Alternative Splicing GalleryENSG00000104998
Gene ExpressionIL27RA [ NCBI-GEO ]   IL27RA [ EBI - ARRAY_EXPRESS ]   IL27RA [ SEEK ]   IL27RA [ MEM ]
Gene Expression Viewer (FireBrowse)IL27RA [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9466
GTEX Portal (Tissue expression)IL27RA
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6UWB1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6UWB1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6UWB1
Splice isoforms : SwissVarQ6UWB1
PhosPhoSitePlusQ6UWB1
Domaine pattern : Prosite (Expaxy)FN3 (PS50853)   
Domains : Interpro (EBI)FN3_dom    Ig-like_fold   
Domain families : Pfam (Sanger)fn3 (PF00041)   
Domain families : Pfam (NCBI)pfam00041   
Domain families : Smart (EMBL)FN3 (SM00060)  
Conserved Domain (NCBI)IL27RA
DMDM Disease mutations9466
Blocks (Seattle)IL27RA
SuperfamilyQ6UWB1
Human Protein AtlasENSG00000104998
Peptide AtlasQ6UWB1
HPRD09247
IPIIPI00006774   
Protein Interaction databases
DIP (DOE-UCLA)Q6UWB1
IntAct (EBI)Q6UWB1
FunCoupENSG00000104998
BioGRIDIL27RA
STRING (EMBL)IL27RA
ZODIACIL27RA
Ontologies - Pathways
QuickGOQ6UWB1
Ontology : AmiGOpositive regulation of T-helper 1 type immune response  negative regulation of type 2 immune response  transmembrane signaling receptor activity  plasma membrane  integral component of plasma membrane  immune response  cell surface receptor signaling pathway  positive regulation of interferon-gamma production  interleukin-27 receptor activity  regulation of isotype switching to IgG isotypes  defense response to Gram-positive bacterium  interleukin-27-mediated signaling pathway  
Ontology : EGO-EBIpositive regulation of T-helper 1 type immune response  negative regulation of type 2 immune response  transmembrane signaling receptor activity  plasma membrane  integral component of plasma membrane  immune response  cell surface receptor signaling pathway  positive regulation of interferon-gamma production  interleukin-27 receptor activity  regulation of isotype switching to IgG isotypes  defense response to Gram-positive bacterium  interleukin-27-mediated signaling pathway  
NDEx NetworkIL27RA
Atlas of Cancer Signalling NetworkIL27RA
Wikipedia pathwaysIL27RA
Orthology - Evolution
OrthoDB9466
GeneTree (enSembl)ENSG00000104998
Phylogenetic Trees/Animal Genes : TreeFamIL27RA
HOVERGENQ6UWB1
HOGENOMQ6UWB1
Homologs : HomoloGeneIL27RA
Homology/Alignments : Family Browser (UCSC)IL27RA
Gene fusions - Rearrangements
Fusion : MitelmanIL27RA/RLN3 [19p13.12/19p13.12]  
Fusion: TCGAIL27RA 19p13.12 RLN3 19p13.12 BRCA HNSC KIRC OV
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIL27RA [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IL27RA
dbVarIL27RA
ClinVarIL27RA
1000_GenomesIL27RA 
Exome Variant ServerIL27RA
ExAC (Exome Aggregation Consortium)IL27RA (select the gene name)
Genetic variants : HAPMAP9466
Genomic Variants (DGV)IL27RA [DGVbeta]
DECIPHER (Syndromes)19:14142552-14163717  ENSG00000104998
CONAN: Copy Number AnalysisIL27RA 
Mutations
ICGC Data PortalIL27RA 
TCGA Data PortalIL27RA 
Broad Tumor PortalIL27RA
OASIS PortalIL27RA [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIL27RA  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDIL27RA
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch IL27RA
DgiDB (Drug Gene Interaction Database)IL27RA
DoCM (Curated mutations)IL27RA (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)IL27RA (select a term)
intoGenIL27RA
Cancer3DIL27RA(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605350   
Orphanet
MedgenIL27RA
Genetic Testing Registry IL27RA
NextProtQ6UWB1 [Medical]
TSGene9466
GENETestsIL27RA
Huge Navigator IL27RA [HugePedia]
snp3D : Map Gene to Disease9466
BioCentury BCIQIL27RA
ClinGenIL27RA
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9466
Chemical/Pharm GKB GenePA134891276
Clinical trialIL27RA
Miscellaneous
canSAR (ICR)IL27RA (select the gene name)
Probes
Litterature
PubMed19 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineIL27RA
EVEXIL27RA
GoPubMedIL27RA
iHOPIL27RA
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:10:41 CET 2017

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