IL2RA (interleukin 2 receptor, alpha)

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Taking over the Atlas
Dear Colleagues,
The Atlas, once more, is in great danger, and I will have to proceed to a collective economic lay-off of all the team involved in the Atlas before the begining of April 2015 (a foundation having suddenly withdrawn its commitment to support the Atlas). I ask you herein if any Scientific Society (a Society of Cytogenetics, of Clinical Genetics, of Hematology, or a Cancer Society, or any other...), any University and/or Hospital, any Charity, or any database would be interested in taking over the Atlas, in whole or in part. If taking charge of the whole lot is too big, a consortium of various actors could be the solution (I am myself trying to find partners). Could you please spread the information, contact the relevant authorities, and find partners.
Survival of the Atlas will be critically dependant upon your ability to find solutions (and urgently!).
Kind regards.
Jean-Loup Huret
Donations are also welcome

IL2RA (interleukin 2 receptor, alpha)

Identity

Other names	CD25
	IDDM10
	IL2R
	TCGFR
HGNC (Hugo)	IL2RA
LocusID (NCBI)	3559
Location	10p15.1
Location_base_pair	Starts at 6052657 and ends at 6104333 bp from pter ( according to hg19-Feb_2009)
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to How to contribute

DNA/RNA

External links

	Nomenclature
HGNC (Hugo)	IL2RA 6008
	Cards
Entrez_Gene (NCBI)	IL2RA 3559 interleukin 2 receptor, alpha
GeneCards (Weizmann)	IL2RA
Ensembl hg19 (Hinxton)	ENSG00000134460 [Gene_View] chr10:6052657-6104333 [Contig_View] IL2RA [Vega]
Ensembl hg38 (Hinxton)	ENSG00000134460 [Gene_View] chr10:6052657-6104333 [Contig_View] IL2RA [Vega]
ICGC DataPortal	ENSG00000134460
cBioPortal	IL2RA
AceView (NCBI)	IL2RA
Genatlas (Paris)	IL2RA
WikiGenes	3559
SOURCE (Princeton)	IL2RA
	Genomic and cartography
GoldenPath hg19 (UCSC)	IL2RA - chr10:6052657-6104333 - 10p15.1 [Description] (hg19-Feb_2009)
GoldenPath hg38 (UCSC)	IL2RA - 10p15.1 [Description] (hg38-Dec_2013)
Ensembl	IL2RA - 10p15.1 [CytoView hg19] IL2RA - 10p15.1 [CytoView hg38]
Mapping of homologs : NCBI	IL2RA [Mapview hg19] IL2RA [Mapview hg38]
OMIM	147730 601942 606367
	Gene and transcription
Genbank (Entrez)	AF008556 AK223313 AK313847 BC152889 BC156627
RefSeq transcript (Entrez)	NM_000417
RefSeq genomic (Entrez)	AC_000142 NC_000010 NC_018921 NG_007403 NT_008705 NW_001837931 NW_004929370
Consensus coding sequences : CCDS (NCBI)	IL2RA
Cluster EST : Unigene	Hs.231367 [ NCBI ]
CGAP (NCI)	Hs.231367
Alternative Splicing : Fast-db (Paris)	GSHG0003847
Alternative Splicing Gallery	ENSG00000134460
Gene Expression	IL2RA [ NCBI-GEO ] IL2RA [ SEEK ] IL2RA [ MEM ]
SOURCE (Princeton)	Expression in : [Normal Tissue Atlas] [carcinoma Classsification] [NCI60]
	Protein : pattern, domain, 3D structure
UniProt/SwissProt	P01589 (Uniprot)
NextProt	P01589 [Medical]
With graphics : InterPro	P01589
Splice isoforms : SwissVar	P01589 (Swissvar)
Domaine pattern : Prosite (Expaxy)	SUSHI (PS50923)
Domains : Interpro (EBI)	IL-2_rcpt_alpha Sushi_SCR_CCP
Related proteins : CluSTr	P01589
Domain families : Pfam (Sanger)	Sushi (PF00084)
Domain families : Pfam (NCBI)	pfam00084
Domain families : Smart (EMBL)	CCP (SM00032)
DMDM Disease mutations	3559
Blocks (Seattle)	P01589
PDB (SRS)	1ILM 1ILN 1Z92 2B5I 2ERJ 3IU3 3NFP
PDB (PDBSum)	1ILM 1ILN 1Z92 2B5I 2ERJ 3IU3 3NFP
PDB (IMB)	1ILM 1ILN 1Z92 2B5I 2ERJ 3IU3 3NFP
PDB (RSDB)	1ILM 1ILN 1Z92 2B5I 2ERJ 3IU3 3NFP
Human Protein Atlas	ENSG00000134460
Peptide Atlas	P01589
HPRD	00986
IPI	IPI00003101 IPI00023369 IPI00479039 IPI00644604
	Protein Interaction databases
DIP (DOE-UCLA)	P01589
IntAct (EBI)	P01589
FunCoup	ENSG00000134460
BioGRID	IL2RA
