Atlas of Genetics and Cytogenetics in Oncology and Haematology

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IL2RA (interleukin 2 receptor subunit alpha)

Identity

Alias_namesIL2R
IDDM10
insulin-dependent diabetes mellitus 10
interleukin 2 receptor, alpha
Alias_symbol (synonym)CD25
Other aliasIMD41
TCGFR
p55
HGNC (Hugo) IL2RA
LocusID (NCBI) 3559
Atlas_Id 40957
Location 10p15.1  [Link to chromosome band 10p15]
Location_base_pair Starts at 6010694 and ends at 6062370 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(6;14)(p25.3;q11.2) TRA/IRF4

External links

Nomenclature
HGNC (Hugo)IL2RA   6008
LRG (Locus Reference Genomic)LRG_73
Cards
Entrez_Gene (NCBI)IL2RA  3559  interleukin 2 receptor subunit alpha
AliasesCD25; IDDM10; IL2R; IMD41; 
TCGFR; p55
GeneCards (Weizmann)IL2RA
Ensembl hg19 (Hinxton)ENSG00000134460 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000134460 [Gene_View]  chr10:6010694-6062370 [Contig_View]  IL2RA [Vega]
ICGC DataPortalENSG00000134460
TCGA cBioPortalIL2RA
AceView (NCBI)IL2RA
Genatlas (Paris)IL2RA
WikiGenes3559
SOURCE (Princeton)IL2RA
Genetics Home Reference (NIH)IL2RA
Genomic and cartography
GoldenPath hg38 (UCSC)IL2RA  -     chr10:6010694-6062370 -  10p15.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)IL2RA  -     10p15.1   [Description]    (hg19-Feb_2009)
EnsemblIL2RA - 10p15.1 [CytoView hg19]  IL2RA - 10p15.1 [CytoView hg38]
Mapping of homologs : NCBIIL2RA [Mapview hg19]  IL2RA [Mapview hg38]
OMIM147730   601942   606367   
Gene and transcription
Genbank (Entrez)AF008556 AK223313 AK313847 CD701954 CR996090
RefSeq transcript (Entrez)NM_000417 NM_001308242 NM_001308243
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)IL2RA
Cluster EST : UnigeneHs.231367 [ NCBI ]
CGAP (NCI)Hs.231367
Alternative Splicing GalleryENSG00000134460
Gene ExpressionIL2RA [ NCBI-GEO ]   IL2RA [ EBI - ARRAY_EXPRESS ]   IL2RA [ SEEK ]   IL2RA [ MEM ]
Gene Expression Viewer (FireBrowse)IL2RA [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3559
GTEX Portal (Tissue expression)IL2RA
Human Protein AtlasENSG00000134460-IL2RA [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP01589   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP01589  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP01589
Splice isoforms : SwissVarP01589
PhosPhoSitePlusP01589
Domaine pattern : Prosite (Expaxy)SUSHI (PS50923)   
Domains : Interpro (EBI)IL-2_rcpt_alpha    Sushi_SCR_CCP_dom   
Domain families : Pfam (Sanger)Sushi (PF00084)   
Domain families : Pfam (NCBI)pfam00084   
Domain families : Smart (EMBL)CCP (SM00032)  
Conserved Domain (NCBI)IL2RA
DMDM Disease mutations3559
Blocks (Seattle)IL2RA
PDB (SRS)1ILM    1ILN    1Z92    2B5I    2ERJ    3IU3    3NFP   
PDB (PDBSum)1ILM    1ILN    1Z92    2B5I    2ERJ    3IU3    3NFP   
PDB (IMB)1ILM    1ILN    1Z92    2B5I    2ERJ    3IU3    3NFP   
PDB (RSDB)1ILM    1ILN    1Z92    2B5I    2ERJ    3IU3    3NFP   
Structural Biology KnowledgeBase1ILM    1ILN    1Z92    2B5I    2ERJ    3IU3    3NFP   
SCOP (Structural Classification of Proteins)1ILM    1ILN    1Z92    2B5I    2ERJ    3IU3    3NFP   
CATH (Classification of proteins structures)1ILM    1ILN    1Z92    2B5I    2ERJ    3IU3    3NFP   
SuperfamilyP01589
Human Protein Atlas [tissue]ENSG00000134460-IL2RA [tissue]
Peptide AtlasP01589
HPRD00986
IPIIPI00003101   IPI00023369   IPI00479039   IPI00644604   
Protein Interaction databases
DIP (DOE-UCLA)P01589
IntAct (EBI)P01589
FunCoupENSG00000134460
BioGRIDIL2RA
STRING (EMBL)IL2RA
ZODIACIL2RA
Ontologies - Pathways
QuickGOP01589
