Atlas of Genetics and Cytogenetics in Oncology and Haematology

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IL2RA (interleukin 2 receptor, alpha)

Identity

Other namesCD25
IDDM10
IL2R
TCGFR
HGNC (Hugo) IL2RA
LocusID (NCBI) 3559
Location 10p15.1
Location_base_pair Starts at 6052657 and ends at 6104333 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)IL2RA   6008
Cards
Entrez_Gene (NCBI)IL2RA  3559  interleukin 2 receptor, alpha
GeneCards (Weizmann)IL2RA
Ensembl hg19 (Hinxton)ENSG00000134460 [Gene_View]  chr10:6052657-6104333 [Contig_View]  IL2RA [Vega]
Ensembl hg38 (Hinxton)ENSG00000134460 [Gene_View]  chr10:6052657-6104333 [Contig_View]  IL2RA [Vega]
ICGC DataPortalENSG00000134460
cBioPortalIL2RA
AceView (NCBI)IL2RA
Genatlas (Paris)IL2RA
WikiGenes3559
SOURCE (Princeton)IL2RA
Genomic and cartography
GoldenPath hg19 (UCSC)IL2RA  -     chr10:6052657-6104333 -  10p15.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)IL2RA  -     10p15.1   [Description]    (hg38-Dec_2013)
EnsemblIL2RA - 10p15.1 [CytoView hg19]  IL2RA - 10p15.1 [CytoView hg38]
Mapping of homologs : NCBIIL2RA [Mapview hg19]  IL2RA [Mapview hg38]
OMIM147730   601942   606367   
Gene and transcription
Genbank (Entrez)AF008556 AK223313 AK313847 BC152889 BC156627
RefSeq transcript (Entrez)NM_000417
RefSeq genomic (Entrez)AC_000142 NC_000010 NC_018921 NG_007403 NT_008705 NW_001837931 NW_004929370
Consensus coding sequences : CCDS (NCBI)IL2RA
Cluster EST : UnigeneHs.231367 [ NCBI ]
CGAP (NCI)Hs.231367
Alternative Splicing : Fast-db (Paris)GSHG0003847
Alternative Splicing GalleryENSG00000134460
Gene ExpressionIL2RA [ NCBI-GEO ]     IL2RA [ SEEK ]   IL2RA [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP01589 (Uniprot)
NextProtP01589  [Medical]
With graphics : InterProP01589
Splice isoforms : SwissVarP01589 (Swissvar)
Domaine pattern : Prosite (Expaxy)SUSHI (PS50923)   
Domains : Interpro (EBI)IL-2_rcpt_alpha    Sushi_SCR_CCP   
Related proteins : CluSTrP01589
Domain families : Pfam (Sanger)Sushi (PF00084)   
Domain families : Pfam (NCBI)pfam00084   
Domain families : Smart (EMBL)CCP (SM00032)  
DMDM Disease mutations3559
Blocks (Seattle)P01589
PDB (SRS)1ILM    1ILN    1Z92    2B5I    2ERJ    3IU3    3NFP   
PDB (PDBSum)1ILM    1ILN    1Z92    2B5I    2ERJ    3IU3    3NFP   
PDB (IMB)1ILM    1ILN    1Z92    2B5I    2ERJ    3IU3    3NFP   
PDB (RSDB)1ILM    1ILN    1Z92    2B5I    2ERJ    3IU3    3NFP   
Human Protein AtlasENSG00000134460
Peptide AtlasP01589
HPRD00986
IPIIPI00003101   IPI00023369   IPI00479039   IPI00644604   
Protein Interaction databases
DIP (DOE-UCLA)P01589
IntAct (EBI)P01589
FunCoupENSG00000134460
BioGRIDIL2RA
IntegromeDBIL2RA
STRING (EMBL)IL2RA
Ontologies - Pathways
QuickGOP01589
Ontology : AmiGOinflammatory response to antigenic stimulus  interleukin-2 receptor activity  plasma membrane  apoptotic process  activation-induced cell death of T cells  immune response  cell surface receptor signaling pathway  Notch signaling pathway  drug binding  cell proliferation  external side of plasma membrane  integral component of membrane  interleukin-2 binding  interleukin-2-mediated signaling pathway  positive regulation of activated T cell proliferation  negative regulation of T cell proliferation  positive regulation of T cell differentiation  regulation of T cell homeostatic proliferation  negative regulation of defense response to virus  negative regulation of inflammatory response  negative regulation of immune response  
Ontology : EGO-EBIinflammatory response to antigenic stimulus  interleukin-2 receptor activity  plasma membrane  apoptotic process  activation-induced cell death of T cells  immune response  cell surface receptor signaling pathway  Notch signaling pathway  drug binding  cell proliferation  external side of plasma membrane  integral component of membrane  interleukin-2 binding  interleukin-2-mediated signaling pathway  positive regulation of activated T cell proliferation  negative regulation of T cell proliferation  positive regulation of T cell differentiation  regulation of T cell homeostatic proliferation  negative regulation of defense response to virus  negative regulation of inflammatory response  negative regulation of immune response  
Pathways : BIOCARTARole of Tob in T-cell activation [Genes]    IL 2 signaling pathway [Genes]    IL-2 Receptor Beta Chain in T cell Activation [Genes]    Th1/Th2 Differentiation [Genes]   
Pathways : KEGGCytokine-cytokine receptor interaction    Endocytosis    PI3K-Akt signaling pathway    Jak-STAT signaling pathway    Hematopoietic cell lineage    Measles    HTLV-I infection   
Protein Interaction DatabaseIL2RA
DoCM (Curated mutations)IL2RA
Wikipedia pathwaysIL2RA
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerIL2RA [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IL2RA
dbVarIL2RA
ClinVarIL2RA
1000_GenomesIL2RA 
Exome Variant ServerIL2RA
SNP (GeneSNP Utah)IL2RA
SNP : HGBaseIL2RA
Genetic variants : HAPMAPIL2RA
Genomic VariantsIL2RA  IL2RA [DGVbeta]
Mutations
ICGC Data PortalENSG00000134460 
Somatic Mutations in Cancer : COSMICIL2RA 
CONAN: Copy Number AnalysisIL2RA 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)**PUBLIC** CCHMC Molecular Genetics Laboratory Mutation Database
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)10:6052657-6104333
Mutations and Diseases : HGMDIL2RA
OMIM147730    601942    606367   
MedgenIL2RA
NextProtP01589 [Medical]
GENETestsIL2RA
Disease Genetic AssociationIL2RA
Huge Navigator IL2RA [HugePedia]  IL2RA [HugeCancerGEM]
snp3D : Map Gene to Disease3559
DGIdb (Drug Gene Interaction db)IL2RA
General knowledge
Homologs : HomoloGeneIL2RA
Homology/Alignments : Family Browser (UCSC)IL2RA
Phylogenetic Trees/Animal Genes : TreeFamIL2RA
Chemical/Protein Interactions : CTD3559
Chemical/Pharm GKB GenePA29828
Clinical trialIL2RA
Cancer Resource (Charite)ENSG00000134460
Other databases
Probes
Litterature
PubMed373 Pubmed reference(s) in Entrez
CoreMineIL2RA
GoPubMedIL2RA
iHOPIL2RA
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2014Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Dec 20 22:09:33 CET 2014
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