IntegromeDB	IL2RA
STRING (EMBL)	IL2RA
	Ontologies - Pathways
QuickGO	P01589
Ontology : AmiGO	inflammatory response to antigenic stimulus interleukin-2 receptor activity plasma membrane apoptotic process activation-induced cell death of T cells immune response cell surface receptor signaling pathway Notch signaling pathway drug binding cell proliferation external side of plasma membrane integral component of membrane interleukin-2 binding interleukin-2-mediated signaling pathway positive regulation of activated T cell proliferation negative regulation of T cell proliferation positive regulation of T cell differentiation regulation of T cell homeostatic proliferation negative regulation of defense response to virus negative regulation of inflammatory response negative regulation of immune response
Ontology : EGO-EBI	inflammatory response to antigenic stimulus interleukin-2 receptor activity plasma membrane apoptotic process activation-induced cell death of T cells immune response cell surface receptor signaling pathway Notch signaling pathway drug binding cell proliferation external side of plasma membrane integral component of membrane interleukin-2 binding interleukin-2-mediated signaling pathway positive regulation of activated T cell proliferation negative regulation of T cell proliferation positive regulation of T cell differentiation regulation of T cell homeostatic proliferation negative regulation of defense response to virus negative regulation of inflammatory response negative regulation of immune response
Pathways : BIOCARTA	Role of Tob in T-cell activation [Genes] IL 2 signaling pathway [Genes] IL-2 Receptor Beta Chain in T cell Activation [Genes] Th1/Th2 Differentiation [Genes]
Pathways : KEGG	Cytokine-cytokine receptor interaction Endocytosis PI3K-Akt signaling pathway Jak-STAT signaling pathway Hematopoietic cell lineage Measles HTLV-I infection
Protein Interaction Database	IL2RA
DoCM (Curated mutations)	IL2RA
Wikipedia pathways	IL2RA
	Gene fusion - rearrangements
	Polymorphisms : SNP, variants
NCBI Variation Viewer	IL2RA [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)	IL2RA
dbVar	IL2RA
ClinVar	IL2RA
1000_Genomes	IL2RA
Exome Variant Server	IL2RA
SNP (GeneSNP Utah)	IL2RA
SNP : HGBase	IL2RA
Genetic variants : HAPMAP	IL2RA
Genomic Variants (DGV)	IL2RA [DGVbeta]
	Mutations
ICGC Data Portal	ENSG00000134460
Somatic Mutations in Cancer : COSMIC	IL2RA
CONAN: Copy Number Analysis	IL2RA
LOVD (Leiden Open Variation Database)	Whole genome datasets
LOVD (Leiden Open Variation Database)	LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)	LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)	PUBLIC CCHMC Molecular Genetics Laboratory Mutation Database
Impact of mutations	[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor]
	Diseases
DECIPHER (Syndromes)	10:6052657-6104333
Mutations and Diseases : HGMD	IL2RA
OMIM	147730 601942 606367
Medgen	IL2RA
NextProt	P01589 [Medical]
GENETests	IL2RA
Disease Genetic Association	IL2RA
Huge Navigator	IL2RA [HugePedia] IL2RA [HugeCancerGEM]
snp3D : Map Gene to Disease	3559
DGIdb (Drug Gene Interaction db)	IL2RA
	General knowledge
Homologs : HomoloGene	IL2RA
Homology/Alignments : Family Browser (UCSC)	IL2RA
Phylogenetic Trees/Animal Genes : TreeFam	IL2RA
Chemical/Protein Interactions : CTD	3559
Chemical/Pharm GKB Gene	PA29828
Clinical trial	IL2RA
Cancer Resource (Charite)	ENSG00000134460
	Other databases
	Probes
	Litterature
PubMed	373 Pubmed reference(s) in Entrez
CoreMine	IL2RA
GoPubMed	IL2RA
iHOP	IL2RA

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S

Updated	12-2014	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Sat Feb 14 16:19:44 CET 2015

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