Ontology : AmiGOMAPK cascade  inflammatory response to antigenic stimulus  regulation of T cell tolerance induction  interleukin-2 receptor activity  Ras guanyl-nucleotide exchange factor activity  protein binding  intracellular  plasma membrane  apoptotic process  activation-induced cell death of T cells  inflammatory response  immune response  cell surface receptor signaling pathway  Notch signaling pathway  drug binding  cell proliferation  external side of plasma membrane  integral component of membrane  cytokine-mediated signaling pathway  interleukin-2 binding  interleukin-2-mediated signaling pathway  positive regulation of activated T cell proliferation  negative regulation of T cell proliferation  positive regulation of T cell differentiation  regulation of regulatory T cell differentiation  regulation of T cell homeostatic proliferation  negative regulation of defense response to virus  negative regulation of inflammatory response  negative regulation of immune response  regulation of molecular function  
Ontology : EGO-EBIMAPK cascade  inflammatory response to antigenic stimulus  regulation of T cell tolerance induction  interleukin-2 receptor activity  Ras guanyl-nucleotide exchange factor activity  protein binding  intracellular  plasma membrane  apoptotic process  activation-induced cell death of T cells  inflammatory response  immune response  cell surface receptor signaling pathway  Notch signaling pathway  drug binding  cell proliferation  external side of plasma membrane  integral component of membrane  cytokine-mediated signaling pathway  interleukin-2 binding  interleukin-2-mediated signaling pathway  positive regulation of activated T cell proliferation  negative regulation of T cell proliferation  positive regulation of T cell differentiation  regulation of regulatory T cell differentiation  regulation of T cell homeostatic proliferation  negative regulation of defense response to virus  negative regulation of inflammatory response  negative regulation of immune response  regulation of molecular function  
Pathways : BIOCARTARole of Tob in T-cell activation [Genes]    IL 2 signaling pathway [Genes]    IL-2 Receptor Beta Chain in T cell Activation [Genes]    Th1/Th2 Differentiation [Genes]   
Pathways : KEGGHematopoietic cell lineage    Jak-STAT signaling pathway    Cytokine-cytokine receptor interaction   
NDEx NetworkIL2RA
Atlas of Cancer Signalling NetworkIL2RA
Wikipedia pathwaysIL2RA
Orthology - Evolution
OrthoDB3559
GeneTree (enSembl)ENSG00000134460
Phylogenetic Trees/Animal Genes : TreeFamIL2RA
HOVERGENP01589
HOGENOMP01589
Homologs : HomoloGeneIL2RA
Homology/Alignments : Family Browser (UCSC)IL2RA
Gene fusions - Rearrangements
Fusion : QuiverIL2RA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIL2RA [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IL2RA
dbVarIL2RA
ClinVarIL2RA
1000_GenomesIL2RA 
Exome Variant ServerIL2RA
ExAC (Exome Aggregation Consortium)ENSG00000134460
GNOMAD BrowserENSG00000134460
Genetic variants : HAPMAP3559
Genomic Variants (DGV)IL2RA [DGVbeta]
DECIPHERIL2RA [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisIL2RA 
Mutations
ICGC Data PortalIL2RA 
TCGA Data PortalIL2RA 
Broad Tumor PortalIL2RA
OASIS PortalIL2RA [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIL2RA  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDIL2RA
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)**PUBLIC** CCHMC Molecular Genetics Laboratory Mutation Database
BioMutasearch IL2RA
DgiDB (Drug Gene Interaction Database)IL2RA
DoCM (Curated mutations)IL2RA (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)IL2RA (select a term)
intoGenIL2RA
Cancer3DIL2RA(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM147730    601942    606367   
Orphanet17820    11710    11709   
DisGeNETIL2RA
MedgenIL2RA
Genetic Testing Registry IL2RA
NextProtP01589 [Medical]
TSGene3559
GENETestsIL2RA
Target ValidationIL2RA
Huge Navigator IL2RA [HugePedia]
snp3D : Map Gene to Disease3559
BioCentury BCIQIL2RA
ClinGenIL2RA
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3559
Chemical/Pharm GKB GenePA29828
Clinical trialIL2RA
Miscellaneous
canSAR (ICR)IL2RA (select the gene name)
Probes
Litterature
PubMed482 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineIL2RA
EVEXIL2RA
GoPubMedIL2RA
iHOPIL2RA
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Jun 18 19:25:49 CEST 2018
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