Atlas of Genetics and Cytogenetics in Oncology and Haematology


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IL2RA (interleukin 2 receptor subunit alpha)

Identity

Alias (NCBI)CD25
IDDM10
IL2R
IMD41
TCGFR
p55
HGNC (Hugo) IL2RA
HGNC Alias symbCD25
HGNC Previous nameIL2R
 IDDM10
HGNC Previous nameinsulin-dependent diabetes mellitus 10
 interleukin 2 receptor, alpha
LocusID (NCBI) 3559
Atlas_Id 40957
Location 10p15.1  [Link to chromosome band 10p15]
Location_base_pair Starts at 6010692 and ends at 6062367 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(6;14)(p25.3;q11.2) TRA/IRF4


External links

 

Nomenclature
HGNC (Hugo)IL2RA   6008
LRG (Locus Reference Genomic)LRG_73
Cards
Entrez_Gene (NCBI)IL2RA    interleukin 2 receptor subunit alpha
AliasesCD25; IDDM10; IL2R; IMD41; 
TCGFR; p55
GeneCards (Weizmann)IL2RA
Ensembl hg19 (Hinxton)ENSG00000134460 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000134460 [Gene_View]  ENSG00000134460 [Sequence]  chr10:6010692-6062367 [Contig_View]  IL2RA [Vega]
ICGC DataPortalENSG00000134460
TCGA cBioPortalIL2RA
AceView (NCBI)IL2RA
Genatlas (Paris)IL2RA
SOURCE (Princeton)IL2RA
Genetics Home Reference (NIH)IL2RA
Genomic and cartography
GoldenPath hg38 (UCSC)IL2RA  -     chr10:6010692-6062367 -  10p15.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)IL2RA  -     10p15.1   [Description]    (hg19-Feb_2009)
GoldenPathIL2RA - 10p15.1 [CytoView hg19]  IL2RA - 10p15.1 [CytoView hg38]
ImmunoBaseENSG00000134460
Genome Data Viewer NCBIIL2RA [Mapview hg19]  
OMIM147730   601942   606367   
Gene and transcription
Genbank (Entrez)AF008556 AK223313 AK313847 CD701954 CR996090
RefSeq transcript (Entrez)NM_000417 NM_001308242 NM_001308243
Consensus coding sequences : CCDS (NCBI)IL2RA
Gene ExpressionIL2RA [ NCBI-GEO ]   IL2RA [ EBI - ARRAY_EXPRESS ]   IL2RA [ SEEK ]   IL2RA [ MEM ]
Gene Expression Viewer (FireBrowse)IL2RA [ Firebrowse - Broad ]
GenevisibleExpression of IL2RA in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3559
GTEX Portal (Tissue expression)IL2RA
Human Protein AtlasENSG00000134460-IL2RA [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP01589   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP01589  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP01589
PhosPhoSitePlusP01589
Domaine pattern : Prosite (Expaxy)SUSHI (PS50923)   
Domains : Interpro (EBI)IL-2_rcpt_alpha    Sushi/SCR/CCP_sf    Sushi_SCR_CCP_dom   
Domain families : Pfam (Sanger)Sushi (PF00084)   
Domain families : Pfam (NCBI)pfam00084   
Domain families : Smart (EMBL)CCP (SM00032)  
Conserved Domain (NCBI)IL2RA
PDB (RSDB)1ILM    1ILN    1Z92    2B5I    2ERJ    3IU3    3NFP    6VWU   
PDB Europe1ILM    1ILN    1Z92    2B5I    2ERJ    3IU3    3NFP    6VWU   
PDB (PDBSum)1ILM    1ILN    1Z92    2B5I    2ERJ    3IU3    3NFP    6VWU   
PDB (IMB)1ILM    1ILN    1Z92    2B5I    2ERJ    3IU3    3NFP    6VWU   
Structural Biology KnowledgeBase1ILM    1ILN    1Z92    2B5I    2ERJ    3IU3    3NFP    6VWU   
SCOP (Structural Classification of Proteins)1ILM    1ILN    1Z92    2B5I    2ERJ    3IU3    3NFP    6VWU   
CATH (Classification of proteins structures)1ILM    1ILN    1Z92    2B5I    2ERJ    3IU3    3NFP    6VWU   
SuperfamilyP01589
AlphaFold pdb e-kbP01589   
Human Protein Atlas [tissue]ENSG00000134460-IL2RA [tissue]
HPRD00986
Protein Interaction databases
DIP (DOE-UCLA)P01589
IntAct (EBI)P01589
BioGRIDIL2RA
STRING (EMBL)IL2RA
ZODIACIL2RA
Ontologies - Pathways
QuickGOP01589
Ontology : AmiGOMAPK cascade  inflammatory response to antigenic stimulus  regulation of T cell tolerance induction  interleukin-2 receptor activity  protein binding  plasma membrane  interleukin-2 receptor complex  apoptotic process  activation-induced cell death of T cells  inflammatory response  immune response  cell surface receptor signaling pathway  Notch signaling pathway  external side of plasma membrane  cytokine-mediated signaling pathway  interleukin-2 binding  interleukin-2-mediated signaling pathway  positive regulation of activated T cell proliferation  negative regulation of T cell proliferation  positive regulation of T cell differentiation  regulation of regulatory T cell differentiation  regulation of T cell homeostatic proliferation  negative regulation of inflammatory response  
Ontology : EGO-EBIMAPK cascade  inflammatory response to antigenic stimulus  regulation of T cell tolerance induction  interleukin-2 receptor activity  protein binding  plasma membrane  interleukin-2 receptor complex  apoptotic process  activation-induced cell death of T cells  inflammatory response  immune response  cell surface receptor signaling pathway  Notch signaling pathway  external side of plasma membrane  cytokine-mediated signaling pathway  interleukin-2 binding  interleukin-2-mediated signaling pathway  positive regulation of activated T cell proliferation  negative regulation of T cell proliferation  positive regulation of T cell differentiation  regulation of regulatory T cell differentiation  regulation of T cell homeostatic proliferation  negative regulation of inflammatory response  
Pathways : BIOCARTARole of Tob in T-cell activation [Genes]    IL 2 signaling pathway [Genes]    IL-2 Receptor Beta Chain in T cell Activation [Genes]    Th1/Th2 Differentiation [Genes]   
Pathways : KEGGCytokine-cytokine receptor interaction    Endocytosis    PI3K-Akt signaling pathway    Jak-STAT signaling pathway    Hematopoietic cell lineage    Measles    HTLV-I infection   
NDEx NetworkIL2RA
Atlas of Cancer Signalling NetworkIL2RA
Wikipedia pathwaysIL2RA
Orthology - Evolution
OrthoDB3559
GeneTree (enSembl)ENSG00000134460
Phylogenetic Trees/Animal Genes : TreeFamIL2RA
Homologs : HomoloGeneIL2RA
Homology/Alignments : Family Browser (UCSC)IL2RA
Gene fusions - Rearrangements
Fusion : QuiverIL2RA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIL2RA [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IL2RA
dbVarIL2RA
ClinVarIL2RA
MonarchIL2RA
1000_GenomesIL2RA 
Exome Variant ServerIL2RA
GNOMAD BrowserENSG00000134460
Varsome BrowserIL2RA
ACMGIL2RA variants
VarityP01589
Genomic Variants (DGV)IL2RA [DGVbeta]
DECIPHERIL2RA [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisIL2RA 
Mutations
ICGC Data PortalIL2RA 
TCGA Data PortalIL2RA 
Broad Tumor PortalIL2RA
OASIS PortalIL2RA [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIL2RA  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DIL2RA
Mutations and Diseases : HGMDIL2RA
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaIL2RA
DgiDB (Drug Gene Interaction Database)IL2RA
DoCM (Curated mutations)IL2RA
CIViC (Clinical Interpretations of Variants in Cancer)IL2RA
Cancer3DIL2RA
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM147730    601942    606367   
Orphanet17820    11710    11709   
DisGeNETIL2RA
MedgenIL2RA
Genetic Testing Registry IL2RA
NextProtP01589 [Medical]
GENETestsIL2RA
Target ValidationIL2RA
Huge Navigator IL2RA [HugePedia]
ClinGenIL2RA
Clinical trials, drugs, therapy
MyCancerGenomeIL2RA
Protein Interactions : CTDIL2RA
Pharm GKB GenePA29828
PharosP01589
Clinical trialIL2RA
Miscellaneous
canSAR (ICR)IL2RA
HarmonizomeIL2RA
DataMed IndexIL2RA
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXIL2RA
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 15:13:50 CEST 2021

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